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Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles
Journal of Extracellular Vesicles, Volume: 10, Issue: 7
Swansea University Author:
Jason Webber
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DOI (Published version): 10.1002/jev2.12093
Abstract
Urine is commonly used for clinical diagnosis and biomedical research. The discovery of extracellular vesicles (EV) in urine opened a new fast-growing scientific field. In the last decade urinary extracellular vesicles (uEVs) were shown to mirror molecular processes as well as physiological and path...
Published in: | Journal of Extracellular Vesicles |
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ISSN: | 2001-3078 |
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2021
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In the last decade urinary extracellular vesicles (uEVs) were shown to mirror molecular processes as well as physiological and pathological conditions in kidney, urothelial and prostate tissue. Therefore, several methods to isolate and characterize uEVs have been developed. However, methodological aspects of EV separation and analysis, including normalization of results, need further optimization and standardization to foster scientific advances in uEV research and a subsequent successful translation into clinical practice. This position paper is written by the Urine Task Force of the Rigor and Standardization Subcommittee of ISEV consisting of nephrologists, urologists, cardiologists and biologists with active experience in uEV research. Our aim is to present the state of the art and identify challenges and gaps in current uEV-based analyses for clinical applications. 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AL is supported by Norges Forskningsråd, Kreftforeningen and Helse Sør-Øst RHF (NO). UE is supported by the NIH, National Heart, Lung, and Blood Institute, Award number K23-HL-126101. CJB and EJH are supported by the Dutch Kidney Foundation (Nierstichting), Award number: CP18.05.</funders><projectreference/><lastEdited>2023-11-27T16:29:08.2678016</lastEdited><Created>2023-10-11T11:54:30.7774834</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Biomedical Science</level></path><authors><author><firstname>Uta</firstname><surname>Erdbrügger</surname><order>1</order></author><author><firstname>Charles J.</firstname><surname>Blijdorp</surname><order>2</order></author><author><firstname>Irene V.</firstname><surname>Bijnsdorp</surname><order>3</order></author><author><firstname>Francesc E.</firstname><surname>Borràs</surname><order>4</order></author><author><firstname>Dylan</firstname><surname>Burger</surname><order>5</order></author><author><firstname>Benedetta</firstname><surname>Bussolati</surname><order>6</order></author><author><firstname>James Brian</firstname><surname>Byrd</surname><order>7</order></author><author><firstname>Aled</firstname><surname>Clayton</surname><order>8</order></author><author><firstname>James W.</firstname><surname>Dear</surname><order>9</order></author><author><firstname>Juan M.</firstname><surname>Falcón‐Pérez</surname><order>10</order></author><author><firstname>Cristina</firstname><surname>Grange</surname><order>11</order></author><author><firstname>Andrew F.</firstname><surname>Hill</surname><order>12</order></author><author><firstname>Harry</firstname><surname>Holthöfer</surname><order>13</order></author><author><firstname>Ewout J.</firstname><surname>Hoorn</surname><order>14</order></author><author><firstname>Guido</firstname><surname>Jenster</surname><order>15</order></author><author><firstname>Connie R.</firstname><surname>Jimenez</surname><order>16</order></author><author><firstname>Kerstin</firstname><surname>Junker</surname><order>17</order></author><author><firstname>John</firstname><surname>Klein</surname><order>18</order></author><author><firstname>Mark A.</firstname><surname>Knepper</surname><order>19</order></author><author><firstname>Erik H.</firstname><surname>Koritzinsky</surname><order>20</order></author><author><firstname>James M.</firstname><surname>Luther</surname><order>21</order></author><author><firstname>Metka</firstname><surname>Lenassi</surname><order>22</order></author><author><firstname>Janne</firstname><surname>Leivo</surname><order>23</order></author><author><firstname>Inge</firstname><surname>Mertens</surname><order>24</order></author><author><firstname>Luca</firstname><surname>Musante</surname><order>25</order></author><author><firstname>Eline</firstname><surname>Oeyen</surname><order>26</order></author><author><firstname>Maija</firstname><surname>Puhka</surname><order>27</order></author><author><firstname>Martin E. van</firstname><surname>Royen</surname><order>28</order></author><author><firstname>Catherine</firstname><surname>Sánchez</surname><order>29</order></author><author><firstname>Carolina</firstname><surname>Soekmadji</surname><order>30</order></author><author><firstname>Visith</firstname><surname>Thongboonkerd</surname><order>31</order></author><author><firstname>Volkert van</firstname><surname>Steijn</surname><order>32</order></author><author><firstname>Gerald</firstname><surname>Verhaegh</surname><order>33</order></author><author><firstname>Jason</firstname><surname>Webber</surname><orcid>0000-0003-4772-3014</orcid><order>34</order></author><author><firstname>Kenneth</firstname><surname>Witwer</surname><order>35</order></author><author><firstname>Peter S.T.</firstname><surname>Yuen</surname><order>36</order></author><author><firstname>Lei</firstname><surname>Zheng</surname><order>37</order></author><author><firstname>Alicia</firstname><surname>Llorente</surname><order>38</order></author><author><firstname>Elena S.</firstname><surname>Martens‐Uzunova</surname><order>39</order></author></authors><documents><document><filename>64711__29125__583c76c5b6d141a99e4eb7b29a4f6d0c.pdf</filename><originalFilename>64711.VOR.pdf</originalFilename><uploaded>2023-11-27T16:26:26.6157247</uploaded><type>Output</type><contentLength>2828141</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>© 2021 The Authors. 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v2 64711 2023-10-11 Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles 25d1a26f9b8bb556bd9412080e40351d 0000-0003-4772-3014 Jason Webber Jason Webber true false 2023-10-11 BMS Urine is commonly used for clinical diagnosis and biomedical research. The discovery of extracellular vesicles (EV) in urine opened a new fast-growing scientific field. In the last decade urinary extracellular vesicles (uEVs) were shown to mirror molecular processes as well as physiological and pathological conditions in kidney, urothelial and prostate tissue. Therefore, several methods to isolate and characterize uEVs have been developed. However, methodological aspects of EV separation and analysis, including normalization of results, need further optimization and standardization to foster scientific advances in uEV research and a subsequent successful translation into clinical practice. This position paper is written by the Urine Task Force of the Rigor and Standardization Subcommittee of ISEV consisting of nephrologists, urologists, cardiologists and biologists with active experience in uEV research. Our aim is to present the state of the art and identify challenges and gaps in current uEV-based analyses for clinical applications. Finally, recommendations for improved rigor, reproducibility and interoperability in uEV research are provided in order to facilitate advances in the field. Journal Article Journal of Extracellular Vesicles 10 7 Wiley 2001-3078 Biobank, biomarkers, bladder, extracellular vesicles, kidney, liquid biopsy, prostate, rigor and standardization, urine 31 5 2021 2021-05-31 10.1002/jev2.12093 http://dx.doi.org/10.1002/jev2.12093 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University Another institution paid the OA fee ESM-U, CG, GV, GJ, IVB, MvR, and VvS, are members of the “IMMPROVE” consortium (Innovative Measurements and Markers for Prostate Cancer Diagnosis and Prognosis using Extracellular Vesicles), which is sponsored by an Alpe d'HuZes grant of the Dutch Cancer Society (grant #EMCR2015-8022). AL is supported by Norges Forskningsråd, Kreftforeningen and Helse Sør-Øst RHF (NO). UE is supported by the NIH, National Heart, Lung, and Blood Institute, Award number K23-HL-126101. CJB and EJH are supported by the Dutch Kidney Foundation (Nierstichting), Award number: CP18.05. 2023-11-27T16:29:08.2678016 2023-10-11T11:54:30.7774834 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Uta Erdbrügger 1 Charles J. Blijdorp 2 Irene V. Bijnsdorp 3 Francesc E. Borràs 4 Dylan Burger 5 Benedetta Bussolati 6 James Brian Byrd 7 Aled Clayton 8 James W. Dear 9 Juan M. Falcón‐Pérez 10 Cristina Grange 11 Andrew F. Hill 12 Harry Holthöfer 13 Ewout J. Hoorn 14 Guido Jenster 15 Connie R. Jimenez 16 Kerstin Junker 17 John Klein 18 Mark A. Knepper 19 Erik H. Koritzinsky 20 James M. Luther 21 Metka Lenassi 22 Janne Leivo 23 Inge Mertens 24 Luca Musante 25 Eline Oeyen 26 Maija Puhka 27 Martin E. van Royen 28 Catherine Sánchez 29 Carolina Soekmadji 30 Visith Thongboonkerd 31 Volkert van Steijn 32 Gerald Verhaegh 33 Jason Webber 0000-0003-4772-3014 34 Kenneth Witwer 35 Peter S.T. Yuen 36 Lei Zheng 37 Alicia Llorente 38 Elena S. Martens‐Uzunova 39 64711__29125__583c76c5b6d141a99e4eb7b29a4f6d0c.pdf 64711.VOR.pdf 2023-11-27T16:26:26.6157247 Output 2828141 application/pdf Version of Record true © 2021 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles. Distributed under the terms of a Creative Commons Attribution 4.0 International License (CC BY 4.0). true eng https://creativecommons.org/licenses/by/4.0/ |
title |
Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles |
spellingShingle |
Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles Jason Webber |
title_short |
Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles |
title_full |
Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles |
title_fullStr |
Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles |
title_full_unstemmed |
Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles |
title_sort |
Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles |
author_id_str_mv |
25d1a26f9b8bb556bd9412080e40351d |
author_id_fullname_str_mv |
25d1a26f9b8bb556bd9412080e40351d_***_Jason Webber |
author |
Jason Webber |
author2 |
Uta Erdbrügger Charles J. Blijdorp Irene V. Bijnsdorp Francesc E. Borràs Dylan Burger Benedetta Bussolati James Brian Byrd Aled Clayton James W. Dear Juan M. Falcón‐Pérez Cristina Grange Andrew F. Hill Harry Holthöfer Ewout J. Hoorn Guido Jenster Connie R. Jimenez Kerstin Junker John Klein Mark A. Knepper Erik H. Koritzinsky James M. Luther Metka Lenassi Janne Leivo Inge Mertens Luca Musante Eline Oeyen Maija Puhka Martin E. van Royen Catherine Sánchez Carolina Soekmadji Visith Thongboonkerd Volkert van Steijn Gerald Verhaegh Jason Webber Kenneth Witwer Peter S.T. Yuen Lei Zheng Alicia Llorente Elena S. Martens‐Uzunova |
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Journal of Extracellular Vesicles |
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7 |
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2021 |
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Swansea University |
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2001-3078 |
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10.1002/jev2.12093 |
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Wiley |
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Faculty of Medicine, Health and Life Sciences |
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http://dx.doi.org/10.1002/jev2.12093 |
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description |
Urine is commonly used for clinical diagnosis and biomedical research. The discovery of extracellular vesicles (EV) in urine opened a new fast-growing scientific field. In the last decade urinary extracellular vesicles (uEVs) were shown to mirror molecular processes as well as physiological and pathological conditions in kidney, urothelial and prostate tissue. Therefore, several methods to isolate and characterize uEVs have been developed. However, methodological aspects of EV separation and analysis, including normalization of results, need further optimization and standardization to foster scientific advances in uEV research and a subsequent successful translation into clinical practice. This position paper is written by the Urine Task Force of the Rigor and Standardization Subcommittee of ISEV consisting of nephrologists, urologists, cardiologists and biologists with active experience in uEV research. Our aim is to present the state of the art and identify challenges and gaps in current uEV-based analyses for clinical applications. Finally, recommendations for improved rigor, reproducibility and interoperability in uEV research are provided in order to facilitate advances in the field. |
published_date |
2021-05-31T16:29:08Z |
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11.021648 |