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Molecularly imprinted polymer (MIP) based electrochemical sensors and their recent advances in health applications
Sensors and Actuators Reports, Volume: 5, Start page: 100153
Swansea University Author: Wei Zhang
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Molecularly imprinted polymer (MIP)-based electrochemical sensors have received growing attention over past decades owing to its robust nature, simple electrochemical control for template removal and cavity regeneration, and go-as-you-please cavity designs into various geometries specific to target...
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Molecularly imprinted polymer (MIP)-based electrochemical sensors have received growing attention over past decades owing to its robust nature, simple electrochemical control for template removal and cavity regeneration, and go-as-you-please cavity designs into various geometries specific to target analytes. The strength of MIP scheme, in combination with the advantages of electrochemical sensing techniques such as operation simplicity, rapid response, and high sensitivity, provide a synergistic effort to form a highly effective sensing platform suitable for an extremely wide range of interest. In this Review, the introduction of MIP and the comparison between electrochemical sensing methods and other detection strategies are briefly discussed. Then, a broad range of analytes determined using MIP-based electrochemical sensors are listed and critically reviewed, mainly focusing on the applied electrochemical technique, presented linear range along with limit of detection (LOD), biological fluid used in real testing, and pretreatment for real sample. Other sensor performances like selectivity towards analyte, signal repeatability, sensor-to-sensor reproducibility, and stability, are carefully compared with other reported papers. MIP sensors fabricated via the nanoMIP technology, and the ones integrated with portable analyzers, are given in more details as good results are always observed in such instances. Finally, a conclusionregarding recent advances on MIP-based electrochemical sensors is presented, followed by current issues and future development depicted at the last section of the Review.
Molecularly imprinted polymer (MIP), Electrochemical, Sensor, Health application, Clinical
Faculty of Science and Engineering
Mr Matthew Pagett would like to acknowledge the financial support from EPSRC DTP program for his PhD scholarship (Ep/R51312x/1).