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Causes of death in children with congenital anomalies up to age 10 in eight European countries
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Joachim Tan ,
Svetlana V Glinianaia,
Judith Rankin,
Anna Pierini,
Michele Santoro,
Alessio Coi,
Ester Garne,
Maria Loane,
Joanne Given,
Abigail Reid,
Amaia Aizpurua,
Diana Akhmedzhanova,
Elisa Ballardini,
Ingeborg Barisic ,
Clara Cavero-Carbonell ,
Hermien E K de Walle,
Miriam Gatt,
Mika Gissler,
Anna Heino,
Sue Jordan ,
Stine Kjaer Urhoj ,
Kari Klungsøyr,
Renee Lutke,
Olatz Mokoroa,
Amanda Julie Neville,
Daniel S Thayer,
Diana G Wellesley,
Lyubov Yevtushok,
Oscar Zurriaga,
Joan Morris
BMJ Paediatrics Open, Volume: 7, Issue: 1, Start page: e001617
Swansea University Author:
Sue Jordan
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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial.
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DOI (Published version): 10.1136/bmjpo-2022-001617
Abstract
Background Congenital anomalies (CAs) increase the risk of death during infancy and childhood. This study aimed to evaluate the accuracy of using death certificates to estimate the burden of CAs on mortality for children under 10 years old.Methods Children born alive with a major CA between 1 Januar...
| Published in: | BMJ Paediatrics Open |
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| ISSN: | 2399-9772 |
| Published: |
BMJ
2023
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa64004 |
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| Abstract: |
Background Congenital anomalies (CAs) increase the risk of death during infancy and childhood. This study aimed to evaluate the accuracy of using death certificates to estimate the burden of CAs on mortality for children under 10 years old.Methods Children born alive with a major CA between 1 January 1995 and 31 December 2014, from 13 population-based European CA registries were linked to mortality records up to their 10th birthday or 31 December 2015, whichever was earlier.Results In total 4199 neonatal, 2100 postneonatal and 1087 deaths in children aged 1–9 years were reported. The underlying cause of death was a CA in 71% (95% CI 64% to 78%) of neonatal and 68% (95% CI 61% to 74%) of postneonatal infant deaths. For neonatal deaths the proportions varied by registry from 45% to 89% and by anomaly from 53% for Down syndrome to 94% for tetralogy of Fallot. In children aged 1–9, 49% (95% CI 42% to 57%) were attributed to a CA. Comparing mortality in children with anomalies to population mortality predicts that over 90% of all deaths at all ages are attributable to the anomalies. The specific CA was often not reported on the death certificate, even for lethal anomalies such as trisomy 13 (only 80% included the code for trisomy 13).Conclusions Data on the underlying cause of death from death certificates alone are not sufficient to evaluate the burden of CAs on infant and childhood mortality across countries and over time. Linked data from CA registries and death certificates are necessary for obtaining accurate estimates. |
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| Item Description: |
Data are available on reasonable request. The aggregate data that support the findings of this study are available from the authors for scientifically valid requests and with permission of the participating registries of congenital anomalies. |
| Keywords: |
Infant and child mortality, death, congenital anomalies |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
Horizon 2020 |
| Issue: |
1 |
| Start Page: |
e001617 |