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Therapeutic Exosomes as Novel Treatment for Ovarian Cancer / CLAIRE DONNELLY

Swansea University Author: CLAIRE DONNELLY

  • E-Thesis – open access under embargo until: 26th October 2027

DOI (Published version): 10.23889/SUthesis.62107

Abstract

Ovarian cancer (OC) has the highest mortality rate of all gynecological cancers, with a low 5-year survival rate. This is in part due to resistance to chemotherapy drugs and recurrence, which causes OC treatments to become inadequate. Exosomes are a type of extracellular vesicle (EV), along with mic...

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Published: Swansea 2022
Institution: Swansea University
Degree level: Doctoral
Degree name: Ph.D
Supervisor: Gonzalez, Deyarina
URI: https://cronfa.swan.ac.uk/Record/cronfa62107
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Abstract: Ovarian cancer (OC) has the highest mortality rate of all gynecological cancers, with a low 5-year survival rate. This is in part due to resistance to chemotherapy drugs and recurrence, which causes OC treatments to become inadequate. Exosomes are a type of extracellular vesicle (EV), along with microvesicles and apoptotic bodies. Exosomes act as key mediators of intercellular communication. This leads to the involvement of exosomes in many normal physiological processes including immune responses. However, exosomes derived from tumour cells are implicated in pathological processes, such as cancer progression and metastasis. This study evaluated the role of tumour derived exosomes in OC. This included assessing their biomarker potential. In contrast, non-tumour derived exosomes were evaluated to determine therapeutic ability.
Keywords: Exosomes, Extracellular Vesicles, Ovarian Cancer, Therapeutic, 3D Culture
College: Faculty of Medicine, Health and Life Sciences