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The role of the amygdala during emotional processing in Huntington's disease: From pre-manifest to late stage disease

Sarah L. Mason, Jiaxiang Zhang Orcid Logo, Faye Begeti, Natalie Valle Guzman, Alpar S. Lazar, James B. Rowe, Roger A. Barker, Adam Hampshire

Neuropsychologia, Volume: 70, Pages: 80 - 89

Swansea University Author: Jiaxiang Zhang Orcid Logo

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DOI (Published version): 10.1016/j.neuropsychologia.2015.02.017

Abstract

BackgroundDeficits in emotional processing can be detected in the pre-manifest stage of Huntington's disease and negative emotion recognition has been identified as a predictor of clinical diagnosis. The underlying neuropathological correlates of such deficits are typically established using co...

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Published in: Neuropsychologia
ISSN: 0028-3932
Published: Elsevier BV 2015
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URI: https://cronfa.swan.ac.uk/Record/cronfa61342
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2022-10-11T12:38:28.3323860</datestamp><bib-version>v2</bib-version><id>61342</id><entry>2022-09-26</entry><title>The role of the amygdala during emotional processing in Huntington's disease: From pre-manifest to late stage disease</title><swanseaauthors><author><sid>555e06e0ed9a87608f2d035b3bde3a87</sid><ORCID>0000-0002-4758-0394</ORCID><firstname>Jiaxiang</firstname><surname>Zhang</surname><name>Jiaxiang Zhang</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2022-09-26</date><deptcode>SCS</deptcode><abstract>BackgroundDeficits in emotional processing can be detected in the pre-manifest stage of Huntington's disease and negative emotion recognition has been identified as a predictor of clinical diagnosis. The underlying neuropathological correlates of such deficits are typically established using correlative structural MRI studies. This approach does not take into consideration the impact of disruption to the complex interactions between multiple brain circuits on emotional processing. Therefore, exploration of the neural substrates of emotional processing in pre-manifest HD using fMRI connectivity analysis may be a useful way of evaluating the way brain regions interrelate in the period prior to diagnosis.MethodsWe investigated the impact of predicted time to disease onset on brain activation when participants were exposed to pictures of faces with angry and neutral expressions, in 20 pre-manifest HD gene carriers and 23 healthy controls. On the basis of the results of this initial study went on to look at amygdala dependent cognitive performance in 79 Huntington's disease patients from a cross-section of disease stages (pre-manifest to late disease) and 26 healthy controls, using a validated theory of mind task: &#x201C;the Reading the Mind in the Eyes Test&#x201D; which has been previously been shown to be amygdala dependent.ResultsPsychophysiological interaction analysis identified reduced connectivity between the left amygdala and right fusiform facial area in pre-manifest HD gene carriers compared to controls when viewing angry compared to neutral faces. Change in PPI connectivity scores correlated with predicted time to disease onset (r=0.45, p&lt;0.05). Furthermore, performance on the &#x201C;Reading the Mind in the Eyes Test&#x201D; correlated negatively with proximity to disease onset and became progressively worse with each stage of disease.ConclusionAbnormalities in the neural networks underlying social cognition and emotional processing can be detected prior to clinical diagnosis in Huntington's disease. Connectivity between the amygdala and other brain regions is impacted by the disease process in pre-manifest HD and may therefore be a useful way of identifying participants who are approaching a clinical diagnosis. Furthermore, the &#x201C;Reading the Mind in the Eyes Test&#x201D; is a surrogate measure of amygdala function that is clinically useful across the entire cross-section of disease stages in HD.</abstract><type>Journal Article</type><journal>Neuropsychologia</journal><volume>70</volume><journalNumber/><paginationStart>80</paginationStart><paginationEnd>89</paginationEnd><publisher>Elsevier BV</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0028-3932</issnPrint><issnElectronic/><keywords>fMRI; Theory of mind; Amygdala; Effective connectivity; Reading the mind in the eyes</keywords><publishedDay>1</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2015</publishedYear><publishedDate>2015-04-01</publishedDate><doi>10.1016/j.neuropsychologia.2015.02.017</doi><url/><notes/><college>COLLEGE NANME</college><department>Computer Science</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>SCS</DepartmentCode><institution>Swansea University</institution><apcterm/><funders>The work included in this manuscript has been partially funded by financial support from the NIHR Cambridge Biomedical Research Centre and the Cambridge University NHS Foundation Trust. JBR is supported by the Wellcome Trust (088324).</funders><projectreference/><lastEdited>2022-10-11T12:38:28.3323860</lastEdited><Created>2022-09-26T11:36:37.6584193</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Mathematics and Computer Science - Computer Science</level></path><authors><author><firstname>Sarah L.</firstname><surname>Mason</surname><order>1</order></author><author><firstname>Jiaxiang</firstname><surname>Zhang</surname><orcid>0000-0002-4758-0394</orcid><order>2</order></author><author><firstname>Faye</firstname><surname>Begeti</surname><order>3</order></author><author><firstname>Natalie Valle</firstname><surname>Guzman</surname><order>4</order></author><author><firstname>Alpar S.</firstname><surname>Lazar</surname><order>5</order></author><author><firstname>James B.</firstname><surname>Rowe</surname><order>6</order></author><author><firstname>Roger A.</firstname><surname>Barker</surname><order>7</order></author><author><firstname>Adam</firstname><surname>Hampshire</surname><order>8</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2022-10-11T12:38:28.3323860 v2 61342 2022-09-26 The role of the amygdala during emotional processing in Huntington's disease: From pre-manifest to late stage disease 555e06e0ed9a87608f2d035b3bde3a87 0000-0002-4758-0394 Jiaxiang Zhang Jiaxiang Zhang true false 2022-09-26 SCS BackgroundDeficits in emotional processing can be detected in the pre-manifest stage of Huntington's disease and negative emotion recognition has been identified as a predictor of clinical diagnosis. The underlying neuropathological correlates of such deficits are typically established using correlative structural MRI studies. This approach does not take into consideration the impact of disruption to the complex interactions between multiple brain circuits on emotional processing. Therefore, exploration of the neural substrates of emotional processing in pre-manifest HD using fMRI connectivity analysis may be a useful way of evaluating the way brain regions interrelate in the period prior to diagnosis.MethodsWe investigated the impact of predicted time to disease onset on brain activation when participants were exposed to pictures of faces with angry and neutral expressions, in 20 pre-manifest HD gene carriers and 23 healthy controls. On the basis of the results of this initial study went on to look at amygdala dependent cognitive performance in 79 Huntington's disease patients from a cross-section of disease stages (pre-manifest to late disease) and 26 healthy controls, using a validated theory of mind task: “the Reading the Mind in the Eyes Test” which has been previously been shown to be amygdala dependent.ResultsPsychophysiological interaction analysis identified reduced connectivity between the left amygdala and right fusiform facial area in pre-manifest HD gene carriers compared to controls when viewing angry compared to neutral faces. Change in PPI connectivity scores correlated with predicted time to disease onset (r=0.45, p<0.05). Furthermore, performance on the “Reading the Mind in the Eyes Test” correlated negatively with proximity to disease onset and became progressively worse with each stage of disease.ConclusionAbnormalities in the neural networks underlying social cognition and emotional processing can be detected prior to clinical diagnosis in Huntington's disease. Connectivity between the amygdala and other brain regions is impacted by the disease process in pre-manifest HD and may therefore be a useful way of identifying participants who are approaching a clinical diagnosis. Furthermore, the “Reading the Mind in the Eyes Test” is a surrogate measure of amygdala function that is clinically useful across the entire cross-section of disease stages in HD. Journal Article Neuropsychologia 70 80 89 Elsevier BV 0028-3932 fMRI; Theory of mind; Amygdala; Effective connectivity; Reading the mind in the eyes 1 4 2015 2015-04-01 10.1016/j.neuropsychologia.2015.02.017 COLLEGE NANME Computer Science COLLEGE CODE SCS Swansea University The work included in this manuscript has been partially funded by financial support from the NIHR Cambridge Biomedical Research Centre and the Cambridge University NHS Foundation Trust. JBR is supported by the Wellcome Trust (088324). 2022-10-11T12:38:28.3323860 2022-09-26T11:36:37.6584193 Faculty of Science and Engineering School of Mathematics and Computer Science - Computer Science Sarah L. Mason 1 Jiaxiang Zhang 0000-0002-4758-0394 2 Faye Begeti 3 Natalie Valle Guzman 4 Alpar S. Lazar 5 James B. Rowe 6 Roger A. Barker 7 Adam Hampshire 8
title The role of the amygdala during emotional processing in Huntington's disease: From pre-manifest to late stage disease
spellingShingle The role of the amygdala during emotional processing in Huntington's disease: From pre-manifest to late stage disease
Jiaxiang Zhang
title_short The role of the amygdala during emotional processing in Huntington's disease: From pre-manifest to late stage disease
title_full The role of the amygdala during emotional processing in Huntington's disease: From pre-manifest to late stage disease
title_fullStr The role of the amygdala during emotional processing in Huntington's disease: From pre-manifest to late stage disease
title_full_unstemmed The role of the amygdala during emotional processing in Huntington's disease: From pre-manifest to late stage disease
title_sort The role of the amygdala during emotional processing in Huntington's disease: From pre-manifest to late stage disease
author_id_str_mv 555e06e0ed9a87608f2d035b3bde3a87
author_id_fullname_str_mv 555e06e0ed9a87608f2d035b3bde3a87_***_Jiaxiang Zhang
author Jiaxiang Zhang
author2 Sarah L. Mason
Jiaxiang Zhang
Faye Begeti
Natalie Valle Guzman
Alpar S. Lazar
James B. Rowe
Roger A. Barker
Adam Hampshire
format Journal article
container_title Neuropsychologia
container_volume 70
container_start_page 80
publishDate 2015
institution Swansea University
issn 0028-3932
doi_str_mv 10.1016/j.neuropsychologia.2015.02.017
publisher Elsevier BV
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Mathematics and Computer Science - Computer Science{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Mathematics and Computer Science - Computer Science
document_store_str 0
active_str 0
description BackgroundDeficits in emotional processing can be detected in the pre-manifest stage of Huntington's disease and negative emotion recognition has been identified as a predictor of clinical diagnosis. The underlying neuropathological correlates of such deficits are typically established using correlative structural MRI studies. This approach does not take into consideration the impact of disruption to the complex interactions between multiple brain circuits on emotional processing. Therefore, exploration of the neural substrates of emotional processing in pre-manifest HD using fMRI connectivity analysis may be a useful way of evaluating the way brain regions interrelate in the period prior to diagnosis.MethodsWe investigated the impact of predicted time to disease onset on brain activation when participants were exposed to pictures of faces with angry and neutral expressions, in 20 pre-manifest HD gene carriers and 23 healthy controls. On the basis of the results of this initial study went on to look at amygdala dependent cognitive performance in 79 Huntington's disease patients from a cross-section of disease stages (pre-manifest to late disease) and 26 healthy controls, using a validated theory of mind task: “the Reading the Mind in the Eyes Test” which has been previously been shown to be amygdala dependent.ResultsPsychophysiological interaction analysis identified reduced connectivity between the left amygdala and right fusiform facial area in pre-manifest HD gene carriers compared to controls when viewing angry compared to neutral faces. Change in PPI connectivity scores correlated with predicted time to disease onset (r=0.45, p<0.05). Furthermore, performance on the “Reading the Mind in the Eyes Test” correlated negatively with proximity to disease onset and became progressively worse with each stage of disease.ConclusionAbnormalities in the neural networks underlying social cognition and emotional processing can be detected prior to clinical diagnosis in Huntington's disease. Connectivity between the amygdala and other brain regions is impacted by the disease process in pre-manifest HD and may therefore be a useful way of identifying participants who are approaching a clinical diagnosis. Furthermore, the “Reading the Mind in the Eyes Test” is a surrogate measure of amygdala function that is clinically useful across the entire cross-section of disease stages in HD.
published_date 2015-04-01T04:20:07Z
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score 10.998093

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