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Caffeine and attentional control: improved and impaired performance in healthy older adults and Parkinson’s disease according to task demands
Psychopharmacology, Volume: 239, Issue: 2, Pages: 605 - 619
Swansea University Author:
Gary Christopher
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DOI (Published version): 10.1007/s00213-021-06054-9
Abstract
IntroductionCaffeine is frequently consumed to boost goal-directed attention. These procognitive effects may occur due to the adenosine-mediated enhancement of monoamines, such as dopamine, after caffeine administration. As such, caffeine’s beneficial effects may be altered in conditions such as Par...
Published in: | Psychopharmacology |
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ISSN: | 0033-3158 1432-2072 |
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Springer Science and Business Media LLC
2022
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URI: | https://cronfa.swan.ac.uk/Record/cronfa62607 |
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<?xml version="1.0"?><rfc1807><datestamp>2023-02-23T13:42:48.7421323</datestamp><bib-version>v2</bib-version><id>62607</id><entry>2023-02-08</entry><title>Caffeine and attentional control: improved and impaired performance in healthy older adults and Parkinson’s disease according to task demands</title><swanseaauthors><author><sid>8092562c67809dfda89f7bb8582874d3</sid><ORCID>0000-0002-7175-6644</ORCID><firstname>Gary</firstname><surname>Christopher</surname><name>Gary Christopher</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2023-02-08</date><deptcode>PHAC</deptcode><abstract>IntroductionCaffeine is frequently consumed to boost goal-directed attention. These procognitive effects may occur due to the adenosine-mediated enhancement of monoamines, such as dopamine, after caffeine administration. As such, caffeine’s beneficial effects may be altered in conditions such as Parkinson’s disease (PD). However, whether caffeine improves cognition, and at what cost, has not been experimentally established in patients with neurodegenerative disease.MethodsSingle-dose trials to probe cognitive effects of caffeine are often confounded by short-term caffeine abstinence which conflates caffeine’s effects with treatment of withdrawal. Using a placebo controlled, blinded, randomised trial design, we assessed the effect of 100 mg of caffeine across well-established tasks (Choice reaction time, Stroop Task and Rapid Serial Visual Presentation Task; RSVP) that probe different aspects of attention in PD patients (n = 24) and controls (n = 44). Critically, participants withdrew from caffeine for a week prior to testing to eliminate the possibility that withdrawal reversal explained any cognitive benefit.ResultsCaffeine administration was found to reduce the overall number of errors in patients and controls on the Stroop (p = .018, η2p = .086) and Choice reaction time (p < . 0001, η2p = .588) tasks, but there was no specific effect of caffeine on ignoring irrelevant information in the Stroop task. On the RSVP task, caffeine improved dual item accuracy (p = .037) but impaired single item accuracy (p = .044). Across all tasks, there was little evidence that caffeine has different effects in PD participants and controls.ConclusionWhen removing withdrawal effects as a factor, we demonstrate caffeine has beneficial effects on selective attention but is a double-edge sword for visual temporal attention and would need careful targeting to be clinically useful.</abstract><type>Journal Article</type><journal>Psychopharmacology</journal><volume>239</volume><journalNumber>2</journalNumber><paginationStart>605</paginationStart><paginationEnd>619</paginationEnd><publisher>Springer Science and Business Media LLC</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0033-3158</issnPrint><issnElectronic>1432-2072</issnElectronic><keywords>Caffeine; Attention; Yerkes-Dodson; Withdrawal; Parkinson’s disease</keywords><publishedDay>1</publishedDay><publishedMonth>2</publishedMonth><publishedYear>2022</publishedYear><publishedDate>2022-02-01</publishedDate><doi>10.1007/s00213-021-06054-9</doi><url/><notes/><college>COLLEGE NANME</college><department>Public Health</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>PHAC</DepartmentCode><institution>Swansea University</institution><apcterm/><funders/><projectreference/><lastEdited>2023-02-23T13:42:48.7421323</lastEdited><Created>2023-02-08T10:27:16.1371001</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">School of Health and Social Care - Public Health</level></path><authors><author><firstname>Kanch</firstname><surname>Sharma</surname><orcid>0000-0003-3337-3527</orcid><order>1</order></author><author><firstname>Sean James</firstname><surname>Fallon</surname><order>2</order></author><author><firstname>Thomas</firstname><surname>Davis</surname><order>3</order></author><author><firstname>Scott</firstname><surname>Ankrett</surname><order>4</order></author><author><firstname>Greg</firstname><surname>Munro</surname><order>5</order></author><author><firstname>Gary</firstname><surname>Christopher</surname><orcid>0000-0002-7175-6644</orcid><order>6</order></author><author><firstname>Elizabeth</firstname><surname>Coulthard</surname><order>7</order></author></authors><documents><document><filename>62607__26667__dadc9c861afb4bfd818849a431895a12.pdf</filename><originalFilename>62607_VoR.pdf</originalFilename><uploaded>2023-02-23T13:41:52.4994491</uploaded><type>Output</type><contentLength>1288867</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>This article is licensed under a Creative Commons Attribution 4.0 International License</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807> |
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2023-02-23T13:42:48.7421323 v2 62607 2023-02-08 Caffeine and attentional control: improved and impaired performance in healthy older adults and Parkinson’s disease according to task demands 8092562c67809dfda89f7bb8582874d3 0000-0002-7175-6644 Gary Christopher Gary Christopher true false 2023-02-08 PHAC IntroductionCaffeine is frequently consumed to boost goal-directed attention. These procognitive effects may occur due to the adenosine-mediated enhancement of monoamines, such as dopamine, after caffeine administration. As such, caffeine’s beneficial effects may be altered in conditions such as Parkinson’s disease (PD). However, whether caffeine improves cognition, and at what cost, has not been experimentally established in patients with neurodegenerative disease.MethodsSingle-dose trials to probe cognitive effects of caffeine are often confounded by short-term caffeine abstinence which conflates caffeine’s effects with treatment of withdrawal. Using a placebo controlled, blinded, randomised trial design, we assessed the effect of 100 mg of caffeine across well-established tasks (Choice reaction time, Stroop Task and Rapid Serial Visual Presentation Task; RSVP) that probe different aspects of attention in PD patients (n = 24) and controls (n = 44). Critically, participants withdrew from caffeine for a week prior to testing to eliminate the possibility that withdrawal reversal explained any cognitive benefit.ResultsCaffeine administration was found to reduce the overall number of errors in patients and controls on the Stroop (p = .018, η2p = .086) and Choice reaction time (p < . 0001, η2p = .588) tasks, but there was no specific effect of caffeine on ignoring irrelevant information in the Stroop task. On the RSVP task, caffeine improved dual item accuracy (p = .037) but impaired single item accuracy (p = .044). Across all tasks, there was little evidence that caffeine has different effects in PD participants and controls.ConclusionWhen removing withdrawal effects as a factor, we demonstrate caffeine has beneficial effects on selective attention but is a double-edge sword for visual temporal attention and would need careful targeting to be clinically useful. Journal Article Psychopharmacology 239 2 605 619 Springer Science and Business Media LLC 0033-3158 1432-2072 Caffeine; Attention; Yerkes-Dodson; Withdrawal; Parkinson’s disease 1 2 2022 2022-02-01 10.1007/s00213-021-06054-9 COLLEGE NANME Public Health COLLEGE CODE PHAC Swansea University 2023-02-23T13:42:48.7421323 2023-02-08T10:27:16.1371001 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Public Health Kanch Sharma 0000-0003-3337-3527 1 Sean James Fallon 2 Thomas Davis 3 Scott Ankrett 4 Greg Munro 5 Gary Christopher 0000-0002-7175-6644 6 Elizabeth Coulthard 7 62607__26667__dadc9c861afb4bfd818849a431895a12.pdf 62607_VoR.pdf 2023-02-23T13:41:52.4994491 Output 1288867 application/pdf Version of Record true This article is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/ |
title |
Caffeine and attentional control: improved and impaired performance in healthy older adults and Parkinson’s disease according to task demands |
spellingShingle |
Caffeine and attentional control: improved and impaired performance in healthy older adults and Parkinson’s disease according to task demands Gary Christopher |
title_short |
Caffeine and attentional control: improved and impaired performance in healthy older adults and Parkinson’s disease according to task demands |
title_full |
Caffeine and attentional control: improved and impaired performance in healthy older adults and Parkinson’s disease according to task demands |
title_fullStr |
Caffeine and attentional control: improved and impaired performance in healthy older adults and Parkinson’s disease according to task demands |
title_full_unstemmed |
Caffeine and attentional control: improved and impaired performance in healthy older adults and Parkinson’s disease according to task demands |
title_sort |
Caffeine and attentional control: improved and impaired performance in healthy older adults and Parkinson’s disease according to task demands |
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8092562c67809dfda89f7bb8582874d3 |
author_id_fullname_str_mv |
8092562c67809dfda89f7bb8582874d3_***_Gary Christopher |
author |
Gary Christopher |
author2 |
Kanch Sharma Sean James Fallon Thomas Davis Scott Ankrett Greg Munro Gary Christopher Elizabeth Coulthard |
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Journal article |
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Psychopharmacology |
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239 |
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2 |
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605 |
publishDate |
2022 |
institution |
Swansea University |
issn |
0033-3158 1432-2072 |
doi_str_mv |
10.1007/s00213-021-06054-9 |
publisher |
Springer Science and Business Media LLC |
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Faculty of Medicine, Health and Life Sciences |
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facultyofmedicinehealthandlifesciences |
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Faculty of Medicine, Health and Life Sciences |
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School of Health and Social Care - Public Health{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Public Health |
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description |
IntroductionCaffeine is frequently consumed to boost goal-directed attention. These procognitive effects may occur due to the adenosine-mediated enhancement of monoamines, such as dopamine, after caffeine administration. As such, caffeine’s beneficial effects may be altered in conditions such as Parkinson’s disease (PD). However, whether caffeine improves cognition, and at what cost, has not been experimentally established in patients with neurodegenerative disease.MethodsSingle-dose trials to probe cognitive effects of caffeine are often confounded by short-term caffeine abstinence which conflates caffeine’s effects with treatment of withdrawal. Using a placebo controlled, blinded, randomised trial design, we assessed the effect of 100 mg of caffeine across well-established tasks (Choice reaction time, Stroop Task and Rapid Serial Visual Presentation Task; RSVP) that probe different aspects of attention in PD patients (n = 24) and controls (n = 44). Critically, participants withdrew from caffeine for a week prior to testing to eliminate the possibility that withdrawal reversal explained any cognitive benefit.ResultsCaffeine administration was found to reduce the overall number of errors in patients and controls on the Stroop (p = .018, η2p = .086) and Choice reaction time (p < . 0001, η2p = .588) tasks, but there was no specific effect of caffeine on ignoring irrelevant information in the Stroop task. On the RSVP task, caffeine improved dual item accuracy (p = .037) but impaired single item accuracy (p = .044). Across all tasks, there was little evidence that caffeine has different effects in PD participants and controls.ConclusionWhen removing withdrawal effects as a factor, we demonstrate caffeine has beneficial effects on selective attention but is a double-edge sword for visual temporal attention and would need careful targeting to be clinically useful. |
published_date |
2022-02-01T04:22:21Z |
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1763754473172238336 |
score |
11.021648 |