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Hospital length of stay among children with and without congenital anomalies across 11 European regions—A population-based data linkage study

Stine Kjaer Urhoj, Joachim Tan, Joan K. Morris Orcid Logo, Joanne Given, Gianni Astolfi, Silvia Baldacci, Ingeborg Barisic, Joanna Brigden, Clara Cavero-Carbonell, Hannah Evans, Mika Gissler, Anna Heino, Sue Jordan Orcid Logo, Renée Lutke, Ljubica Odak, Aurora Puccini, Michele Santoro, Ieuan Scanlon, Hermien E. K. de Walle, Diana Wellesley, Óscar Zurriaga Orcid Logo, Maria Loane, Ester Garne Orcid Logo

PLOS ONE, Volume: 17, Issue: 7, Start page: e0269874

Swansea University Authors: Sue Jordan Orcid Logo, Ieuan Scanlon

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DOI (Published version): 10.1371/journal.pone.0269874

Abstract

BackgroundCongenital anomalies are a leading cause of childhood morbidity, but little is known about the long-term outcomes.ObjectiveTo quantify the burden of disease in childhood for children with congenital anomalies by assessing the risk of hospitalisation, the number of days spent in hospital an...

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ISSN: 1932-6203
Published: Public Library of Science (PLoS) 2022
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The children were born between 1995 and 2014 and were followed to their tenth birthday or 31/12/2015. European meta-analyses of the outcome measures were performed by two age groups, &lt;1 year and 1&#x2013;4 years.Results99,416 EUROCAT children and 2,021,772 reference children were linked to hospital databases. Among EUROCAT children, 85% (95%-CI: 79&#x2013;90%) were hospitalised in the first year and 56% (95%-CI: 51&#x2013;61%) at ages 1&#x2013;4 years, compared to 31% (95%-CI: 26&#x2013;37%) and 25% (95%-CI: 19&#x2013;31%) of the reference children. Median length of stay was 2&#x2013;3 times longer for EUROCAT children in both age groups. The percentages of children with extended stays (&#x2265;10 days) in the first year were 24% (95%-CI: 20&#x2013;29%) for EUROCAT children and 1% (95%-CI: 1&#x2013;2%) for reference children. The median length of stay varied greatly between congenital anomaly subgroups, with children with gastrointestinal anomalies and congenital heart defects having the longest stays.ConclusionsChildren with congenital anomalies were more frequently hospitalised and median length of stay was longer. The outlook improves after the first year. Parents of children with congenital anomalies should be informed about the increased hospitalisations required for their child&#x2019;s care and the impact on family life and siblings, and they should be adequately supported.</abstract><type>Journal Article</type><journal>PLOS ONE</journal><volume>17</volume><journalNumber>7</journalNumber><paginationStart>e0269874</paginationStart><paginationEnd/><publisher>Public Library of Science (PLoS)</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>1932-6203</issnElectronic><keywords/><publishedDay>22</publishedDay><publishedMonth>7</publishedMonth><publishedYear>2022</publishedYear><publishedDate>2022-07-22</publishedDate><doi>10.1371/journal.pone.0269874</doi><url/><notes>Data Availability Statement: The data that support the findings of this study are available from theparticipating registries of congenital anomalies but restrictions apply to the availability of these data,which were used under license for the current study, and so are not publicly available. These dataare however available from the authors for scientifically valid requests and with permission ofthe participating registries of congenital anomalies. To apply for the data please complete the data request form available on https://www.eurolinkcat.eu/contactinformationanddatarequests.</notes><college>COLLEGE NANME</college><department>Health and Social Care School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>HSOC</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>This project has received funding from the European Union&#x2019;s Horizon 2020 research and innovation programme under grant agreement No. 733001.</funders><projectreference/><lastEdited>2022-08-04T11:50:35.5835437</lastEdited><Created>2022-07-28T21:46:49.5405727</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">School of Health and Social Care - Nursing</level></path><authors><author><firstname>Stine Kjaer</firstname><surname>Urhoj</surname><order>1</order></author><author><firstname>Joachim</firstname><surname>Tan</surname><order>2</order></author><author><firstname>Joan K.</firstname><surname>Morris</surname><orcid>0000-0002-7164-612x</orcid><order>3</order></author><author><firstname>Joanne</firstname><surname>Given</surname><order>4</order></author><author><firstname>Gianni</firstname><surname>Astolfi</surname><order>5</order></author><author><firstname>Silvia</firstname><surname>Baldacci</surname><order>6</order></author><author><firstname>Ingeborg</firstname><surname>Barisic</surname><order>7</order></author><author><firstname>Joanna</firstname><surname>Brigden</surname><order>8</order></author><author><firstname>Clara</firstname><surname>Cavero-Carbonell</surname><order>9</order></author><author><firstname>Hannah</firstname><surname>Evans</surname><order>10</order></author><author><firstname>Mika</firstname><surname>Gissler</surname><order>11</order></author><author><firstname>Anna</firstname><surname>Heino</surname><order>12</order></author><author><firstname>Sue</firstname><surname>Jordan</surname><orcid>0000-0002-5691-2987</orcid><order>13</order></author><author><firstname>Ren&#xE9;e</firstname><surname>Lutke</surname><order>14</order></author><author><firstname>Ljubica</firstname><surname>Odak</surname><order>15</order></author><author><firstname>Aurora</firstname><surname>Puccini</surname><order>16</order></author><author><firstname>Michele</firstname><surname>Santoro</surname><order>17</order></author><author><firstname>Ieuan</firstname><surname>Scanlon</surname><order>18</order></author><author><firstname>Hermien E. K. de</firstname><surname>Walle</surname><order>19</order></author><author><firstname>Diana</firstname><surname>Wellesley</surname><order>20</order></author><author><firstname>&#xD3;scar</firstname><surname>Zurriaga</surname><orcid>0000-0001-7279-432x</orcid><order>21</order></author><author><firstname>Maria</firstname><surname>Loane</surname><order>22</order></author><author><firstname>Ester</firstname><surname>Garne</surname><orcid>0000-0003-0430-2594</orcid><order>23</order></author></authors><documents><document><filename>60675__24838__88018b8e79e54884b19ded1c05c6d190.pdf</filename><originalFilename>60675.pdf</originalFilename><uploaded>2022-08-04T11:49:44.1260475</uploaded><type>Output</type><contentLength>993145</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>&#xA9; 2022 Urhoj et al. 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spelling 2022-08-04T11:50:35.5835437 v2 60675 2022-07-28 Hospital length of stay among children with and without congenital anomalies across 11 European regions—A population-based data linkage study 24ce9db29b4bde1af4e83b388aae0ea1 0000-0002-5691-2987 Sue Jordan Sue Jordan true false 9fcb224c6bd804a4d41a2a8570a71185 Ieuan Scanlon Ieuan Scanlon true false 2022-07-28 HSOC BackgroundCongenital anomalies are a leading cause of childhood morbidity, but little is known about the long-term outcomes.ObjectiveTo quantify the burden of disease in childhood for children with congenital anomalies by assessing the risk of hospitalisation, the number of days spent in hospital and proportion of children with extended stays (≥10 days).MethodsEuropean population-based record-linkage study in 11 regions in eight countries including children with congenital anomalies (EUROCAT children) and without congenital anomalies (reference children) living in the same regions. The children were born between 1995 and 2014 and were followed to their tenth birthday or 31/12/2015. European meta-analyses of the outcome measures were performed by two age groups, <1 year and 1–4 years.Results99,416 EUROCAT children and 2,021,772 reference children were linked to hospital databases. Among EUROCAT children, 85% (95%-CI: 79–90%) were hospitalised in the first year and 56% (95%-CI: 51–61%) at ages 1–4 years, compared to 31% (95%-CI: 26–37%) and 25% (95%-CI: 19–31%) of the reference children. Median length of stay was 2–3 times longer for EUROCAT children in both age groups. The percentages of children with extended stays (≥10 days) in the first year were 24% (95%-CI: 20–29%) for EUROCAT children and 1% (95%-CI: 1–2%) for reference children. The median length of stay varied greatly between congenital anomaly subgroups, with children with gastrointestinal anomalies and congenital heart defects having the longest stays.ConclusionsChildren with congenital anomalies were more frequently hospitalised and median length of stay was longer. The outlook improves after the first year. Parents of children with congenital anomalies should be informed about the increased hospitalisations required for their child’s care and the impact on family life and siblings, and they should be adequately supported. Journal Article PLOS ONE 17 7 e0269874 Public Library of Science (PLoS) 1932-6203 22 7 2022 2022-07-22 10.1371/journal.pone.0269874 Data Availability Statement: The data that support the findings of this study are available from theparticipating registries of congenital anomalies but restrictions apply to the availability of these data,which were used under license for the current study, and so are not publicly available. These dataare however available from the authors for scientifically valid requests and with permission ofthe participating registries of congenital anomalies. To apply for the data please complete the data request form available on https://www.eurolinkcat.eu/contactinformationanddatarequests. COLLEGE NANME Health and Social Care School COLLEGE CODE HSOC Swansea University Another institution paid the OA fee This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 733001. 2022-08-04T11:50:35.5835437 2022-07-28T21:46:49.5405727 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Nursing Stine Kjaer Urhoj 1 Joachim Tan 2 Joan K. Morris 0000-0002-7164-612x 3 Joanne Given 4 Gianni Astolfi 5 Silvia Baldacci 6 Ingeborg Barisic 7 Joanna Brigden 8 Clara Cavero-Carbonell 9 Hannah Evans 10 Mika Gissler 11 Anna Heino 12 Sue Jordan 0000-0002-5691-2987 13 Renée Lutke 14 Ljubica Odak 15 Aurora Puccini 16 Michele Santoro 17 Ieuan Scanlon 18 Hermien E. K. de Walle 19 Diana Wellesley 20 Óscar Zurriaga 0000-0001-7279-432x 21 Maria Loane 22 Ester Garne 0000-0003-0430-2594 23 60675__24838__88018b8e79e54884b19ded1c05c6d190.pdf 60675.pdf 2022-08-04T11:49:44.1260475 Output 993145 application/pdf Version of Record true © 2022 Urhoj et al. This is an open access article distributed under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title Hospital length of stay among children with and without congenital anomalies across 11 European regions—A population-based data linkage study
spellingShingle Hospital length of stay among children with and without congenital anomalies across 11 European regions—A population-based data linkage study
Sue Jordan
Ieuan Scanlon
title_short Hospital length of stay among children with and without congenital anomalies across 11 European regions—A population-based data linkage study
title_full Hospital length of stay among children with and without congenital anomalies across 11 European regions—A population-based data linkage study
title_fullStr Hospital length of stay among children with and without congenital anomalies across 11 European regions—A population-based data linkage study
title_full_unstemmed Hospital length of stay among children with and without congenital anomalies across 11 European regions—A population-based data linkage study
title_sort Hospital length of stay among children with and without congenital anomalies across 11 European regions—A population-based data linkage study
author_id_str_mv 24ce9db29b4bde1af4e83b388aae0ea1
9fcb224c6bd804a4d41a2a8570a71185
author_id_fullname_str_mv 24ce9db29b4bde1af4e83b388aae0ea1_***_Sue Jordan
9fcb224c6bd804a4d41a2a8570a71185_***_Ieuan Scanlon
author Sue Jordan
Ieuan Scanlon
author2 Stine Kjaer Urhoj
Joachim Tan
Joan K. Morris
Joanne Given
Gianni Astolfi
Silvia Baldacci
Ingeborg Barisic
Joanna Brigden
Clara Cavero-Carbonell
Hannah Evans
Mika Gissler
Anna Heino
Sue Jordan
Renée Lutke
Ljubica Odak
Aurora Puccini
Michele Santoro
Ieuan Scanlon
Hermien E. K. de Walle
Diana Wellesley
Óscar Zurriaga
Maria Loane
Ester Garne
format Journal article
container_title PLOS ONE
container_volume 17
container_issue 7
container_start_page e0269874
publishDate 2022
institution Swansea University
issn 1932-6203
doi_str_mv 10.1371/journal.pone.0269874
publisher Public Library of Science (PLoS)
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care - Nursing{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Nursing
document_store_str 1
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description BackgroundCongenital anomalies are a leading cause of childhood morbidity, but little is known about the long-term outcomes.ObjectiveTo quantify the burden of disease in childhood for children with congenital anomalies by assessing the risk of hospitalisation, the number of days spent in hospital and proportion of children with extended stays (≥10 days).MethodsEuropean population-based record-linkage study in 11 regions in eight countries including children with congenital anomalies (EUROCAT children) and without congenital anomalies (reference children) living in the same regions. The children were born between 1995 and 2014 and were followed to their tenth birthday or 31/12/2015. European meta-analyses of the outcome measures were performed by two age groups, <1 year and 1–4 years.Results99,416 EUROCAT children and 2,021,772 reference children were linked to hospital databases. Among EUROCAT children, 85% (95%-CI: 79–90%) were hospitalised in the first year and 56% (95%-CI: 51–61%) at ages 1–4 years, compared to 31% (95%-CI: 26–37%) and 25% (95%-CI: 19–31%) of the reference children. Median length of stay was 2–3 times longer for EUROCAT children in both age groups. The percentages of children with extended stays (≥10 days) in the first year were 24% (95%-CI: 20–29%) for EUROCAT children and 1% (95%-CI: 1–2%) for reference children. The median length of stay varied greatly between congenital anomaly subgroups, with children with gastrointestinal anomalies and congenital heart defects having the longest stays.ConclusionsChildren with congenital anomalies were more frequently hospitalised and median length of stay was longer. The outlook improves after the first year. Parents of children with congenital anomalies should be informed about the increased hospitalisations required for their child’s care and the impact on family life and siblings, and they should be adequately supported.
published_date 2022-07-22T02:32:56Z
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