Journal article 451 views 34 downloads
Non-thermal disruption of β-adrenergic receptor-activated Ca2+ signalling and apoptosis in human ES-derived cardiomyocytes by microwave electric fields at 2.4 GHz
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Catherine Hather,
Jainaba Sallah Conteh,
Jingjing Zhang,
Raluca Popa,
Anthony Owen,
Cara Jonas,
Heungjae Choi ,
Rhian M. Daniel,
David Lloyd,
Adrian Porch,
Christopher George
Biochemical and Biophysical Research Communications, Volume: 661, Pages: 89 - 98
Swansea University Authors:
Raluca Popa, Anthony Owen, Cara Jonas, Christopher George
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DOI (Published version): 10.1016/j.bbrc.2023.04.038
Abstract
The ubiquity of wireless electronic-device connectivity has seen microwaves emerge as one of the fastest growing forms of electromagnetic exposure. A growing evidence-base refutes the claim that wireless technologies pose no risk to human health at current safety levels designed to limit thermal (he...
| Published in: | Biochemical and Biophysical Research Communications |
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| ISSN: | 0006-291X |
| Published: |
Elsevier BV
2023
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa63176 |
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| Abstract: |
The ubiquity of wireless electronic-device connectivity has seen microwaves emerge as one of the fastest growing forms of electromagnetic exposure. A growing evidence-base refutes the claim that wireless technologies pose no risk to human health at current safety levels designed to limit thermal (heating) effects. The potential impact of non-thermal effects of microwave exposure, especially in electrically-excitable tissues (e.g., heart), remains controversial. We exposed human embryonic stem-cell derived cardiomyocytes (CM), under baseline and beta-adrenergic receptor (β-AR)-stimulated conditions, to microwaves at 2.4 GHz, a frequency used extensively in wireless communication (e.g., 4G, Bluetooth™ and WiFi). To control for any effect of sample heating, experiments were done in CM subjected to matched rates of direct heating or CM maintained at 37 °C throughout experiments. Detailed profiling of the temporal and amplitude features of Ca2+ signalling in CM under these experimental conditions was reconciled with the extent and spatial clustering of apoptosis. The data show that exposure of CM to 2.4 GHz EMF eliminated the normal Ca2+ signalling response to β-AR stimulation and provoked spatially-clustered apoptosis. This is first evidence that non-thermal effects of 2.4 GHz microwaves might have profound effects on human CM function, responsiveness to activation, and survival. |
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| Keywords: |
Microwaves, Electric field, Non-thermal, Cardiomyocytes, Calcium, Apoptosis. |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
Welsh Government, British Heart Foundation, Wellcome Trust, European Union |
| Start Page: |
89 |
| End Page: |
98 |