A Review of Compartmentalised Inflammation and Tertiary Lymphoid Structures in the Pathophysiology of Multiple Sclerosis

Kee, Rachael; Naughton, Michelle; McDonnell, Gavin V.; Howell, Owain; Fitzgerald, Denise C.

doi:10.3390/biomedicines10102604

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A Review of Compartmentalised Inflammation and Tertiary Lymphoid Structures in the Pathophysiology of Multiple Sclerosis

Rachael Kee, Michelle Naughton

, Gavin V. McDonnell, Owain Howell

, Denise C. Fitzgerald

Biomedicines, Volume: 10, Issue: 10, Start page: 2604

Swansea University Author: Owain Howell

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DOI (Published version): 10.3390/biomedicines10102604

Abstract

Multiple sclerosis (MS) is a chronic, immune-mediated, demyelinating disease of the central nervous system (CNS). The most common form of MS is a relapsing–remitting disease characterised by acute episodes of demyelination associated with the breakdown of the blood–brain barrier (BBB). In the relaps...

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Published in:	Biomedicines
ISSN:	2227-9059
Published:	MDPI AG 2022
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URI:	https://cronfa.swan.ac.uk/Record/cronfa65355
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spelling	v2 65355 2023-12-20 A Review of Compartmentalised Inflammation and Tertiary Lymphoid Structures in the Pathophysiology of Multiple Sclerosis 58c995486fc93a242b987640b692db8c 0000-0003-2157-9157 Owain Howell Owain Howell true false 2023-12-20 BMS Multiple sclerosis (MS) is a chronic, immune-mediated, demyelinating disease of the central nervous system (CNS). The most common form of MS is a relapsing–remitting disease characterised by acute episodes of demyelination associated with the breakdown of the blood–brain barrier (BBB). In the relapsing–remitting phase there is often relative recovery (remission) from relapses characterised clinically by complete or partial resolution of neurological symptoms. In the later and progressive stages of the disease process, accrual of neurological disability occurs in a pathological process independent of acute episodes of demyelination and is accompanied by a trapped or compartmentalised inflammatory response, most notable in the connective tissue spaces of the vasculature and leptomeninges occurring behind an intact BBB. This review focuses on compartmentalised inflammation in MS and in particular, what we know about meningeal tertiary lymphoid structures (TLS; also called B cell follicles) which are organised clusters of immune cells, associated with more severe and progressive forms of MS. Meningeal inflammation and TLS could represent an important fluid or imaging marker of disease activity, whose therapeutic abrogation might be necessary to stop the most severe outcomes of disease. Journal Article Biomedicines 10 10 2604 MDPI AG 2227-9059 multiple sclerosis; progressive multiple sclerosis; nervous system; compartmentalised inflammation; meningeal inflammation; tertiary lymphoid structures; disease modifying therapy 17 10 2022 2022-10-17 10.3390/biomedicines10102604 http://dx.doi.org/10.3390/biomedicines10102604 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University Another institution paid the OA fee This work was supported by HSC R&D Division, Public Health Agency [EAT/5496/18] (to R.K.) and Wellcome Trust Grant [110138/Z/15/Z] (to D.C.F.). 2024-03-22T16:38:55.3809771 2023-12-20T11:04:43.3246714 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Rachael Kee 1 Michelle Naughton 0000-0002-7233-913x 2 Gavin V. McDonnell 3 Owain Howell 0000-0003-2157-9157 4 Denise C. Fitzgerald 5 65355__29390__27469faeb7bc45e8be431e02d7966e0e.pdf 65355.pdf 2024-01-05T12:29:49.2271610 Output 1019230 application/pdf Version of Record true This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/) false eng https://creativecommons.org/licenses/by/4.0/
title	A Review of Compartmentalised Inflammation and Tertiary Lymphoid Structures in the Pathophysiology of Multiple Sclerosis
spellingShingle	A Review of Compartmentalised Inflammation and Tertiary Lymphoid Structures in the Pathophysiology of Multiple Sclerosis Owain Howell
title_short	A Review of Compartmentalised Inflammation and Tertiary Lymphoid Structures in the Pathophysiology of Multiple Sclerosis
title_full	A Review of Compartmentalised Inflammation and Tertiary Lymphoid Structures in the Pathophysiology of Multiple Sclerosis
title_fullStr	A Review of Compartmentalised Inflammation and Tertiary Lymphoid Structures in the Pathophysiology of Multiple Sclerosis
title_full_unstemmed	A Review of Compartmentalised Inflammation and Tertiary Lymphoid Structures in the Pathophysiology of Multiple Sclerosis
title_sort	A Review of Compartmentalised Inflammation and Tertiary Lymphoid Structures in the Pathophysiology of Multiple Sclerosis
author_id_str_mv	58c995486fc93a242b987640b692db8c
author_id_fullname_str_mv	58c995486fc93a242b987640b692db8c_***_Owain Howell
author	Owain Howell
author2	Rachael Kee Michelle Naughton Gavin V. McDonnell Owain Howell Denise C. Fitzgerald
format	Journal article
container_title	Biomedicines
container_volume	10
container_issue	10
container_start_page	2604
publishDate	2022
institution	Swansea University
issn	2227-9059
doi_str_mv	10.3390/biomedicines10102604
publisher	MDPI AG
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
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department_str	Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
url	http://dx.doi.org/10.3390/biomedicines10102604
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description	Multiple sclerosis (MS) is a chronic, immune-mediated, demyelinating disease of the central nervous system (CNS). The most common form of MS is a relapsing–remitting disease characterised by acute episodes of demyelination associated with the breakdown of the blood–brain barrier (BBB). In the relapsing–remitting phase there is often relative recovery (remission) from relapses characterised clinically by complete or partial resolution of neurological symptoms. In the later and progressive stages of the disease process, accrual of neurological disability occurs in a pathological process independent of acute episodes of demyelination and is accompanied by a trapped or compartmentalised inflammatory response, most notable in the connective tissue spaces of the vasculature and leptomeninges occurring behind an intact BBB. This review focuses on compartmentalised inflammation in MS and in particular, what we know about meningeal tertiary lymphoid structures (TLS; also called B cell follicles) which are organised clusters of immune cells, associated with more severe and progressive forms of MS. Meningeal inflammation and TLS could represent an important fluid or imaging marker of disease activity, whose therapeutic abrogation might be necessary to stop the most severe outcomes of disease.
published_date	2022-10-17T16:38:54Z
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A Review of Compartmentalised Inflammation and Tertiary Lymphoid Structures in the Pathophysiology of Multiple Sclerosis

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