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The Physical Exercise and Cardiovascular Adaptation Monitoring in Pregnancy (PE-CAMP) Randomised Controlled Trial Protocol

Olga Roldan Reoyo, Kelly Mackintosh Orcid Logo, Melitta McNarry Orcid Logo, S. Jones, S. Emery Orcid Logo, O. Uzun, Michael Lewis

medRxiv

Swansea University Authors: Olga Roldan Reoyo, Kelly Mackintosh Orcid Logo, Melitta McNarry Orcid Logo, Michael Lewis

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DOI (Published version): 10.1101/2022.04.27.22274359

Abstract

Background Exercise can be beneficial to cardiovascular system function, but its influence during pregnancy is less well understood. Heterogeneity in research studies has led to a lack of consensus on whether physical exercise during pregnancy can elicit cardiovascular adaptations during a period in...

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Published in: medRxiv
Published: Cold Spring Harbor Laboratory 2022
URI: https://cronfa.swan.ac.uk/Record/cronfa62066
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Abstract: Background Exercise can be beneficial to cardiovascular system function, but its influence during pregnancy is less well understood. Heterogeneity in research studies has led to a lack of consensus on whether physical exercise during pregnancy can elicit cardiovascular adaptations during a period in which the cardiovascular system is already being challenged. Furthermore, little research has been conducted regarding the influence of physical exercise on foetal heart rate (FHR). This paper presents the protocol for a randomised controlled trial which will evaluate the influence of supervised antenatal physical exercise on cardiovascular adaptations during and after pregnancy, as well as the FHR response to acute and chronic maternal exercise. Methods: The PE-CAMP Study (Physical Exercise and Cardiovascular Adaptation Monitoring in Pregnancy) is a randomised controlled trial (RCT) in which pregnant women will be randomised into an intervention group (INT), which attended supervised physical exercise programme up to three days per week, or a comparison group (COMP) which followed standard health care. All participants were assessed at three time-points i) 18-22 weeks pregnant, time-point 1; ii) 33-37 weeks pregnant, time-point 2; and iii) 12-16 weeks postnatal, time-point 3. A standardised experimental protocol was used for data collection, including body composition assessment, upper-body flexibility and strength assessment, physical activity assessment via questionnaires and acceletometry, and haemodynamic and cardiovascular evaluation before, during and after an acute 10-minute exercise bout. Foetal heart rate will be assessed at the time point 2 before, during and after acute exercise. Discussion: Although it is necessary and informative to continue investigating the effects of exercise on maternal cardiac and haemodynamic responses using specific laboratory-based tests, it is also critical to evaluate It is made available under a CC-BY-NC-ND 4.0 International license . (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. medRxiv preprint doi: https://doi.org/10.1101/2022.04.27.22274359; this version posted April 28, 2022. The copyright holder for this preprintThe PE-CAMP research project. Protocol paper3these influences during activities that are more achievable and realistic for pregnant women. The PE-CAMP study will provide data on the cardiac and haemodynamic responses to a typical acute bout of exercise, which could help inform future decisions and policies on maternal exercise prescription made by maternity healthcare providers and exercise professionals.Clinical Trials Registration Number: NCT03748888
Item Description: Preprint article before certification by peer review.
College: Faculty of Science and Engineering