Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation

MAISTO, ANTONIO; McDowall, Daniel; Adams, Dave J.; Giudice, Francesco Del

doi:10.1021/acsaenm.2c00060

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Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation

ANTONIO MAISTO, Daniel McDowall, Dave J. Adams

, Francesco Del Giudice

ACS Applied Engineering Materials, Volume: 1, Issue: 1

Swansea University Authors: ANTONIO MAISTO, Francesco Del Giudice

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DOI (Published version): 10.1021/acsaenm.2c00060

Abstract

Fibers loaded with either particles or cells are widely employed across a variety of fields, including material science, tissue engineering, and pharmaceutical research. However, the concentration of such objects along the fiber length remains stochastic, thus resulting in fibers having heterogeneou...

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Published in:	ACS Applied Engineering Materials
ISSN:	2771-9545
Published:	American Chemical Society (ACS) 2022
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa61178
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first_indexed	2022-09-12T09:27:31Z
last_indexed	2023-01-27T04:14:48Z
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spelling	v2 61178 2022-09-12 Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation 339ad01cbcff2d76c3986c100c96d442 ANTONIO MAISTO ANTONIO MAISTO true false 742d483071479b44d7888e16166b1309 0000-0002-9414-6937 Francesco Del Giudice Francesco Del Giudice true false 2022-09-12 Fibers loaded with either particles or cells are widely employed across a variety of fields, including material science, tissue engineering, and pharmaceutical research. However, the concentration of such objects along the fiber length remains stochastic, thus resulting in fibers having heterogeneous properties along their length. We here introduce a new class of material featuring fibers loaded with “equally spaced” microparticles. The fibers were obtained thanks to the combination between the recently discovered viscoelastic particle ordering phenomenon and the well-established process of fiber synthesis via ex situ ionic gelation. We employed a simple experimental apparatus made of a syringe pump connected to a 100 μm tube ending in a calcium chloride bath. The liquid forming the fiber was an aqueous solution of hyaluronic acid and sodium alginate. We studied the effect of volumetric flow rate, sodium alginate concentration, and spinning speed on the fiber diameter and the particle-spacing in the fiber. We also discussed the advantages of this type of fiber over the existing ones and suggested potential applications across several fields. Journal Article ACS Applied Engineering Materials 1 1 American Chemical Society (ACS) 2771-9545 particle ordering, viscoelasticity, biomaterials, fibers, non-Newtonian fluids, gelation 23 9 2022 2022-09-23 10.1021/acsaenm.2c00060 COLLEGE NANME COLLEGE CODE Swansea University SU Library paid the OA fee (TA Institutional Deal) EPSRC: EP/S036490/1; Leverhulme Trust: RPG-2018-013 2023-06-12T17:09:15.1137396 2022-09-12T10:25:20.0906411 Faculty of Science and Engineering School of Engineering and Applied Sciences - Uncategorised ANTONIO MAISTO 1 Daniel McDowall 2 Dave J. Adams 0000-0002-3176-1350 3 Francesco Del Giudice 0000-0002-9414-6937 4 61178__25321__d97593c3da9945e3badd3a1fa451fbdc.pdf 61178_VoR.pdf 2022-10-06T11:53:59.4289340 Output 5232844 application/pdf Version of Record true Released under the terms of a Creative Commons Attribution 4.0 International (CC BY 4.0) License. true eng https://creativecommons.org/licenses/by/4.0/
title	Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation
spellingShingle	Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation ANTONIO MAISTO Francesco Del Giudice
title_short	Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation
title_full	Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation
title_fullStr	Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation
title_full_unstemmed	Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation
title_sort	Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation
author_id_str_mv	339ad01cbcff2d76c3986c100c96d442 742d483071479b44d7888e16166b1309
author_id_fullname_str_mv	339ad01cbcff2d76c3986c100c96d442_*_ANTONIO MAISTO 742d483071479b44d7888e16166b1309_*_Francesco Del Giudice
author	ANTONIO MAISTO Francesco Del Giudice
author2	ANTONIO MAISTO Daniel McDowall Dave J. Adams Francesco Del Giudice
format	Journal article
container_title	ACS Applied Engineering Materials
container_volume	1
container_issue	1
publishDate	2022
institution	Swansea University
issn	2771-9545
doi_str_mv	10.1021/acsaenm.2c00060
publisher	American Chemical Society (ACS)
college_str	Faculty of Science and Engineering
hierarchytype
hierarchy_top_id	facultyofscienceandengineering
hierarchy_top_title	Faculty of Science and Engineering
hierarchy_parent_id	facultyofscienceandengineering
hierarchy_parent_title	Faculty of Science and Engineering
department_str	School of Engineering and Applied Sciences - Uncategorised{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Uncategorised
document_store_str	1
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description	Fibers loaded with either particles or cells are widely employed across a variety of fields, including material science, tissue engineering, and pharmaceutical research. However, the concentration of such objects along the fiber length remains stochastic, thus resulting in fibers having heterogeneous properties along their length. We here introduce a new class of material featuring fibers loaded with “equally spaced” microparticles. The fibers were obtained thanks to the combination between the recently discovered viscoelastic particle ordering phenomenon and the well-established process of fiber synthesis via ex situ ionic gelation. We employed a simple experimental apparatus made of a syringe pump connected to a 100 μm tube ending in a calcium chloride bath. The liquid forming the fiber was an aqueous solution of hyaluronic acid and sodium alginate. We studied the effect of volumetric flow rate, sodium alginate concentration, and spinning speed on the fiber diameter and the particle-spacing in the fiber. We also discussed the advantages of this type of fiber over the existing ones and suggested potential applications across several fields.
published_date	2022-09-23T17:09:13Z
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score	11.016235

Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation

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