Glucagon-Like Peptide 1 Therapy: From Discovery to Type 2 Diabetes and Beyond

Viljoen, Adie; Bain, Steve

doi:10.3803/enm.2022.1642

Journal article 696 views 194 downloads

Glucagon-Like Peptide 1 Therapy: From Discovery to Type 2 Diabetes and Beyond

Adie Viljoen, Steve Bain

Endocrinology and Metabolism, Volume: 38, Issue: 1, Pages: 25 - 33

Swansea University Author: Steve Bain

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DOI (Published version): 10.3803/enm.2022.1642

Abstract

The therapeutic benefits of the incretin hormone, glucagon-like peptide 1 (GLP1), for people with type 2 diabetes and/or obesity, are now firmly established. The evidence-base arising from head-to-head comparative effectiveness studies in people with type 2 diabetes, as well as the recommendations b...

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Published in:	Endocrinology and Metabolism
ISSN:	2093-596X 2093-5978
Published:	Korean Endocrine Society 2023
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa62654

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spelling	2023-03-06T10:51:24.2323767 v2 62654 2023-02-14 Glucagon-Like Peptide 1 Therapy: From Discovery to Type 2 Diabetes and Beyond 5399f4c6e6a70f3608a084ddb938511a 0000-0001-8519-4964 Steve Bain Steve Bain true false 2023-02-14 MEDS The therapeutic benefits of the incretin hormone, glucagon-like peptide 1 (GLP1), for people with type 2 diabetes and/or obesity, are now firmly established. The evidence-base arising from head-to-head comparative effectiveness studies in people with type 2 diabetes, as well as the recommendations by professional guidelines suggest that GLP1 receptor agonists should replace more traditional treatment options such as sulfonylureas and dipeptidyl-peptidase 4 (DPP4) inhibitors. Furthermore, their benefits in reducing cardiovascular events in people with type 2 diabetes beyond improvements in glycaemic control has led to numerous clinical trials seeking to translate this benefit beyond type 2 diabetes. Following early trial results their therapeutic benefit is currently being tested in other conditions including fatty liver disease, kidney disease, and Alzheimer’s disease. Journal Article Endocrinology and Metabolism 38 1 25 33 Korean Endocrine Society 2093-596X 2093-5978 Glucagon-like peptide 1; Diabetes mellitus, type 2; Renal insufficiency, chronic 6 2 2023 2023-02-06 10.3803/enm.2022.1642 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University 2023-03-06T10:51:24.2323767 2023-02-14T08:49:02.2160982 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Adie Viljoen 1 Steve Bain 0000-0001-8519-4964 2 62654__26745__7f2181f2bc4c46d98a476215319909c9.pdf 62654_VoR.pdf 2023-03-06T10:49:27.6749583 Output 322484 application/pdf Version of Record true Copyright © 2023 Korean Endocrine Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License true eng https://creativecommons.org/licenses/by-nc/4.0/
title	Glucagon-Like Peptide 1 Therapy: From Discovery to Type 2 Diabetes and Beyond
spellingShingle	Glucagon-Like Peptide 1 Therapy: From Discovery to Type 2 Diabetes and Beyond Steve Bain
title_short	Glucagon-Like Peptide 1 Therapy: From Discovery to Type 2 Diabetes and Beyond
title_full	Glucagon-Like Peptide 1 Therapy: From Discovery to Type 2 Diabetes and Beyond
title_fullStr	Glucagon-Like Peptide 1 Therapy: From Discovery to Type 2 Diabetes and Beyond
title_full_unstemmed	Glucagon-Like Peptide 1 Therapy: From Discovery to Type 2 Diabetes and Beyond
title_sort	Glucagon-Like Peptide 1 Therapy: From Discovery to Type 2 Diabetes and Beyond
author_id_str_mv	5399f4c6e6a70f3608a084ddb938511a
author_id_fullname_str_mv	5399f4c6e6a70f3608a084ddb938511a_***_Steve Bain
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author2	Adie Viljoen Steve Bain
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container_title	Endocrinology and Metabolism
container_volume	38
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publishDate	2023
institution	Swansea University
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description	The therapeutic benefits of the incretin hormone, glucagon-like peptide 1 (GLP1), for people with type 2 diabetes and/or obesity, are now firmly established. The evidence-base arising from head-to-head comparative effectiveness studies in people with type 2 diabetes, as well as the recommendations by professional guidelines suggest that GLP1 receptor agonists should replace more traditional treatment options such as sulfonylureas and dipeptidyl-peptidase 4 (DPP4) inhibitors. Furthermore, their benefits in reducing cardiovascular events in people with type 2 diabetes beyond improvements in glycaemic control has led to numerous clinical trials seeking to translate this benefit beyond type 2 diabetes. Following early trial results their therapeutic benefit is currently being tested in other conditions including fatty liver disease, kidney disease, and Alzheimer’s disease.
published_date	2023-02-06T05:06:27Z
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Glucagon-Like Peptide 1 Therapy: From Discovery to Type 2 Diabetes and Beyond

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