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Prepartum heat stress in dairy cows increases postpartum inflammatory responses in blood of lactating dairy cows

Paula C.C. Molinari Orcid Logo, Brittney D. Davidson Orcid Logo, Jimena Laporta Orcid Logo, Geoffrey E. Dahl Orcid Logo, Martin Sheldon Orcid Logo, John J. Bromfield Orcid Logo

Journal of Dairy Science, Volume: 106, Issue: 2, Pages: 1464 - 1474

Swansea University Author: Martin Sheldon Orcid Logo

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DOI (Published version): 10.3168/jds.2022-22405

Abstract

Uterine diseases and heat stress (HS) are major challenges for the dairy cow. Heat stress alters host immune resilience, making cows more susceptible to the development of uterine disease. Although HS increases the incidence of uterine disease, the mechanisms by which this occurs are unclear. We hyp...

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Published in: Journal of Dairy Science
ISSN: 0022-0302
Published: American Dairy Science Association 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa63601
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We hypothesize that evaporative cooling (CL) to alleviate HS in prepartum cows has carry-over effects on postpartum innate immunity. Nulliparous pregnant Holstein heifers were assigned to receive either forced CL that resulted in cool conditions (shade with water soakers and fans; n = 14) or to remain under HS conditions (barn shade only; n = 16) for 60 d prepartum. Postpartum, all cows were housed in a freestall barn equipped with shade, water soakers, and fans. Respiratory rate and rectal temperature during the prepartum period were greater in HS heifers compared with CL heifers, indicative of HS. Although milk production was decreased in HS cows compared with CL cows, the incidence of uterine disease and content of total or pathogenic bacteria in vaginal mucus on d 7 or d 21 postpartum was not affected by treatment. Whole blood was collected on d 21 and subjected to in vitro stimulation with lipopolysaccharide. Lipopolysaccharide-induced accumulation of IL-1β, IL-10, and MIP-1α was greater in blood collected from HS cows compared with CL cows. 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spelling v2 63601 2023-06-07 Prepartum heat stress in dairy cows increases postpartum inflammatory responses in blood of lactating dairy cows ab0f74b794e59cc270c69e63ee1d9748 0000-0001-7902-5558 Martin Sheldon Martin Sheldon true false 2023-06-07 BMS Uterine diseases and heat stress (HS) are major challenges for the dairy cow. Heat stress alters host immune resilience, making cows more susceptible to the development of uterine disease. Although HS increases the incidence of uterine disease, the mechanisms by which this occurs are unclear. We hypothesize that evaporative cooling (CL) to alleviate HS in prepartum cows has carry-over effects on postpartum innate immunity. Nulliparous pregnant Holstein heifers were assigned to receive either forced CL that resulted in cool conditions (shade with water soakers and fans; n = 14) or to remain under HS conditions (barn shade only; n = 16) for 60 d prepartum. Postpartum, all cows were housed in a freestall barn equipped with shade, water soakers, and fans. Respiratory rate and rectal temperature during the prepartum period were greater in HS heifers compared with CL heifers, indicative of HS. Although milk production was decreased in HS cows compared with CL cows, the incidence of uterine disease and content of total or pathogenic bacteria in vaginal mucus on d 7 or d 21 postpartum was not affected by treatment. Whole blood was collected on d 21 and subjected to in vitro stimulation with lipopolysaccharide. Lipopolysaccharide-induced accumulation of IL-1β, IL-10, and MIP-1α was greater in blood collected from HS cows compared with CL cows. Our results imply that prepartum HS during late pregnancy has carry-over effects on postpartum innate immunity, which may contribute to the increased incidence of uterine disease observed in cows exposed to prepartum HS. Journal Article Journal of Dairy Science 106 2 1464 1474 American Dairy Science Association 0022-0302 heat stress, innate immunity, uterine disease 1 2 2023 2023-02-01 10.3168/jds.2022-22405 http://dx.doi.org/10.3168/jds.2022-22405 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University Another institution paid the OA fee Funding was provided by Agriculture and Food Research Initiative Competitive (Grant no. 2020-67015-31015) from the USDA National Institute of Food and Agriculture. The authors have not stated any conflicts of interest. 2023-06-21T15:27:23.0268286 2023-06-07T09:24:24.8243152 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Paula C.C. Molinari 0000-0001-7085-2071 1 Brittney D. Davidson 0000-0002-6632-9824 2 Jimena Laporta 0000-0002-3186-5360 3 Geoffrey E. Dahl 0000-0002-2182-6317 4 Martin Sheldon 0000-0001-7902-5558 5 John J. Bromfield 0000-0001-5438-2137 6 63601__27732__ce070130b19140f192324d0ccbe3779d.pdf JDS2023Molinari.pdf 2023-06-07T09:26:43.7671979 Output 1442962 application/pdf Version of Record true © 2023, The Authors. Published by Elsevier Inc. and Fass Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). true eng https://creativecommons.org/licenses/by/4.0/
title Prepartum heat stress in dairy cows increases postpartum inflammatory responses in blood of lactating dairy cows
spellingShingle Prepartum heat stress in dairy cows increases postpartum inflammatory responses in blood of lactating dairy cows
Martin Sheldon
title_short Prepartum heat stress in dairy cows increases postpartum inflammatory responses in blood of lactating dairy cows
title_full Prepartum heat stress in dairy cows increases postpartum inflammatory responses in blood of lactating dairy cows
title_fullStr Prepartum heat stress in dairy cows increases postpartum inflammatory responses in blood of lactating dairy cows
title_full_unstemmed Prepartum heat stress in dairy cows increases postpartum inflammatory responses in blood of lactating dairy cows
title_sort Prepartum heat stress in dairy cows increases postpartum inflammatory responses in blood of lactating dairy cows
author_id_str_mv ab0f74b794e59cc270c69e63ee1d9748
author_id_fullname_str_mv ab0f74b794e59cc270c69e63ee1d9748_***_Martin Sheldon
author Martin Sheldon
author2 Paula C.C. Molinari
Brittney D. Davidson
Jimena Laporta
Geoffrey E. Dahl
Martin Sheldon
John J. Bromfield
format Journal article
container_title Journal of Dairy Science
container_volume 106
container_issue 2
container_start_page 1464
publishDate 2023
institution Swansea University
issn 0022-0302
doi_str_mv 10.3168/jds.2022-22405
publisher American Dairy Science Association
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://dx.doi.org/10.3168/jds.2022-22405
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description Uterine diseases and heat stress (HS) are major challenges for the dairy cow. Heat stress alters host immune resilience, making cows more susceptible to the development of uterine disease. Although HS increases the incidence of uterine disease, the mechanisms by which this occurs are unclear. We hypothesize that evaporative cooling (CL) to alleviate HS in prepartum cows has carry-over effects on postpartum innate immunity. Nulliparous pregnant Holstein heifers were assigned to receive either forced CL that resulted in cool conditions (shade with water soakers and fans; n = 14) or to remain under HS conditions (barn shade only; n = 16) for 60 d prepartum. Postpartum, all cows were housed in a freestall barn equipped with shade, water soakers, and fans. Respiratory rate and rectal temperature during the prepartum period were greater in HS heifers compared with CL heifers, indicative of HS. Although milk production was decreased in HS cows compared with CL cows, the incidence of uterine disease and content of total or pathogenic bacteria in vaginal mucus on d 7 or d 21 postpartum was not affected by treatment. Whole blood was collected on d 21 and subjected to in vitro stimulation with lipopolysaccharide. Lipopolysaccharide-induced accumulation of IL-1β, IL-10, and MIP-1α was greater in blood collected from HS cows compared with CL cows. Our results imply that prepartum HS during late pregnancy has carry-over effects on postpartum innate immunity, which may contribute to the increased incidence of uterine disease observed in cows exposed to prepartum HS.
published_date 2023-02-01T15:27:23Z
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