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Utilising micron scale 3D printed morphologies for particle adhesion reduction

Georgina Marsh Orcid Logo, Matt J. Bunker, Morgan R. Alexander, Ricky D. Wildman, Mark Nicholas, Clive J. Roberts

Powder Technology, Volume: 404, Start page: 117418

Swansea University Author: Georgina Marsh Orcid Logo

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DOI (Published version): 10.1016/j.powtec.2022.117418

Abstract

In the pharmaceutical industry, the ability to improve the understanding of the effect of surface roughness on interparticulate interactions is critical. Dry powder inhalers often possess poor efficiency, as the powder formulations are inherently adhesive and cohesive due to their size. The complex...

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Published in: Powder Technology
ISSN: 0032-5910 1873-328X
Published: Elsevier BV 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa64800
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first_indexed 2023-10-23T14:44:30Z
last_indexed 2023-10-23T14:44:30Z
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spelling v2 64800 2023-10-23 Utilising micron scale 3D printed morphologies for particle adhesion reduction 60eb67dc80ac6072cbea39caa88d662c 0000-0001-8621-2925 Georgina Marsh Georgina Marsh true false 2023-10-23 PHAR In the pharmaceutical industry, the ability to improve the understanding of the effect of surface roughness on interparticulate interactions is critical. Dry powder inhalers often possess poor efficiency, as the powder formulations are inherently adhesive and cohesive due to their size. The complex interplay of factors that affect interparticulate interactions, means it has been difficult to isolate the effect of surface morphology. Using two photon polymerisation, this study shows the fabrication of bespoke sub-micron geometric structures, with a consistent surface chemistry. These are used to investigate the effect of surface morphologies on particle adhesion by utilising AFM force-volume mapping, to model spheres and carrier particles. This demonstrates the significant effect varying surface morphology can have on particle-surface adhesion. This approach allows for the first time an in-depth examination of the local variation effect of surface features on particle adhesion and may facilitate the design and optimisation of powder processes. Journal Article Powder Technology 404 117418 Elsevier BV 0032-5910 1873-328X Two photon polymerisation, AFM, Particle-surface adhesion, Surface roughness 31 5 2022 2022-05-31 10.1016/j.powtec.2022.117418 http://dx.doi.org/10.1016/j.powtec.2022.117418 COLLEGE NANME Pharmacy COLLEGE CODE PHAR Swansea University Another institution paid the OA fee AstraZeneca and the EPSRC (EP/L01646X) for funding is gratefully acknowledged. 2023-11-27T11:12:22.7972592 2023-10-23T14:57:54.4202939 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Pharmacy Georgina Marsh 0000-0001-8621-2925 1 Matt J. Bunker 2 Morgan R. Alexander 3 Ricky D. Wildman 4 Mark Nicholas 5 Clive J. Roberts 6 64800__29117__cbfd9813c53349da8e0cc2b447944144.pdf 64800.VOR.pdf 2023-11-27T11:09:25.4981432 Output 2431184 application/pdf Version of Record true © 2022 The Authors. Published by Elsevier B.V. Distributed under the terms of a Creative Commons Attribution 4.0 International License (CC BY 4.0). true eng https://creativecommons.org/licenses/by/4.0/
title Utilising micron scale 3D printed morphologies for particle adhesion reduction
spellingShingle Utilising micron scale 3D printed morphologies for particle adhesion reduction
Georgina Marsh
title_short Utilising micron scale 3D printed morphologies for particle adhesion reduction
title_full Utilising micron scale 3D printed morphologies for particle adhesion reduction
title_fullStr Utilising micron scale 3D printed morphologies for particle adhesion reduction
title_full_unstemmed Utilising micron scale 3D printed morphologies for particle adhesion reduction
title_sort Utilising micron scale 3D printed morphologies for particle adhesion reduction
author_id_str_mv 60eb67dc80ac6072cbea39caa88d662c
author_id_fullname_str_mv 60eb67dc80ac6072cbea39caa88d662c_***_Georgina Marsh
author Georgina Marsh
author2 Georgina Marsh
Matt J. Bunker
Morgan R. Alexander
Ricky D. Wildman
Mark Nicholas
Clive J. Roberts
format Journal article
container_title Powder Technology
container_volume 404
container_start_page 117418
publishDate 2022
institution Swansea University
issn 0032-5910
1873-328X
doi_str_mv 10.1016/j.powtec.2022.117418
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Pharmacy{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Pharmacy
url http://dx.doi.org/10.1016/j.powtec.2022.117418
document_store_str 1
active_str 0
description In the pharmaceutical industry, the ability to improve the understanding of the effect of surface roughness on interparticulate interactions is critical. Dry powder inhalers often possess poor efficiency, as the powder formulations are inherently adhesive and cohesive due to their size. The complex interplay of factors that affect interparticulate interactions, means it has been difficult to isolate the effect of surface morphology. Using two photon polymerisation, this study shows the fabrication of bespoke sub-micron geometric structures, with a consistent surface chemistry. These are used to investigate the effect of surface morphologies on particle adhesion by utilising AFM force-volume mapping, to model spheres and carrier particles. This demonstrates the significant effect varying surface morphology can have on particle-surface adhesion. This approach allows for the first time an in-depth examination of the local variation effect of surface features on particle adhesion and may facilitate the design and optimisation of powder processes.
published_date 2022-05-31T11:12:23Z
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score 11.016235

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