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Longitudinal analysis of the relationship between motor and psychiatric symptoms in idiopathic dystonia
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Anna Rawlings,
Fatemeh Torabi,
Owen Pickrell ,
Kathryn J. Peall
European Journal of Neurology, Volume: 29, Issue: 12, Pages: 3513 - 3527
Swansea University Authors:
Anna Rawlings, Fatemeh Torabi, Owen Pickrell
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DOI (Published version): 10.1111/ene.15530
Abstract
Background and purposeAlthough psychiatric diagnoses are recognized in idiopathic dystonia, no previous studies have examined the temporal relationship between idiopathic dystonia and psychiatric diagnoses at scale. Here, we determine rates of psychiatric diagnoses and psychiatric medication prescri...
| Published in: | European Journal of Neurology |
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| ISSN: | 1351-5101 1468-1331 |
| Published: |
Wiley
2022
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa62203 |
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| Abstract: |
Background and purposeAlthough psychiatric diagnoses are recognized in idiopathic dystonia, no previous studies have examined the temporal relationship between idiopathic dystonia and psychiatric diagnoses at scale. Here, we determine rates of psychiatric diagnoses and psychiatric medication prescription in those diagnosed with idiopathic dystsuponia compared to matched controls.MethodsA longitudinal population-based cohort study using anonymized electronic health care data in Wales (UK) was conducted to identify individuals with idiopathic dystonia and comorbid psychiatric diagnoses/prescriptions between 1 January 1994 and 31 December 2017. Psychiatric diagnoses/prescriptions were identified from primary and secondary health care records.ResultsIndividuals with idiopathic dystonia (n = 52,589) had higher rates of psychiatric diagnosis and psychiatric medication prescription when compared to controls (n = 216,754, 43% vs. 31%, p < 0.001; 45% vs. 37.9%, p < 0.001, respectively), with depression and anxiety being most common (cases: 31% and 28%). Psychiatric diagnoses predominantly predated dystonia diagnosis, particularly in the 12 months prior to diagnosis (incidence rate ratio [IRR] = 1.98, 95% confidence interval [CI] = 1.9–2.1), with an IRR of 12.4 (95% CI = 11.8–13.1) for anxiety disorders. There was, however, an elevated rate of most psychiatric diagnoses throughout the study period, including the 12 months after dystonia diagnosis (IRR = 1.96, 95% CI = 1.85–2.07).ConclusionsThis study suggests a bidirectional relationship between psychiatric disorders and dystonia, particularly with mood disorders. Psychiatric and motor symptoms in dystonia may have common aetiological mechanisms, with psychiatric disorders potentially forming prodromal symptoms of idiopathic dystonia. |
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| Keywords: |
dystonia, movement disorders, neurological disorders, psychiatric disorders |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
Brain Repair and Intracranial Neurotherapeutics. Grant Number: UA05
British Heart Foundation
Cardiff University
Chief Scientist Office of the Scottish Government Health and Social Care Directorates
Department of Health and Social Care
Economic and Social Research Council
Engineering and Physical Sciences Research Council
European Social Fund
Health and Care Research Wales
Health and Social Care Research and Development Division (Welsh Government)
Health Data Research UK. Grant Number: HDR-9006
KESS 2. Grant Number: 517008
Llywodraeth Cymru
Medical Research Council. Grant Number: MR/P008593/1
Public Health Agency
Wellcome Trust |
| Issue: |
12 |
| Start Page: |
3513 |
| End Page: |
3527 |