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Conventional extraction of fucoidan from Irish brown seaweed Fucus vesiculosus followed by ultrasound-assisted depolymerization

Viruja Ummat, Saravana Periaswamy Sivagnanam, Dilip K. Rai, Colm O’Donnell, Gill Conway Orcid Logo, Shane Heffernan Orcid Logo, Stephen Fitzpatrick, Henry Lyons, James Curtin, Brijesh Kumar Tiwari

Scientific Reports, Volume: 14, Issue: 1

Swansea University Authors: Gill Conway Orcid Logo, Shane Heffernan Orcid Logo

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Abstract

Fucoidan, has gained a lot of interest from researchers and pharmaceuticals owing to its anti-oxidant, anti-coagulant, anti-inflammatory, anti-tumor and health promoting properties. However, extraction of fucoidan from seaweeds, involves use of harsh chemicals, thereby creating a need for alternativ...

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Published in: Scientific Reports
ISSN: 2045-2322
Published: Springer Science and Business Media LLC 2024
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa65672
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Abstract: Fucoidan, has gained a lot of interest from researchers and pharmaceuticals owing to its anti-oxidant, anti-coagulant, anti-inflammatory, anti-tumor and health promoting properties. However, extraction of fucoidan from seaweeds, involves use of harsh chemicals, thereby creating a need for alternative solvents. Also, the high viscosity and low cell permeability of the high molecular mass fucoidan, leads to low functionality in drug action, while the low molecular weight (Mw) fractions demonstrate enhanced biological activity and are also used as food supplements. The objectives of the study were 1) to extract fucoidan from seaweed Fucus vesiculosus (FV) using a green solvent and compare with the most commonly used extraction solvent i.e. hydrochloric acid 2) Determine the effect of ultrasound assisted depolymerization of the fucoidan extracts in reducing the Mw and investigating the cytotoxic effect of the different Mw fractions. The results showed that the green depolymerization solvent along with ultrasound with a short treatment time, was efficient in reducing the Mw of the sample. Furthermore, a significant reduction of cell viability was observed in a selection of samples demonstrating anticancer potential. Ultrasound was therefore, found to be an efficient depolymerization method and can be used for carrying out depolymerization of crude fucoidan from seaweed Fucus Vesiculosus.
Keywords: Seaweed, Fucoidan, Extraction, Ultrasound, Depolymerization
College: Faculty of Science and Engineering
Funders: This research was supported by the BiOrbic SFI Bioeconomy Research Centre, funded by Ireland’s European Structural and Investment Programmes, Science Foundation Ireland (16/RC/3889) and the European Regional Development Fund.
Issue: 1