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Conventional extraction of fucoidan from Irish brown seaweed Fucus vesiculosus followed by ultrasound-assisted depolymerization
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Shane Heffernan ,
Stephen Fitzpatrick,
Henry Lyons,
James Curtin,
Brijesh Kumar Tiwari
Scientific Reports, Volume: 14, Issue: 1
Swansea University Authors:
Gill Conway , Shane Heffernan
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DOI (Published version): 10.1038/s41598-024-55225-z
Abstract
Fucoidan, has gained a lot of interest from researchers and pharmaceuticals owing to its anti-oxidant, anti-coagulant, anti-inflammatory, anti-tumor and health promoting properties. However, extraction of fucoidan from seaweeds, involves use of harsh chemicals, thereby creating a need for alternativ...
| Published in: | Scientific Reports |
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| ISSN: | 2045-2322 |
| Published: |
Springer Science and Business Media LLC
2024
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa65672 |
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| Abstract: |
Fucoidan, has gained a lot of interest from researchers and pharmaceuticals owing to its anti-oxidant, anti-coagulant, anti-inflammatory, anti-tumor and health promoting properties. However, extraction of fucoidan from seaweeds, involves use of harsh chemicals, thereby creating a need for alternative solvents. Also, the high viscosity and low cell permeability of the high molecular mass fucoidan, leads to low functionality in drug action, while the low molecular weight (Mw) fractions demonstrate enhanced biological activity and are also used as food supplements. The objectives of the study were 1) to extract fucoidan from seaweed Fucus vesiculosus (FV) using a green solvent and compare with the most commonly used extraction solvent i.e. hydrochloric acid 2) Determine the effect of ultrasound assisted depolymerization of the fucoidan extracts in reducing the Mw and investigating the cytotoxic effect of the different Mw fractions. The results showed that the green depolymerization solvent along with ultrasound with a short treatment time, was efficient in reducing the Mw of the sample. Furthermore, a significant reduction of cell viability was observed in a selection of samples demonstrating anticancer potential. Ultrasound was therefore, found to be an efficient depolymerization method and can be used for carrying out depolymerization of crude fucoidan from seaweed Fucus Vesiculosus. |
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| Keywords: |
Seaweed, Fucoidan, Extraction, Ultrasound, Depolymerization |
| College: |
Faculty of Science and Engineering |
| Funders: |
This research was supported by the BiOrbic SFI Bioeconomy Research Centre, funded by Ireland’s European Structural and Investment Programmes, Science Foundation Ireland (16/RC/3889) and the European Regional Development Fund. |
| Issue: |
1 |