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Parameters controlling octadecyl phosphonic acid self-assembled monolayers on titanium dioxide for anti-fouling biomedical applications

Liana Azizova, David Morgan, Jeff Rowlands, Emmanuel Brousseau, Tetiana Kulik, Borys Palianytsia, Jason Peter Mansell, James Birchall, Thomas Wilkinson Orcid Logo, Alastair Sloan, Wayne Nishio Ayre

Applied Surface Science, Volume: 604, Start page: 154462

Swansea University Author: Thomas Wilkinson Orcid Logo

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DOI (Published version): 10.1016/j.apsusc.2022.154462

Abstract

Octadecylphosphonic acid (ODPA) self-assembled monolayers (SAMs) have demonstrated potential for deterring bacterial attachment to titanium, however the coating process is time consuming and uses toxic solvents. In this study, ODPA SAM quantity, quality, and structure were evaluated on titanium quar...

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Published in: Applied Surface Science
ISSN: 0169-4332
Published: Elsevier BV 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa61765
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In this study, ODPA SAM quantity, quality, and structure were evaluated on titanium quartz crystal microbalance (QCM) sensors by varying solvent type (anisole or cyclopentyl methyl ether (CPME), environmentally friendly non-polar solvents); ODPA concentration (0.5 mM or 1 mM); and temperature (21 °C or 60 °C). Surfaces were characterised using QCM frequency and dissipation measurements and Sauerbrey mass calculations; X-ray photoelectron spectroscopy; water contact angle measurements; and temperature-programmed desorption mass spectrometry (TPD-MS). Anti-fouling ability was established against Staphylococcus aureus. Incubation in 0.5 mM ODPA in CPME at 21 °C rapidly formed uniform rigid ODPA SAMs as demonstrated by high Sauerbrey mass (≈285-290 ng/cm2), viscoelastic modelling, high atomic percentage surface phosphorus (1.1 %) and high water contact angles (117.6 ± 2.5°), consistent across the entire sample surface. High temperatures or the use of anisole resulted in suspected multilayer formation, which reduced bacterial attachment. TPD-MS confirmed covalent bonding of ODPA SAMs on TiO2 at ≈ 110–120 °C and thermal stability below 300 °C. 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spelling v2 61765 2022-11-02 Parameters controlling octadecyl phosphonic acid self-assembled monolayers on titanium dioxide for anti-fouling biomedical applications 86cca6bf31bfe8572de27c1b441420d8 0000-0003-0397-6079 Thomas Wilkinson Thomas Wilkinson true false 2022-11-02 BMS Octadecylphosphonic acid (ODPA) self-assembled monolayers (SAMs) have demonstrated potential for deterring bacterial attachment to titanium, however the coating process is time consuming and uses toxic solvents. In this study, ODPA SAM quantity, quality, and structure were evaluated on titanium quartz crystal microbalance (QCM) sensors by varying solvent type (anisole or cyclopentyl methyl ether (CPME), environmentally friendly non-polar solvents); ODPA concentration (0.5 mM or 1 mM); and temperature (21 °C or 60 °C). Surfaces were characterised using QCM frequency and dissipation measurements and Sauerbrey mass calculations; X-ray photoelectron spectroscopy; water contact angle measurements; and temperature-programmed desorption mass spectrometry (TPD-MS). Anti-fouling ability was established against Staphylococcus aureus. Incubation in 0.5 mM ODPA in CPME at 21 °C rapidly formed uniform rigid ODPA SAMs as demonstrated by high Sauerbrey mass (≈285-290 ng/cm2), viscoelastic modelling, high atomic percentage surface phosphorus (1.1 %) and high water contact angles (117.6 ± 2.5°), consistent across the entire sample surface. High temperatures or the use of anisole resulted in suspected multilayer formation, which reduced bacterial attachment. TPD-MS confirmed covalent bonding of ODPA SAMs on TiO2 at ≈ 110–120 °C and thermal stability below 300 °C. This study demonstrates the key parameters that control ODPA SAM formation on titanium and their future potential for biomedical applications. Journal Article Applied Surface Science 604 154462 Elsevier BV 0169-4332 Octadecylphosphonic acid (ODPA); Self-assembled monolayers (SAMs); Titanium; Quartz crystal microbalance (QCM); Atomic force microscopy (AFM); X-ray photoelectron spectroscopy (XPS); Water contact angle; Temperature-programmed mass spectrometry (TPD-MS); Mono- and bidentate attachment 1 12 2022 2022-12-01 10.1016/j.apsusc.2022.154462 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University Another institution paid the OA fee This work was supported by the Engineering and Physical Sciences Research Council (EPSRC) grant number EP/T016124/1. XPS data collection was performed at the EPSRC National Facility for XPS (‘HarwellXPS’), operated by Cardiff University and UCL, under contract No. PR16195. We would also like to thank the Armed Forces of Ukraine for providing security to perform this work. For the purpose of open access, the author has applied a CC BY public copyright licence (‘CC BY-ND public copyright licence’) to any Author Accepted Manuscript version arising. 2023-09-13T17:05:20.2846524 2022-11-02T16:00:35.7161140 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Liana Azizova 1 David Morgan 2 Jeff Rowlands 3 Emmanuel Brousseau 4 Tetiana Kulik 5 Borys Palianytsia 6 Jason Peter Mansell 7 James Birchall 8 Thomas Wilkinson 0000-0003-0397-6079 9 Alastair Sloan 10 Wayne Nishio Ayre 11 61765__25643__33ae6af62a3d447c81e9852172de7f10.pdf AzizovaL2022.pdf 2022-11-02T16:11:25.1557306 Output 7849865 application/pdf Version of Record true © 2022 The Authors. This is an open access article under the CC BY license true eng https://creativecommons.org/licenses/by/4.0/
title Parameters controlling octadecyl phosphonic acid self-assembled monolayers on titanium dioxide for anti-fouling biomedical applications
spellingShingle Parameters controlling octadecyl phosphonic acid self-assembled monolayers on titanium dioxide for anti-fouling biomedical applications
Thomas Wilkinson
title_short Parameters controlling octadecyl phosphonic acid self-assembled monolayers on titanium dioxide for anti-fouling biomedical applications
title_full Parameters controlling octadecyl phosphonic acid self-assembled monolayers on titanium dioxide for anti-fouling biomedical applications
title_fullStr Parameters controlling octadecyl phosphonic acid self-assembled monolayers on titanium dioxide for anti-fouling biomedical applications
title_full_unstemmed Parameters controlling octadecyl phosphonic acid self-assembled monolayers on titanium dioxide for anti-fouling biomedical applications
title_sort Parameters controlling octadecyl phosphonic acid self-assembled monolayers on titanium dioxide for anti-fouling biomedical applications
author_id_str_mv 86cca6bf31bfe8572de27c1b441420d8
author_id_fullname_str_mv 86cca6bf31bfe8572de27c1b441420d8_***_Thomas Wilkinson
author Thomas Wilkinson
author2 Liana Azizova
David Morgan
Jeff Rowlands
Emmanuel Brousseau
Tetiana Kulik
Borys Palianytsia
Jason Peter Mansell
James Birchall
Thomas Wilkinson
Alastair Sloan
Wayne Nishio Ayre
format Journal article
container_title Applied Surface Science
container_volume 604
container_start_page 154462
publishDate 2022
institution Swansea University
issn 0169-4332
doi_str_mv 10.1016/j.apsusc.2022.154462
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description Octadecylphosphonic acid (ODPA) self-assembled monolayers (SAMs) have demonstrated potential for deterring bacterial attachment to titanium, however the coating process is time consuming and uses toxic solvents. In this study, ODPA SAM quantity, quality, and structure were evaluated on titanium quartz crystal microbalance (QCM) sensors by varying solvent type (anisole or cyclopentyl methyl ether (CPME), environmentally friendly non-polar solvents); ODPA concentration (0.5 mM or 1 mM); and temperature (21 °C or 60 °C). Surfaces were characterised using QCM frequency and dissipation measurements and Sauerbrey mass calculations; X-ray photoelectron spectroscopy; water contact angle measurements; and temperature-programmed desorption mass spectrometry (TPD-MS). Anti-fouling ability was established against Staphylococcus aureus. Incubation in 0.5 mM ODPA in CPME at 21 °C rapidly formed uniform rigid ODPA SAMs as demonstrated by high Sauerbrey mass (≈285-290 ng/cm2), viscoelastic modelling, high atomic percentage surface phosphorus (1.1 %) and high water contact angles (117.6 ± 2.5°), consistent across the entire sample surface. High temperatures or the use of anisole resulted in suspected multilayer formation, which reduced bacterial attachment. TPD-MS confirmed covalent bonding of ODPA SAMs on TiO2 at ≈ 110–120 °C and thermal stability below 300 °C. This study demonstrates the key parameters that control ODPA SAM formation on titanium and their future potential for biomedical applications.
published_date 2022-12-01T17:05:22Z
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