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Experimental investigations of the human oesophagus: anisotropic properties of the embalmed mucosa–submucosa layer under large deformation

Ciara Durcan, Mokarram Hossain Orcid Logo, Grégory Chagnon, Djordje Perić, Georges Karam, Lara Bsiesy, Edouard Girard

Biomechanics and Modeling in Mechanobiology, Volume: 21, Pages: 1685 - 1702

Swansea University Author: Mokarram Hossain Orcid Logo

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DOI (Published version): 10.1007/s10237-022-01613-1

Abstract

Mechanical characterisation of the layer-specific, viscoelastic properties of the human oesophagus is crucial in furthering the development of devices emerging in the field, such as robotic endoscopic biopsy devices, as well as in enhancing the realism, and therefore effectiveness, of surgical simul...

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Published in: Biomechanics and Modeling in Mechanobiology
ISSN: 1617-7959 1617-7940
Published: Springer Science and Business Media LLC 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa60596
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In this study, the viscoelastic and stress-softening behaviour of the passive human oesophagus was investigated through ex vivo cyclic mechanical tests. Due to restrictions placed on the laboratory as a result of COVID-19, only oesophagi from cadavers fixed in formalin were allowed for testing. Three oesophagi in total were separated into their two main layers and the mucosa&#x2013;submucosa layer was investigated. A series of uniaxial tensile tests were conducted in the form of increasing stretch level cyclic tests at two different strain rates: 1% s&#x2212;1 and 10% s&#x2212;1. Rectangular samples in both the longitudinal and circumferential directions were tested to observe any anisotropy. Histological analysis was also performed through a variety of staining methods. Overall, the longitudinal direction was found to be much stiffer than the circumferential direction. Stress-softening was observed in both directions, as well as permanent set and hysteresis. Strain rate-dependent behaviour was also apparent in the two directions, with an increase in strain rate resulting in an increase in stiffness. This strain rate dependency was more pronounced in the longitudinal direction than the circumferential direction. 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spelling 2023-01-06T16:17:35.5971505 v2 60596 2022-07-22 Experimental investigations of the human oesophagus: anisotropic properties of the embalmed mucosa–submucosa layer under large deformation 140f4aa5c5ec18ec173c8542a7fddafd 0000-0002-4616-1104 Mokarram Hossain Mokarram Hossain true false 2022-07-22 GENG Mechanical characterisation of the layer-specific, viscoelastic properties of the human oesophagus is crucial in furthering the development of devices emerging in the field, such as robotic endoscopic biopsy devices, as well as in enhancing the realism, and therefore effectiveness, of surgical simulations. In this study, the viscoelastic and stress-softening behaviour of the passive human oesophagus was investigated through ex vivo cyclic mechanical tests. Due to restrictions placed on the laboratory as a result of COVID-19, only oesophagi from cadavers fixed in formalin were allowed for testing. Three oesophagi in total were separated into their two main layers and the mucosa–submucosa layer was investigated. A series of uniaxial tensile tests were conducted in the form of increasing stretch level cyclic tests at two different strain rates: 1% s−1 and 10% s−1. Rectangular samples in both the longitudinal and circumferential directions were tested to observe any anisotropy. Histological analysis was also performed through a variety of staining methods. Overall, the longitudinal direction was found to be much stiffer than the circumferential direction. Stress-softening was observed in both directions, as well as permanent set and hysteresis. Strain rate-dependent behaviour was also apparent in the two directions, with an increase in strain rate resulting in an increase in stiffness. This strain rate dependency was more pronounced in the longitudinal direction than the circumferential direction. Finally, the results were discussed in regard to the histological content of the layer, and the behaviour was modelled and validated using a visco-hyperelastic matrix-fibre model. Journal Article Biomechanics and Modeling in Mechanobiology 21 1685 1702 Springer Science and Business Media LLC 1617-7959 1617-7940 Human oesophagus; Cyclic testing; Visco-hyperelasticity; Anisotropy; Stress-softening; Damage mechanics 28 8 2022 2022-08-28 10.1007/s10237-022-01613-1 COLLEGE NANME General Engineering COLLEGE CODE GENG Swansea University SU Library paid the OA fee (TA Institutional Deal) Swansea University: SUSPRS 2023-01-06T16:17:35.5971505 2022-07-22T09:38:11.7260853 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - General Engineering Ciara Durcan 1 Mokarram Hossain 0000-0002-4616-1104 2 Grégory Chagnon 3 Djordje Perić 4 Georges Karam 5 Lara Bsiesy 6 Edouard Girard 7 60596__25819__5cbca25d9baf4cd4bfe000641e44e4d2.pdf 60596.pdf 2022-11-17T14:25:54.8993255 Output 3558239 application/pdf Version of Record true © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/
title Experimental investigations of the human oesophagus: anisotropic properties of the embalmed mucosa–submucosa layer under large deformation
spellingShingle Experimental investigations of the human oesophagus: anisotropic properties of the embalmed mucosa–submucosa layer under large deformation
Mokarram Hossain
title_short Experimental investigations of the human oesophagus: anisotropic properties of the embalmed mucosa–submucosa layer under large deformation
title_full Experimental investigations of the human oesophagus: anisotropic properties of the embalmed mucosa–submucosa layer under large deformation
title_fullStr Experimental investigations of the human oesophagus: anisotropic properties of the embalmed mucosa–submucosa layer under large deformation
title_full_unstemmed Experimental investigations of the human oesophagus: anisotropic properties of the embalmed mucosa–submucosa layer under large deformation
title_sort Experimental investigations of the human oesophagus: anisotropic properties of the embalmed mucosa–submucosa layer under large deformation
author_id_str_mv 140f4aa5c5ec18ec173c8542a7fddafd
author_id_fullname_str_mv 140f4aa5c5ec18ec173c8542a7fddafd_***_Mokarram Hossain
author Mokarram Hossain
author2 Ciara Durcan
Mokarram Hossain
Grégory Chagnon
Djordje Perić
Georges Karam
Lara Bsiesy
Edouard Girard
format Journal article
container_title Biomechanics and Modeling in Mechanobiology
container_volume 21
container_start_page 1685
publishDate 2022
institution Swansea University
issn 1617-7959
1617-7940
doi_str_mv 10.1007/s10237-022-01613-1
publisher Springer Science and Business Media LLC
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - General Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - General Engineering
document_store_str 1
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description Mechanical characterisation of the layer-specific, viscoelastic properties of the human oesophagus is crucial in furthering the development of devices emerging in the field, such as robotic endoscopic biopsy devices, as well as in enhancing the realism, and therefore effectiveness, of surgical simulations. In this study, the viscoelastic and stress-softening behaviour of the passive human oesophagus was investigated through ex vivo cyclic mechanical tests. Due to restrictions placed on the laboratory as a result of COVID-19, only oesophagi from cadavers fixed in formalin were allowed for testing. Three oesophagi in total were separated into their two main layers and the mucosa–submucosa layer was investigated. A series of uniaxial tensile tests were conducted in the form of increasing stretch level cyclic tests at two different strain rates: 1% s−1 and 10% s−1. Rectangular samples in both the longitudinal and circumferential directions were tested to observe any anisotropy. Histological analysis was also performed through a variety of staining methods. Overall, the longitudinal direction was found to be much stiffer than the circumferential direction. Stress-softening was observed in both directions, as well as permanent set and hysteresis. Strain rate-dependent behaviour was also apparent in the two directions, with an increase in strain rate resulting in an increase in stiffness. This strain rate dependency was more pronounced in the longitudinal direction than the circumferential direction. Finally, the results were discussed in regard to the histological content of the layer, and the behaviour was modelled and validated using a visco-hyperelastic matrix-fibre model.
published_date 2022-08-28T04:18:50Z
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score 11.012678

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