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Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study
Archives of Disease in Childhood, Volume: 108, Issue: 1, Pages: 47 - 52
Swansea University Authors:
Gareth Dunseath , Steve Luzio
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DOI (Published version): 10.1136/archdischild-2022-324203
Abstract
Introduction Resistant starch (RS) has beneficial effects on postprandial glucose metabolism in both animals and adults. Hitherto, there have been no studies in children of the acute metabolic and hormonal effects of RS-containing meals.Objectives We aimed to compare serial plasma glucose, insulin,...
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ISSN: | 0003-9888 1468-2044 |
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2022
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<?xml version="1.0"?><rfc1807 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><datestamp>2023-01-20T14:49:35.5211615</datestamp><bib-version>v2</bib-version><id>61944</id><entry>2022-11-18</entry><title>Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study</title><swanseaauthors><author><sid>fccbba9edcaee08a839a3c5cff8cbe19</sid><ORCID>0000-0001-6022-862X</ORCID><firstname>Gareth</firstname><surname>Dunseath</surname><name>Gareth Dunseath</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>01491e1cd582746a654fad9addf0de16</sid><ORCID>0000-0002-7206-6530</ORCID><firstname>Steve</firstname><surname>Luzio</surname><name>Steve Luzio</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2022-11-18</date><deptcode>BMS</deptcode><abstract>Introduction Resistant starch (RS) has beneficial effects on postprandial glucose metabolism in both animals and adults. Hitherto, there have been no studies in children of the acute metabolic and hormonal effects of RS-containing meals.Objectives We aimed to compare serial plasma glucose, insulin, gut hormone, leptin profiles and satiety scores in obese children after meals containing variable amounts of RS.Methods This was a single blind, non-randomised, crossover study of 20 obese children aged 10–14 years old without comorbidities. Three test meals containing rice (M1), rice cooked with coconut oil (M2), rice cooked in coconut oil with lentils (M3) were given in sequence after a 12-hour fast . Blood samples were analysed for glucose (PG), insulin, leptin, glucagon-like polypeptide (GLP) 1, ghrelin and peptide YY (PYY) at appropriate times between 0 and 180 min.Results Meal M2 resulted in significantly lower postprandial glucose values compared with meal M1 (maximal incremental glucose, ∆Cmax, p<0.05; area under the curve, ∆AUC0–3, p<0.01) and meal M3 (maximal concentration, Cmax, p<0.01; ∆Cmax, p<0.001, and ∆AUC0–3p<0.01). M2 also produced lower insulin values compared with M1 (p<0.05). Postprandial ghrelin was significantly higher after M1 compared with M3 (p<0.05). PYY, GLP1 and median satiety scores were not significantly different between the three meals.Conclusion This study shows that M2, the meal containing RS alone, induced beneficial effects on acute postprandial glucose, insulin and ghrelin concentrations in obese children without diabetes. Acute postprandial satiety scores were not significantly affected by the three meals.Trial registration number SLCTR/2020/007.</abstract><type>Journal Article</type><journal>Archives of Disease in Childhood</journal><volume>108</volume><journalNumber>1</journalNumber><paginationStart>47</paginationStart><paginationEnd>52</paginationEnd><publisher>BMJ</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0003-9888</issnPrint><issnElectronic>1468-2044</issnElectronic><keywords/><publishedDay>15</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2022</publishedYear><publishedDate>2022-12-15</publishedDate><doi>10.1136/archdischild-2022-324203</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BMS</DepartmentCode><institution>Swansea University</institution><apcterm>Not Required</apcterm><funders>This work was supported by Stella de Silva Research grant of Sri Lanka College of Paediatricians.</funders><projectreference/><lastEdited>2023-01-20T14:49:35.5211615</lastEdited><Created>2022-11-18T09:39:33.0227225</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Jananie</firstname><surname>Suntharesan</surname><order>1</order></author><author><firstname>Navoda</firstname><surname>Atapattu</surname><orcid>0000-0002-3398-2536</orcid><order>2</order></author><author><firstname>Eresha</firstname><surname>Jasinghe</surname><order>3</order></author><author><firstname>Sagarika</firstname><surname>Ekanayake</surname><order>4</order></author><author><firstname>Delpachitra Acharige Gajabahu Haren de</firstname><surname>Silva</surname><order>5</order></author><author><firstname>Gareth</firstname><surname>Dunseath</surname><orcid>0000-0001-6022-862X</orcid><order>6</order></author><author><firstname>Steve</firstname><surname>Luzio</surname><orcid>0000-0002-7206-6530</orcid><order>7</order></author><author><firstname>Lakdasa</firstname><surname>Premawardhana</surname><orcid>0000-0003-0931-3700</orcid><order>8</order></author></authors><documents><document><filename>61944__25871__8e71575411644e91abd46dc799ee3bd0.pdf</filename><originalFilename>61944.pdf</originalFilename><uploaded>2022-11-22T15:54:38.2429757</uploaded><type>Output</type><contentLength>411676</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>© Author(s) (or their employer(s)) 2022. 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2023-01-20T14:49:35.5211615 v2 61944 2022-11-18 Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study fccbba9edcaee08a839a3c5cff8cbe19 0000-0001-6022-862X Gareth Dunseath Gareth Dunseath true false 01491e1cd582746a654fad9addf0de16 0000-0002-7206-6530 Steve Luzio Steve Luzio true false 2022-11-18 BMS Introduction Resistant starch (RS) has beneficial effects on postprandial glucose metabolism in both animals and adults. Hitherto, there have been no studies in children of the acute metabolic and hormonal effects of RS-containing meals.Objectives We aimed to compare serial plasma glucose, insulin, gut hormone, leptin profiles and satiety scores in obese children after meals containing variable amounts of RS.Methods This was a single blind, non-randomised, crossover study of 20 obese children aged 10–14 years old without comorbidities. Three test meals containing rice (M1), rice cooked with coconut oil (M2), rice cooked in coconut oil with lentils (M3) were given in sequence after a 12-hour fast . Blood samples were analysed for glucose (PG), insulin, leptin, glucagon-like polypeptide (GLP) 1, ghrelin and peptide YY (PYY) at appropriate times between 0 and 180 min.Results Meal M2 resulted in significantly lower postprandial glucose values compared with meal M1 (maximal incremental glucose, ∆Cmax, p<0.05; area under the curve, ∆AUC0–3, p<0.01) and meal M3 (maximal concentration, Cmax, p<0.01; ∆Cmax, p<0.001, and ∆AUC0–3p<0.01). M2 also produced lower insulin values compared with M1 (p<0.05). Postprandial ghrelin was significantly higher after M1 compared with M3 (p<0.05). PYY, GLP1 and median satiety scores were not significantly different between the three meals.Conclusion This study shows that M2, the meal containing RS alone, induced beneficial effects on acute postprandial glucose, insulin and ghrelin concentrations in obese children without diabetes. Acute postprandial satiety scores were not significantly affected by the three meals.Trial registration number SLCTR/2020/007. Journal Article Archives of Disease in Childhood 108 1 47 52 BMJ 0003-9888 1468-2044 15 12 2022 2022-12-15 10.1136/archdischild-2022-324203 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University Not Required This work was supported by Stella de Silva Research grant of Sri Lanka College of Paediatricians. 2023-01-20T14:49:35.5211615 2022-11-18T09:39:33.0227225 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Jananie Suntharesan 1 Navoda Atapattu 0000-0002-3398-2536 2 Eresha Jasinghe 3 Sagarika Ekanayake 4 Delpachitra Acharige Gajabahu Haren de Silva 5 Gareth Dunseath 0000-0001-6022-862X 6 Steve Luzio 0000-0002-7206-6530 7 Lakdasa Premawardhana 0000-0003-0931-3700 8 61944__25871__8e71575411644e91abd46dc799ee3bd0.pdf 61944.pdf 2022-11-22T15:54:38.2429757 Output 411676 application/pdf Version of Record true © Author(s) (or their employer(s)) 2022. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license true eng http://creativecommons.org/licenses/by-nc/4.0/ 140 |
title |
Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study |
spellingShingle |
Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study Gareth Dunseath Steve Luzio |
title_short |
Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study |
title_full |
Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study |
title_fullStr |
Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study |
title_full_unstemmed |
Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study |
title_sort |
Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study |
author_id_str_mv |
fccbba9edcaee08a839a3c5cff8cbe19 01491e1cd582746a654fad9addf0de16 |
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fccbba9edcaee08a839a3c5cff8cbe19_***_Gareth Dunseath 01491e1cd582746a654fad9addf0de16_***_Steve Luzio |
author |
Gareth Dunseath Steve Luzio |
author2 |
Jananie Suntharesan Navoda Atapattu Eresha Jasinghe Sagarika Ekanayake Delpachitra Acharige Gajabahu Haren de Silva Gareth Dunseath Steve Luzio Lakdasa Premawardhana |
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Journal article |
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Archives of Disease in Childhood |
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108 |
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1 |
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47 |
publishDate |
2022 |
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Swansea University |
issn |
0003-9888 1468-2044 |
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10.1136/archdischild-2022-324203 |
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BMJ |
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Faculty of Medicine, Health and Life Sciences |
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facultyofmedicinehealthandlifesciences |
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Faculty of Medicine, Health and Life Sciences |
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Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine |
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description |
Introduction Resistant starch (RS) has beneficial effects on postprandial glucose metabolism in both animals and adults. Hitherto, there have been no studies in children of the acute metabolic and hormonal effects of RS-containing meals.Objectives We aimed to compare serial plasma glucose, insulin, gut hormone, leptin profiles and satiety scores in obese children after meals containing variable amounts of RS.Methods This was a single blind, non-randomised, crossover study of 20 obese children aged 10–14 years old without comorbidities. Three test meals containing rice (M1), rice cooked with coconut oil (M2), rice cooked in coconut oil with lentils (M3) were given in sequence after a 12-hour fast . Blood samples were analysed for glucose (PG), insulin, leptin, glucagon-like polypeptide (GLP) 1, ghrelin and peptide YY (PYY) at appropriate times between 0 and 180 min.Results Meal M2 resulted in significantly lower postprandial glucose values compared with meal M1 (maximal incremental glucose, ∆Cmax, p<0.05; area under the curve, ∆AUC0–3, p<0.01) and meal M3 (maximal concentration, Cmax, p<0.01; ∆Cmax, p<0.001, and ∆AUC0–3p<0.01). M2 also produced lower insulin values compared with M1 (p<0.05). Postprandial ghrelin was significantly higher after M1 compared with M3 (p<0.05). PYY, GLP1 and median satiety scores were not significantly different between the three meals.Conclusion This study shows that M2, the meal containing RS alone, induced beneficial effects on acute postprandial glucose, insulin and ghrelin concentrations in obese children without diabetes. Acute postprandial satiety scores were not significantly affected by the three meals.Trial registration number SLCTR/2020/007. |
published_date |
2022-12-15T04:21:10Z |
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11.021648 |