Journal article 367 views 49 downloads
Larval Therapy and Larval Excretions/Secretions: A Potential Treatment for Biofilm in Chronic Wounds? A Systematic Review
,
Daniel Morris,
Micah Flores ,
Llinos Harris ,
Yamni Nigam
Microorganisms, Volume: 11, Issue: 2, Start page: 457
Swansea University Authors:
John Gammon , Llinos Harris
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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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DOI (Published version): 10.3390/microorganisms11020457
Abstract
Chronic wounds present a global healthcare challenge and are increasing in prevalence, with bacterial biofilms being the primary roadblock to healing in most cases. A systematic review of the to-date knowledge on larval therapy’s interaction with chronic-wound biofilm is presented here. The findings...
| Published in: | Microorganisms |
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| ISSN: | 2076-2607 |
| Published: |
MDPI
Microorganisms
MDPI AG
2023
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa63189 |
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| Abstract: |
Chronic wounds present a global healthcare challenge and are increasing in prevalence, with bacterial biofilms being the primary roadblock to healing in most cases. A systematic review of the to-date knowledge on larval therapy’s interaction with chronic-wound biofilm is presented here. The findings detail how larval therapy—the controlled application of necrophagous blowfly larvae—acts on biofilms produced by chronic-wound-relevant bacteria through their principle pharmacological mode of action: the secretion and excretion of biologically active substances into the wound bed. A total of 12 inclusion-criteria-meeting publications were identified following the application of a PRISMA-guided methodology for a systematic review. The findings of these publications were qualitatively analyzed to provide a summary of the prevailing understanding of larval therapy’s effects on bacterial biofilm. A further review assessed the quality of the existing evidence to identify knowledge gaps and suggest ways these may be bridged. In summary, larval therapy has a seemingly unarguable ability to inhibit and degrade bacterial biofilms associated with impaired wound healing. However, further research is needed to clarify and standardize the methodological approach in this area of investigation. Such research may lead to the clinical application of larval therapy or derivative treatments for the management of chronic-wound biofilms and improve patient healing outcomes at a time when alternative therapies are desperately needed. |
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| Keywords: |
chronic wound; biofilm; larval therapy; wound healing; Staphylococcus aureus; Pseudomonas aeruginosa; Lucilia sericata; maggot therapy |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
Biomonde |
| Issue: |
2 |
| Start Page: |
457 |