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Methadone maintenance treatment and impulsivity: premature responding

Kathrin Weidacker Orcid Logo, Yijie Zhao, Yingying Zhang, Sebastian Whiteford Orcid Logo, Qihuan Ren, Chencheng Zhang, Valerie Voon

Journal of Clinical and Experimental Neuropsychology, Volume: 45, Issue: 6, Pages: 606 - 617

Swansea University Authors: Kathrin Weidacker Orcid Logo, Sebastian Whiteford Orcid Logo

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DOI (Published version): 10.1080/13803395.2023.2276483

Abstract

Introduction: Previous research showed that methadone maintenance treatment (MMT) is linked to impulsivity, with higher impulsivity levels being associated with for example, increased drug use. One aspect of impulsivity, most commonly studied in rodent research, is premature responding, the failure...

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Published in: Journal of Clinical and Experimental Neuropsychology
ISSN: 1380-3395 1744-411X
Published: Taylor & Francis 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa64902
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One aspect of impulsivity, most commonly studied in rodent research, is premature responding, the failure to wait for a starting signal. Premature responding is of high translational significance since it predicts the development of addiction-like behaviors in rodents. Methods: We assessed 45 MMT patients and 46 demographically matched (age, sex, education, and handedness) healthy volunteers (HVs) on premature responding alongside action and inhibition of instructed and intentional trials using the Intentional Hand Task (IHT). Results: The results showed markedly enhanced premature responses in the MMT vs. the HV group, which correlated positively with methadone dosage in the MMT patients. Throughout the task, MMT patients were faster across all trial parts and less accurate in response to instructed trials compared to HVs. Conclusions: The increase in premature motor reactions during variable waiting periods alongside increased motion speed and lower accuracy might reflect a specific motor inhibition deficit in MMT, a subcomponent of impulsivity not previously assessed in MMT. Incorporating an experimentally defined measure of impulsivity, such as premature responding, into existing test batteries used by clinicians might enable more tailored treatments addressing the increased impulsivity levels and associated dysfunctional behaviors in MMT.</abstract><type>Journal Article</type><journal>Journal of Clinical and Experimental Neuropsychology</journal><volume>45</volume><journalNumber>6</journalNumber><paginationStart>606</paginationStart><paginationEnd>617</paginationEnd><publisher>Taylor &amp; Francis</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1380-3395</issnPrint><issnElectronic>1744-411X</issnElectronic><keywords>Premature responses, methadone, addiction, heroin, impulsivity</keywords><publishedDay>2</publishedDay><publishedMonth>11</publishedMonth><publishedYear>2023</publishedYear><publishedDate>2023-11-02</publishedDate><doi>10.1080/13803395.2023.2276483</doi><url/><notes/><college>COLLEGE NANME</college><department>Psychology School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>PSYS</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders/><projectreference/><lastEdited>2024-09-30T13:57:23.4231659</lastEdited><Created>2023-11-02T10:46:50.4534754</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">School of Psychology</level></path><authors><author><firstname>Kathrin</firstname><surname>Weidacker</surname><orcid>0000-0002-5742-6016</orcid><order>1</order></author><author><firstname>Yijie</firstname><surname>Zhao</surname><order>2</order></author><author><firstname>Yingying</firstname><surname>Zhang</surname><order>3</order></author><author><firstname>Sebastian</firstname><surname>Whiteford</surname><orcid>0000-0003-3859-7220</orcid><order>4</order></author><author><firstname>Qihuan</firstname><surname>Ren</surname><order>5</order></author><author><firstname>Chencheng</firstname><surname>Zhang</surname><order>6</order></author><author><firstname>Valerie</firstname><surname>Voon</surname><order>7</order></author></authors><documents><document><filename>64902__29194__354102ffab374888b532958791ab30c3.pdf</filename><originalFilename>64902.VOR.pdf</originalFilename><uploaded>2023-12-04T13:57:07.7021017</uploaded><type>Output</type><contentLength>2179859</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>© 2023 The Author(s). 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spelling v2 64902 2023-11-02 Methadone maintenance treatment and impulsivity: premature responding 4fed7fdf5381ec1a577001d6bd3d74d8 0000-0002-5742-6016 Kathrin Weidacker Kathrin Weidacker true false 5bcf7b504f5cb2b2ad68192efc3983f5 0000-0003-3859-7220 Sebastian Whiteford Sebastian Whiteford true false 2023-11-02 PSYS Introduction: Previous research showed that methadone maintenance treatment (MMT) is linked to impulsivity, with higher impulsivity levels being associated with for example, increased drug use. One aspect of impulsivity, most commonly studied in rodent research, is premature responding, the failure to wait for a starting signal. Premature responding is of high translational significance since it predicts the development of addiction-like behaviors in rodents. Methods: We assessed 45 MMT patients and 46 demographically matched (age, sex, education, and handedness) healthy volunteers (HVs) on premature responding alongside action and inhibition of instructed and intentional trials using the Intentional Hand Task (IHT). Results: The results showed markedly enhanced premature responses in the MMT vs. the HV group, which correlated positively with methadone dosage in the MMT patients. Throughout the task, MMT patients were faster across all trial parts and less accurate in response to instructed trials compared to HVs. Conclusions: The increase in premature motor reactions during variable waiting periods alongside increased motion speed and lower accuracy might reflect a specific motor inhibition deficit in MMT, a subcomponent of impulsivity not previously assessed in MMT. Incorporating an experimentally defined measure of impulsivity, such as premature responding, into existing test batteries used by clinicians might enable more tailored treatments addressing the increased impulsivity levels and associated dysfunctional behaviors in MMT. Journal Article Journal of Clinical and Experimental Neuropsychology 45 6 606 617 Taylor & Francis 1380-3395 1744-411X Premature responses, methadone, addiction, heroin, impulsivity 2 11 2023 2023-11-02 10.1080/13803395.2023.2276483 COLLEGE NANME Psychology School COLLEGE CODE PSYS Swansea University Another institution paid the OA fee 2024-09-30T13:57:23.4231659 2023-11-02T10:46:50.4534754 Faculty of Medicine, Health and Life Sciences School of Psychology Kathrin Weidacker 0000-0002-5742-6016 1 Yijie Zhao 2 Yingying Zhang 3 Sebastian Whiteford 0000-0003-3859-7220 4 Qihuan Ren 5 Chencheng Zhang 6 Valerie Voon 7 64902__29194__354102ffab374888b532958791ab30c3.pdf 64902.VOR.pdf 2023-12-04T13:57:07.7021017 Output 2179859 application/pdf Version of Record true © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Distributed under the terms of a Creative Commons Attribution 4.0 International License (CC BY 4.0). true eng https://creativecommons.org/licenses/by/4.0/
title Methadone maintenance treatment and impulsivity: premature responding
spellingShingle Methadone maintenance treatment and impulsivity: premature responding
Kathrin Weidacker
Sebastian Whiteford
title_short Methadone maintenance treatment and impulsivity: premature responding
title_full Methadone maintenance treatment and impulsivity: premature responding
title_fullStr Methadone maintenance treatment and impulsivity: premature responding
title_full_unstemmed Methadone maintenance treatment and impulsivity: premature responding
title_sort Methadone maintenance treatment and impulsivity: premature responding
author_id_str_mv 4fed7fdf5381ec1a577001d6bd3d74d8
5bcf7b504f5cb2b2ad68192efc3983f5
author_id_fullname_str_mv 4fed7fdf5381ec1a577001d6bd3d74d8_***_Kathrin Weidacker
5bcf7b504f5cb2b2ad68192efc3983f5_***_Sebastian Whiteford
author Kathrin Weidacker
Sebastian Whiteford
author2 Kathrin Weidacker
Yijie Zhao
Yingying Zhang
Sebastian Whiteford
Qihuan Ren
Chencheng Zhang
Valerie Voon
format Journal article
container_title Journal of Clinical and Experimental Neuropsychology
container_volume 45
container_issue 6
container_start_page 606
publishDate 2023
institution Swansea University
issn 1380-3395
1744-411X
doi_str_mv 10.1080/13803395.2023.2276483
publisher Taylor & Francis
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
document_store_str 1
active_str 0
description Introduction: Previous research showed that methadone maintenance treatment (MMT) is linked to impulsivity, with higher impulsivity levels being associated with for example, increased drug use. One aspect of impulsivity, most commonly studied in rodent research, is premature responding, the failure to wait for a starting signal. Premature responding is of high translational significance since it predicts the development of addiction-like behaviors in rodents. Methods: We assessed 45 MMT patients and 46 demographically matched (age, sex, education, and handedness) healthy volunteers (HVs) on premature responding alongside action and inhibition of instructed and intentional trials using the Intentional Hand Task (IHT). Results: The results showed markedly enhanced premature responses in the MMT vs. the HV group, which correlated positively with methadone dosage in the MMT patients. Throughout the task, MMT patients were faster across all trial parts and less accurate in response to instructed trials compared to HVs. Conclusions: The increase in premature motor reactions during variable waiting periods alongside increased motion speed and lower accuracy might reflect a specific motor inhibition deficit in MMT, a subcomponent of impulsivity not previously assessed in MMT. Incorporating an experimentally defined measure of impulsivity, such as premature responding, into existing test batteries used by clinicians might enable more tailored treatments addressing the increased impulsivity levels and associated dysfunctional behaviors in MMT.
published_date 2023-11-02T13:57:21Z
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