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Challenges in optical micro-rheometry for blood clot detection / LAURA O'DEA

Swansea University Author: LAURA O'DEA

  • E-Thesis under embargo until: 15th May 2028

DOI (Published version): 10.23889/SUthesis.64089

Abstract

The need for rapid, cheap and accessible method to accurately quantify the rheological state of a clotting sample of blood has been highlighted by the recent COVID-19 pandemic. Such a device would be significant for use for theranostic application in trauma care and warfarin clinics. Extensive resea...

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Published: Swansea, Wales, UK 2023
Institution: Swansea University
Degree level: Doctoral
Degree name: Ph.D
Supervisor: Curtis, Daniel.
URI: https://cronfa.swan.ac.uk/Record/cronfa64089
first_indexed 2023-08-21T09:52:20Z
last_indexed 2024-11-25T14:13:25Z
id cronfa64089
recordtype RisThesis
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spelling 2023-10-05T15:19:00.0511625 v2 64089 2023-08-21 Challenges in optical micro-rheometry for blood clot detection bd85065cb9bb2acc5c87e28805009a81 LAURA O'DEA LAURA O'DEA true false 2023-08-21 The need for rapid, cheap and accessible method to accurately quantify the rheological state of a clotting sample of blood has been highlighted by the recent COVID-19 pandemic. Such a device would be significant for use for theranostic application in trauma care and warfarin clinics. Extensive research based on conventional rheometric approaches have established the Gel Point (GP) as a biometric for healthy coagulation. Translation of these conventional techniques to the clinical environment however, is challenging and an alternative rheometrical assay that is more amenable to deployment in a clinical setting is required. Presented here, for the first time, is a desktop, point-of-care light scattering technique capable of identifying the GP in a sample undergoing gelation. This is done using standard Diffusing Wave Spectroscopy techniques, with the method extended to gelatin samples with decreased scatterer concentration to mimic scattering properties of biological samples such as blood, using modified Laser Speckle Rheology methods. E-Thesis Swansea, Wales, UK Gel point, clot detection, laser speckle rheometry, diffusing wave spectroscopy 3 3 2023 2023-03-03 10.23889/SUthesis.64089 COLLEGE NANME COLLEGE CODE Swansea University Curtis, Daniel. Doctoral Ph.D EPSRC 2023-10-05T15:19:00.0511625 2023-08-21T10:48:02.8064423 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Electronic and Electrical Engineering LAURA O'DEA 1 Under embargo Under embargo 2023-08-21T10:52:43.1973665 Output 10012742 application/pdf E-Thesis true 2028-05-15T00:00:00.0000000 Copyright: The Author, Laura J. O'Dea, 2023. true eng
title Challenges in optical micro-rheometry for blood clot detection
spellingShingle Challenges in optical micro-rheometry for blood clot detection
LAURA O'DEA
title_short Challenges in optical micro-rheometry for blood clot detection
title_full Challenges in optical micro-rheometry for blood clot detection
title_fullStr Challenges in optical micro-rheometry for blood clot detection
title_full_unstemmed Challenges in optical micro-rheometry for blood clot detection
title_sort Challenges in optical micro-rheometry for blood clot detection
author_id_str_mv bd85065cb9bb2acc5c87e28805009a81
author_id_fullname_str_mv bd85065cb9bb2acc5c87e28805009a81_***_LAURA O'DEA
author LAURA O'DEA
author2 LAURA O'DEA
format E-Thesis
publishDate 2023
institution Swansea University
doi_str_mv 10.23889/SUthesis.64089
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Electronic and Electrical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Electronic and Electrical Engineering
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description The need for rapid, cheap and accessible method to accurately quantify the rheological state of a clotting sample of blood has been highlighted by the recent COVID-19 pandemic. Such a device would be significant for use for theranostic application in trauma care and warfarin clinics. Extensive research based on conventional rheometric approaches have established the Gel Point (GP) as a biometric for healthy coagulation. Translation of these conventional techniques to the clinical environment however, is challenging and an alternative rheometrical assay that is more amenable to deployment in a clinical setting is required. Presented here, for the first time, is a desktop, point-of-care light scattering technique capable of identifying the GP in a sample undergoing gelation. This is done using standard Diffusing Wave Spectroscopy techniques, with the method extended to gelatin samples with decreased scatterer concentration to mimic scattering properties of biological samples such as blood, using modified Laser Speckle Rheology methods.
published_date 2023-03-03T05:12:15Z
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score 11.099239

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