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Viscoelastic Particle Encapsulation Using a Hyaluronic Acid Solution in a T-Junction Microfluidic Device

Anoshanth Jeyasountharan, Francesco Del Giudice Orcid Logo

Micromachines, Volume: 14, Issue: 3, Start page: 563

Swansea University Author: Francesco Del Giudice Orcid Logo

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DOI (Published version): 10.3390/mi14030563

Abstract

The encapsulation of particles and cells in droplets is highly relevant in biomedical engineering as well as in material science. So far, however, the majority of the studies in this area have focused on the encapsulation of particles or cells suspended in Newtonian liquids. We here studied the part...

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Published in: Micromachines
ISSN: 2072-666X
Published: MDPI AG 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa63217
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first_indexed 2023-04-20T08:37:47Z
last_indexed 2023-04-20T08:37:47Z
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spelling v2 63217 2023-04-20 Viscoelastic Particle Encapsulation Using a Hyaluronic Acid Solution in a T-Junction Microfluidic Device 742d483071479b44d7888e16166b1309 0000-0002-9414-6937 Francesco Del Giudice Francesco Del Giudice true false 2023-04-20 CHEG The encapsulation of particles and cells in droplets is highly relevant in biomedical engineering as well as in material science. So far, however, the majority of the studies in this area have focused on the encapsulation of particles or cells suspended in Newtonian liquids. We here studied the particle encapsulation phenomenon in a T-junction microfluidic device, using a non-Newtonian viscoelastic hyaluronic acid solution in phosphate buffer saline as suspending liquid for the particles. We first studied the non-Newtonian droplet formation mechanism, finding that the data for the normalised droplet length scaled as the Newtonian ones. We then performed viscoelastic encapsulation experiments, where we exploited the fact that particles self-assembled in equally-spaced structures before approaching the encapsulation area, to then identify some experimental conditions for which the single encapsulation efficiency was larger than the stochastic limit predicted by the Poisson statistics. Journal Article Micromachines 14 3 563 MDPI AG 2072-666X droplet microfluidics, viscoelasticity, non-newtonian liquids 27 2 2023 2023-02-27 10.3390/mi14030563 http://dx.doi.org/10.3390/mi14030563 COLLEGE NANME Chemical Engineering COLLEGE CODE CHEG Swansea University EPSRC EP/S036490/1 2023-05-24T10:27:03.8278547 2023-04-20T09:35:00.7306474 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Anoshanth Jeyasountharan 1 Francesco Del Giudice 0000-0002-9414-6937 2 63217__27142__787c163abe47499ca6b3ffe7b8b63ff4.pdf 63217.pdf 2023-04-20T09:37:04.7515529 Output 1101054 application/pdf Version of Record true This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). true eng https://creativecommons.org/licenses/by/4.0/
title Viscoelastic Particle Encapsulation Using a Hyaluronic Acid Solution in a T-Junction Microfluidic Device
spellingShingle Viscoelastic Particle Encapsulation Using a Hyaluronic Acid Solution in a T-Junction Microfluidic Device
Francesco Del Giudice
title_short Viscoelastic Particle Encapsulation Using a Hyaluronic Acid Solution in a T-Junction Microfluidic Device
title_full Viscoelastic Particle Encapsulation Using a Hyaluronic Acid Solution in a T-Junction Microfluidic Device
title_fullStr Viscoelastic Particle Encapsulation Using a Hyaluronic Acid Solution in a T-Junction Microfluidic Device
title_full_unstemmed Viscoelastic Particle Encapsulation Using a Hyaluronic Acid Solution in a T-Junction Microfluidic Device
title_sort Viscoelastic Particle Encapsulation Using a Hyaluronic Acid Solution in a T-Junction Microfluidic Device
author_id_str_mv 742d483071479b44d7888e16166b1309
author_id_fullname_str_mv 742d483071479b44d7888e16166b1309_***_Francesco Del Giudice
author Francesco Del Giudice
author2 Anoshanth Jeyasountharan
Francesco Del Giudice
format Journal article
container_title Micromachines
container_volume 14
container_issue 3
container_start_page 563
publishDate 2023
institution Swansea University
issn 2072-666X
doi_str_mv 10.3390/mi14030563
publisher MDPI AG
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
url http://dx.doi.org/10.3390/mi14030563
document_store_str 1
active_str 0
description The encapsulation of particles and cells in droplets is highly relevant in biomedical engineering as well as in material science. So far, however, the majority of the studies in this area have focused on the encapsulation of particles or cells suspended in Newtonian liquids. We here studied the particle encapsulation phenomenon in a T-junction microfluidic device, using a non-Newtonian viscoelastic hyaluronic acid solution in phosphate buffer saline as suspending liquid for the particles. We first studied the non-Newtonian droplet formation mechanism, finding that the data for the normalised droplet length scaled as the Newtonian ones. We then performed viscoelastic encapsulation experiments, where we exploited the fact that particles self-assembled in equally-spaced structures before approaching the encapsulation area, to then identify some experimental conditions for which the single encapsulation efficiency was larger than the stochastic limit predicted by the Poisson statistics.
published_date 2023-02-27T10:27:02Z
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score 11.012678

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