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New insights into the genetic etiology of Alzheimer’s disease and related dementias

Céline Bellenguez Orcid Logo, Fahri Küçükali Orcid Logo, Iris E. Jansen, Luca Kleineidam, Sonia Moreno-Grau, Najaf Amin Orcid Logo, Adam C. Naj, Rafael Campos-Martin, Benjamin Grenier-Boley, Victor Andrade, Peter A. Holmans Orcid Logo, Anne Boland, Vincent Damotte, Sven J. van der Lee Orcid Logo, Marcos R. Costa Orcid Logo, Teemu Kuulasmaa Orcid Logo, Qiong Yang Orcid Logo, Itziar de Rojas Orcid Logo, Joshua C. Bis Orcid Logo, Amber Yaqub Orcid Logo, Ivana Prokic Orcid Logo, Julien Chapuis Orcid Logo, Shahzad Ahmad Orcid Logo, Vilmantas Giedraitis Orcid Logo, Dag Aarsland, Pablo Garcia-Gonzalez Orcid Logo, Carla Abdelnour, Emilio Alarcón-Martín, Daniel Alcolea Orcid Logo, Montserrat Alegret, Ignacio Alvarez Orcid Logo, Victoria Álvarez, Nicola J. Armstrong, Anthoula Tsolaki Orcid Logo, Carmen Antúnez, Ildebrando Appollonio, Marina Arcaro, Silvana Archetti, Alfonso Arias Pastor, Beatrice Arosio, Lavinia Athanasiu, Henri Bailly, Nerisa Banaj, Miquel Baquero Orcid Logo, Sandra Barral, Alexa Beiser, Ana Belén Pastor Orcid Logo, Jennifer E. Below, Penelope Benchek, Luisa Benussi, Claudine Berr Orcid Logo, Céline Besse, Valentina Bessi Orcid Logo, Giuliano Binetti, Alessandra Bizarro, Rafael Blesa, Mercè Boada Orcid Logo, Eric Boerwinkle, Barbara Borroni, Silvia Boschi, Paola Bossù Orcid Logo, Geir Bråthen Orcid Logo, Jan Bressler Orcid Logo, Catherine Bresner Orcid Logo, Henry Brodaty Orcid Logo, Keeley J. Brookes Orcid Logo, Luis Ignacio Brusco, Dolores Buiza-Rueda, Katharina Bûrger, Vanessa Burholt Orcid Logo, William S. Bush Orcid Logo, Miguel Calero Orcid Logo, Laura B. Cantwell, Geneviève Chene, Jaeyoon Chung Orcid Logo, Michael L. Cuccaro, Ángel Carracedo, Roberta Cecchetti, Laura Cervera-Carles Orcid Logo, Camille Charbonnier, Hung-Hsin Chen, Caterina Chillotti, Simona Ciccone, Jurgen A. H. R. Claassen, Christopher Clark, Elisa Conti, Anaïs Corma-Gómez, Emanuele Costantini Orcid Logo, Carlo Custodero, Delphine Daian, Maria Carolina Dalmasso Orcid Logo, Antonio Daniele, Efthimios Dardiotis, Jean-François Dartigues, Peter Paul de Deyn, Katia de Paiva Lopes Orcid Logo, Lot D. de Witte Orcid Logo, Stéphanie Debette Orcid Logo, Jürgen Deckert, Teodoro del Ser Orcid Logo, Nicola Denning, Anita DeStefano, Martin Dichgans Orcid Logo, Janine Diehl-Schmid Orcid Logo, Mónica Diez-Fairen Orcid Logo, Paolo Dionigi Rossi, Srdjan Djurovic Orcid Logo, Emmanuelle Duron, Emrah Düzel, Carole Dufouil Orcid Logo, Gudny Eiriksdottir, Sebastiaan Engelborghs, Valentina Escott-Price Orcid Logo, Ana Espinosa, Michael Ewers Orcid Logo, Kelley M. Faber, Tagliavini Fabrizio Orcid Logo, Sune Fallgaard Nielsen, David W. Fardo, Lucia Farotti, Chiara Fenoglio, Marta Fernández-Fuertes, Raffaele Ferrari, Catarina B. Ferreira, Evelyn Ferri, Bertrand Fin, Peter Fischer, Tormod Fladby Orcid Logo, Klaus Fließbach, Bernard Fongang, Myriam Fornage Orcid Logo, Juan Fortea, Tatiana M. Foroud, Silvia Fostinelli, Nick C. Fox Orcid Logo, Emlio Franco-Macías, María J. Bullido Orcid Logo, Ana Frank-García, Lutz Froelich Orcid Logo, Brian Fulton-Howard, Daniela Galimberti Orcid Logo, Jose Maria García-Alberca Orcid Logo, Pablo García-González, Sebastian Garcia-Madrona, Guillermo Garcia-Ribas, Roberta Ghidoni, Ina Giegling, Giaccone Giorgio, Alison M. Goate Orcid Logo, Oliver Goldhardt, Duber Gomez-Fonseca, Antonio González-Pérez Orcid Logo, Caroline Graff, Giulia Grande, Emma Green Orcid Logo, Timo Grimmer, Edna Grünblatt Orcid Logo, Michelle Grunin, Vilmundur Gudnason Orcid Logo, Tamar Guetta-Baranes, Annakaisa Haapasalo Orcid Logo, Georgios Hadjigeorgiou, Jonathan L. Haines, Kara L. Hamilton-Nelson, Harald Hampel, Olivier Hanon, John Hardy, Annette M. Hartmann, Lucrezia Hausner, Janet Harwood Orcid Logo, Stefanie Heilmann-Heimbach Orcid Logo, Seppo Helisalmi, Michael T. Heneka, Isabel Hernández, Martin J. Herrmann Orcid Logo, Per Hoffmann, Clive Holmes, Henne Holstege Orcid Logo, Raquel Huerto Vilas, Marc Hulsman, Jack Humphrey, Geert Jan Biessels Orcid Logo, Xueqiu Jian Orcid Logo, Charlotte Johansson Orcid Logo, Gyungah R. Jun Orcid Logo, Yuriko Kastumata Orcid Logo, John Kauwe, Patrick G. Kehoe Orcid Logo, Lena Kilander, Anne Kinhult Ståhlbom, Miia Kivipelto, Anne Koivisto, Johannes Kornhuber Orcid Logo, Mary H. Kosmidis Orcid Logo, Walter A. Kukull, Pavel P. Kuksa, Brian W. Kunkle, Amanda B. Kuzma, Carmen Lage Orcid Logo, Erika J. Laukka, Lenore Launer Orcid Logo, Alessandra Lauria, Chien-Yueh Lee Orcid Logo, Jenni Lehtisalo, Ondrej Lerch, Alberto Lleó Orcid Logo, William Longstreth, Oscar Lopez Orcid Logo, Adolfo Lopez de Munain Orcid Logo, Seth Love, Malin Löwemark, Lauren Luckcuck, Kathryn L. Lunetta Orcid Logo, Yiyi Ma Orcid Logo, Juan Macías, Catherine A. MacLeod Orcid Logo, Wolfgang Maier, Francesca Mangialasche, Marco Spallazzi, Marta Marquié Orcid Logo, Rachel Marshall, Eden R. Martin, Angel Martín Montes Orcid Logo, Carmen Martínez Rodríguez, Carlo Masullo, Richard Mayeux, Simon Mead Orcid Logo, Patrizia Mecocci, Miguel Medina Orcid Logo, Alun Meggy, Shima Mehrabian, Silvia Mendoza, Manuel Menéndez-González Orcid Logo, Pablo Mir, Susanne Moebus, Merel Mol Orcid Logo, Laura Molina-Porcel, Laura Montrreal, Laura Morelli, Fermin Moreno, Kevin Morgan Orcid Logo, Thomas Mosley, Markus M. Nöthen Orcid Logo, Carolina Muchnik Orcid Logo, Shubhabrata Mukherjee, Benedetta Nacmias Orcid Logo, Tiia Ngandu, Gael Nicolas Orcid Logo, Børge G. Nordestgaard Orcid Logo, Robert Olaso, Adelina Orellana, Michela Orsini, Gemma Ortega, Alessandro Padovani, Caffarra Paolo, Goran Papenberg, Lucilla Parnetti, Florence Pasquier Orcid Logo, Pau Pastor Orcid Logo, Gina Peloso Orcid Logo, Alba Pérez-Cordón Orcid Logo, Jordi Pérez-Tur Orcid Logo, Pierre Pericard Orcid Logo, Oliver Peters, Yolande A. L. Pijnenburg, Juan A. Pineda Orcid Logo, Gerard Piñol-Ripoll, Claudia Pisanu Orcid Logo, Thomas Polak, Julius Popp, Danielle Posthuma Orcid Logo, Josef Priller, Raquel Puerta Orcid Logo, Olivier Quenez Orcid Logo, Inés Quintela, Jesper Qvist Thomassen Orcid Logo, Alberto Rábano, Innocenzo Rainero, Farid Rajabli, Inez Ramakers, Luis M. Real Orcid Logo, Marcel J. T. Reinders Orcid Logo, Christiane Reitz Orcid Logo, Dolly Reyes-Dumeyer, Perry Ridge, Steffi Riedel-Heller Orcid Logo, Peter Riederer, Natalia Roberto, Eloy Rodriguez-Rodriguez Orcid Logo, Arvid Rongve Orcid Logo, Irene Rosas Allende, Maitée Rosende-Roca, Jose Luis Royo, Elisa Rubino, Dan Rujescu, María Eugenia Sáez Orcid Logo, Paraskevi Sakka, Ingvild Saltvedt Orcid Logo, Ángela Sanabria, María Bernal Sánchez-Arjona, Florentino Sanchez-Garcia, Pascual Sánchez Juan Orcid Logo, Raquel Sánchez-Valle, Sigrid B. Sando, Chloé Sarnowski Orcid Logo, Claudia L. Satizabal Orcid Logo, Michela Scamosci, Nikolaos Scarmeas, Elio Scarpini, Philip Scheltens, Norbert Scherbaum, Martin Scherer, Matthias Schmid, Anja Schneider, Jonathan M. Schott Orcid Logo, Geir Selbæk Orcid Logo, Davide Seripa, Manuel Serrano, Jin Sha, Alexey A. Shadrin Orcid Logo, Olivia Skrobot, Susan Slifer, Gijsje J. L. Snijders, Hilkka Soininen Orcid Logo, Vincenzo Solfrizzi Orcid Logo, Alina Solomon, Yeunjoo Song Orcid Logo, Sandro Sorbi, Oscar Sotolongo-Grau Orcid Logo, Gianfranco Spalletta Orcid Logo, Annika Spottke, Alessio Squassina Orcid Logo, Eystein Stordal Orcid Logo, Juan Pablo Tartan, Lluís Tárraga, Niccolo Tesí, Anbupalam Thalamuthu, Tegos Thomas, Giuseppe Tosto Orcid Logo, Latchezar Traykov, Lucio Tremolizzo, Anne Tybjærg-Hansen, Andre Uitterlinden Orcid Logo, Abbe Ullgren, Ingun Ulstein, Sergi Valero, Otto Valladares Orcid Logo, Christine Van Broeckhoven Orcid Logo, Jeffery Vance, Badri N. Vardarajan, Aad van der Lugt, Jasper Van Dongen, Jeroen van Rooij, John van Swieten, Rik Vandenberghe, Frans Verhey, Jean-Sébastien Vidal Orcid Logo, Jonathan Vogelgsang Orcid Logo, Martin Vyhnalek, Michael Wagner Orcid Logo, David Wallon Orcid Logo, Li-San Wang, Ruiqi Wang, Leonie Weinhold, Jens Wiltfang Orcid Logo, Gill Windle, Bob Woods Orcid Logo, Mary Yannakoulia Orcid Logo, Habil Zare Orcid Logo, Yi Zhao, Xiaoling Zhang Orcid Logo, Congcong Zhu, Miren Zulaica, Jan Laczo, Vaclav Matoska, Maria Serpente, Francesca Assogna, Fabrizio Piras, Federica Piras, Valentina Ciullo, Jacob Shofany, Carlo Ferrarese, Simona Andreoni, Gessica Sala, Chiara Paola Zoia, Maria Del Zompo, Alberto Benussi, Patrizia Bastiani, Mari Takalo, Teemu Natunen, Tiina Laatikainen, Jaakko Tuomilehto, Riitta Antikainen, Timo Strandberg, Jaana Lindström, Markku Peltonen, Richard Abraham, Ammar Al-Chalabi, Nicholas J. Bass, Carol Brayne, Kristelle S. Brown, John Collinge, David Craig, Pangiotis Deloukas, Nick Fox, Amy Gerrish, Michael Gill, Rhian Gwilliam, Denise Harold, Paul Hollingworth, Jarret A. Johnston, Lesley Jones, Brian Lawlor, Gill Livingston, Simon Lovestone, Michelle Lupton, Aoibhinn Lynch, David Mann, Bernadette McGuinness, Andrew McQuillin, Michael C. O’Donovan, Michael J. Owen, Peter Passmore, John F. Powell, Petra Proitsi, Martin Rossor, Christopher E. Shaw, A. David Smith, Hugh Gurling, Stephen Todd, Catherine Mummery, Nathalie Ryan, Giordano Lacidogna, Ad Adarmes-Gómez, Ana Mauleón, Ana Pancho, Anna Gailhajenet, Asunción Lafuente, D. Macias-García, Elvira Martín, Esther Pelejà, F. Carrillo, Isabel Sastre Merlín, L. Garrote-Espina, Liliana Vargas, M. Carrion-Claro, M. Marín, Ma Labrador, Mar Buendia, María Dolores Alonso, Marina Guitart, Mariona Moreno, Marta Ibarria, Mt Periñán, Nuria Aguilera, P. Gómez-Garre, Pilar Cañabate, R. Escuela, R. Pineda-Sánchez, R. Vigo-Ortega, S. 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Nature Genetics, Volume: 54, Issue: 4, Pages: 412 - 436

Swansea University Author: Vanessa Burholt Orcid Logo

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Abstract

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘pro...

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Published in: Nature Genetics
ISSN: 1061-4036 1546-1718
Published: Springer Science and Business Media LLC 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa60592
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fullrecord <?xml version="1.0" encoding="utf-8"?><rfc1807 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><bib-version>v2</bib-version><id>60592</id><entry>2022-07-22</entry><title>New insights into the genetic etiology of Alzheimer’s disease and related dementias</title><swanseaauthors><author><sid>cf7fe9863906cd54df5b0a99904d535e</sid><ORCID>0000-0002-6789-127X</ORCID><firstname>Vanessa</firstname><surname>Burholt</surname><name>Vanessa Burholt</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2022-07-22</date><deptcode>PHAC</deptcode><abstract>Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.</abstract><type>Journal Article</type><journal>Nature Genetics</journal><volume>54</volume><journalNumber>4</journalNumber><paginationStart>412</paginationStart><paginationEnd>436</paginationEnd><publisher>Springer Science and Business Media LLC</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1061-4036</issnPrint><issnElectronic>1546-1718</issnElectronic><keywords/><publishedDay>4</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2022</publishedYear><publishedDate>2022-04-04</publishedDate><doi>10.1038/s41588-022-01024-z</doi><url/><notes/><college>COLLEGE NANME</college><department>Public Health</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>PHAC</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>This work was funded by a grant (EADB) from the EU Joint Programme – Neurodegenerative Disease Research. INSERM UMR1167 is also funded by the INSERM, Institut Pasteur de Lille, Lille Métropole Communauté Urbaine and French government’s LABEX DISTALZ program (development of innovative strategies for a transdisciplinary approach to AD).</funders><projectreference/><lastEdited>2022-10-27T15:32:42.3517882</lastEdited><Created>2022-07-22T00:35:51.2392001</Created><path><level id="1">College of Human and Health Sciences</level><level id="2">Centre for Innovative Ageing</level></path><authors><author><firstname>Céline</firstname><surname>Bellenguez</surname><orcid>0000-0002-1240-7874</orcid><order>1</order></author><author><firstname>Fahri</firstname><surname>Küçükali</surname><orcid>0000-0002-3835-9639</orcid><order>2</order></author><author><firstname>Iris E.</firstname><surname>Jansen</surname><order>3</order></author><author><firstname>Luca</firstname><surname>Kleineidam</surname><order>4</order></author><author><firstname>Sonia</firstname><surname>Moreno-Grau</surname><order>5</order></author><author><firstname>Najaf</firstname><surname>Amin</surname><orcid>0000-0002-8944-1771</orcid><order>6</order></author><author><firstname>Adam C.</firstname><surname>Naj</surname><order>7</order></author><author><firstname>Rafael</firstname><surname>Campos-Martin</surname><order>8</order></author><author><firstname>Benjamin</firstname><surname>Grenier-Boley</surname><order>9</order></author><author><firstname>Victor</firstname><surname>Andrade</surname><order>10</order></author><author><firstname>Peter A.</firstname><surname>Holmans</surname><orcid>0000-0003-0870-9412</orcid><order>11</order></author><author><firstname>Anne</firstname><surname>Boland</surname><order>12</order></author><author><firstname>Vincent</firstname><surname>Damotte</surname><order>13</order></author><author><firstname>Sven J. van der</firstname><surname>Lee</surname><orcid>0000-0003-1606-8643</orcid><order>14</order></author><author><firstname>Marcos R.</firstname><surname>Costa</surname><orcid>0000-0002-4928-2163</orcid><order>15</order></author><author><firstname>Teemu</firstname><surname>Kuulasmaa</surname><orcid>0000-0002-1795-7314</orcid><order>16</order></author><author><firstname>Qiong</firstname><surname>Yang</surname><orcid>0000-0002-3658-1375</orcid><order>17</order></author><author><firstname>Itziar de</firstname><surname>Rojas</surname><orcid>0000-0002-2148-381x</orcid><order>18</order></author><author><firstname>Joshua 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Pablo</firstname><surname>Tartan</surname><order>334</order></author><author><firstname>Lluís</firstname><surname>Tárraga</surname><order>335</order></author><author><firstname>Niccolo</firstname><surname>Tesí</surname><order>336</order></author><author><firstname>Anbupalam</firstname><surname>Thalamuthu</surname><order>337</order></author><author><firstname>Tegos</firstname><surname>Thomas</surname><order>338</order></author><author><firstname>Giuseppe</firstname><surname>Tosto</surname><orcid>0000-0001-7075-8245</orcid><order>339</order></author><author><firstname>Latchezar</firstname><surname>Traykov</surname><order>340</order></author><author><firstname>Lucio</firstname><surname>Tremolizzo</surname><order>341</order></author><author><firstname>Anne</firstname><surname>Tybjærg-Hansen</surname><order>342</order></author><author><firstname>Andre</firstname><surname>Uitterlinden</surname><orcid>0000-0002-7276-3387</orcid><order>343</order></author><author><firstname>Abbe</firstname><surname>Ullgren</surname><order>344</order></author><author><firstname>Ingun</firstname><surname>Ulstein</surname><order>345</order></author><author><firstname>Sergi</firstname><surname>Valero</surname><order>346</order></author><author><firstname>Otto</firstname><surname>Valladares</surname><orcid>0000-0001-8055-2187</orcid><order>347</order></author><author><firstname>Christine Van</firstname><surname>Broeckhoven</surname><orcid>0000-0003-0183-7665</orcid><order>348</order></author><author><firstname>Jeffery</firstname><surname>Vance</surname><order>349</order></author><author><firstname>Badri N.</firstname><surname>Vardarajan</surname><order>350</order></author><author><firstname>Aad van der</firstname><surname>Lugt</surname><order>351</order></author><author><firstname>Jasper Van</firstname><surname>Dongen</surname><order>352</order></author><author><firstname>Jeroen van</firstname><surname>Rooij</surname><order>353</order></author><author><firstname>John van</firstname><surname>Swieten</surname><order>354</order></author><author><firstname>Rik</firstname><surname>Vandenberghe</surname><order>355</order></author><author><firstname>Frans</firstname><surname>Verhey</surname><order>356</order></author><author><firstname>Jean-Sébastien</firstname><surname>Vidal</surname><orcid>0000-0001-6770-0720</orcid><order>357</order></author><author><firstname>Jonathan</firstname><surname>Vogelgsang</surname><orcid>0000-0001-9326-8193</orcid><order>358</order></author><author><firstname>Martin</firstname><surname>Vyhnalek</surname><order>359</order></author><author><firstname>Michael</firstname><surname>Wagner</surname><orcid>0000-0003-2589-6440</orcid><order>360</order></author><author><firstname>David</firstname><surname>Wallon</surname><orcid>0000-0002-2634-7198</orcid><order>361</order></author><author><firstname>Li-San</firstname><surname>Wang</surname><order>362</order></author><author><firstname>Ruiqi</firstname><surname>Wang</surname><order>363</order></author><author><firstname>Leonie</firstname><surname>Weinhold</surname><order>364</order></author><author><firstname>Jens</firstname><surname>Wiltfang</surname><orcid>0000-0003-1492-5330</orcid><order>365</order></author><author><firstname>Gill</firstname><surname>Windle</surname><order>366</order></author><author><firstname>Bob</firstname><surname>Woods</surname><orcid>0000-0002-6781-651x</orcid><order>367</order></author><author><firstname>Mary</firstname><surname>Yannakoulia</surname><orcid>0000-0003-2171-7337</orcid><order>368</order></author><author><firstname>Habil</firstname><surname>Zare</surname><orcid>0000-0001-5902-6238</orcid><order>369</order></author><author><firstname>Yi</firstname><surname>Zhao</surname><order>370</order></author><author><firstname>Xiaoling</firstname><surname>Zhang</surname><orcid>0000-0001-8237-1857</orcid><order>371</order></author><author><firstname>Congcong</firstname><surname>Zhu</surname><order>372</order></author><author><firstname>Miren</firstname><surname>Zulaica</surname><order>373</order></author><author><firstname>Jan</firstname><surname>Laczo</surname><order>374</order></author><author><firstname>Vaclav</firstname><surname>Matoska</surname><order>375</order></author><author><firstname>Maria</firstname><surname>Serpente</surname><order>376</order></author><author><firstname>Francesca</firstname><surname>Assogna</surname><order>377</order></author><author><firstname>Fabrizio</firstname><surname>Piras</surname><order>378</order></author><author><firstname>Federica</firstname><surname>Piras</surname><order>379</order></author><author><firstname>Valentina</firstname><surname>Ciullo</surname><order>380</order></author><author><firstname>Jacob</firstname><surname>Shofany</surname><order>381</order></author><author><firstname>Carlo</firstname><surname>Ferrarese</surname><order>382</order></author><author><firstname>Simona</firstname><surname>Andreoni</surname><order>383</order></author><author><firstname>Gessica</firstname><surname>Sala</surname><order>384</order></author><author><firstname>Chiara Paola</firstname><surname>Zoia</surname><order>385</order></author><author><firstname>Maria Del</firstname><surname>Zompo</surname><order>386</order></author><author><firstname>Alberto</firstname><surname>Benussi</surname><order>387</order></author><author><firstname>Patrizia</firstname><surname>Bastiani</surname><order>388</order></author><author><firstname>Mari</firstname><surname>Takalo</surname><order>389</order></author><author><firstname>Teemu</firstname><surname>Natunen</surname><order>390</order></author><author><firstname>Tiina</firstname><surname>Laatikainen</surname><order>391</order></author><author><firstname>Jaakko</firstname><surname>Tuomilehto</surname><order>392</order></author><author><firstname>Riitta</firstname><surname>Antikainen</surname><order>393</order></author><author><firstname>Timo</firstname><surname>Strandberg</surname><order>394</order></author><author><firstname>Jaana</firstname><surname>Lindström</surname><order>395</order></author><author><firstname>Markku</firstname><surname>Peltonen</surname><order>396</order></author><author><firstname>Richard</firstname><surname>Abraham</surname><order>397</order></author><author><firstname>Ammar</firstname><surname>Al-Chalabi</surname><order>398</order></author><author><firstname>Nicholas J.</firstname><surname>Bass</surname><order>399</order></author><author><firstname>Carol</firstname><surname>Brayne</surname><order>400</order></author><author><firstname>Kristelle S.</firstname><surname>Brown</surname><order>401</order></author><author><firstname>John</firstname><surname>Collinge</surname><order>402</order></author><author><firstname>David</firstname><surname>Craig</surname><order>403</order></author><author><firstname>Pangiotis</firstname><surname>Deloukas</surname><order>404</order></author><author><firstname>Nick</firstname><surname>Fox</surname><order>405</order></author><author><firstname>Amy</firstname><surname>Gerrish</surname><order>406</order></author><author><firstname>Michael</firstname><surname>Gill</surname><order>407</order></author><author><firstname>Rhian</firstname><surname>Gwilliam</surname><order>408</order></author><author><firstname>Denise</firstname><surname>Harold</surname><order>409</order></author><author><firstname>Paul</firstname><surname>Hollingworth</surname><order>410</order></author><author><firstname>Jarret A.</firstname><surname>Johnston</surname><order>411</order></author><author><firstname>Lesley</firstname><surname>Jones</surname><order>412</order></author><author><firstname>Brian</firstname><surname>Lawlor</surname><order>413</order></author><author><firstname>Gill</firstname><surname>Livingston</surname><order>414</order></author><author><firstname>Simon</firstname><surname>Lovestone</surname><order>415</order></author><author><firstname>Michelle</firstname><surname>Lupton</surname><order>416</order></author><author><firstname>Aoibhinn</firstname><surname>Lynch</surname><order>417</order></author><author><firstname>David</firstname><surname>Mann</surname><order>418</order></author><author><firstname>Bernadette</firstname><surname>McGuinness</surname><order>419</order></author><author><firstname>Andrew</firstname><surname>McQuillin</surname><order>420</order></author><author><firstname>Michael C.</firstname><surname>O’Donovan</surname><order>421</order></author><author><firstname>Michael J.</firstname><surname>Owen</surname><order>422</order></author><author><firstname>Peter</firstname><surname>Passmore</surname><order>423</order></author><author><firstname>John F.</firstname><surname>Powell</surname><order>424</order></author><author><firstname>Petra</firstname><surname>Proitsi</surname><order>425</order></author><author><firstname>Martin</firstname><surname>Rossor</surname><order>426</order></author><author><firstname>Christopher E.</firstname><surname>Shaw</surname><order>427</order></author><author><firstname>A. David</firstname><surname>Smith</surname><order>428</order></author><author><firstname>Hugh</firstname><surname>Gurling</surname><order>429</order></author><author><firstname>Stephen</firstname><surname>Todd</surname><order>430</order></author><author><firstname>Catherine</firstname><surname>Mummery</surname><order>431</order></author><author><firstname>Nathalie</firstname><surname>Ryan</surname><order>432</order></author><author><firstname>Giordano</firstname><surname>Lacidogna</surname><order>433</order></author><author><firstname>Ad</firstname><surname>Adarmes-Gómez</surname><order>434</order></author><author><firstname>Ana</firstname><surname>Mauleón</surname><order>435</order></author><author><firstname>Ana</firstname><surname>Pancho</surname><order>436</order></author><author><firstname>Anna</firstname><surname>Gailhajenet</surname><order>437</order></author><author><firstname>Asunción</firstname><surname>Lafuente</surname><order>438</order></author><author><firstname>D.</firstname><surname>Macias-García</surname><order>439</order></author><author><firstname>Elvira</firstname><surname>Martín</surname><order>440</order></author><author><firstname>Esther</firstname><surname>Pelejà</surname><order>441</order></author><author><firstname>F.</firstname><surname>Carrillo</surname><order>442</order></author><author><firstname>Isabel Sastre</firstname><surname>Merlín</surname><order>443</order></author><author><firstname>L.</firstname><surname>Garrote-Espina</surname><order>444</order></author><author><firstname>Liliana</firstname><surname>Vargas</surname><order>445</order></author><author><firstname>M.</firstname><surname>Carrion-Claro</surname><order>446</order></author><author><firstname>M.</firstname><surname>Marín</surname><order>447</order></author><author><firstname>Ma</firstname><surname>Labrador</surname><order>448</order></author><author><firstname>Mar</firstname><surname>Buendia</surname><order>449</order></author><author><firstname>María Dolores</firstname><surname>Alonso</surname><order>450</order></author><author><firstname>Marina</firstname><surname>Guitart</surname><order>451</order></author><author><firstname>Mariona</firstname><surname>Moreno</surname><order>452</order></author><author><firstname>Marta</firstname><surname>Ibarria</surname><order>453</order></author><author><firstname>Mt</firstname><surname>Periñán</surname><order>454</order></author><author><firstname>Nuria</firstname><surname>Aguilera</surname><order>455</order></author><author><firstname>P.</firstname><surname>Gómez-Garre</surname><order>456</order></author><author><firstname>Pilar</firstname><surname>Cañabate</surname><order>457</order></author><author><firstname>R.</firstname><surname>Escuela</surname><order>458</order></author><author><firstname>R.</firstname><surname>Pineda-Sánchez</surname><order>459</order></author><author><firstname>R.</firstname><surname>Vigo-Ortega</surname><order>460</order></author><author><firstname>S.</firstname><surname>Jesús</surname><order>461</order></author><author><firstname>Silvia</firstname><surname>Preckler</surname><order>462</order></author><author><firstname>Silvia</firstname><surname>Rodrigo-Herrero</surname><order>463</order></author><author><firstname>Susana</firstname><surname>Diego</surname><order>464</order></author><author><firstname>Alessandro</firstname><surname>Vacca</surname><order>465</order></author><author><firstname>Fausto</firstname><surname>Roveta</surname><order>466</order></author><author><firstname>Nicola</firstname><surname>Salvadori</surname><order>467</order></author><author><firstname>Elena</firstname><surname>Chipi</surname><order>468</order></author><author><firstname>Henning</firstname><surname>Boecker</surname><order>469</order></author><author><firstname>Christoph</firstname><surname>Laske</surname><order>470</order></author><author><firstname>Robert</firstname><surname>Perneczky</surname><order>471</order></author><author><firstname>Costas</firstname><surname>Anastasiou</surname><order>472</order></author><author><firstname>Daniel</firstname><surname>Janowitz</surname><order>473</order></author><author><firstname>Rainer</firstname><surname>Malik</surname><order>474</order></author><author><firstname>Anna</firstname><surname>Anastasiou</surname><order>475</order></author><author><firstname>Kayenat</firstname><surname>Parveen</surname><order>476</order></author><author><firstname>Carmen</firstname><surname>Lage</surname><order>477</order></author><author><firstname>Sara</firstname><surname>López-García</surname><order>478</order></author><author><firstname>Anna</firstname><surname>Antonell</surname><order>479</order></author><author><firstname>Kalina Yonkova</firstname><surname>Mihova</surname><order>480</order></author><author><firstname>Diyana</firstname><surname>Belezhanska</surname><order>481</order></author><author><firstname>Heike</firstname><surname>Weber</surname><order>482</order></author><author><firstname>Silvia</firstname><surname>Kochen</surname><order>483</order></author><author><firstname>Patricia</firstname><surname>Solis</surname><order>484</order></author><author><firstname>Nancy</firstname><surname>Medel</surname><order>485</order></author><author><firstname>Julieta</firstname><surname>Lisso</surname><order>486</order></author><author><firstname>Zulma</firstname><surname>Sevillano</surname><order>487</order></author><author><firstname>Daniel G.</firstname><surname>Politis</surname><order>488</order></author><author><firstname>Valeria</firstname><surname>Cores</surname><order>489</order></author><author><firstname>Carolina</firstname><surname>Cuesta</surname><order>490</order></author><author><firstname>Cecilia</firstname><surname>Ortiz</surname><order>491</order></author><author><firstname>Juan Ignacio</firstname><surname>Bacha</surname><order>492</order></author><author><firstname>Mario</firstname><surname>Rios</surname><order>493</order></author><author><firstname>Aldo</firstname><surname>Saenz</surname><order>494</order></author><author><firstname>Mariana Sanchez</firstname><surname>Abalos</surname><order>495</order></author><author><firstname>Eduardo</firstname><surname>Kohler</surname><order>496</order></author><author><firstname>Dana Lis</firstname><surname>Palacio</surname><order>497</order></author><author><firstname>Ignacio</firstname><surname>Etchepareborda</surname><order>498</order></author><author><firstname>Matias</firstname><surname>Kohler</surname><order>499</order></author><author><firstname>Gisela</firstname><surname>Novack</surname><order>500</order></author><author><firstname>Federico Ariel</firstname><surname>Prestia</surname><order>501</order></author><author><firstname>Pablo</firstname><surname>Galeano</surname><order>502</order></author><author><firstname>Eduardo M.</firstname><surname>Castaño</surname><order>503</order></author><author><firstname>Sandra</firstname><surname>Germani</surname><order>504</order></author><author><firstname>Carlos Reyes</firstname><surname>Toso</surname><order>505</order></author><author><firstname>Matias</firstname><surname>Rojo</surname><order>506</order></author><author><firstname>Carlos</firstname><surname>Ingino</surname><order>507</order></author><author><firstname>Carlos</firstname><surname>Mangone</surname><order>508</order></author><author><firstname>David C.</firstname><surname>Rubinsztein</surname><order>509</order></author><author><firstname>Stefan</firstname><surname>Teipel</surname><order>510</order></author><author><firstname>Nathalie</firstname><surname>Fievet</surname><order>511</order></author><author><firstname>Vincent</firstname><surname>Deramerourt</surname><order>512</order></author><author><firstname>Charlotte</firstname><surname>Forsell</surname><order>513</order></author><author><firstname>Håkan</firstname><surname>Thonberg</surname><order>514</order></author><author><firstname>Maria</firstname><surname>Bjerke</surname><order>515</order></author><author><firstname>Ellen De</firstname><surname>Roeck</surname><order>516</order></author><author><firstname>María Teresa</firstname><surname>Martínez-Larrad</surname><order>517</order></author><author><firstname>Natividad</firstname><surname>Olivar</surname><order>518</order></author><author><firstname>Nuria</firstname><surname>Aguilera</surname><order>519</order></author><author><firstname>Amanda</firstname><surname>Cano</surname><order>520</order></author><author><firstname>Pilar</firstname><surname>Cañabate</surname><order>521</order></author><author><firstname>Juan</firstname><surname>Macias</surname><order>522</order></author><author><firstname>Olalla</firstname><surname>Maroñas</surname><order>523</order></author><author><firstname>Raúl</firstname><surname>Nuñez-Llaves</surname><order>524</order></author><author><firstname>Clàudia</firstname><surname>Olivé</surname><order>525</order></author><author><firstname>Ester</firstname><surname>Pelejá</surname><order>526</order></author><author><firstname>Astrid D.</firstname><surname>Adarmes-Gómez</surname><order>527</order></author><author><firstname>María Dolores</firstname><surname>Alonso</surname><order>528</order></author><author><firstname>Guillermo</firstname><surname>Amer-Ferrer</surname><order>529</order></author><author><firstname>Martirio</firstname><surname>Antequera</surname><order>530</order></author><author><firstname>Juan Andrés</firstname><surname>Burguera</surname><order>531</order></author><author><firstname>Fátima</firstname><surname>Carrillo</surname><order>532</order></author><author><firstname>Mario</firstname><surname>Carrión-Claro</surname><order>533</order></author><author><firstname>María José</firstname><surname>Casajeros</surname><order>534</order></author><author><firstname>Marian Martinez de</firstname><surname>Pancorbo</surname><order>535</order></author><author><firstname>Rocío</firstname><surname>Escuela</surname><order>536</order></author><author><firstname>Lorena</firstname><surname>Garrote-Espina</surname><order>537</order></author><author><firstname>Pilar</firstname><surname>Gómez-Garre</surname><order>538</order></author><author><firstname>Saray</firstname><surname>Hevilla</surname><order>539</order></author><author><firstname>Silvia</firstname><surname>Jesús</surname><order>540</order></author><author><firstname>Miguel Angel Labrador</firstname><surname>Espinosa</surname><order>541</order></author><author><firstname>Agustina</firstname><surname>Legaz</surname><order>542</order></author><author><firstname>Sara</firstname><surname>López-García</surname><order>543</order></author><author><firstname>Daniel</firstname><surname>Macias-García</surname><order>544</order></author><author><firstname>Salvadora</firstname><surname>Manzanares</surname><order>545</order></author><author><firstname>Marta</firstname><surname>Marín</surname><order>546</order></author><author><firstname>Juan</firstname><surname>Marín-Muñoz</surname><order>547</order></author><author><firstname>Tamara</firstname><surname>Marín</surname><order>548</order></author><author><firstname>Begoña</firstname><surname>Martínez</surname><order>549</order></author><author><firstname>Victoriana</firstname><surname>Martínez</surname><order>550</order></author><author><firstname>Pablo Martínez-Lage</firstname><surname>Álvarez</surname><order>551</order></author><author><firstname>Maite Mendioroz</firstname><surname>Iriarte</surname><order>552</order></author><author><firstname>María Teresa</firstname><surname>Periñán-Tocino</surname><order>553</order></author><author><firstname>Rocío</firstname><surname>Pineda-Sánchez</surname><order>554</order></author><author><firstname>Diego Real de</firstname><surname>Asúa</surname><order>555</order></author><author><firstname>Silvia</firstname><surname>Rodrigo</surname><order>556</order></author><author><firstname>Isabel</firstname><surname>Sastre</surname><order>557</order></author><author><firstname>Maria Pilar</firstname><surname>Vicente</surname><order>558</order></author><author><firstname>Rosario</firstname><surname>Vigo-Ortega</surname><order>559</order></author><author><firstname>Liliana</firstname><surname>Vivancos</surname><order>560</order></author><author><firstname>Jacques</firstname><surname>Epelbaum</surname><order>561</order></author><author><firstname>Didier</firstname><surname>Hannequin</surname><order>562</order></author><author><firstname>Dominique</firstname><surname>campion</surname><order>563</order></author><author><firstname>Vincent</firstname><surname>Deramecourt</surname><order>564</order></author><author><firstname>Christophe</firstname><surname>Tzourio</surname><order>565</order></author><author><firstname>Alexis</firstname><surname>Brice</surname><order>566</order></author><author><firstname>Bruno</firstname><surname>Dubois</surname><order>567</order></author><author><firstname>Amy</firstname><surname>Williams</surname><order>568</order></author><author><firstname>Charlene</firstname><surname>Thomas</surname><order>569</order></author><author><firstname>Chloe</firstname><surname>Davies</surname><order>570</order></author><author><firstname>William</firstname><surname>Nash</surname><order>571</order></author><author><firstname>Kimberley</firstname><surname>Dowzell</surname><order>572</order></author><author><firstname>Atahualpa Castillo</firstname><surname>Morales</surname><order>573</order></author><author><firstname>Mateus</firstname><surname>Bernardo-Harrington</surname><order>574</order></author><author><firstname>James</firstname><surname>Turton</surname><order>575</order></author><author><firstname>Jenny</firstname><surname>Lord</surname><order>576</order></author><author><firstname>Kristelle</firstname><surname>Brown</surname><order>577</order></author><author><firstname>Emma</firstname><surname>Vardy</surname><order>578</order></author><author><firstname>Elizabeth</firstname><surname>Fisher</surname><order>579</order></author><author><firstname>Jason D.</firstname><surname>Warren</surname><order>580</order></author><author><firstname>Martin</firstname><surname>Rossor</surname><order>581</order></author><author><firstname>Natalie S.</firstname><surname>Ryan</surname><order>582</order></author><author><firstname>Rita</firstname><surname>Guerreiro</surname><order>583</order></author><author><firstname>James</firstname><surname>Uphill</surname><order>584</order></author><author><firstname>Nick</firstname><surname>Bass</surname><order>585</order></author><author><firstname>Reinhard</firstname><surname>Heun</surname><order>586</order></author><author><firstname>Heike</firstname><surname>Kölsch</surname><order>587</order></author><author><firstname>Britta</firstname><surname>Schürmann</surname><order>588</order></author><author><firstname>André</firstname><surname>Lacour</surname><order>589</order></author><author><firstname>Christine</firstname><surname>Herold</surname><order>590</order></author><author><firstname>Janet A.</firstname><surname>Johnston</surname><order>591</order></author><author><firstname>Peter</firstname><surname>Passmore</surname><order>592</order></author><author><firstname>John</firstname><surname>Powell</surname><order>593</order></author><author><firstname>Yogen</firstname><surname>Patel</surname><order>594</order></author><author><firstname>Angela</firstname><surname>Hodges</surname><order>595</order></author><author><firstname>Tim</firstname><surname>Becker</surname><order>596</order></author><author><firstname>Donald</firstname><surname>Warden</surname><order>597</order></author><author><firstname>Gordon</firstname><surname>Wilcock</surname><order>598</order></author><author><firstname>Robert</firstname><surname>Clarke</surname><order>599</order></author><author><firstname>Panagiotis</firstname><surname>Deloukas</surname><order>600</order></author><author><firstname>Yoav</firstname><surname>Ben-Shlomo</surname><order>601</order></author><author><firstname>Nigel M.</firstname><surname>Hooper</surname><order>602</order></author><author><firstname>Stuart</firstname><surname>Pickering-Brown</surname><order>603</order></author><author><firstname>Rebecca</firstname><surname>Sussams</surname><order>604</order></author><author><firstname>Nick</firstname><surname>Warner</surname><order>605</order></author><author><firstname>Anthony</firstname><surname>Bayer</surname><order>606</order></author><author><firstname>Isabella</firstname><surname>Heuser</surname><order>607</order></author><author><firstname>Dmitriy</firstname><surname>Drichel</surname><order>608</order></author><author><firstname>Norman</firstname><surname>Klopp</surname><order>609</order></author><author><firstname>Manuel</firstname><surname>Mayhaus</surname><order>610</order></author><author><firstname>Matthias</firstname><surname>Riemenschneider</surname><order>611</order></author><author><firstname>Sabrina</firstname><surname>Pinchler</surname><order>612</order></author><author><firstname>Thomas</firstname><surname>Feulner</surname><order>613</order></author><author><firstname>Wei</firstname><surname>Gu</surname><order>614</order></author><author><firstname>Hendrik van den</firstname><surname>Bussche</surname><order>615</order></author><author><firstname>Michael</firstname><surname>Hüll</surname><order>616</order></author><author><firstname>Lutz</firstname><surname>Frölich</surname><order>617</order></author><author><firstname>H-Erich</firstname><surname>Wichmann</surname><order>618</order></author><author><firstname>Karl-Heinz</firstname><surname>Jöckel</surname><order>619</order></author><author><firstname>Michael</firstname><surname>O’Donovan</surname><order>620</order></author><author><firstname>Michael</firstname><surname>Owen</surname><order>621</order></author><author><firstname>Shahram</firstname><surname>Bahrami</surname><order>622</order></author><author><firstname>Ingunn</firstname><surname>Bosnes</surname><order>623</order></author><author><firstname>Per</firstname><surname>Selnes</surname><order>624</order></author><author><firstname>Sverre</firstname><surname>Bergh</surname><order>625</order></author><author><firstname>Aarno</firstname><surname>Palotie</surname><order>626</order></author><author><firstname>Mark</firstname><surname>Daly</surname><order>627</order></author><author><firstname>Howard</firstname><surname>Jacob</surname><order>628</order></author><author><firstname>Athena</firstname><surname>Matakidou</surname><order>629</order></author><author><firstname>Heiko</firstname><surname>Runz</surname><order>630</order></author><author><firstname>Sally</firstname><surname>John</surname><order>631</order></author><author><firstname>Robert</firstname><surname>Plenge</surname><order>632</order></author><author><firstname>Mark</firstname><surname>McCarthy</surname><order>633</order></author><author><firstname>Julie</firstname><surname>Hunkapiller</surname><order>634</order></author><author><firstname>Meg</firstname><surname>Ehm</surname><order>635</order></author><author><firstname>Dawn</firstname><surname>Waterworth</surname><order>636</order></author><author><firstname>Caroline</firstname><surname>Fox</surname><order>637</order></author><author><firstname>Anders</firstname><surname>Malarstig</surname><order>638</order></author><author><firstname>Kathy</firstname><surname>Klinger</surname><order>639</order></author><author><firstname>Kathy</firstname><surname>Call</surname><order>640</order></author><author><firstname>Tim</firstname><surname>Behrens</surname><order>641</order></author><author><firstname>Patrick</firstname><surname>Loerch</surname><order>642</order></author><author><firstname>Tomi</firstname><surname>Mäkelä</surname><order>643</order></author><author><firstname>Jaakko</firstname><surname>Kaprio</surname><order>644</order></author><author><firstname>Petri</firstname><surname>Virolainen</surname><order>645</order></author><author><firstname>Kari</firstname><surname>Pulkki</surname><order>646</order></author><author><firstname>Terhi</firstname><surname>Kilpi</surname><order>647</order></author><author><firstname>Markus</firstname><surname>Perola</surname><order>648</order></author><author><firstname>Jukka</firstname><surname>Partanen</surname><order>649</order></author><author><firstname>Anne</firstname><surname>Pitkäranta</surname><order>650</order></author><author><firstname>Riitta</firstname><surname>Kaarteenaho</surname><order>651</order></author><author><firstname>Seppo</firstname><surname>Vainio</surname><order>652</order></author><author><firstname>Miia</firstname><surname>Turpeinen</surname><order>653</order></author><author><firstname>Raisa</firstname><surname>Serpi</surname><order>654</order></author><author><firstname>Tarja</firstname><surname>Laitinen</surname><order>655</order></author><author><firstname>Johanna</firstname><surname>Mäkelä</surname><order>656</order></author><author><firstname>Veli-Matti</firstname><surname>Kosma</surname><order>657</order></author><author><firstname>Urho</firstname><surname>Kujala</surname><order>658</order></author><author><firstname>Outi</firstname><surname>Tuovila</surname><order>659</order></author><author><firstname>Minna</firstname><surname>Hendolin</surname><order>660</order></author><author><firstname>Raimo</firstname><surname>Pakkanen</surname><order>661</order></author><author><firstname>Jeff</firstname><surname>Waring</surname><order>662</order></author><author><firstname>Bridget</firstname><surname>Riley-Gillis</surname><order>663</order></author><author><firstname>Jimmy</firstname><surname>Liu</surname><order>664</order></author><author><firstname>Shameek</firstname><surname>Biswas</surname><order>665</order></author><author><firstname>Dorothee</firstname><surname>Diogo</surname><order>666</order></author><author><firstname>Catherine</firstname><surname>Marshall</surname><order>667</order></author><author><firstname>Xinli</firstname><surname>Hu</surname><order>668</order></author><author><firstname>Matthias</firstname><surname>Gossel</surname><order>669</order></author><author><firstname>Robert</firstname><surname>Graham</surname><order>670</order></author><author><firstname>Beryl</firstname><surname>Cummings</surname><order>671</order></author><author><firstname>Samuli</firstname><surname>Ripatti</surname><order>672</order></author><author><firstname>Johanna</firstname><surname>Schleutker</surname><order>673</order></author><author><firstname>Mikko</firstname><surname>Arvas</surname><order>674</order></author><author><firstname>Olli</firstname><surname>Carpén</surname><order>675</order></author><author><firstname>Reetta</firstname><surname>Hinttala</surname><order>676</order></author><author><firstname>Johannes</firstname><surname>Kettunen</surname><order>677</order></author><author><firstname>Arto</firstname><surname>Mannermaa</surname><order>678</order></author><author><firstname>Jari</firstname><surname>Laukkanen</surname><order>679</order></author><author><firstname>Valtteri</firstname><surname>Julkunen</surname><order>680</order></author><author><firstname>Anne</firstname><surname>Remes</surname><order>681</order></author><author><firstname>Reetta</firstname><surname>Kälviäinen</surname><order>682</order></author><author><firstname>Jukka</firstname><surname>Peltola</surname><order>683</order></author><author><firstname>Pentti</firstname><surname>Tienari</surname><order>684</order></author><author><firstname>Juha</firstname><surname>Rinne</surname><order>685</order></author><author><firstname>Adam</firstname><surname>Ziemann</surname><order>686</order></author><author><firstname>Jeffrey</firstname><surname>Waring</surname><order>687</order></author><author><firstname>Sahar</firstname><surname>Esmaeeli</surname><order>688</order></author><author><firstname>Nizar</firstname><surname>Smaoui</surname><order>689</order></author><author><firstname>Anne</firstname><surname>Lehtonen</surname><order>690</order></author><author><firstname>Susan</firstname><surname>Eaton</surname><order>691</order></author><author><firstname>Sanni</firstname><surname>Lahdenperä</surname><order>692</order></author><author><firstname>Janet van</firstname><surname>Adelsberg</surname><order>693</order></author><author><firstname>John</firstname><surname>Michon</surname><order>694</order></author><author><firstname>Geoff</firstname><surname>Kerchner</surname><order>695</order></author><author><firstname>Natalie</firstname><surname>Bowers</surname><order>696</order></author><author><firstname>Edmond</firstname><surname>Teng</surname><order>697</order></author><author><firstname>John</firstname><surname>Eicher</surname><order>698</order></author><author><firstname>Vinay</firstname><surname>Mehta</surname><order>699</order></author><author><firstname>Padhraig</firstname><surname>Gormley</surname><order>700</order></author><author><firstname>Kari</firstname><surname>Linden</surname><order>701</order></author><author><firstname>Christopher</firstname><surname>Whelan</surname><order>702</order></author><author><firstname>Fanli</firstname><surname>Xu</surname><order>703</order></author><author><firstname>David</firstname><surname>Pulford</surname><order>704</order></author><author><firstname>Martti</firstname><surname>Färkkilä</surname><order>705</order></author><author><firstname>Sampsa</firstname><surname>Pikkarainen</surname><order>706</order></author><author><firstname>Airi</firstname><surname>Jussila</surname><order>707</order></author><author><firstname>Timo</firstname><surname>Blomster</surname><order>708</order></author><author><firstname>Mikko</firstname><surname>Kiviniemi</surname><order>709</order></author><author><firstname>Markku</firstname><surname>Voutilainen</surname><order>710</order></author><author><firstname>Bob</firstname><surname>Georgantas</surname><order>711</order></author><author><firstname>Graham</firstname><surname>Heap</surname><order>712</order></author><author><firstname>Fedik</firstname><surname>Rahimov</surname><order>713</order></author><author><firstname>Keith</firstname><surname>Usiskin</surname><order>714</order></author><author><firstname>Tim</firstname><surname>Lu</surname><order>715</order></author><author><firstname>Danny</firstname><surname>Oh</surname><order>716</order></author><author><firstname>Kirsi</firstname><surname>Kalpala</surname><order>717</order></author><author><firstname>Melissa</firstname><surname>Miller</surname><order>718</order></author><author><firstname>Linda</firstname><surname>McCarthy</surname><order>719</order></author><author><firstname>Kari</firstname><surname>Eklund</surname><order>720</order></author><author><firstname>Antti</firstname><surname>Palomäki</surname><order>721</order></author><author><firstname>Pia</firstname><surname>Isomäki</surname><order>722</order></author><author><firstname>Laura</firstname><surname>Pirilä</surname><order>723</order></author><author><firstname>Oili</firstname><surname>Kaipiainen-Seppänen</surname><order>724</order></author><author><firstname>Johanna</firstname><surname>Huhtakangas</surname><order>725</order></author><author><firstname>Apinya</firstname><surname>Lertratanakul</surname><order>726</order></author><author><firstname>Marla</firstname><surname>Hochfeld</surname><order>727</order></author><author><firstname>Nan</firstname><surname>Bing</surname><order>728</order></author><author><firstname>Jorge Esparza</firstname><surname>Gordillo</surname><order>729</order></author><author><firstname>Nina</firstname><surname>Mars</surname><order>730</order></author><author><firstname>Margit</firstname><surname>Pelkonen</surname><order>731</order></author><author><firstname>Paula</firstname><surname>Kauppi</surname><order>732</order></author><author><firstname>Hannu</firstname><surname>Kankaanranta</surname><order>733</order></author><author><firstname>Terttu</firstname><surname>Harju</surname><order>734</order></author><author><firstname>David</firstname><surname>Close</surname><order>735</order></author><author><firstname>Steven</firstname><surname>Greenberg</surname><order>736</order></author><author><firstname>Hubert</firstname><surname>Chen</surname><order>737</order></author><author><firstname>Jo</firstname><surname>Betts</surname><order>738</order></author><author><firstname>Soumitra</firstname><surname>Ghosh</surname><order>739</order></author><author><firstname>Veikko</firstname><surname>Salomaa</surname><order>740</order></author><author><firstname>Teemu</firstname><surname>Niiranen</surname><order>741</order></author><author><firstname>Markus</firstname><surname>Juonala</surname><order>742</order></author><author><firstname>Kaj</firstname><surname>Metsärinne</surname><order>743</order></author><author><firstname>Mika</firstname><surname>Kähönen</surname><order>744</order></author><author><firstname>Juhani</firstname><surname>Junttila</surname><order>745</order></author><author><firstname>Markku</firstname><surname>Laakso</surname><order>746</order></author><author><firstname>Jussi</firstname><surname>Pihlajamäki</surname><order>747</order></author><author><firstname>Juha</firstname><surname>Sinisalo</surname><order>748</order></author><author><firstname>Marja-Riitta</firstname><surname>Taskinen</surname><order>749</order></author><author><firstname>Tiinamaija</firstname><surname>Tuomi</surname><order>750</order></author><author><firstname>Ben</firstname><surname>Challis</surname><order>751</order></author><author><firstname>Andrew</firstname><surname>Peterson</surname><order>752</order></author><author><firstname>Audrey</firstname><surname>Chu</surname><order>753</order></author><author><firstname>Jaakko</firstname><surname>Parkkinen</surname><order>754</order></author><author><firstname>Anthony</firstname><surname>Muslin</surname><order>755</order></author><author><firstname>Heikki</firstname><surname>Joensuu</surname><order>756</order></author><author><firstname>Tuomo</firstname><surname>Meretoja</surname><order>757</order></author><author><firstname>Lauri</firstname><surname>Aaltonen</surname><order>758</order></author><author><firstname>Johanna</firstname><surname>Mattson</surname><order>759</order></author><author><firstname>Annika</firstname><surname>Auranen</surname><order>760</order></author><author><firstname>Peeter</firstname><surname>Karihtala</surname><order>761</order></author><author><firstname>Saila</firstname><surname>Kauppila</surname><order>762</order></author><author><firstname>Päivi</firstname><surname>Auvinen</surname><order>763</order></author><author><firstname>Klaus</firstname><surname>Elenius</surname><order>764</order></author><author><firstname>Relja</firstname><surname>Popovic</surname><order>765</order></author><author><firstname>Jennifer</firstname><surname>Schutzman</surname><order>766</order></author><author><firstname>Andrey</firstname><surname>Loboda</surname><order>767</order></author><author><firstname>Aparna</firstname><surname>Chhibber</surname><order>768</order></author><author><firstname>Heli</firstname><surname>Lehtonen</surname><order>769</order></author><author><firstname>Stefan</firstname><surname>McDonough</surname><order>770</order></author><author><firstname>Marika</firstname><surname>Crohns</surname><order>771</order></author><author><firstname>Diptee</firstname><surname>Kulkarni</surname><order>772</order></author><author><firstname>Kai</firstname><surname>Kaarniranta</surname><order>773</order></author><author><firstname>Joni A.</firstname><surname>Turunen</surname><order>774</order></author><author><firstname>Terhi</firstname><surname>Ollila</surname><order>775</order></author><author><firstname>Sanna</firstname><surname>Seitsonen</surname><order>776</order></author><author><firstname>Hannu</firstname><surname>Uusitalo</surname><order>777</order></author><author><firstname>Vesa</firstname><surname>Aaltonen</surname><order>778</order></author><author><firstname>Hannele</firstname><surname>Uusitalo-Järvinen</surname><order>779</order></author><author><firstname>Marja</firstname><surname>Luodonpää</surname><order>780</order></author><author><firstname>Nina</firstname><surname>Hautala</surname><order>781</order></author><author><firstname>Stephanie</firstname><surname>Loomis</surname><order>782</order></author><author><firstname>Erich</firstname><surname>Strauss</surname><order>783</order></author><author><firstname>Hao</firstname><surname>Chen</surname><order>784</order></author><author><firstname>Anna</firstname><surname>Podgornaia</surname><order>785</order></author><author><firstname>Joshua</firstname><surname>Hoffman</surname><order>786</order></author><author><firstname>Kaisa</firstname><surname>Tasanen</surname><order>787</order></author><author><firstname>Laura</firstname><surname>Huilaja</surname><order>788</order></author><author><firstname>Katariina</firstname><surname>Hannula-Jouppi</surname><order>789</order></author><author><firstname>Teea</firstname><surname>Salmi</surname><order>790</order></author><author><firstname>Sirkku</firstname><surname>Peltonen</surname><order>791</order></author><author><firstname>Leena</firstname><surname>Koulu</surname><order>792</order></author><author><firstname>Ilkka</firstname><surname>Harvima</surname><order>793</order></author><author><firstname>Ying</firstname><surname>Wu</surname><order>794</order></author><author><firstname>David</firstname><surname>Choy</surname><order>795</order></author><author><firstname>Pirkko</firstname><surname>Pussinen</surname><order>796</order></author><author><firstname>Aino</firstname><surname>Salminen</surname><order>797</order></author><author><firstname>Tuula</firstname><surname>Salo</surname><order>798</order></author><author><firstname>David</firstname><surname>Rice</surname><order>799</order></author><author><firstname>Pekka</firstname><surname>Nieminen</surname><order>800</order></author><author><firstname>Ulla</firstname><surname>Palotie</surname><order>801</order></author><author><firstname>Maria</firstname><surname>Siponen</surname><order>802</order></author><author><firstname>Liisa</firstname><surname>Suominen</surname><order>803</order></author><author><firstname>Päivi</firstname><surname>Mäntylä</surname><order>804</order></author><author><firstname>Ulvi</firstname><surname>Gursoy</surname><order>805</order></author><author><firstname>Vuokko</firstname><surname>Anttonen</surname><order>806</order></author><author><firstname>Kirsi</firstname><surname>Sipilä</surname><order>807</order></author><author><firstname>Justin Wade</firstname><surname>Davis</surname><order>808</order></author><author><firstname>Danjuma</firstname><surname>Quarless</surname><order>809</order></author><author><firstname>Slavé</firstname><surname>Petrovski</surname><order>810</order></author><author><firstname>Eleonor</firstname><surname>Wigmore</surname><order>811</order></author><author><firstname>Chia-Yen</firstname><surname>Chen</surname><order>812</order></author><author><firstname>Paola</firstname><surname>Bronson</surname><order>813</order></author><author><firstname>Ellen</firstname><surname>Tsai</surname><order>814</order></author><author><firstname>Yunfeng</firstname><surname>Huang</surname><order>815</order></author><author><firstname>Joseph</firstname><surname>Maranville</surname><order>816</order></author><author><firstname>Elmutaz</firstname><surname>Shaikho</surname><order>817</order></author><author><firstname>Elhaj</firstname><surname>Mohammed</surname><order>818</order></author><author><firstname>Samir</firstname><surname>Wadhawan</surname><order>819</order></author><author><firstname>Erika</firstname><surname>Kvikstad</surname><order>820</order></author><author><firstname>Minal</firstname><surname>Caliskan</surname><order>821</order></author><author><firstname>Diana</firstname><surname>Chang</surname><order>822</order></author><author><firstname>Tushar</firstname><surname>Bhangale</surname><order>823</order></author><author><firstname>Sarah</firstname><surname>Pendergrass</surname><order>824</order></author><author><firstname>Emily</firstname><surname>Holzinger</surname><order>825</order></author><author><firstname>Xing</firstname><surname>Chen</surname><order>826</order></author><author><firstname>Åsa</firstname><surname>Hedman</surname><order>827</order></author><author><firstname>Karen S.</firstname><surname>King</surname><order>828</order></author><author><firstname>Clarence</firstname><surname>Wang</surname><order>829</order></author><author><firstname>Ethan</firstname><surname>Xu</surname><order>830</order></author><author><firstname>Franck</firstname><surname>Auge</surname><order>831</order></author><author><firstname>Clement</firstname><surname>Chatelain</surname><order>832</order></author><author><firstname>Deepak</firstname><surname>Rajpal</surname><order>833</order></author><author><firstname>Dongyu</firstname><surname>Liu</surname><order>834</order></author><author><firstname>Katherine</firstname><surname>Call</surname><order>835</order></author><author><firstname>Tai-he</firstname><surname>Xia</surname><order>836</order></author><author><firstname>Matt</firstname><surname>Brauer</surname><order>837</order></author><author><firstname>Mitja</firstname><surname>Kurki</surname><order>838</order></author><author><firstname>Juha</firstname><surname>Karjalainen</surname><order>839</order></author><author><firstname>Aki</firstname><surname>Havulinna</surname><order>840</order></author><author><firstname>Anu</firstname><surname>Jalanko</surname><order>841</order></author><author><firstname>Priit</firstname><surname>Palta</surname><order>842</order></author><author><firstname>Pietro 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spelling v2 60592 2022-07-22 New insights into the genetic etiology of Alzheimer’s disease and related dementias cf7fe9863906cd54df5b0a99904d535e 0000-0002-6789-127X Vanessa Burholt Vanessa Burholt true false 2022-07-22 PHAC Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. Journal Article Nature Genetics 54 4 412 436 Springer Science and Business Media LLC 1061-4036 1546-1718 4 4 2022 2022-04-04 10.1038/s41588-022-01024-z COLLEGE NANME Public Health COLLEGE CODE PHAC Swansea University Another institution paid the OA fee This work was funded by a grant (EADB) from the EU Joint Programme – Neurodegenerative Disease Research. INSERM UMR1167 is also funded by the INSERM, Institut Pasteur de Lille, Lille Métropole Communauté Urbaine and French government’s LABEX DISTALZ program (development of innovative strategies for a transdisciplinary approach to AD). 2022-10-27T15:32:42.3517882 2022-07-22T00:35:51.2392001 College of Human and Health Sciences Centre for Innovative Ageing Céline Bellenguez 0000-0002-1240-7874 1 Fahri Küçükali 0000-0002-3835-9639 2 Iris E. Jansen 3 Luca Kleineidam 4 Sonia Moreno-Grau 5 Najaf Amin 0000-0002-8944-1771 6 Adam C. Naj 7 Rafael Campos-Martin 8 Benjamin Grenier-Boley 9 Victor Andrade 10 Peter A. Holmans 0000-0003-0870-9412 11 Anne Boland 12 Vincent Damotte 13 Sven J. van der Lee 0000-0003-1606-8643 14 Marcos R. Costa 0000-0002-4928-2163 15 Teemu Kuulasmaa 0000-0002-1795-7314 16 Qiong Yang 0000-0002-3658-1375 17 Itziar de Rojas 0000-0002-2148-381x 18 Joshua C. Bis 0000-0002-3409-1110 19 Amber Yaqub 0000-0002-3579-8054 20 Ivana Prokic 0000-0002-0370-1473 21 Julien Chapuis 0000-0002-5802-2857 22 Shahzad Ahmad 0000-0002-8658-3790 23 Vilmantas Giedraitis 0000-0003-3423-2021 24 Dag Aarsland 25 Pablo Garcia-Gonzalez 0000-0003-0125-5403 26 Carla Abdelnour 27 Emilio Alarcón-Martín 28 Daniel Alcolea 0000-0002-3819-3245 29 Montserrat Alegret 30 Ignacio Alvarez 0000-0002-8537-3935 31 Victoria Álvarez 32 Nicola J. Armstrong 33 Anthoula Tsolaki 0000-0002-5563-7776 34 Carmen Antúnez 35 Ildebrando Appollonio 36 Marina Arcaro 37 Silvana Archetti 38 Alfonso Arias Pastor 39 Beatrice Arosio 40 Lavinia Athanasiu 41 Henri Bailly 42 Nerisa Banaj 43 Miquel Baquero 0000-0002-6861-1831 44 Sandra Barral 45 Alexa Beiser 46 Ana Belén Pastor 0000-0001-9637-4688 47 Jennifer E. Below 48 Penelope Benchek 49 Luisa Benussi 50 Claudine Berr 0000-0001-5254-7655 51 Céline Besse 52 Valentina Bessi 0000-0002-6176-3584 53 Giuliano Binetti 54 Alessandra Bizarro 55 Rafael Blesa 56 Mercè Boada 0000-0003-2617-3009 57 Eric Boerwinkle 58 Barbara Borroni 59 Silvia Boschi 60 Paola Bossù 0000-0002-1432-0078 61 Geir Bråthen 0000-0003-3224-7983 62 Jan Bressler 0000-0001-6578-4772 63 Catherine Bresner 0000-0003-2673-9762 64 Henry Brodaty 0000-0001-9487-6617 65 Keeley J. Brookes 0000-0003-2427-2513 66 Luis Ignacio Brusco 67 Dolores Buiza-Rueda 68 Katharina Bûrger 69 Vanessa Burholt 0000-0002-6789-127X 70 William S. Bush 0000-0002-9729-6519 71 Miguel Calero 0000-0001-5366-3324 72 Laura B. Cantwell 73 Geneviève Chene 74 Jaeyoon Chung 0000-0002-6431-9454 75 Michael L. Cuccaro 76 Ángel Carracedo 77 Roberta Cecchetti 78 Laura Cervera-Carles 0000-0003-2286-200x 79 Camille Charbonnier 80 Hung-Hsin Chen 81 Caterina Chillotti 82 Simona Ciccone 83 Jurgen A. H. R. Claassen 84 Christopher Clark 85 Elisa Conti 86 Anaïs Corma-Gómez 87 Emanuele Costantini 0000-0002-1096-8221 88 Carlo Custodero 89 Delphine Daian 90 Maria Carolina Dalmasso 0000-0002-4901-9955 91 Antonio Daniele 92 Efthimios Dardiotis 93 Jean-François Dartigues 94 Peter Paul de Deyn 95 Katia de Paiva Lopes 0000-0002-0240-0126 96 Lot D. de Witte 0000-0002-7235-9958 97 Stéphanie Debette 0000-0001-8675-7968 98 Jürgen Deckert 99 Teodoro del Ser 0000-0001-9806-7083 100 Nicola Denning 101 Anita DeStefano 102 Martin Dichgans 0000-0002-0654-387x 103 Janine Diehl-Schmid 0000-0002-7745-1382 104 Mónica Diez-Fairen 0000-0003-1882-0309 105 Paolo Dionigi Rossi 106 Srdjan Djurovic 0000-0002-8140-8061 107 Emmanuelle Duron 108 Emrah Düzel 109 Carole Dufouil 0000-0003-2442-4476 110 Gudny Eiriksdottir 111 Sebastiaan Engelborghs 112 Valentina Escott-Price 0000-0003-1784-5483 113 Ana Espinosa 114 Michael Ewers 0000-0001-5231-1714 115 Kelley M. Faber 116 Tagliavini Fabrizio 0000-0003-1039-7315 117 Sune Fallgaard Nielsen 118 David W. Fardo 119 Lucia Farotti 120 Chiara Fenoglio 121 Marta Fernández-Fuertes 122 Raffaele Ferrari 123 Catarina B. Ferreira 124 Evelyn Ferri 125 Bertrand Fin 126 Peter Fischer 127 Tormod Fladby 0000-0002-9984-9797 128 Klaus Fließbach 129 Bernard Fongang 130 Myriam Fornage 0000-0003-0677-8158 131 Juan Fortea 132 Tatiana M. Foroud 133 Silvia Fostinelli 134 Nick C. Fox 0000-0002-6660-657x 135 Emlio Franco-Macías 136 María J. Bullido 0000-0002-6477-1117 137 Ana Frank-García 138 Lutz Froelich 0000-0003-1494-0813 139 Brian Fulton-Howard 140 Daniela Galimberti 0000-0002-9284-5953 141 Jose Maria García-Alberca 0000-0003-2951-6644 142 Pablo García-González 143 Sebastian Garcia-Madrona 144 Guillermo Garcia-Ribas 145 Roberta Ghidoni 146 Ina Giegling 147 Giaccone Giorgio 148 Alison M. Goate 0000-0002-0576-2472 149 Oliver Goldhardt 150 Duber Gomez-Fonseca 151 Antonio González-Pérez 0000-0001-9771-5982 152 Caroline Graff 153 Giulia Grande 154 Emma Green 0000-0002-8687-5590 155 Timo Grimmer 156 Edna Grünblatt 0000-0001-8505-7265 157 Michelle Grunin 158 Vilmundur Gudnason 0000-0001-5696-0084 159 Tamar Guetta-Baranes 160 Annakaisa Haapasalo 0000-0003-0959-2957 161 Georgios Hadjigeorgiou 162 Jonathan L. Haines 163 Kara L. Hamilton-Nelson 164 Harald Hampel 165 Olivier Hanon 166 John Hardy 167 Annette M. Hartmann 168 Lucrezia Hausner 169 Janet Harwood 0000-0002-3225-0069 170 Stefanie Heilmann-Heimbach 0000-0003-1057-465x 171 Seppo Helisalmi 172 Michael T. Heneka 173 Isabel Hernández 174 Martin J. Herrmann 0000-0001-9970-2122 175 Per Hoffmann 176 Clive Holmes 177 Henne Holstege 0000-0002-7688-3087 178 Raquel Huerto Vilas 179 Marc Hulsman 180 Jack Humphrey 181 Geert Jan Biessels 0000-0001-6862-2496 182 Xueqiu Jian 0000-0002-0313-6494 183 Charlotte Johansson 0000-0002-5351-1950 184 Gyungah R. Jun 0000-0002-3230-8697 185 Yuriko Kastumata 0000-0002-0188-8094 186 John Kauwe 187 Patrick G. Kehoe 0000-0002-7542-1139 188 Lena Kilander 189 Anne Kinhult Ståhlbom 190 Miia Kivipelto 191 Anne Koivisto 192 Johannes Kornhuber 0000-0002-8096-3987 193 Mary H. Kosmidis 0000-0001-8790-1220 194 Walter A. Kukull 195 Pavel P. Kuksa 196 Brian W. Kunkle 197 Amanda B. Kuzma 198 Carmen Lage 0000-0003-1703-121x 199 Erika J. Laukka 200 Lenore Launer 0000-0002-3238-7612 201 Alessandra Lauria 202 Chien-Yueh Lee 0000-0002-4304-974x 203 Jenni Lehtisalo 204 Ondrej Lerch 205 Alberto Lleó 0000-0002-2568-5478 206 William Longstreth 207 Oscar Lopez 0000-0002-8546-8256 208 Adolfo Lopez de Munain 0000-0002-9509-4032 209 Seth Love 210 Malin Löwemark 211 Lauren Luckcuck 212 Kathryn L. Lunetta 0000-0002-9268-810x 213 Yiyi Ma 0000-0002-3609-8877 214 Juan Macías 215 Catherine A. MacLeod 0000-0002-9314-7380 216 Wolfgang Maier 217 Francesca Mangialasche 218 Marco Spallazzi 219 Marta Marquié 0000-0002-0660-0950 220 Rachel Marshall 221 Eden R. Martin 222 Angel Martín Montes 0000-0002-1694-786x 223 Carmen Martínez Rodríguez 224 Carlo Masullo 225 Richard Mayeux 226 Simon Mead 0000-0002-4326-1468 227 Patrizia Mecocci 228 Miguel Medina 0000-0002-7016-5340 229 Alun Meggy 230 Shima Mehrabian 231 Silvia Mendoza 232 Manuel Menéndez-González 0000-0002-5218-0774 233 Pablo Mir 234 Susanne Moebus 235 Merel Mol 0000-0003-2533-2530 236 Laura Molina-Porcel 237 Laura Montrreal 238 Laura Morelli 239 Fermin Moreno 240 Kevin Morgan 0000-0002-8217-2396 241 Thomas Mosley 242 Markus M. Nöthen 0000-0002-8770-2464 243 Carolina Muchnik 0000-0002-1542-3706 244 Shubhabrata Mukherjee 245 Benedetta Nacmias 0000-0001-9338-9040 246 Tiia Ngandu 247 Gael Nicolas 0000-0001-9391-7800 248 Børge G. Nordestgaard 0000-0002-1954-7220 249 Robert Olaso 250 Adelina Orellana 251 Michela Orsini 252 Gemma Ortega 253 Alessandro Padovani 254 Caffarra Paolo 255 Goran Papenberg 256 Lucilla Parnetti 257 Florence Pasquier 0000-0001-9880-9788 258 Pau Pastor 0000-0002-7493-8777 259 Gina Peloso 0000-0002-5355-8636 260 Alba Pérez-Cordón 0000-0002-6028-0791 261 Jordi Pérez-Tur 0000-0002-9111-1712 262 Pierre Pericard 0000-0001-8167-6448 263 Oliver Peters 264 Yolande A. L. Pijnenburg 265 Juan A. Pineda 0000-0002-3751-0296 266 Gerard Piñol-Ripoll 267 Claudia Pisanu 0000-0002-9151-4319 268 Thomas Polak 269 Julius Popp 270 Danielle Posthuma 0000-0001-7582-2365 271 Josef Priller 272 Raquel Puerta 0000-0002-1191-5893 273 Olivier Quenez 0000-0002-8273-8505 274 Inés Quintela 275 Jesper Qvist Thomassen 0000-0003-3484-9531 276 Alberto Rábano 277 Innocenzo Rainero 278 Farid Rajabli 279 Inez Ramakers 280 Luis M. Real 0000-0003-4932-7429 281 Marcel J. T. Reinders 0000-0002-1148-1562 282 Christiane Reitz 0000-0001-8757-7889 283 Dolly Reyes-Dumeyer 284 Perry Ridge 285 Steffi Riedel-Heller 0000-0003-4321-6090 286 Peter Riederer 287 Natalia Roberto 288 Eloy Rodriguez-Rodriguez 0000-0001-7742-677x 289 Arvid Rongve 0000-0002-0476-4134 290 Irene Rosas Allende 291 Maitée Rosende-Roca 292 Jose Luis Royo 293 Elisa Rubino 294 Dan Rujescu 295 María Eugenia Sáez 0000-0001-9299-2534 296 Paraskevi Sakka 297 Ingvild Saltvedt 0000-0002-7897-9808 298 Ángela Sanabria 299 María Bernal Sánchez-Arjona 300 Florentino Sanchez-Garcia 301 Pascual Sánchez Juan 0000-0002-6081-8037 302 Raquel Sánchez-Valle 303 Sigrid B. Sando 304 Chloé Sarnowski 0000-0002-6090-7099 305 Claudia L. Satizabal 0000-0002-1115-4430 306 Michela Scamosci 307 Nikolaos Scarmeas 308 Elio Scarpini 309 Philip Scheltens 310 Norbert Scherbaum 311 Martin Scherer 312 Matthias Schmid 313 Anja Schneider 314 Jonathan M. Schott 0000-0003-2059-024x 315 Geir Selbæk 0000-0001-6511-8219 316 Davide Seripa 317 Manuel Serrano 318 Jin Sha 319 Alexey A. Shadrin 0000-0002-7467-250x 320 Olivia Skrobot 321 Susan Slifer 322 Gijsje J. L. Snijders 323 Hilkka Soininen 0000-0002-2785-9937 324 Vincenzo Solfrizzi 0000-0002-8524-0315 325 Alina Solomon 326 Yeunjoo Song 0000-0002-7452-3731 327 Sandro Sorbi 328 Oscar Sotolongo-Grau 0000-0002-9679-0670 329 Gianfranco Spalletta 0000-0002-7432-4249 330 Annika Spottke 331 Alessio Squassina 0000-0001-7415-7607 332 Eystein Stordal 0000-0002-2443-7923 333 Juan Pablo Tartan 334 Lluís Tárraga 335 Niccolo Tesí 336 Anbupalam Thalamuthu 337 Tegos Thomas 338 Giuseppe Tosto 0000-0001-7075-8245 339 Latchezar Traykov 340 Lucio Tremolizzo 341 Anne Tybjærg-Hansen 342 Andre Uitterlinden 0000-0002-7276-3387 343 Abbe Ullgren 344 Ingun Ulstein 345 Sergi Valero 346 Otto Valladares 0000-0001-8055-2187 347 Christine Van Broeckhoven 0000-0003-0183-7665 348 Jeffery Vance 349 Badri N. Vardarajan 350 Aad van der Lugt 351 Jasper Van Dongen 352 Jeroen van Rooij 353 John van Swieten 354 Rik Vandenberghe 355 Frans Verhey 356 Jean-Sébastien Vidal 0000-0001-6770-0720 357 Jonathan Vogelgsang 0000-0001-9326-8193 358 Martin Vyhnalek 359 Michael Wagner 0000-0003-2589-6440 360 David Wallon 0000-0002-2634-7198 361 Li-San Wang 362 Ruiqi Wang 363 Leonie Weinhold 364 Jens Wiltfang 0000-0003-1492-5330 365 Gill Windle 366 Bob Woods 0000-0002-6781-651x 367 Mary Yannakoulia 0000-0003-2171-7337 368 Habil Zare 0000-0001-5902-6238 369 Yi Zhao 370 Xiaoling Zhang 0000-0001-8237-1857 371 Congcong Zhu 372 Miren Zulaica 373 Jan Laczo 374 Vaclav Matoska 375 Maria Serpente 376 Francesca Assogna 377 Fabrizio Piras 378 Federica Piras 379 Valentina Ciullo 380 Jacob Shofany 381 Carlo Ferrarese 382 Simona Andreoni 383 Gessica Sala 384 Chiara Paola Zoia 385 Maria Del Zompo 386 Alberto Benussi 387 Patrizia Bastiani 388 Mari Takalo 389 Teemu Natunen 390 Tiina Laatikainen 391 Jaakko Tuomilehto 392 Riitta Antikainen 393 Timo Strandberg 394 Jaana Lindström 395 Markku Peltonen 396 Richard Abraham 397 Ammar Al-Chalabi 398 Nicholas J. Bass 399 Carol Brayne 400 Kristelle S. Brown 401 John Collinge 402 David Craig 403 Pangiotis Deloukas 404 Nick Fox 405 Amy Gerrish 406 Michael Gill 407 Rhian Gwilliam 408 Denise Harold 409 Paul Hollingworth 410 Jarret A. Johnston 411 Lesley Jones 412 Brian Lawlor 413 Gill Livingston 414 Simon Lovestone 415 Michelle Lupton 416 Aoibhinn Lynch 417 David Mann 418 Bernadette McGuinness 419 Andrew McQuillin 420 Michael C. O’Donovan 421 Michael J. Owen 422 Peter Passmore 423 John F. Powell 424 Petra Proitsi 425 Martin Rossor 426 Christopher E. Shaw 427 A. David Smith 428 Hugh Gurling 429 Stephen Todd 430 Catherine Mummery 431 Nathalie Ryan 432 Giordano Lacidogna 433 Ad Adarmes-Gómez 434 Ana Mauleón 435 Ana Pancho 436 Anna Gailhajenet 437 Asunción Lafuente 438 D. Macias-García 439 Elvira Martín 440 Esther Pelejà 441 F. Carrillo 442 Isabel Sastre Merlín 443 L. Garrote-Espina 444 Liliana Vargas 445 M. Carrion-Claro 446 M. Marín 447 Ma Labrador 448 Mar Buendia 449 María Dolores Alonso 450 Marina Guitart 451 Mariona Moreno 452 Marta Ibarria 453 Mt Periñán 454 Nuria Aguilera 455 P. Gómez-Garre 456 Pilar Cañabate 457 R. Escuela 458 R. Pineda-Sánchez 459 R. Vigo-Ortega 460 S. Jesús 461 Silvia Preckler 462 Silvia Rodrigo-Herrero 463 Susana Diego 464 Alessandro Vacca 465 Fausto Roveta 466 Nicola Salvadori 467 Elena Chipi 468 Henning Boecker 469 Christoph Laske 470 Robert Perneczky 471 Costas Anastasiou 472 Daniel Janowitz 473 Rainer Malik 474 Anna Anastasiou 475 Kayenat Parveen 476 Carmen Lage 477 Sara López-García 478 Anna Antonell 479 Kalina Yonkova Mihova 480 Diyana Belezhanska 481 Heike Weber 482 Silvia Kochen 483 Patricia Solis 484 Nancy Medel 485 Julieta Lisso 486 Zulma Sevillano 487 Daniel G. Politis 488 Valeria Cores 489 Carolina Cuesta 490 Cecilia Ortiz 491 Juan Ignacio Bacha 492 Mario Rios 493 Aldo Saenz 494 Mariana Sanchez Abalos 495 Eduardo Kohler 496 Dana Lis Palacio 497 Ignacio Etchepareborda 498 Matias Kohler 499 Gisela Novack 500 Federico Ariel Prestia 501 Pablo Galeano 502 Eduardo M. Castaño 503 Sandra Germani 504 Carlos Reyes Toso 505 Matias Rojo 506 Carlos Ingino 507 Carlos Mangone 508 David C. Rubinsztein 509 Stefan Teipel 510 Nathalie Fievet 511 Vincent Deramerourt 512 Charlotte Forsell 513 Håkan Thonberg 514 Maria Bjerke 515 Ellen De Roeck 516 María Teresa Martínez-Larrad 517 Natividad Olivar 518 Nuria Aguilera 519 Amanda Cano 520 Pilar Cañabate 521 Juan Macias 522 Olalla Maroñas 523 Raúl Nuñez-Llaves 524 Clàudia Olivé 525 Ester Pelejá 526 Astrid D. Adarmes-Gómez 527 María Dolores Alonso 528 Guillermo Amer-Ferrer 529 Martirio Antequera 530 Juan Andrés Burguera 531 Fátima Carrillo 532 Mario Carrión-Claro 533 María José Casajeros 534 Marian Martinez de Pancorbo 535 Rocío Escuela 536 Lorena Garrote-Espina 537 Pilar Gómez-Garre 538 Saray Hevilla 539 Silvia Jesús 540 Miguel Angel Labrador Espinosa 541 Agustina Legaz 542 Sara López-García 543 Daniel Macias-García 544 Salvadora Manzanares 545 Marta Marín 546 Juan Marín-Muñoz 547 Tamara Marín 548 Begoña Martínez 549 Victoriana Martínez 550 Pablo Martínez-Lage Álvarez 551 Maite Mendioroz Iriarte 552 María Teresa Periñán-Tocino 553 Rocío Pineda-Sánchez 554 Diego Real de Asúa 555 Silvia Rodrigo 556 Isabel Sastre 557 Maria Pilar Vicente 558 Rosario Vigo-Ortega 559 Liliana Vivancos 560 Jacques Epelbaum 561 Didier Hannequin 562 Dominique campion 563 Vincent Deramecourt 564 Christophe Tzourio 565 Alexis Brice 566 Bruno Dubois 567 Amy Williams 568 Charlene Thomas 569 Chloe Davies 570 William Nash 571 Kimberley Dowzell 572 Atahualpa Castillo Morales 573 Mateus Bernardo-Harrington 574 James Turton 575 Jenny Lord 576 Kristelle Brown 577 Emma Vardy 578 Elizabeth Fisher 579 Jason D. Warren 580 Martin Rossor 581 Natalie S. Ryan 582 Rita Guerreiro 583 James Uphill 584 Nick Bass 585 Reinhard Heun 586 Heike Kölsch 587 Britta Schürmann 588 André Lacour 589 Christine Herold 590 Janet A. Johnston 591 Peter Passmore 592 John Powell 593 Yogen Patel 594 Angela Hodges 595 Tim Becker 596 Donald Warden 597 Gordon Wilcock 598 Robert Clarke 599 Panagiotis Deloukas 600 Yoav Ben-Shlomo 601 Nigel M. Hooper 602 Stuart Pickering-Brown 603 Rebecca Sussams 604 Nick Warner 605 Anthony Bayer 606 Isabella Heuser 607 Dmitriy Drichel 608 Norman Klopp 609 Manuel Mayhaus 610 Matthias Riemenschneider 611 Sabrina Pinchler 612 Thomas Feulner 613 Wei Gu 614 Hendrik van den Bussche 615 Michael Hüll 616 Lutz Frölich 617 H-Erich Wichmann 618 Karl-Heinz Jöckel 619 Michael O’Donovan 620 Michael Owen 621 Shahram Bahrami 622 Ingunn Bosnes 623 Per Selnes 624 Sverre Bergh 625 Aarno Palotie 626 Mark Daly 627 Howard Jacob 628 Athena Matakidou 629 Heiko Runz 630 Sally John 631 Robert Plenge 632 Mark McCarthy 633 Julie Hunkapiller 634 Meg Ehm 635 Dawn Waterworth 636 Caroline Fox 637 Anders Malarstig 638 Kathy Klinger 639 Kathy Call 640 Tim Behrens 641 Patrick Loerch 642 Tomi Mäkelä 643 Jaakko Kaprio 644 Petri Virolainen 645 Kari Pulkki 646 Terhi Kilpi 647 Markus Perola 648 Jukka Partanen 649 Anne Pitkäranta 650 Riitta Kaarteenaho 651 Seppo Vainio 652 Miia Turpeinen 653 Raisa Serpi 654 Tarja Laitinen 655 Johanna Mäkelä 656 Veli-Matti Kosma 657 Urho Kujala 658 Outi Tuovila 659 Minna Hendolin 660 Raimo Pakkanen 661 Jeff Waring 662 Bridget Riley-Gillis 663 Jimmy Liu 664 Shameek Biswas 665 Dorothee Diogo 666 Catherine Marshall 667 Xinli Hu 668 Matthias Gossel 669 Robert Graham 670 Beryl Cummings 671 Samuli Ripatti 672 Johanna Schleutker 673 Mikko Arvas 674 Olli Carpén 675 Reetta Hinttala 676 Johannes Kettunen 677 Arto Mannermaa 678 Jari Laukkanen 679 Valtteri Julkunen 680 Anne Remes 681 Reetta Kälviäinen 682 Jukka Peltola 683 Pentti Tienari 684 Juha Rinne 685 Adam Ziemann 686 Jeffrey Waring 687 Sahar Esmaeeli 688 Nizar Smaoui 689 Anne Lehtonen 690 Susan Eaton 691 Sanni Lahdenperä 692 Janet van Adelsberg 693 John Michon 694 Geoff Kerchner 695 Natalie Bowers 696 Edmond Teng 697 John Eicher 698 Vinay Mehta 699 Padhraig Gormley 700 Kari Linden 701 Christopher Whelan 702 Fanli Xu 703 David Pulford 704 Martti Färkkilä 705 Sampsa Pikkarainen 706 Airi Jussila 707 Timo Blomster 708 Mikko Kiviniemi 709 Markku Voutilainen 710 Bob Georgantas 711 Graham Heap 712 Fedik Rahimov 713 Keith Usiskin 714 Tim Lu 715 Danny Oh 716 Kirsi Kalpala 717 Melissa Miller 718 Linda McCarthy 719 Kari Eklund 720 Antti Palomäki 721 Pia Isomäki 722 Laura Pirilä 723 Oili Kaipiainen-Seppänen 724 Johanna Huhtakangas 725 Apinya Lertratanakul 726 Marla Hochfeld 727 Nan Bing 728 Jorge Esparza Gordillo 729 Nina Mars 730 Margit Pelkonen 731 Paula Kauppi 732 Hannu Kankaanranta 733 Terttu Harju 734 David Close 735 Steven Greenberg 736 Hubert Chen 737 Jo Betts 738 Soumitra Ghosh 739 Veikko Salomaa 740 Teemu Niiranen 741 Markus Juonala 742 Kaj Metsärinne 743 Mika Kähönen 744 Juhani Junttila 745 Markku Laakso 746 Jussi Pihlajamäki 747 Juha Sinisalo 748 Marja-Riitta Taskinen 749 Tiinamaija Tuomi 750 Ben Challis 751 Andrew Peterson 752 Audrey Chu 753 Jaakko Parkkinen 754 Anthony Muslin 755 Heikki Joensuu 756 Tuomo Meretoja 757 Lauri Aaltonen 758 Johanna Mattson 759 Annika Auranen 760 Peeter Karihtala 761 Saila Kauppila 762 Päivi Auvinen 763 Klaus Elenius 764 Relja Popovic 765 Jennifer Schutzman 766 Andrey Loboda 767 Aparna Chhibber 768 Heli Lehtonen 769 Stefan McDonough 770 Marika Crohns 771 Diptee Kulkarni 772 Kai Kaarniranta 773 Joni A. Turunen 774 Terhi Ollila 775 Sanna Seitsonen 776 Hannu Uusitalo 777 Vesa Aaltonen 778 Hannele Uusitalo-Järvinen 779 Marja Luodonpää 780 Nina Hautala 781 Stephanie Loomis 782 Erich Strauss 783 Hao Chen 784 Anna Podgornaia 785 Joshua Hoffman 786 Kaisa Tasanen 787 Laura Huilaja 788 Katariina Hannula-Jouppi 789 Teea Salmi 790 Sirkku Peltonen 791 Leena Koulu 792 Ilkka Harvima 793 Ying Wu 794 David Choy 795 Pirkko Pussinen 796 Aino Salminen 797 Tuula Salo 798 David Rice 799 Pekka Nieminen 800 Ulla Palotie 801 Maria Siponen 802 Liisa Suominen 803 Päivi Mäntylä 804 Ulvi Gursoy 805 Vuokko Anttonen 806 Kirsi Sipilä 807 Justin Wade Davis 808 Danjuma Quarless 809 Slavé Petrovski 810 Eleonor Wigmore 811 Chia-Yen Chen 812 Paola Bronson 813 Ellen Tsai 814 Yunfeng Huang 815 Joseph Maranville 816 Elmutaz Shaikho 817 Elhaj Mohammed 818 Samir Wadhawan 819 Erika Kvikstad 820 Minal Caliskan 821 Diana Chang 822 Tushar Bhangale 823 Sarah Pendergrass 824 Emily Holzinger 825 Xing Chen 826 Åsa Hedman 827 Karen S. King 828 Clarence Wang 829 Ethan Xu 830 Franck Auge 831 Clement Chatelain 832 Deepak Rajpal 833 Dongyu Liu 834 Katherine Call 835 Tai-he Xia 836 Matt Brauer 837 Mitja Kurki 838 Juha Karjalainen 839 Aki Havulinna 840 Anu Jalanko 841 Priit Palta 842 Pietro della Briotta Parolo 843 Wei Zhou 844 Susanna Lemmelä 845 Manuel Rivas 846 Jarmo Harju 847 Arto Lehisto 848 Andrea Ganna 849 Vincent Llorens 850 Hannele Laivuori 851 Sina Rüeger 852 Mari E. Niemi 853 Taru Tukiainen 854 Mary Pat Reeve 855 Henrike Heyne 856 Kimmo Palin 857 Javier Garcia-Tabuenca 858 Harri Siirtola 859 Tuomo Kiiskinen 860 Jiwoo Lee 861 Kristin Tsuo 862 Amanda Elliott 863 Kati Kristiansson 864 Kati Hyvärinen 865 Jarmo Ritari 866 Miika Koskinen 867 Katri Pylkäs 868 Marita Kalaoja 869 Minna Karjalainen 870 Tuomo Mantere 871 Eeva Kangasniemi 872 Sami Heikkinen 873 Eija Laakkonen 874 Csilla Sipeky 875 Samuel Heron 876 Antti Karlsson 877 Dhanaprakash Jambulingam 878 Venkat Subramaniam Rathinakannan 879 Risto Kajanne 880 Mervi Aavikko 881 Manuel González Jiménez 882 Pietro della Briotta Parola 883 Arto Lehistö 884 Masahiro Kanai 885 Mari Kaunisto 886 Elina Kilpeläinen 887 Timo P. Sipilä 888 Georg Brein 889 Ghazal Awaisa 890 Anastasia Shcherban 891 Kati Donner 892 Anu Loukola 893 Päivi Laiho 894 Tuuli Sistonen 895 Essi Kaiharju 896 Markku Laukkanen 897 Elina Järvensivu 898 Sini Lähteenmäki 899 Lotta Männikkö 900 Regis Wong 901 Hannele Mattsson 902 Tero Hiekkalinna 903 Teemu Paajanen 904 Kalle Pärn 905 Javier Gracia-Tabuenca 906 Erin Abner 907 Perrie M. Adams 908 Alyssa Aguirre 909 Marilyn S. Albert 910 Roger L. Albin 911 Mariet Allen 912 Lisa Alvarez 913 Liana G. Apostolova 914 Steven E. Arnold 915 Sanjay Asthana 916 Craig S. Atwood 917 Gayle Ayres 918 Clinton T. Baldwin 919 Robert C. Barber 920 Lisa L. Barnes 921 Sandra Barral 922 Thomas G. Beach 923 James T. Becker 924 Gary W. Beecham 925 Duane Beekly 926 Jennifer E. Below 0000-0002-1346-1872 927 Penelope Benchek 928 Bruno A. Benitez 929 David Bennett 930 John Bertelson 931 Flanagan E. Margaret 932 Thomas D. Bird 933 Deborah Blacker 934 Bradley F. Boeve 935 James D. Bowen 936 Adam Boxer 937 James Brewer 938 James R. Burke 939 Jeffrey M. Burns 940 Will S. Bush 941 Joseph D. Buxbaum 942 Nigel J. Cairns 943 Chuanhai Cao 944 Christopher S. Carlson 945 Cynthia M. Carlsson 946 Regina M. Carney 947 Minerva M. Carrasquillo 948 Scott Chasse 949 Marie-Francoise Chesselet 950 Alessandra Chesi 951 Nathaniel A. Chin 952 Helena C. Chui 953 Jaeyoon Chung 954 Suzanne Craft 955 Paul K. Crane 956 David H. Cribbs 957 Elizabeth A. Crocco 958 Carlos Cruchaga 959 Michael L. Cuccaro 960 Munro Cullum 961 Eveleen Darby 962 Barbara Davis 963 Philip L. De Jager 964 Charles DeCarli 965 John DeToledo 966 Malcolm Dick 967 Dennis W. Dickson 968 Beth A. Dombroski 969 Rachelle S. Doody 970 Ranjan Duara 971 Nilüfer Ertekin-Taner 972 Denis A. Evans 973 Thomas J. Fairchild 974 Kenneth B. Fallon 975 Martin R. Farlow 976 John J. Farrell 977 Victoria Fernandez-Hernandez 978 Steven Ferris 979 Matthew P. Frosch 980 Brian Fulton-Howard 981 Douglas R. Galasko 982 Adriana Gamboa 983 Marla Gearing 984 Daniel H. Geschwind 985 Bernardino Ghetti 986 John R. Gilbert 987 Thomas J. Grabowski 988 Neill R. Graff-Radford 989 Struan F. A. Grant 990 Robert C. Green 991 John H. Growdon 992 Jonathan L. Haines 993 Hakon Hakonarson 994 James Hall 995 Ronald L. Hamilton 996 Oscar Harari 997 Lindy E. Harrell 998 Jacob Haut 999 Elizabeth Head 1000 Victor W. Henderson 1001 Michelle Hernandez 1002 Timothy Hohman 1003 Lawrence S. Honig 1004 Ryan M. Huebinger 1005 Matthew J. Huentelman 1006 Christine M. Hulette 1007 Bradley T. Hyman 1008 Linda S. Hynan 1009 Laura Ibanez 1010 Gail P. Jarvik 1011 Suman Jayadev 1012 Lee-Way Jin 1013 Kim Johnson 1014 Leigh Johnson 1015 M. Ilyas Kamboh 1016 Anna M. Karydas 1017 Mindy J. Katz 1018 Jeffrey A. Kaye 1019 C. Dirk Keene 1020 Aisha Khaleeq 1021 Ronald Kim 1022 Janice Knebl 1023 Neil W. Kowall 1024 Joel H. Kramer 1025 Pavel P. Kuksa 1026 Frank M. LaFerla 1027 James J. Lah 1028 Eric B. Larson 1029 Chien-Yueh Lee 1030 Edward B. Lee 1031 Alan Lerner 1032 Yuk Yee Leung 1033 James B. Leverenz 1034 Allan I. Levey 1035 Mingyao Li 1036 Andrew P. Lieberman 1037 Richard B. Lipton 1038 Mark Logue 1039 Constantine G. Lyketsos 1040 John Malamon 1041 Douglas Mains 1042 Daniel C. Marson 1043 Frank Martiniuk 1044 Deborah C. Mash 1045 Eliezer Masliah 1046 Paul Massman 1047 Arjun Masurkar 1048 Wayne C. McCormick 1049 Susan M. McCurry 1050 Andrew N. McDavid 1051 Stefan McDonough 1052 Ann C. McKee 1053 Marsel Mesulam 1054 Jesse Mez 1055 Bruce L. Miller 1056 Carol A. Miller 1057 Joshua W. Miller 1058 Thomas J. Montine 1059 Edwin S. Monuki 1060 John C. Morris 1061 Amanda J. Myers 1062 Trung Nguyen 1063 Sid O’Bryant 1064 John M. Olichney 1065 Marcia Ory 1066 Raymond Palmer 1067 Joseph E. Parisi 1068 Henry L. Paulson 1069 Valory Pavlik 1070 David Paydarfar 1071 Victoria Perez 1072 Elaine Peskind 1073 Ronald C. Petersen 1074 Jennifer E. Phillips-Cremins 1075 Aimee Pierce 1076 Marsha Polk 1077 Wayne W. Poon 1078 Huntington Potter 1079 Liming Qu 1080 Mary Quiceno 1081 Joseph F. Quinn 1082 Ashok Raj 1083 Murray Raskind 1084 Eric M. Reiman 1085 Barry Reisberg 1086 Joan S. Reisch 1087 John M. Ringman 1088 Erik D. Roberson 1089 Monica Rodriguear 1090 Ekaterina Rogaeva 1091 Howard J. Rosen 1092 Roger N. Rosenberg 1093 Donald R. Royall 1094 Mark A. Sager 1095 Mary Sano 1096 Andrew J. Saykin 1097 Julie A. Schneider 1098 Lon S. Schneider 1099 William W. Seeley 1100 Susan H. Slifer 1101 Scott Small 1102 Amanda G. Smith 1103 Janet P. Smith 1104 Yeunjoo E. Song 1105 Joshua A. Sonnen 1106 Salvatore Spina 1107 Peter St George-Hyslop 1108 Robert A. Stern 1109 Alan B. Stevens 1110 Stephen M. Strittmatter 1111 David Sultzer 1112 Russell H. Swerdlow 1113 Rudolph E. Tanzi 1114 Jeffrey L. Tilson 1115 John Q. Trojanowski 1116 Juan C. Troncoso 1117 Debby W. Tsuang 1118 Otto Valladares 1119 Vivianna M. Van Deerlin 1120 Linda J. van Eldik 1121 Robert Vassar 1122 Harry V. Vinters 1123 Jean-Paul Vonsattel 1124 Sandra Weintraub 1125 Kathleen A. Welsh-Bohmer 1126 Patrice L. Whitehead 1127 Ellen M. Wijsman 1128 Kirk C. Wilhelmsen 1129 Benjamin Williams 1130 Jennifer Williamson 1131 Henrik Wilms 1132 Thomas S. Wingo 1133 Thomas Wisniewski 1134 Randall L. Woltjer 1135 Martin Woon 1136 Clinton B. Wright 1137 Chuang-Kuo Wu 1138 Steven G. Younkin 1139 Chang-En Yu 1140 Lei Yu 1141 Yuanchao Zhang 1142 Yi Zhao 1143 Xiongwei Zhu 1144 Hieab Adams 1145 Rufus O. Akinyemi 1146 Muhammad Ali 1147 Nicola Armstrong 1148 Hugo J. Aparicio 1149 Maryam Bahadori 1150 James T. Becker 1151 Monique Breteler 1152 Daniel Chasman 1153 Ganesh Chauhan 1154 Hata Comic 1155 Simon Cox 1156 Adrienne L. Cupples 1157 Gail Davies 1158 Charles S. DeCarli 1159 Marie-Gabrielle Duperron 1160 Josée Dupuis 1161 Tavia Evans 1162 Frank Fan 1163 Annette Fitzpatrick 1164 Alison E. Fohner 1165 Mary Ganguli 1166 Mirjam Geerlings 1167 Stephen J. Glatt 1168 Hector M. Gonzalez 1169 Monica Goss 1170 Hans Grabe 1171 Mohamad Habes 1172 Susan R. Heckbert 1173 Edith Hofer 1174 Elliot Hong 1175 Timothy Hughes 1176 Tiffany F. Kautz 1177 Maria Knol 1178 William Kremen 1179 Paul Lacaze 1180 Jari Lahti 1181 Quentin Le Grand 1182 Elizabeth Litkowski 1183 Shuo Li 1184 Dan Liu 1185 Xuan Liu 1186 Marisa Loitfelder 1187 Alisa Manning 1188 Pauline Maillard 1189 Riccardo Marioni 1190 Bernard Mazoyer 1191 Debora Melo van Lent 1192 Hao Mei 1193 Aniket Mishra 1194 Paul Nyquist 1195 Jeffrey O’Connell 1196 Yash Patel 1197 Tomas Paus 1198 Zdenka Pausova 1199 Katri Raikkonen-Talvitie 1200 Moeen Riaz 1201 Stephen Rich 1202 Jerome Rotter 1203 Jose Romero 1204 Gena Roshchupkin 1205 Yasaman Saba 1206 Murali Sargurupremraj 1207 Helena Schmidt 1208 Reinhold Schmidt 1209 Joshua M. Shulman 1210 Jennifer Smith 1211 Hema Sekhar 1212 Reddy Rajula 1213 Jean Shin 1214 Jeannette Simino 1215 Eeva Sliz 1216 Alexander Teumer 1217 Alvin Thomas 1218 Adrienne Tin 1219 Elliot Tucker-Drob 1220 Dina Vojinovic 1221 Yanbing Wang 1222 Galit Weinstein 1223 Dylan Williams 1224 Katharina Wittfeld 1225 Lisa Yanek 1226 Yunju Yang 1227 Lindsay A. Farrer 0000-0001-5533-4225 1228 Bruce M. Psaty 0000-0002-7278-2190 1229 Mohsen Ghanbari 0000-0002-9476-7143 1230 Towfique Raj 0000-0002-9355-5704 1231 Perminder Sachdev 0000-0002-9595-3220 1232 Karen Mather 0000-0003-4143-8941 1233 Frank Jessen 1234 M. Arfan Ikram 0000-0003-0372-8585 1235 Alexandre de Mendonça 1236 Jakub Hort 1237 Magda Tsolaki 0000-0002-2072-8010 1238 Margaret A. Pericak-Vance 0000-0001-7283-8804 1239 Philippe Amouyel 0000-0001-9088-234x 1240 Julie Williams 0000-0002-4069-0259 1241 Ruth Frikke-Schmidt 0000-0003-4084-5027 1242 Jordi Clarimon 1243 Jean-François Deleuze 1244 Giacomina Rossi 1245 Sudha Seshadri 0000-0001-6135-2622 1246 Ole A. Andreassen 0000-0002-4461-3568 1247 Martin Ingelsson 1248 Mikko Hiltunen 1249 Kristel Sleegers 0000-0002-0283-2332 1250 Gerard D. Schellenberg 1251 Cornelia M. van Duijn 0000-0002-2374-9204 1252 Rebecca Sims 0000-0002-3885-1199 1253 Wiesje M. van der Flier 0000-0001-8766-6224 1254 Agustín Ruiz 1255 Alfredo Ramirez 0000-0003-4991-763x 1256 Jean-Charles Lambert 0000-0003-0829-7817 1257 (EADB) 1258 (GR@ACE) 1259 (DEGESCO) 1260 (EADI) 1261 (GERAD) 1262 (Demgene) 1263 (FinnGen) 1264 (ADGC) 1265 (CHARGE) 1266 60592__24701__607010dbc38d49ec97f23e93bc54faa6.pdf New insights into the genetic etiology ADRD.pdf 2022-07-22T00:42:45.0712012 Output 5163465 application/pdf Version of Record true This article is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/
title New insights into the genetic etiology of Alzheimer’s disease and related dementias
spellingShingle New insights into the genetic etiology of Alzheimer’s disease and related dementias
Vanessa Burholt
title_short New insights into the genetic etiology of Alzheimer’s disease and related dementias
title_full New insights into the genetic etiology of Alzheimer’s disease and related dementias
title_fullStr New insights into the genetic etiology of Alzheimer’s disease and related dementias
title_full_unstemmed New insights into the genetic etiology of Alzheimer’s disease and related dementias
title_sort New insights into the genetic etiology of Alzheimer’s disease and related dementias
author_id_str_mv cf7fe9863906cd54df5b0a99904d535e
author_id_fullname_str_mv cf7fe9863906cd54df5b0a99904d535e_***_Vanessa Burholt
author Vanessa Burholt
author2 Céline Bellenguez
Fahri Küçükali
Iris E. Jansen
Luca Kleineidam
Sonia Moreno-Grau
Najaf Amin
Adam C. Naj
Rafael Campos-Martin
Benjamin Grenier-Boley
Victor Andrade
Peter A. Holmans
Anne Boland
Vincent Damotte
Sven J. van der Lee
Marcos R. Costa
Teemu Kuulasmaa
Qiong Yang
Itziar de Rojas
Joshua C. Bis
Amber Yaqub
Ivana Prokic
Julien Chapuis
Shahzad Ahmad
Vilmantas Giedraitis
Dag Aarsland
Pablo Garcia-Gonzalez
Carla Abdelnour
Emilio Alarcón-Martín
Daniel Alcolea
Montserrat Alegret
Ignacio Alvarez
Victoria Álvarez
Nicola J. Armstrong
Anthoula Tsolaki
Carmen Antúnez
Ildebrando Appollonio
Marina Arcaro
Silvana Archetti
Alfonso Arias Pastor
Beatrice Arosio
Lavinia Athanasiu
Henri Bailly
Nerisa Banaj
Miquel Baquero
Sandra Barral
Alexa Beiser
Ana Belén Pastor
Jennifer E. Below
Penelope Benchek
Luisa Benussi
Claudine Berr
Céline Besse
Valentina Bessi
Giuliano Binetti
Alessandra Bizarro
Rafael Blesa
Mercè Boada
Eric Boerwinkle
Barbara Borroni
Silvia Boschi
Paola Bossù
Geir Bråthen
Jan Bressler
Catherine Bresner
Henry Brodaty
Keeley J. Brookes
Luis Ignacio Brusco
Dolores Buiza-Rueda
Katharina Bûrger
Vanessa Burholt
William S. Bush
Miguel Calero
Laura B. Cantwell
Geneviève Chene
Jaeyoon Chung
Michael L. Cuccaro
Ángel Carracedo
Roberta Cecchetti
Laura Cervera-Carles
Camille Charbonnier
Hung-Hsin Chen
Caterina Chillotti
Simona Ciccone
Jurgen A. H. R. Claassen
Christopher Clark
Elisa Conti
Anaïs Corma-Gómez
Emanuele Costantini
Carlo Custodero
Delphine Daian
Maria Carolina Dalmasso
Antonio Daniele
Efthimios Dardiotis
Jean-François Dartigues
Peter Paul de Deyn
Katia de Paiva Lopes
Lot D. de Witte
Stéphanie Debette
Jürgen Deckert
Teodoro del Ser
Nicola Denning
Anita DeStefano
Martin Dichgans
Janine Diehl-Schmid
Mónica Diez-Fairen
Paolo Dionigi Rossi
Srdjan Djurovic
Emmanuelle Duron
Emrah Düzel
Carole Dufouil
Gudny Eiriksdottir
Sebastiaan Engelborghs
Valentina Escott-Price
Ana Espinosa
Michael Ewers
Kelley M. Faber
Tagliavini Fabrizio
Sune Fallgaard Nielsen
David W. Fardo
Lucia Farotti
Chiara Fenoglio
Marta Fernández-Fuertes
Raffaele Ferrari
Catarina B. Ferreira
Evelyn Ferri
Bertrand Fin
Peter Fischer
Tormod Fladby
Klaus Fließbach
Bernard Fongang
Myriam Fornage
Juan Fortea
Tatiana M. Foroud
Silvia Fostinelli
Nick C. Fox
Emlio Franco-Macías
María J. Bullido
Ana Frank-García
Lutz Froelich
Brian Fulton-Howard
Daniela Galimberti
Jose Maria García-Alberca
Pablo García-González
Sebastian Garcia-Madrona
Guillermo Garcia-Ribas
Roberta Ghidoni
Ina Giegling
Giaccone Giorgio
Alison M. Goate
Oliver Goldhardt
Duber Gomez-Fonseca
Antonio González-Pérez
Caroline Graff
Giulia Grande
Emma Green
Timo Grimmer
Edna Grünblatt
Michelle Grunin
Vilmundur Gudnason
Tamar Guetta-Baranes
Annakaisa Haapasalo
Georgios Hadjigeorgiou
Jonathan L. Haines
Kara L. Hamilton-Nelson
Harald Hampel
Olivier Hanon
John Hardy
Annette M. Hartmann
Lucrezia Hausner
Janet Harwood
Stefanie Heilmann-Heimbach
Seppo Helisalmi
Michael T. Heneka
Isabel Hernández
Martin J. Herrmann
Per Hoffmann
Clive Holmes
Henne Holstege
Raquel Huerto Vilas
Marc Hulsman
Jack Humphrey
Geert Jan Biessels
Xueqiu Jian
Charlotte Johansson
Gyungah R. Jun
Yuriko Kastumata
John Kauwe
Patrick G. Kehoe
Lena Kilander
Anne Kinhult Ståhlbom
Miia Kivipelto
Anne Koivisto
Johannes Kornhuber
Mary H. Kosmidis
Walter A. Kukull
Pavel P. Kuksa
Brian W. Kunkle
Amanda B. Kuzma
Carmen Lage
Erika J. Laukka
Lenore Launer
Alessandra Lauria
Chien-Yueh Lee
Jenni Lehtisalo
Ondrej Lerch
Alberto Lleó
William Longstreth
Oscar Lopez
Adolfo Lopez de Munain
Seth Love
Malin Löwemark
Lauren Luckcuck
Kathryn L. Lunetta
Yiyi Ma
Juan Macías
Catherine A. MacLeod
Wolfgang Maier
Francesca Mangialasche
Marco Spallazzi
Marta Marquié
Rachel Marshall
Eden R. Martin
Angel Martín Montes
Carmen Martínez Rodríguez
Carlo Masullo
Richard Mayeux
Simon Mead
Patrizia Mecocci
Miguel Medina
Alun Meggy
Shima Mehrabian
Silvia Mendoza
Manuel Menéndez-González
Pablo Mir
Susanne Moebus
Merel Mol
Laura Molina-Porcel
Laura Montrreal
Laura Morelli
Fermin Moreno
Kevin Morgan
Thomas Mosley
Markus M. Nöthen
Carolina Muchnik
Shubhabrata Mukherjee
Benedetta Nacmias
Tiia Ngandu
Gael Nicolas
Børge G. Nordestgaard
Robert Olaso
Adelina Orellana
Michela Orsini
Gemma Ortega
Alessandro Padovani
Caffarra Paolo
Goran Papenberg
Lucilla Parnetti
Florence Pasquier
Pau Pastor
Gina Peloso
Alba Pérez-Cordón
Jordi Pérez-Tur
Pierre Pericard
Oliver Peters
Yolande A. L. Pijnenburg
Juan A. Pineda
Gerard Piñol-Ripoll
Claudia Pisanu
Thomas Polak
Julius Popp
Danielle Posthuma
Josef Priller
Raquel Puerta
Olivier Quenez
Inés Quintela
Jesper Qvist Thomassen
Alberto Rábano
Innocenzo Rainero
Farid Rajabli
Inez Ramakers
Luis M. Real
Marcel J. T. Reinders
Christiane Reitz
Dolly Reyes-Dumeyer
Perry Ridge
Steffi Riedel-Heller
Peter Riederer
Natalia Roberto
Eloy Rodriguez-Rodriguez
Arvid Rongve
Irene Rosas Allende
Maitée Rosende-Roca
Jose Luis Royo
Elisa Rubino
Dan Rujescu
María Eugenia Sáez
Paraskevi Sakka
Ingvild Saltvedt
Ángela Sanabria
María Bernal Sánchez-Arjona
Florentino Sanchez-Garcia
Pascual Sánchez Juan
Raquel Sánchez-Valle
Sigrid B. Sando
Chloé Sarnowski
Claudia L. Satizabal
Michela Scamosci
Nikolaos Scarmeas
Elio Scarpini
Philip Scheltens
Norbert Scherbaum
Martin Scherer
Matthias Schmid
Anja Schneider
Jonathan M. Schott
Geir Selbæk
Davide Seripa
Manuel Serrano
Jin Sha
Alexey A. Shadrin
Olivia Skrobot
Susan Slifer
Gijsje J. L. Snijders
Hilkka Soininen
Vincenzo Solfrizzi
Alina Solomon
Yeunjoo Song
Sandro Sorbi
Oscar Sotolongo-Grau
Gianfranco Spalletta
Annika Spottke
Alessio Squassina
Eystein Stordal
Juan Pablo Tartan
Lluís Tárraga
Niccolo Tesí
Anbupalam Thalamuthu
Tegos Thomas
Giuseppe Tosto
Latchezar Traykov
Lucio Tremolizzo
Anne Tybjærg-Hansen
Andre Uitterlinden
Abbe Ullgren
Ingun Ulstein
Sergi Valero
Otto Valladares
Christine Van Broeckhoven
Jeffery Vance
Badri N. Vardarajan
Aad van der Lugt
Jasper Van Dongen
Jeroen van Rooij
John van Swieten
Rik Vandenberghe
Frans Verhey
Jean-Sébastien Vidal
Jonathan Vogelgsang
Martin Vyhnalek
Michael Wagner
David Wallon
Li-San Wang
Ruiqi Wang
Leonie Weinhold
Jens Wiltfang
Gill Windle
Bob Woods
Mary Yannakoulia
Habil Zare
Yi Zhao
Xiaoling Zhang
Congcong Zhu
Miren Zulaica
Jan Laczo
Vaclav Matoska
Maria Serpente
Francesca Assogna
Fabrizio Piras
Federica Piras
Valentina Ciullo
Jacob Shofany
Carlo Ferrarese
Simona Andreoni
Gessica Sala
Chiara Paola Zoia
Maria Del Zompo
Alberto Benussi
Patrizia Bastiani
Mari Takalo
Teemu Natunen
Tiina Laatikainen
Jaakko Tuomilehto
Riitta Antikainen
Timo Strandberg
Jaana Lindström
Markku Peltonen
Richard Abraham
Ammar Al-Chalabi
Nicholas J. Bass
Carol Brayne
Kristelle S. Brown
John Collinge
David Craig
Pangiotis Deloukas
Nick Fox
Amy Gerrish
Michael Gill
Rhian Gwilliam
Denise Harold
Paul Hollingworth
Jarret A. Johnston
Lesley Jones
Brian Lawlor
Gill Livingston
Simon Lovestone
Michelle Lupton
Aoibhinn Lynch
David Mann
Bernadette McGuinness
Andrew McQuillin
Michael C. O’Donovan
Michael J. Owen
Peter Passmore
John F. Powell
Petra Proitsi
Martin Rossor
Christopher E. Shaw
A. David Smith
Hugh Gurling
Stephen Todd
Catherine Mummery
Nathalie Ryan
Giordano Lacidogna
Ad Adarmes-Gómez
Ana Mauleón
Ana Pancho
Anna Gailhajenet
Asunción Lafuente
D. Macias-García
Elvira Martín
Esther Pelejà
F. Carrillo
Isabel Sastre Merlín
L. Garrote-Espina
Liliana Vargas
M. Carrion-Claro
M. Marín
Ma Labrador
Mar Buendia
María Dolores Alonso
Marina Guitart
Mariona Moreno
Marta Ibarria
Mt Periñán
Nuria Aguilera
P. Gómez-Garre
Pilar Cañabate
R. Escuela
R. Pineda-Sánchez
R. Vigo-Ortega
S. Jesús
Silvia Preckler
Silvia Rodrigo-Herrero
Susana Diego
Alessandro Vacca
Fausto Roveta
Nicola Salvadori
Elena Chipi
Henning Boecker
Christoph Laske
Robert Perneczky
Costas Anastasiou
Daniel Janowitz
Rainer Malik
Anna Anastasiou
Kayenat Parveen
Carmen Lage
Sara López-García
Anna Antonell
Kalina Yonkova Mihova
Diyana Belezhanska
Heike Weber
Silvia Kochen
Patricia Solis
Nancy Medel
Julieta Lisso
Zulma Sevillano
Daniel G. Politis
Valeria Cores
Carolina Cuesta
Cecilia Ortiz
Juan Ignacio Bacha
Mario Rios
Aldo Saenz
Mariana Sanchez Abalos
Eduardo Kohler
Dana Lis Palacio
Ignacio Etchepareborda
Matias Kohler
Gisela Novack
Federico Ariel Prestia
Pablo Galeano
Eduardo M. Castaño
Sandra Germani
Carlos Reyes Toso
Matias Rojo
Carlos Ingino
Carlos Mangone
David C. Rubinsztein
Stefan Teipel
Nathalie Fievet
Vincent Deramerourt
Charlotte Forsell
Håkan Thonberg
Maria Bjerke
Ellen De Roeck
María Teresa Martínez-Larrad
Natividad Olivar
Nuria Aguilera
Amanda Cano
Pilar Cañabate
Juan Macias
Olalla Maroñas
Raúl Nuñez-Llaves
Clàudia Olivé
Ester Pelejá
Astrid D. Adarmes-Gómez
María Dolores Alonso
Guillermo Amer-Ferrer
Martirio Antequera
Juan Andrés Burguera
Fátima Carrillo
Mario Carrión-Claro
María José Casajeros
Marian Martinez de Pancorbo
Rocío Escuela
Lorena Garrote-Espina
Pilar Gómez-Garre
Saray Hevilla
Silvia Jesús
Miguel Angel Labrador Espinosa
Agustina Legaz
Sara López-García
Daniel Macias-García
Salvadora Manzanares
Marta Marín
Juan Marín-Muñoz
Tamara Marín
Begoña Martínez
Victoriana Martínez
Pablo Martínez-Lage Álvarez
Maite Mendioroz Iriarte
María Teresa Periñán-Tocino
Rocío Pineda-Sánchez
Diego Real de Asúa
Silvia Rodrigo
Isabel Sastre
Maria Pilar Vicente
Rosario Vigo-Ortega
Liliana Vivancos
Jacques Epelbaum
Didier Hannequin
Dominique campion
Vincent Deramecourt
Christophe Tzourio
Alexis Brice
Bruno Dubois
Amy Williams
Charlene Thomas
Chloe Davies
William Nash
Kimberley Dowzell
Atahualpa Castillo Morales
Mateus Bernardo-Harrington
James Turton
Jenny Lord
Kristelle Brown
Emma Vardy
Elizabeth Fisher
Jason D. Warren
Martin Rossor
Natalie S. Ryan
Rita Guerreiro
James Uphill
Nick Bass
Reinhard Heun
Heike Kölsch
Britta Schürmann
André Lacour
Christine Herold
Janet A. Johnston
Peter Passmore
John Powell
Yogen Patel
Angela Hodges
Tim Becker
Donald Warden
Gordon Wilcock
Robert Clarke
Panagiotis Deloukas
Yoav Ben-Shlomo
Nigel M. Hooper
Stuart Pickering-Brown
Rebecca Sussams
Nick Warner
Anthony Bayer
Isabella Heuser
Dmitriy Drichel
Norman Klopp
Manuel Mayhaus
Matthias Riemenschneider
Sabrina Pinchler
Thomas Feulner
Wei Gu
Hendrik van den Bussche
Michael Hüll
Lutz Frölich
H-Erich Wichmann
Karl-Heinz Jöckel
Michael O’Donovan
Michael Owen
Shahram Bahrami
Ingunn Bosnes
Per Selnes
Sverre Bergh
Aarno Palotie
Mark Daly
Howard Jacob
Athena Matakidou
Heiko Runz
Sally John
Robert Plenge
Mark McCarthy
Julie Hunkapiller
Meg Ehm
Dawn Waterworth
Caroline Fox
Anders Malarstig
Kathy Klinger
Kathy Call
Tim Behrens
Patrick Loerch
Tomi Mäkelä
Jaakko Kaprio
Petri Virolainen
Kari Pulkki
Terhi Kilpi
Markus Perola
Jukka Partanen
Anne Pitkäranta
Riitta Kaarteenaho
Seppo Vainio
Miia Turpeinen
Raisa Serpi
Tarja Laitinen
Johanna Mäkelä
Veli-Matti Kosma
Urho Kujala
Outi Tuovila
Minna Hendolin
Raimo Pakkanen
Jeff Waring
Bridget Riley-Gillis
Jimmy Liu
Shameek Biswas
Dorothee Diogo
Catherine Marshall
Xinli Hu
Matthias Gossel
Robert Graham
Beryl Cummings
Samuli Ripatti
Johanna Schleutker
Mikko Arvas
Olli Carpén
Reetta Hinttala
Johannes Kettunen
Arto Mannermaa
Jari Laukkanen
Valtteri Julkunen
Anne Remes
Reetta Kälviäinen
Jukka Peltola
Pentti Tienari
Juha Rinne
Adam Ziemann
Jeffrey Waring
Sahar Esmaeeli
Nizar Smaoui
Anne Lehtonen
Susan Eaton
Sanni Lahdenperä
Janet van Adelsberg
John Michon
Geoff Kerchner
Natalie Bowers
Edmond Teng
John Eicher
Vinay Mehta
Padhraig Gormley
Kari Linden
Christopher Whelan
Fanli Xu
David Pulford
Martti Färkkilä
Sampsa Pikkarainen
Airi Jussila
Timo Blomster
Mikko Kiviniemi
Markku Voutilainen
Bob Georgantas
Graham Heap
Fedik Rahimov
Keith Usiskin
Tim Lu
Danny Oh
Kirsi Kalpala
Melissa Miller
Linda McCarthy
Kari Eklund
Antti Palomäki
Pia Isomäki
Laura Pirilä
Oili Kaipiainen-Seppänen
Johanna Huhtakangas
Apinya Lertratanakul
Marla Hochfeld
Nan Bing
Jorge Esparza Gordillo
Nina Mars
Margit Pelkonen
Paula Kauppi
Hannu Kankaanranta
Terttu Harju
David Close
Steven Greenberg
Hubert Chen
Jo Betts
Soumitra Ghosh
Veikko Salomaa
Teemu Niiranen
Markus Juonala
Kaj Metsärinne
Mika Kähönen
Juhani Junttila
Markku Laakso
Jussi Pihlajamäki
Juha Sinisalo
Marja-Riitta Taskinen
Tiinamaija Tuomi
Ben Challis
Andrew Peterson
Audrey Chu
Jaakko Parkkinen
Anthony Muslin
Heikki Joensuu
Tuomo Meretoja
Lauri Aaltonen
Johanna Mattson
Annika Auranen
Peeter Karihtala
Saila Kauppila
Päivi Auvinen
Klaus Elenius
Relja Popovic
Jennifer Schutzman
Andrey Loboda
Aparna Chhibber
Heli Lehtonen
Stefan McDonough
Marika Crohns
Diptee Kulkarni
Kai Kaarniranta
Joni A. Turunen
Terhi Ollila
Sanna Seitsonen
Hannu Uusitalo
Vesa Aaltonen
Hannele Uusitalo-Järvinen
Marja Luodonpää
Nina Hautala
Stephanie Loomis
Erich Strauss
Hao Chen
Anna Podgornaia
Joshua Hoffman
Kaisa Tasanen
Laura Huilaja
Katariina Hannula-Jouppi
Teea Salmi
Sirkku Peltonen
Leena Koulu
Ilkka Harvima
Ying Wu
David Choy
Pirkko Pussinen
Aino Salminen
Tuula Salo
David Rice
Pekka Nieminen
Ulla Palotie
Maria Siponen
Liisa Suominen
Päivi Mäntylä
Ulvi Gursoy
Vuokko Anttonen
Kirsi Sipilä
Justin Wade Davis
Danjuma Quarless
Slavé Petrovski
Eleonor Wigmore
Chia-Yen Chen
Paola Bronson
Ellen Tsai
Yunfeng Huang
Joseph Maranville
Elmutaz Shaikho
Elhaj Mohammed
Samir Wadhawan
Erika Kvikstad
Minal Caliskan
Diana Chang
Tushar Bhangale
Sarah Pendergrass
Emily Holzinger
Xing Chen
Åsa Hedman
Karen S. King
Clarence Wang
Ethan Xu
Franck Auge
Clement Chatelain
Deepak Rajpal
Dongyu Liu
Katherine Call
Tai-he Xia
Matt Brauer
Mitja Kurki
Juha Karjalainen
Aki Havulinna
Anu Jalanko
Priit Palta
Pietro della Briotta Parolo
Wei Zhou
Susanna Lemmelä
Manuel Rivas
Jarmo Harju
Arto Lehisto
Andrea Ganna
Vincent Llorens
Hannele Laivuori
Sina Rüeger
Mari E. Niemi
Taru Tukiainen
Mary Pat Reeve
Henrike Heyne
Kimmo Palin
Javier Garcia-Tabuenca
Harri Siirtola
Tuomo Kiiskinen
Jiwoo Lee
Kristin Tsuo
Amanda Elliott
Kati Kristiansson
Kati Hyvärinen
Jarmo Ritari
Miika Koskinen
Katri Pylkäs
Marita Kalaoja
Minna Karjalainen
Tuomo Mantere
Eeva Kangasniemi
Sami Heikkinen
Eija Laakkonen
Csilla Sipeky
Samuel Heron
Antti Karlsson
Dhanaprakash Jambulingam
Venkat Subramaniam Rathinakannan
Risto Kajanne
Mervi Aavikko
Manuel González Jiménez
Pietro della Briotta Parola
Arto Lehistö
Masahiro Kanai
Mari Kaunisto
Elina Kilpeläinen
Timo P. Sipilä
Georg Brein
Ghazal Awaisa
Anastasia Shcherban
Kati Donner
Anu Loukola
Päivi Laiho
Tuuli Sistonen
Essi Kaiharju
Markku Laukkanen
Elina Järvensivu
Sini Lähteenmäki
Lotta Männikkö
Regis Wong
Hannele Mattsson
Tero Hiekkalinna
Teemu Paajanen
Kalle Pärn
Javier Gracia-Tabuenca
Erin Abner
Perrie M. Adams
Alyssa Aguirre
Marilyn S. Albert
Roger L. Albin
Mariet Allen
Lisa Alvarez
Liana G. Apostolova
Steven E. Arnold
Sanjay Asthana
Craig S. Atwood
Gayle Ayres
Clinton T. Baldwin
Robert C. Barber
Lisa L. Barnes
Sandra Barral
Thomas G. Beach
James T. Becker
Gary W. Beecham
Duane Beekly
Jennifer E. Below
Penelope Benchek
Bruno A. Benitez
David Bennett
John Bertelson
Flanagan E. Margaret
Thomas D. Bird
Deborah Blacker
Bradley F. Boeve
James D. Bowen
Adam Boxer
James Brewer
James R. Burke
Jeffrey M. Burns
Will S. Bush
Joseph D. Buxbaum
Nigel J. Cairns
Chuanhai Cao
Christopher S. Carlson
Cynthia M. Carlsson
Regina M. Carney
Minerva M. Carrasquillo
Scott Chasse
Marie-Francoise Chesselet
Alessandra Chesi
Nathaniel A. Chin
Helena C. Chui
Jaeyoon Chung
Suzanne Craft
Paul K. Crane
David H. Cribbs
Elizabeth A. Crocco
Carlos Cruchaga
Michael L. Cuccaro
Munro Cullum
Eveleen Darby
Barbara Davis
Philip L. De Jager
Charles DeCarli
John DeToledo
Malcolm Dick
Dennis W. Dickson
Beth A. Dombroski
Rachelle S. Doody
Ranjan Duara
Nilüfer Ertekin-Taner
Denis A. Evans
Thomas J. Fairchild
Kenneth B. Fallon
Martin R. Farlow
John J. Farrell
Victoria Fernandez-Hernandez
Steven Ferris
Matthew P. Frosch
Brian Fulton-Howard
Douglas R. Galasko
Adriana Gamboa
Marla Gearing
Daniel H. Geschwind
Bernardino Ghetti
John R. Gilbert
Thomas J. Grabowski
Neill R. Graff-Radford
Struan F. A. Grant
Robert C. Green
John H. Growdon
Jonathan L. Haines
Hakon Hakonarson
James Hall
Ronald L. Hamilton
Oscar Harari
Lindy E. Harrell
Jacob Haut
Elizabeth Head
Victor W. Henderson
Michelle Hernandez
Timothy Hohman
Lawrence S. Honig
Ryan M. Huebinger
Matthew J. Huentelman
Christine M. Hulette
Bradley T. Hyman
Linda S. Hynan
Laura Ibanez
Gail P. Jarvik
Suman Jayadev
Lee-Way Jin
Kim Johnson
Leigh Johnson
M. Ilyas Kamboh
Anna M. Karydas
Mindy J. Katz
Jeffrey A. Kaye
C. Dirk Keene
Aisha Khaleeq
Ronald Kim
Janice Knebl
Neil W. Kowall
Joel H. Kramer
Pavel P. Kuksa
Frank M. LaFerla
James J. Lah
Eric B. Larson
Chien-Yueh Lee
Edward B. Lee
Alan Lerner
Yuk Yee Leung
James B. Leverenz
Allan I. Levey
Mingyao Li
Andrew P. Lieberman
Richard B. Lipton
Mark Logue
Constantine G. Lyketsos
John Malamon
Douglas Mains
Daniel C. Marson
Frank Martiniuk
Deborah C. Mash
Eliezer Masliah
Paul Massman
Arjun Masurkar
Wayne C. McCormick
Susan M. McCurry
Andrew N. McDavid
Stefan McDonough
Ann C. McKee
Marsel Mesulam
Jesse Mez
Bruce L. Miller
Carol A. Miller
Joshua W. Miller
Thomas J. Montine
Edwin S. Monuki
John C. Morris
Amanda J. Myers
Trung Nguyen
Sid O’Bryant
John M. Olichney
Marcia Ory
Raymond Palmer
Joseph E. Parisi
Henry L. Paulson
Valory Pavlik
David Paydarfar
Victoria Perez
Elaine Peskind
Ronald C. Petersen
Jennifer E. Phillips-Cremins
Aimee Pierce
Marsha Polk
Wayne W. Poon
Huntington Potter
Liming Qu
Mary Quiceno
Joseph F. Quinn
Ashok Raj
Murray Raskind
Eric M. Reiman
Barry Reisberg
Joan S. Reisch
John M. Ringman
Erik D. Roberson
Monica Rodriguear
Ekaterina Rogaeva
Howard J. Rosen
Roger N. Rosenberg
Donald R. Royall
Mark A. Sager
Mary Sano
Andrew J. Saykin
Julie A. Schneider
Lon S. Schneider
William W. Seeley
Susan H. Slifer
Scott Small
Amanda G. Smith
Janet P. Smith
Yeunjoo E. Song
Joshua A. Sonnen
Salvatore Spina
Peter St George-Hyslop
Robert A. Stern
Alan B. Stevens
Stephen M. Strittmatter
David Sultzer
Russell H. Swerdlow
Rudolph E. Tanzi
Jeffrey L. Tilson
John Q. Trojanowski
Juan C. Troncoso
Debby W. Tsuang
Otto Valladares
Vivianna M. Van Deerlin
Linda J. van Eldik
Robert Vassar
Harry V. Vinters
Jean-Paul Vonsattel
Sandra Weintraub
Kathleen A. Welsh-Bohmer
Patrice L. Whitehead
Ellen M. Wijsman
Kirk C. Wilhelmsen
Benjamin Williams
Jennifer Williamson
Henrik Wilms
Thomas S. Wingo
Thomas Wisniewski
Randall L. Woltjer
Martin Woon
Clinton B. Wright
Chuang-Kuo Wu
Steven G. Younkin
Chang-En Yu
Lei Yu
Yuanchao Zhang
Yi Zhao
Xiongwei Zhu
Hieab Adams
Rufus O. Akinyemi
Muhammad Ali
Nicola Armstrong
Hugo J. Aparicio
Maryam Bahadori
James T. Becker
Monique Breteler
Daniel Chasman
Ganesh Chauhan
Hata Comic
Simon Cox
Adrienne L. Cupples
Gail Davies
Charles S. DeCarli
Marie-Gabrielle Duperron
Josée Dupuis
Tavia Evans
Frank Fan
Annette Fitzpatrick
Alison E. Fohner
Mary Ganguli
Mirjam Geerlings
Stephen J. Glatt
Hector M. Gonzalez
Monica Goss
Hans Grabe
Mohamad Habes
Susan R. Heckbert
Edith Hofer
Elliot Hong
Timothy Hughes
Tiffany F. Kautz
Maria Knol
William Kremen
Paul Lacaze
Jari Lahti
Quentin Le Grand
Elizabeth Litkowski
Shuo Li
Dan Liu
Xuan Liu
Marisa Loitfelder
Alisa Manning
Pauline Maillard
Riccardo Marioni
Bernard Mazoyer
Debora Melo van Lent
Hao Mei
Aniket Mishra
Paul Nyquist
Jeffrey O’Connell
Yash Patel
Tomas Paus
Zdenka Pausova
Katri Raikkonen-Talvitie
Moeen Riaz
Stephen Rich
Jerome Rotter
Jose Romero
Gena Roshchupkin
Yasaman Saba
Murali Sargurupremraj
Helena Schmidt
Reinhold Schmidt
Joshua M. Shulman
Jennifer Smith
Hema Sekhar
Reddy Rajula
Jean Shin
Jeannette Simino
Eeva Sliz
Alexander Teumer
Alvin Thomas
Adrienne Tin
Elliot Tucker-Drob
Dina Vojinovic
Yanbing Wang
Galit Weinstein
Dylan Williams
Katharina Wittfeld
Lisa Yanek
Yunju Yang
Lindsay A. Farrer
Bruce M. Psaty
Mohsen Ghanbari
Towfique Raj
Perminder Sachdev
Karen Mather
Frank Jessen
M. Arfan Ikram
Alexandre de Mendonça
Jakub Hort
Magda Tsolaki
Margaret A. Pericak-Vance
Philippe Amouyel
Julie Williams
Ruth Frikke-Schmidt
Jordi Clarimon
Jean-François Deleuze
Giacomina Rossi
Sudha Seshadri
Ole A. Andreassen
Martin Ingelsson
Mikko Hiltunen
Kristel Sleegers
Gerard D. Schellenberg
Cornelia M. van Duijn
Rebecca Sims
Wiesje M. van der Flier
Agustín Ruiz
Alfredo Ramirez
Jean-Charles Lambert
(EADB)
(GR@ACE)
(DEGESCO)
(EADI)
(GERAD)
(Demgene)
(FinnGen)
(ADGC)
(CHARGE)
format Journal article
container_title Nature Genetics
container_volume 54
container_issue 4
container_start_page 412
publishDate 2022
institution Swansea University
issn 1061-4036
1546-1718
doi_str_mv 10.1038/s41588-022-01024-z
publisher Springer Science and Business Media LLC
college_str College of Human and Health Sciences
hierarchytype
hierarchy_top_id collegeofhumanandhealthsciences
hierarchy_top_title College of Human and Health Sciences
hierarchy_parent_id collegeofhumanandhealthsciences
hierarchy_parent_title College of Human and Health Sciences
department_str Centre for Innovative Ageing{{{_:::_}}}College of Human and Health Sciences{{{_:::_}}}Centre for Innovative Ageing
document_store_str 1
active_str 0
description Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.
published_date 2022-04-04T15:32:46Z
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