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A bipyridyl quinoline ruthenium(Ⅱ) complex as a “Light Switch” for living cell mitochondrial singlet oxygen

Chaoya Xiong, Hai Chen, Jie Zhang, Hui Deng, Zhihui Feng, Pan Xiang, Yupeng Tian, Lei Chen, Martin Gill Orcid Logo, Xiaohe Tian

Sensors and Actuators B: Chemical, Volume: 388, Start page: 133868

Swansea University Author: Martin Gill Orcid Logo

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Abstract

Visualization of 1O2 in cells is of great significance for revealing the laws of life activities. Although many 1O2 fluorescent probes have been reported, their mechanism of capturing 1O2 has not been innovated. Herein, we report a ruthenium(Ⅱ) bipyridyl complex [Ru(bpy)2L3]PF6 with the ability to s...

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Published in: Sensors and Actuators B: Chemical
ISSN: 0925-4005
Published: Elsevier BV 2023
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa63243
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Abstract: Visualization of 1O2 in cells is of great significance for revealing the laws of life activities. Although many 1O2 fluorescent probes have been reported, their mechanism of capturing 1O2 has not been innovated. Herein, we report a ruthenium(Ⅱ) bipyridyl complex [Ru(bpy)2L3]PF6 with the ability to specifically identify 1O2 based on a novel mechanism of action. The non-fluorescent [Ru(bpy)2L3]PF6 can be accurately oxidized by 1O2 to generate a fluorescent substance with a large Stokes shift (184 nm). [Ru(bpy)2L3]PF6 was successfully applied for visualizing the generation process of 1O2 in living cells and monitoring the morphological changes of mitochondria during photodamage. Therefore, [Ru(bpy)2L3]PF6 has potential to be a useful molecular probe for analyzing physiological processes related to 1O2 in organisms.
College: Faculty of Science and Engineering
Funders: This work was supported by the National Natural Science Foundation of China (32171001) and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University (Y2021YY002).
Start Page: 133868