Prostate cancer exosomes as modulators of the tumor microenvironment

Shephard, Alex P.; Yeung, Vincent; Clayton, Aled; Webber, Jason

doi:10.20517/2394-4722.2017.32

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Prostate cancer exosomes as modulators of the tumor microenvironment

Alex P. Shephard, Vincent Yeung, Aled Clayton, Jason Webber

Journal of Cancer Metastasis and Treatment, Volume: 3, Issue: 12, Start page: 288

Swansea University Author: Jason Webber

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DOI (Published version): 10.20517/2394-4722.2017.32

Abstract

Researchers are currently trying to understand why some men with prostate cancer go on to develop aggressive disease whilst others maintain slow growing tumors. Although endogenous genetic anomalies within the tumor cell are important, the prevailing view is that the tissue microenvironment as a who...

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Published in:	Journal of Cancer Metastasis and Treatment
ISSN:	2394-4722 2454-2857
Published:	OAE Publishing Inc. 2017
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa64723
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first_indexed	2023-11-28T11:14:02Z
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spelling	v2 64723 2023-10-11 Prostate cancer exosomes as modulators of the tumor microenvironment 25d1a26f9b8bb556bd9412080e40351d 0000-0003-4772-3014 Jason Webber Jason Webber true false 2023-10-11 BMS Researchers are currently trying to understand why some men with prostate cancer go on to develop aggressive disease whilst others maintain slow growing tumors. Although endogenous genetic anomalies within the tumor cell are important, the prevailing view is that the tissue microenvironment as a whole is the determinant factor. Many studies have focussed on the role of soluble factors in modulating the nature of the tumor microenvironment. There is however a growing interest in the role of extracellular vesicles, including exosomes, as regulators of disease progression. A variety of resident cells, as well as infiltrating cells, all contribute to a heterogeneous population of exosomes within the tumor microenvironment. Studies focussing on the role of exosomes in prostate cancer are however relatively rare. In this review, evidence from various cancers, including prostate, is used to present numerous potential roles of exosomes in prostate cancer. Whilst further validation of some functions may remain necessary it is clear that exosomes play a major role in intercellular communication between various cell types within the tumor microenvironment and are necessary for driving disease progression. Journal Article Journal of Cancer Metastasis and Treatment 3 12 288 OAE Publishing Inc. 2394-4722 2454-2857 Exosomes, prostate cancer, microenvironment, angiogenesis, stroma, myeloid, matrix metalloproteinases, metabolism 6 12 2017 2017-12-06 10.20517/2394-4722.2017.32 http://dx.doi.org/10.20517/2394-4722.2017.32 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University Not Required The authors are supported by funding from Prostate Cancer UK (awarded to JPW and AS), Cancer Research Wales (awarded to JPW and AC), Life Science Research Network Wales (an initiative funded through the Welsh Government’s Ser Cymru programme; awarded to AC, JPW, and VY), Tenovus Cancer Care (awarded to AC), Cardiff University (awarded to AC) and Welsh Crucible (awarded to JPW). 2023-11-28T11:14:35.1213739 2023-10-11T16:35:53.6071980 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Alex P. Shephard 1 Vincent Yeung 2 Aled Clayton 3 Jason Webber 0000-0003-4772-3014 4 64723__29130__603cfaca8b3046ee8755224bc03bd0ec.pdf 64723.VOR.pdf 2023-11-28T11:12:57.1999725 Output 856445 application/pdf Version of Record true © The Author(s) 2017. Distributed under the terms of a Creative Commons Attribution 4.0 International License (CC BY 4.0). true eng https://creativecommons.org/licenses/by/4.0/
title	Prostate cancer exosomes as modulators of the tumor microenvironment
spellingShingle	Prostate cancer exosomes as modulators of the tumor microenvironment Jason Webber
title_short	Prostate cancer exosomes as modulators of the tumor microenvironment
title_full	Prostate cancer exosomes as modulators of the tumor microenvironment
title_fullStr	Prostate cancer exosomes as modulators of the tumor microenvironment
title_full_unstemmed	Prostate cancer exosomes as modulators of the tumor microenvironment
title_sort	Prostate cancer exosomes as modulators of the tumor microenvironment
author_id_str_mv	25d1a26f9b8bb556bd9412080e40351d
author_id_fullname_str_mv	25d1a26f9b8bb556bd9412080e40351d_***_Jason Webber
author	Jason Webber
author2	Alex P. Shephard Vincent Yeung Aled Clayton Jason Webber
format	Journal article
container_title	Journal of Cancer Metastasis and Treatment
container_volume	3
container_issue	12
container_start_page	288
publishDate	2017
institution	Swansea University
issn	2394-4722 2454-2857
doi_str_mv	10.20517/2394-4722.2017.32
publisher	OAE Publishing Inc.
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
url	http://dx.doi.org/10.20517/2394-4722.2017.32
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description	Researchers are currently trying to understand why some men with prostate cancer go on to develop aggressive disease whilst others maintain slow growing tumors. Although endogenous genetic anomalies within the tumor cell are important, the prevailing view is that the tissue microenvironment as a whole is the determinant factor. Many studies have focussed on the role of soluble factors in modulating the nature of the tumor microenvironment. There is however a growing interest in the role of extracellular vesicles, including exosomes, as regulators of disease progression. A variety of resident cells, as well as infiltrating cells, all contribute to a heterogeneous population of exosomes within the tumor microenvironment. Studies focussing on the role of exosomes in prostate cancer are however relatively rare. In this review, evidence from various cancers, including prostate, is used to present numerous potential roles of exosomes in prostate cancer. Whilst further validation of some functions may remain necessary it is clear that exosomes play a major role in intercellular communication between various cell types within the tumor microenvironment and are necessary for driving disease progression.
published_date	2017-12-06T11:14:36Z
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score	11.016235

Prostate cancer exosomes as modulators of the tumor microenvironment

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