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Beating Poisson stochastic particle encapsulation in flow-focusing microfluidic devices using viscoelastic liquids

Keshvad Shahrivar, Francesco Del Giudice Orcid Logo

Soft Matter, Volume: 18, Issue: 32, Pages: 5928 - 5933

Swansea University Author: Francesco Del Giudice Orcid Logo

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DOI (Published version): 10.1039/d2sm00935h

Abstract

The encapsulation and co-encapsulation of particles in microfluidic flows is essential in applications related to single-cell analysis and material synthesis. However, the whole encapsulation process is stochastic in nature, and its efficiency is limited by the so-called Poisson limit. We here demon...

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Published in: Soft Matter
ISSN: 1744-683X 1744-6848
Published: Royal Society of Chemistry (RSC) 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa60975
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spelling v2 60975 2022-08-30 Beating Poisson stochastic particle encapsulation in flow-focusing microfluidic devices using viscoelastic liquids 742d483071479b44d7888e16166b1309 0000-0002-9414-6937 Francesco Del Giudice Francesco Del Giudice true false 2022-08-30 CHEG The encapsulation and co-encapsulation of particles in microfluidic flows is essential in applications related to single-cell analysis and material synthesis. However, the whole encapsulation process is stochastic in nature, and its efficiency is limited by the so-called Poisson limit. We here demonstrate particle encapsulation in microfluidic devices having flow-focusing geometries with efficiency up to 2-fold larger than the stochastic limit imposed by the Poisson statistics. To this aim, we exploited the recently observed phenomenon of particle train formation in viscoelastic liquids, so that particles could approach the encapsulation area with a constant frequency that was subsequently synchronised to the constant frequency of droplet formation. We also developed a simplified expression based on the experimental results that can guide optimal design of the microfluidic encapsulation system. Finally, we report the first experimental evidence of viscoelastic co-encapsulation of particles coming from different streams. Journal Article Soft Matter 18 32 5928 5933 Royal Society of Chemistry (RSC) 1744-683X 1744-6848 29 7 2022 2022-07-29 10.1039/d2sm00935h COLLEGE NANME Chemical Engineering COLLEGE CODE CHEG Swansea University SU Library paid the OA fee (TA Institutional Deal) F.D.G acknowledges support from EPSRC New Investigator Award, grant EP/S036490/1. 2022-09-14T16:13:10.1690040 2022-08-30T11:44:12.4938285 College of Engineering Engineering Keshvad Shahrivar 1 Francesco Del Giudice 0000-0002-9414-6937 2 60975__25141__821ae50bbac44f57a4038d488928431b.pdf 60975_VoR.pdf 2022-09-14T16:11:46.9340654 Output 1447467 application/pdf Version of Record true This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. true eng http://creativecommons.org/licenses/by/3.0/
title Beating Poisson stochastic particle encapsulation in flow-focusing microfluidic devices using viscoelastic liquids
spellingShingle Beating Poisson stochastic particle encapsulation in flow-focusing microfluidic devices using viscoelastic liquids
Francesco Del Giudice
title_short Beating Poisson stochastic particle encapsulation in flow-focusing microfluidic devices using viscoelastic liquids
title_full Beating Poisson stochastic particle encapsulation in flow-focusing microfluidic devices using viscoelastic liquids
title_fullStr Beating Poisson stochastic particle encapsulation in flow-focusing microfluidic devices using viscoelastic liquids
title_full_unstemmed Beating Poisson stochastic particle encapsulation in flow-focusing microfluidic devices using viscoelastic liquids
title_sort Beating Poisson stochastic particle encapsulation in flow-focusing microfluidic devices using viscoelastic liquids
author_id_str_mv 742d483071479b44d7888e16166b1309
author_id_fullname_str_mv 742d483071479b44d7888e16166b1309_***_Francesco Del Giudice
author Francesco Del Giudice
author2 Keshvad Shahrivar
Francesco Del Giudice
format Journal article
container_title Soft Matter
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publishDate 2022
institution Swansea University
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1744-6848
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publisher Royal Society of Chemistry (RSC)
college_str College of Engineering
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hierarchy_top_title College of Engineering
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hierarchy_parent_title College of Engineering
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description The encapsulation and co-encapsulation of particles in microfluidic flows is essential in applications related to single-cell analysis and material synthesis. However, the whole encapsulation process is stochastic in nature, and its efficiency is limited by the so-called Poisson limit. We here demonstrate particle encapsulation in microfluidic devices having flow-focusing geometries with efficiency up to 2-fold larger than the stochastic limit imposed by the Poisson statistics. To this aim, we exploited the recently observed phenomenon of particle train formation in viscoelastic liquids, so that particles could approach the encapsulation area with a constant frequency that was subsequently synchronised to the constant frequency of droplet formation. We also developed a simplified expression based on the experimental results that can guide optimal design of the microfluidic encapsulation system. Finally, we report the first experimental evidence of viscoelastic co-encapsulation of particles coming from different streams.
published_date 2022-07-29T16:13:08Z
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