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Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors

Sumati Bhatia Orcid Logo, Malte Hilsch, Jose Luis Cuellar‐Camacho Orcid Logo, Kai Ludwig Orcid Logo, Chuanxiong Nie Orcid Logo, Badri Parshad Orcid Logo, Matthias Wallert, Stephan Block Orcid Logo, Daniel Lauster Orcid Logo, Christoph Böttcher, Andreas Herrmann Orcid Logo, Rainer Haag Orcid Logo

Angewandte Chemie, Volume: 132, Issue: 30, Pages: 12517 - 12522

Swansea University Author: Sumati Bhatia Orcid Logo

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DOI (Published version): 10.1002/ange.202006145

Abstract

Flexible multivalent 3D nanosystems that can deform and adapt onto the virus surface via specific ligand–receptor multivalent interactions can efficiently block virus adhesion onto the cell. We here report on the synthesis of a 250 nm sized flexible sialylated nanogel that adapts onto the influenza...

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Published in: Angewandte Chemie
ISSN: 0044-8249 1521-3757
Published: Wiley 2020
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa64864
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Abstract: Flexible multivalent 3D nanosystems that can deform and adapt onto the virus surface via specific ligand–receptor multivalent interactions can efficiently block virus adhesion onto the cell. We here report on the synthesis of a 250 nm sized flexible sialylated nanogel that adapts onto the influenza A virus (IAV) surface via multivalent binding of its sialic acid (SA) residues with hemagglutinin spike proteins on the virus surface. We could demonstrate that the high flexibility of sialylated nanogel improves IAV inhibition by 400 times as compared to a rigid sialylated nanogel in the hemagglutination inhibition assay. The flexible sialylated nanogel efficiently inhibits the influenza A/X31 (H3N2) infection with IC50 values in low picomolar concentrations and also blocks the virus entry into MDCK-II cells.
Keywords: Flexibility, infection inhibition, influenza A virus, polyglycerols, sialylated nanogels
College: Faculty of Science and Engineering
Funders: Deutsche Forschungsgemeinschaft (Grant Number: SFB 765/3-2019).
Issue: 30
Start Page: 12517
End Page: 12522