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The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance
Journal of Sports Sciences, Volume: 41, Issue: 1, Pages: 56 - 62
Swansea University Authors: Shane Heffernan , Alun Williams
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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
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DOI (Published version): 10.1080/02640414.2023.2195737
Abstract
Success in long-distance running relies on multiple factors including oxygen utilisation and lactate metabolism, and genetic associations with athlete status suggest elite competitors are heritably predisposed to superior performance. The Gly allele of the PPARGC1A Gly482Ser rs8192678 polymorphism h...
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ISSN: | 0264-0414 1466-447X |
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2023
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This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by-nc-nd/4.0/</licence></document></documents><OutputDurs/></rfc1807> |
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v2 63006 2023-03-22 The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance 72c0b36891dfbec0378c0d0f7916e807 0000-0002-3297-9335 Shane Heffernan Shane Heffernan true false 050a482b2c9699d25870b9c591541998 Alun Williams Alun Williams true false 2023-03-22 STSC Success in long-distance running relies on multiple factors including oxygen utilisation and lactate metabolism, and genetic associations with athlete status suggest elite competitors are heritably predisposed to superior performance. The Gly allele of the PPARGC1A Gly482Ser rs8192678 polymorphism has been associated with endurance athlete status and favourable aerobic training adaptations. However, the association of this polymorphism with performance amongst long-distance runners remains unclear. Accordingly, this study investigated whether rs8192678 was associated with elite status and competitive performance of long-distance runners. Genomic DNA from 656 Caucasian participants including 288 long-distance runners (201 men, 87 women) and 368 non-athletes (285 men, 83 women) was analysed. Medians of the 10 best UK times (Top10) for 10 km, half-marathon and marathon races were calculated, with all included athletes having personal best (PB) performances within 20% of Top10 (this study’s definition of ‘elite’). Genotype and allele frequencies were compared between athletes and non-athletes, and athlete PB compared between genotypes. There were no differences in genotype frequency between athletes and non-athletes, but athlete Ser allele carriers were 2.5% faster than Gly/Gly homozygotes (p=0.030). This study demonstrates that performance differences between elite long-distance runners are associated with rs8192678 genotype, with the Ser allele appearing to enhance performance. Journal Article Journal of Sports Sciences 41 1 56 62 Informa UK Limited 0264-0414 1466-447X Endurance running, road running, genetics, personal best 2 1 2023 2023-01-02 10.1080/02640414.2023.2195737 http://dx.doi.org/10.1080/02640414.2023.2195737 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2023-04-26T12:09:13.2568856 2023-03-22T11:13:10.3471467 Faculty of Science and Engineering School of Engineering and Applied Sciences - Sport and Exercise Sciences Elliott C.R. Hall 1 Sarah J. Lockey 2 Shane Heffernan 0000-0002-3297-9335 3 Adam J. Herbert 4 Georgina K. Stebbings 5 Stephen H. Day 6 Malcolm Collins 7 Yannis P. Pitsiladis 8 Robert M. Erskine 9 Alun Williams 10 63006__26987__df5d0b5cf7df487b89d9aa0c19db6f93.pdf 63006.pdf 2023-04-05T11:38:24.0136730 Output 779728 application/pdf Version of Record true © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. true eng http://creativecommons.org/licenses/by-nc-nd/4.0/ |
title |
The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance |
spellingShingle |
The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance Shane Heffernan Alun Williams |
title_short |
The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance |
title_full |
The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance |
title_fullStr |
The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance |
title_full_unstemmed |
The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance |
title_sort |
The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance |
author_id_str_mv |
72c0b36891dfbec0378c0d0f7916e807 050a482b2c9699d25870b9c591541998 |
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72c0b36891dfbec0378c0d0f7916e807_***_Shane Heffernan 050a482b2c9699d25870b9c591541998_***_Alun Williams |
author |
Shane Heffernan Alun Williams |
author2 |
Elliott C.R. Hall Sarah J. Lockey Shane Heffernan Adam J. Herbert Georgina K. Stebbings Stephen H. Day Malcolm Collins Yannis P. Pitsiladis Robert M. Erskine Alun Williams |
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Journal of Sports Sciences |
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41 |
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56 |
publishDate |
2023 |
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Swansea University |
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0264-0414 1466-447X |
doi_str_mv |
10.1080/02640414.2023.2195737 |
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Informa UK Limited |
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Faculty of Science and Engineering |
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Faculty of Science and Engineering |
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Faculty of Science and Engineering |
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School of Engineering and Applied Sciences - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Sport and Exercise Sciences |
url |
http://dx.doi.org/10.1080/02640414.2023.2195737 |
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description |
Success in long-distance running relies on multiple factors including oxygen utilisation and lactate metabolism, and genetic associations with athlete status suggest elite competitors are heritably predisposed to superior performance. The Gly allele of the PPARGC1A Gly482Ser rs8192678 polymorphism has been associated with endurance athlete status and favourable aerobic training adaptations. However, the association of this polymorphism with performance amongst long-distance runners remains unclear. Accordingly, this study investigated whether rs8192678 was associated with elite status and competitive performance of long-distance runners. Genomic DNA from 656 Caucasian participants including 288 long-distance runners (201 men, 87 women) and 368 non-athletes (285 men, 83 women) was analysed. Medians of the 10 best UK times (Top10) for 10 km, half-marathon and marathon races were calculated, with all included athletes having personal best (PB) performances within 20% of Top10 (this study’s definition of ‘elite’). Genotype and allele frequencies were compared between athletes and non-athletes, and athlete PB compared between genotypes. There were no differences in genotype frequency between athletes and non-athletes, but athlete Ser allele carriers were 2.5% faster than Gly/Gly homozygotes (p=0.030). This study demonstrates that performance differences between elite long-distance runners are associated with rs8192678 genotype, with the Ser allele appearing to enhance performance. |
published_date |
2023-01-02T12:09:12Z |
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11.035349 |