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Risk Assessment of CHD Using Retinal Images with Machine Learning Approaches for People with Cardiometabolic Disorders

Yimin Qu Orcid Logo, Jack Jock-Wai Lee, Yuanyuan Zhuo Orcid Logo, Shukai Liu, Becky Thomas, David Owens Orcid Logo, Benny Chung-Ying Zee Orcid Logo

Journal of Clinical Medicine, Volume: 11, Issue: 10, Start page: 2687

Swansea University Authors: Becky Thomas, David Owens Orcid Logo

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DOI (Published version): 10.3390/jcm11102687

Abstract

Background: Coronary heart disease (CHD) is the leading cause of death worldwide, constituting a growing health and social burden. People with cardiometabolic disorders are more likely to develop CHD. Retinal image analysis is a novel and noninvasive method to assess microvascular function. We aim t...

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Published in: Journal of Clinical Medicine
ISSN: 2077-0383
Published: MDPI AG 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa60527
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Abstract: Background: Coronary heart disease (CHD) is the leading cause of death worldwide, constituting a growing health and social burden. People with cardiometabolic disorders are more likely to develop CHD. Retinal image analysis is a novel and noninvasive method to assess microvascular function. We aim to investigate whether retinal images can be used for CHD risk estimation for people with cardiometabolic disorders. Methods: We have conducted a case–control study at Shenzhen Traditional Chinese Medicine Hospital, where 188 CHD patients and 128 controls with cardiometabolic disorders were recruited. Retinal images were captured within two weeks of admission. The retinal characteristics were estimated by the automatic retinal imaging analysis (ARIA) algorithm. Risk estimation models were established for CHD patients using machine learning approaches. We divided CHD patients into a diabetes group and a non-diabetes group for sensitivity analysis. A ten-fold cross-validation method was used to validate the results. Results: The sensitivity and specificity were 81.3% and 88.3%, respectively, with an accuracy of 85.4% for CHD risk estimation. The risk estimation model for CHD with diabetes performed better than the model for CHD without diabetes. Conclusions: The ARIA algorithm can be used as a risk assessment tool for CHD for people with cardiometabolic disorders.
Keywords: coronary heart disease; retinal images; machine learning; cardiometabolic disorders
College: Swansea University Medical School
Funders: This study was supported by the General Research Fund (GRF) of the Research Grant Council Hong Kong (RGC Ref No. 14139116) and the Shenzhen Science and Technology Innovation Commission (No: KCXFZ20201221173208024)
Issue: 10
Start Page: 2687