Journal article 41 views 11 downloads
Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook
Seminars in Cell and Developmental Biology
Swansea University Authors: Joana Amaral Duarte De Moura, Kirsty Meldrum, Shareen Doak , Martin Clift
PDF | Proof
© 2022 The Authors. This is an open access article under the CC BY licenseDownload (2.12MB)
DOI (Published version): 10.1016/j.semcdb.2022.12.006
Due to the current relevance of pulmonary toxicology (with focus upon air pollution and the inhalation of hazardous materials), it is important to further develop and implement physiologically relevant models of the entire respiratory tract. Lung model development has the aim to create human relevan...
|Published in:||Seminars in Cell and Developmental Biology|
Check full text
No Tags, Be the first to tag this record!
Due to the current relevance of pulmonary toxicology (with focus upon air pollution and the inhalation of hazardous materials), it is important to further develop and implement physiologically relevant models of the entire respiratory tract. Lung model development has the aim to create human relevant systems that may replace animal use whilst balancing cost, laborious nature and regulatory ambition. There is an imperative need to move away from rodent models and implement models that mimic the holistic characteristics important in lung function. The purpose of this review is therefore, to describe and identify the various alternative models that are being applied towards assessing the pulmonary toxicology of inhaled substances, as well as the current and potential developments of various advanced models and how they may be applied towards toxicology testing strategies. These models aim to mimic various regions of the lung, as well as implementing different exposure methods with the addition of various physiologically relevent conditions (such as fluid-flow and dynamic movement). There is further progress in the type of models used with focus on the development of lung-on-a-chip technologies and bioprinting, as well as and the optimization of such models to fill current knowledge gaps within toxicology.
Lung; In vitro systems; Toxicology; Alternative models; Bio-engineering
Faculty of Medicine, Health and Life Sciences
Horizon 2020 Framework Programme - 760813; Natural Environment Research Council- NE/V015192/1;