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Investigating the potentially important role of psychological flexibility in adherence to antiretroviral therapy in people living with HIV

Anja Harrison Orcid Logo, Whitney Scott Orcid Logo, Liadh Timmins Orcid Logo, Christopher D. Graham Orcid Logo, Anthony M. Harrison Orcid Logo

AIDS Care, Volume: 33, Issue: 3, Pages: 337 - 346

Swansea University Author: Liadh Timmins Orcid Logo

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DOI (Published version): 10.1080/09540121.2020.1771263

Abstract

Antiretroviral therapy (ART) has significantly improved immune health and survival rates in HIV, but these outcomes rely on near perfect adherence. While many psychosocial factors are related to sub-optimal adherence, effectiveness of associated interventions are modest or inconsistent. The Psycholo...

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Published in: AIDS Care
ISSN: 0954-0121 1360-0451
Published: Informa UK Limited 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa63786
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first_indexed 2023-09-22T14:28:08Z
last_indexed 2023-09-22T14:28:08Z
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spelling v2 63786 2023-07-06 Investigating the potentially important role of psychological flexibility in adherence to antiretroviral therapy in people living with HIV 7f227f6f0fc0400bae2893d252d2f5ec 0000-0001-7984-4748 Liadh Timmins Liadh Timmins true false 2023-07-06 HPS Antiretroviral therapy (ART) has significantly improved immune health and survival rates in HIV, but these outcomes rely on near perfect adherence. While many psychosocial factors are related to sub-optimal adherence, effectiveness of associated interventions are modest or inconsistent. The Psychological Flexibility (PF) model underlying Acceptance and Commitment Therapy (ACT) identifies a core set of broadly applicable transdiagnostic processes that may be useful to explain and improve non-adherence. However, PF has not previously been examined in relation to ART adherence. Therefore, this cross-sectional study (n = 275) explored relationships between PF and intentional/unintentional ART non-adherence in people with HIV. Adults with HIV prescribed ART were recruited online. Participants completed online questionnaires assessing self-reported PF, adherence and emotional and general functioning. Logistic regressions examined whether PF processes were associated with intentional/unintentional non-adherence. Fifty-eight percent of participants were classified as nonadherent according to the Medication Adherence Rating Scale, of which 41.0% reported intentional and 94.0% unintentional non-adherence. Correlations between PF and adherence were small. PF did not significantly explain intentional/unintentional non-adherence after controlling for demographic and disease factors. Further clarification of the utility of PF in understanding ART non-adherence is warranted using prospective or experimental designs in conjunction with more objective adherence measures. Journal Article AIDS Care 33 3 337 346 Informa UK Limited 0954-0121 1360-0451 HIV AIDS; acceptance and commitment therapy (ACT); adherence; antiretroviral treatment; psychological flexibility 4 3 2021 2021-03-04 10.1080/09540121.2020.1771263 http://dx.doi.org/10.1080/09540121.2020.1771263 COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University 2023-09-22T15:28:57.1487461 2023-07-06T11:02:04.7245731 Faculty of Medicine, Health and Life Sciences School of Psychology Anja Harrison 0000-0002-7872-1292 1 Whitney Scott 0000-0002-2529-9083 2 Liadh Timmins 0000-0001-7984-4748 3 Christopher D. Graham 0000-0001-8456-9154 4 Anthony M. Harrison 0000-0001-5651-6004 5
title Investigating the potentially important role of psychological flexibility in adherence to antiretroviral therapy in people living with HIV
spellingShingle Investigating the potentially important role of psychological flexibility in adherence to antiretroviral therapy in people living with HIV
Liadh Timmins
title_short Investigating the potentially important role of psychological flexibility in adherence to antiretroviral therapy in people living with HIV
title_full Investigating the potentially important role of psychological flexibility in adherence to antiretroviral therapy in people living with HIV
title_fullStr Investigating the potentially important role of psychological flexibility in adherence to antiretroviral therapy in people living with HIV
title_full_unstemmed Investigating the potentially important role of psychological flexibility in adherence to antiretroviral therapy in people living with HIV
title_sort Investigating the potentially important role of psychological flexibility in adherence to antiretroviral therapy in people living with HIV
author_id_str_mv 7f227f6f0fc0400bae2893d252d2f5ec
author_id_fullname_str_mv 7f227f6f0fc0400bae2893d252d2f5ec_***_Liadh Timmins
author Liadh Timmins
author2 Anja Harrison
Whitney Scott
Liadh Timmins
Christopher D. Graham
Anthony M. Harrison
format Journal article
container_title AIDS Care
container_volume 33
container_issue 3
container_start_page 337
publishDate 2021
institution Swansea University
issn 0954-0121
1360-0451
doi_str_mv 10.1080/09540121.2020.1771263
publisher Informa UK Limited
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
url http://dx.doi.org/10.1080/09540121.2020.1771263
document_store_str 0
active_str 0
description Antiretroviral therapy (ART) has significantly improved immune health and survival rates in HIV, but these outcomes rely on near perfect adherence. While many psychosocial factors are related to sub-optimal adherence, effectiveness of associated interventions are modest or inconsistent. The Psychological Flexibility (PF) model underlying Acceptance and Commitment Therapy (ACT) identifies a core set of broadly applicable transdiagnostic processes that may be useful to explain and improve non-adherence. However, PF has not previously been examined in relation to ART adherence. Therefore, this cross-sectional study (n = 275) explored relationships between PF and intentional/unintentional ART non-adherence in people with HIV. Adults with HIV prescribed ART were recruited online. Participants completed online questionnaires assessing self-reported PF, adherence and emotional and general functioning. Logistic regressions examined whether PF processes were associated with intentional/unintentional non-adherence. Fifty-eight percent of participants were classified as nonadherent according to the Medication Adherence Rating Scale, of which 41.0% reported intentional and 94.0% unintentional non-adherence. Correlations between PF and adherence were small. PF did not significantly explain intentional/unintentional non-adherence after controlling for demographic and disease factors. Further clarification of the utility of PF in understanding ART non-adherence is warranted using prospective or experimental designs in conjunction with more objective adherence measures.
published_date 2021-03-04T15:28:56Z
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score 11.036706

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