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Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model

Husham Ahmed, Matthew Bedding-Tyrrell, Davide Deganello Orcid Logo, Zhidao Xia, Yi Xiong Orcid Logo, Feihu Zhao Orcid Logo

Medicine in Novel Technology and Devices, Volume: 18, Start page: 100223

Swansea University Authors: Davide Deganello Orcid Logo, Feihu Zhao Orcid Logo

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DOI (Published version): 10.1016/j.medntd.2023.100223

Abstract

Mechanical stimulation, such as fluid-induced wall shear stress (WSS), is known that can influence the cellular behaviours. Therefore, in some tissue engineering experiments in vitro, mechanical stimulation is applied via bioreactors to the cells in cell culturing to study cell physiology and pathol...

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Published in: Medicine in Novel Technology and Devices
ISSN: 2590-0935
Published: Elsevier BV 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa62890
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spelling 2023-03-13T09:17:04.8691760 v2 62890 2023-03-09 Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model ea38a0040bdfd3875506189e3629b32a 0000-0001-8341-4177 Davide Deganello Davide Deganello true false 1c6e79b6edd08c88a8d17a241cd78630 0000-0003-0515-6808 Feihu Zhao Feihu Zhao true false 2023-03-09 MECH Mechanical stimulation, such as fluid-induced wall shear stress (WSS), is known that can influence the cellular behaviours. Therefore, in some tissue engineering experiments in vitro, mechanical stimulation is applied via bioreactors to the cells in cell culturing to study cell physiology and pathology. In 3D cell culturing, porous scaffolds are used for housing the cells. It is known that the scaffold porous geometries can influence the scaffold permeability and internal WSS in a bioreactor (such as perfusion bioreactor). To calculate the WSS generated on cells within scaffolds, usually computational fluid dynamics (CFD) simulation is needed. However, the limitations of the computational method for WSS calculation are: (i) the high time cost of the CFD simulation (in particular for the highly irregular geometries); (ii) accessibility to the CFD model for some cell culturing experimentalists due to the knowledge gap. To address these limitations, this study aims to develop an empirical model for calculating the WSS based on scaffold permeability. This model can allow the tissue engineers to efficiently calculate the WSS generated within the scaffold and/or determine the bioreactor loading without performing the computational simulations. Journal Article Medicine in Novel Technology and Devices 18 100223 Elsevier BV 2590-0935 1 6 2023 2023-06-01 10.1016/j.medntd.2023.100223 http://dx.doi.org/10.1016/j.medntd.2023.100223 COLLEGE NANME Mechanical Engineering COLLEGE CODE MECH Swansea University Royal Society, EPSRC – Doctoral Training Partnership (DTP) scholarship RGS/R2/212,280, EP/T517987/1 - 2573181 2023-03-13T09:17:04.8691760 2023-03-09T08:33:00.3383259 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Husham Ahmed 1 Matthew Bedding-Tyrrell 2 Davide Deganello 0000-0001-8341-4177 3 Zhidao Xia 4 Yi Xiong 0000-0002-0184-8607 5 Feihu Zhao 0000-0003-0515-6808 6 62890__26821__76a21ee3d674439faa3f6a93969c4d2a.pdf 62890 (2).pdf 2023-03-13T09:15:49.2446813 Output 1242579 application/pdf Version of Record true This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). false eng http://creativecommons.org/licenses/by/4.0/
title Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model
spellingShingle Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model
Davide Deganello
Feihu Zhao
title_short Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model
title_full Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model
title_fullStr Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model
title_full_unstemmed Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model
title_sort Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model
author_id_str_mv ea38a0040bdfd3875506189e3629b32a
1c6e79b6edd08c88a8d17a241cd78630
author_id_fullname_str_mv ea38a0040bdfd3875506189e3629b32a_***_Davide Deganello
1c6e79b6edd08c88a8d17a241cd78630_***_Feihu Zhao
author Davide Deganello
Feihu Zhao
author2 Husham Ahmed
Matthew Bedding-Tyrrell
Davide Deganello
Zhidao Xia
Yi Xiong
Feihu Zhao
format Journal article
container_title Medicine in Novel Technology and Devices
container_volume 18
container_start_page 100223
publishDate 2023
institution Swansea University
issn 2590-0935
doi_str_mv 10.1016/j.medntd.2023.100223
publisher Elsevier BV
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
url http://dx.doi.org/10.1016/j.medntd.2023.100223
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description Mechanical stimulation, such as fluid-induced wall shear stress (WSS), is known that can influence the cellular behaviours. Therefore, in some tissue engineering experiments in vitro, mechanical stimulation is applied via bioreactors to the cells in cell culturing to study cell physiology and pathology. In 3D cell culturing, porous scaffolds are used for housing the cells. It is known that the scaffold porous geometries can influence the scaffold permeability and internal WSS in a bioreactor (such as perfusion bioreactor). To calculate the WSS generated on cells within scaffolds, usually computational fluid dynamics (CFD) simulation is needed. However, the limitations of the computational method for WSS calculation are: (i) the high time cost of the CFD simulation (in particular for the highly irregular geometries); (ii) accessibility to the CFD model for some cell culturing experimentalists due to the knowledge gap. To address these limitations, this study aims to develop an empirical model for calculating the WSS based on scaffold permeability. This model can allow the tissue engineers to efficiently calculate the WSS generated within the scaffold and/or determine the bioreactor loading without performing the computational simulations.
published_date 2023-06-01T04:23:16Z
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