Fatigue in multiple sclerosis: A UK MS-register based study

Moore, Harriet; Sivaraman, Krishnan Padmakumari; Baster, Kathleen; Middleton, Rod; Paling, David; Sharrack, Basil

doi:10.1016/j.msard.2022.103954

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Fatigue in multiple sclerosis: A UK MS-register based study

Harriet Moore, Krishnan Padmakumari Sivaraman Nair

, Kathleen Baster, Rod Middleton

, David Paling, Basil Sharrack

Multiple Sclerosis and Related Disorders, Volume: 64, Start page: 103954

Swansea University Author: Rod Middleton

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DOI (Published version): 10.1016/j.msard.2022.103954

Abstract

BackgroundFatigue is a widely experienced, incapacitating symptom of MS. It hinders daily functioning and has deleterious effects on quality of life. The UK MS Register is an online registry of over 20,000 participants with MS. The aim of this study was to estimate the prevalence, predictors, and im...

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Published in:	Multiple Sclerosis and Related Disorders
ISSN:	2211-0348
Published:	Elsevier BV 2022
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The aim of this study was to estimate the prevalence, predictors, and impact of fatigue on people with MS using data from the UKMS register.MethodsAll participants who completed the Fatigue Severity Scale (FSS), WebEDSS, Hospital Anxiety and Depression Scale (HADS) within 28 days of each other were selected from the UK MS Register. Data on age, gender, duration and type of MS, use of disease modifying drugs and comorbidities were obtained from the UKMS register. We categorised people with FSS score of 5 or more as with fatigue and those with scores of 4 or less as without fatigue. Descriptive statistics and logistical and multiple regressions were used to explore predictors of fatigue and the effect of fatigue on mobility (MS Walking Scale), physical and psychological aspects of life (MS Impact Scale) and quality of life (European Quality of Life 5D-3 L).ResultsAmongst the 20,946 participants of the UK MS registry, 4620 completed FSS. Out of these, 775 (mean age= 54.71 years, SD= 10.90; mean duration of MS diagnosis =13.21 years, SD=9.75) had completed the FSS, Web EDSS and Hospital Anxiety and Depression Scale within 28 days of each other. 427 (55.1%) of pwMS had a FSS score >5 consistent with clinical fatigue. Logistic regression analysis showed that depression (p=<0.001), duration of MS (p = 0.017), secondary progressive MS (p = 0.001) and EDSS (p=<0.001) predicted fatigue. FSS scores had a significant negative impact on both psychological (p > 0.001) and physical (p > 0.001) domains of the MS Impact scale, MS walking scale (p = 0.003) and EQoL (p = 0.005).ConclusionsFatigue was a common symptom amongst people with MS. Depression, longer duration of MS, secondary progressive MS, and high EDSS predicted fatigue. 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spelling	2022-10-20T15:01:55.3752168 v2 61484 2022-10-07 Fatigue in multiple sclerosis: A UK MS-register based study 005518f819ef1a2a13fdf438529bdfcd 0000-0002-2130-4420 Rod Middleton Rod Middleton true false 2022-10-07 HDAT BackgroundFatigue is a widely experienced, incapacitating symptom of MS. It hinders daily functioning and has deleterious effects on quality of life. The UK MS Register is an online registry of over 20,000 participants with MS. The aim of this study was to estimate the prevalence, predictors, and impact of fatigue on people with MS using data from the UKMS register.MethodsAll participants who completed the Fatigue Severity Scale (FSS), WebEDSS, Hospital Anxiety and Depression Scale (HADS) within 28 days of each other were selected from the UK MS Register. Data on age, gender, duration and type of MS, use of disease modifying drugs and comorbidities were obtained from the UKMS register. We categorised people with FSS score of 5 or more as with fatigue and those with scores of 4 or less as without fatigue. Descriptive statistics and logistical and multiple regressions were used to explore predictors of fatigue and the effect of fatigue on mobility (MS Walking Scale), physical and psychological aspects of life (MS Impact Scale) and quality of life (European Quality of Life 5D-3 L).ResultsAmongst the 20,946 participants of the UK MS registry, 4620 completed FSS. Out of these, 775 (mean age= 54.71 years, SD= 10.90; mean duration of MS diagnosis =13.21 years, SD=9.75) had completed the FSS, Web EDSS and Hospital Anxiety and Depression Scale within 28 days of each other. 427 (55.1%) of pwMS had a FSS score >5 consistent with clinical fatigue. Logistic regression analysis showed that depression (p=<0.001), duration of MS (p = 0.017), secondary progressive MS (p = 0.001) and EDSS (p=<0.001) predicted fatigue. FSS scores had a significant negative impact on both psychological (p > 0.001) and physical (p > 0.001) domains of the MS Impact scale, MS walking scale (p = 0.003) and EQoL (p = 0.005).ConclusionsFatigue was a common symptom amongst people with MS. Depression, longer duration of MS, secondary progressive MS, and high EDSS predicted fatigue. Fatigue had an adverse effect on physical activities, mobility, psychological wellbeing, and quality of life of people with MS. Journal Article Multiple Sclerosis and Related Disorders 64 103954 Elsevier BV 2211-0348 Multiple sclerosis; Fatigue; Depression; Quality of life; Mobility 1 8 2022 2022-08-01 10.1016/j.msard.2022.103954 COLLEGE NANME Health Data Science COLLEGE CODE HDAT Swansea University This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. 2022-10-20T15:01:55.3752168 2022-10-07T12:10:23.9407737 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Harriet Moore 1 Krishnan Padmakumari Sivaraman Nair 0000-0002-4004-2315 2 Kathleen Baster 3 Rod Middleton 0000-0002-2130-4420 4 David Paling 5 Basil Sharrack 6 61484__25535__7e8a3781b84f43de983cbc2512475e35.pdf 61484_VoR.pdf 2022-10-20T15:01:07.7474189 Output 598537 application/pdf Version of Record true © 2022 Published by Elsevier B.V. This is an open access article under the CC BY license true eng http://creativecommons.org/licenses/by/4.0/
title	Fatigue in multiple sclerosis: A UK MS-register based study
spellingShingle	Fatigue in multiple sclerosis: A UK MS-register based study Rod Middleton
title_short	Fatigue in multiple sclerosis: A UK MS-register based study
title_full	Fatigue in multiple sclerosis: A UK MS-register based study
title_fullStr	Fatigue in multiple sclerosis: A UK MS-register based study
title_full_unstemmed	Fatigue in multiple sclerosis: A UK MS-register based study
title_sort	Fatigue in multiple sclerosis: A UK MS-register based study
author_id_str_mv	005518f819ef1a2a13fdf438529bdfcd
author_id_fullname_str_mv	005518f819ef1a2a13fdf438529bdfcd_***_Rod Middleton
author	Rod Middleton
author2	Harriet Moore Krishnan Padmakumari Sivaraman Nair Kathleen Baster Rod Middleton David Paling Basil Sharrack
format	Journal article
container_title	Multiple Sclerosis and Related Disorders
container_volume	64
container_start_page	103954
publishDate	2022
institution	Swansea University
issn	2211-0348
doi_str_mv	10.1016/j.msard.2022.103954
publisher	Elsevier BV
college_str	Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str	1
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description	BackgroundFatigue is a widely experienced, incapacitating symptom of MS. It hinders daily functioning and has deleterious effects on quality of life. The UK MS Register is an online registry of over 20,000 participants with MS. The aim of this study was to estimate the prevalence, predictors, and impact of fatigue on people with MS using data from the UKMS register.MethodsAll participants who completed the Fatigue Severity Scale (FSS), WebEDSS, Hospital Anxiety and Depression Scale (HADS) within 28 days of each other were selected from the UK MS Register. Data on age, gender, duration and type of MS, use of disease modifying drugs and comorbidities were obtained from the UKMS register. We categorised people with FSS score of 5 or more as with fatigue and those with scores of 4 or less as without fatigue. Descriptive statistics and logistical and multiple regressions were used to explore predictors of fatigue and the effect of fatigue on mobility (MS Walking Scale), physical and psychological aspects of life (MS Impact Scale) and quality of life (European Quality of Life 5D-3 L).ResultsAmongst the 20,946 participants of the UK MS registry, 4620 completed FSS. Out of these, 775 (mean age= 54.71 years, SD= 10.90; mean duration of MS diagnosis =13.21 years, SD=9.75) had completed the FSS, Web EDSS and Hospital Anxiety and Depression Scale within 28 days of each other. 427 (55.1%) of pwMS had a FSS score >5 consistent with clinical fatigue. Logistic regression analysis showed that depression (p=<0.001), duration of MS (p = 0.017), secondary progressive MS (p = 0.001) and EDSS (p=<0.001) predicted fatigue. FSS scores had a significant negative impact on both psychological (p > 0.001) and physical (p > 0.001) domains of the MS Impact scale, MS walking scale (p = 0.003) and EQoL (p = 0.005).ConclusionsFatigue was a common symptom amongst people with MS. Depression, longer duration of MS, secondary progressive MS, and high EDSS predicted fatigue. Fatigue had an adverse effect on physical activities, mobility, psychological wellbeing, and quality of life of people with MS.
published_date	2022-08-01T04:20:19Z
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Fatigue in multiple sclerosis: A UK MS-register based study

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