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(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

Céline Cosseau, Olaf Wolkenhauer, Gilda Padalino Orcid Logo, Kathrin K. Geyer, Karl F. Hoffmann, Christoph Grunau

Trends in Parasitology, Volume: 33, Issue: 4, Pages: 285 - 294

Swansea University Author: Gilda Padalino Orcid Logo

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Abstract

The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by ‘inheritance system’. This system, comprised of both genome and epigenome components, colle...

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Published in: Trends in Parasitology
ISSN: 1471-4922
Published: Elsevier BV 2017
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa64439
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Abstract: The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by ‘inheritance system’. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.
Keywords: Schistosoma mansoni, intestinal bilharzia, inheritance system, epigenetic inheritance, genetic inheritance
College: Faculty of Medicine, Health and Life Sciences
Funders: G.P., K.K.G., and K.F.H. acknowledge the UK BBSRC (BB/K005448/1), the Life Sciences Research Network Wales (LSRNW), and the Wellcome Trust (107475/Z/15/Z) for supporting the research activities underlying some of the ideas discussed in this review.
Issue: 4
Start Page: 285
End Page: 294