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The interindividual variability of multimodal brain connectivity maintains spatial heterogeneity and relates to tissue microstructure

Esin Karahan, Luke Tait Orcid Logo, Ruoguang Si, Ayşegül Özkan, Maciek J. Szul Orcid Logo, Kim S. Graham, Andrew D. Lawrence Orcid Logo, Jiaxiang Zhang Orcid Logo

Communications Biology, Volume: 5, Issue: 1

Swansea University Author: Jiaxiang Zhang Orcid Logo

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Abstract

Humans differ from each other in a wide range of biometrics, but to what extent brain connectivity varies between individuals remains largely unknown. By combining diffusion-weighted imaging (DWI) and magnetoencephalography (MEG), this study characterizes the inter-subject variability (ISV) of multi...

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Published in: Communications Biology
ISSN: 2399-3642
Published: Springer Science and Business Media LLC 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa61343
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Abstract: Humans differ from each other in a wide range of biometrics, but to what extent brain connectivity varies between individuals remains largely unknown. By combining diffusion-weighted imaging (DWI) and magnetoencephalography (MEG), this study characterizes the inter-subject variability (ISV) of multimodal brain connectivity. Structural connectivity is characterized by higher ISV in association cortices including the core multiple-demand network and lower ISV in the sensorimotor cortex. MEG ISV exhibits frequency-dependent signatures, and the extent of MEG ISV is consistent with that of structural connectivity ISV in selective macroscopic cortical clusters. Across the cortex, the ISVs of structural connectivity and beta-band MEG functional connectivity are negatively associated with cortical myelin content indexed by the quantitative T1 relaxation rate measured by high-resolution 7 T MRI. Furthermore, MEG ISV from alpha to gamma bands relates to the hindrance and restriction of the white-matter tissue estimated by DWI microstructural models. Our findings depict the inter-relationship between the ISV of brain connectivity from multiple modalities, and highlight the role of tissue microstructure underpinning the ISV.
Item Description: Data availability:DWI, MEG and 7 T MRI data that support the findings of this study and data from all analyses are available in OSF with the unique identifier [https://doi.org/10.17605/osf.io/rqj8a]. A part of data used in the preparation of this work were obtained from the Cam-CAN repository (https://www.cam-can.org).
College: Faculty of Science and Engineering
Funders: This study was supported by the European Research Council (716321), the UK Medical Research Council (MR/N01233X/1) and a Wellcome Trust Institutional Strategic Support Fund (ISSF). This research was funded in part by the Wellcome Trust (104943/Z/14/Z). R.S. was supported by a PhD studentship from the China Scholarship Council. A.Ö. was supported by a PhD studentship from the Turkish Ministry of National Education. M.J.S. was supported by a PhD studentship from Cardiff University School of Psychology.Cam-CAN funding was provided by the UK Biotechnology and Biological Sciences Research Council (BB/H008217/1), together with support from the UK Medical Research Council and the University of Cambridge, UK.
Issue: 1