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COVID-19 and pregnancy: A European study on pre- and post-infection medication use
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Benjamin P. Geisler ,
Angela Lupattelli ,
Beatriz Poblador-Plou ,
Régis Lassalle,
Jérémy Jové,
Marie-Agnes Bernard,
Dunia Sakr,
Gabriel Sanfélix-Gimeno ,
Francisco Sánchez-Saez ,
Clara L. Rodríguez-Bernal ,
Mònica Sabaté ,
Elena Ballarín ,
Cristina Aguilera ,
Sue Jordan ,
Daniel Thayer,
Ian Farr,
Saira Ahmed,
Claudia Bartolini ,
Giorgio Limoncella,
Olga Paoletti,
Rosa Gini ,
Luigi A. Maglanoc ,
Elena Dudukina ,
Vera Ehrenstein ,
Ema Alsina,
Tiago A. Vaz ,
Judit Riera-Arnau ,
Miriam C. J. M. Sturkenboom ,
Hedvig M. E. Nordeng
European Journal of Clinical Pharmacology, Volume: 80, Issue: 5, Pages: 707 - 716
Swansea University Author:
Sue Jordan
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© The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License.
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DOI (Published version): 10.1007/s00228-024-03639-z
Abstract
PurposeThe COVID-19 pandemic has impacted medication needs and prescribing practices, including those affecting pregnant women. Our goal was to investigate patterns of medication use among pregnant women with COVID-19, focusing on variations by trimester of infection and location.MethodsWe conducted...
| Published in: | European Journal of Clinical Pharmacology |
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| ISSN: | 0031-6970 1432-1041 |
| Published: |
Springer Science and Business Media LLC
2024
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa65969 |
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| Abstract: |
PurposeThe COVID-19 pandemic has impacted medication needs and prescribing practices, including those affecting pregnant women. Our goal was to investigate patterns of medication use among pregnant women with COVID-19, focusing on variations by trimester of infection and location.MethodsWe conducted an observational study using six electronic healthcare databases from six European regions (Aragon/Spain; France; Norway; Tuscany, Italy; Valencia/Spain; and Wales/UK). The prevalence of primary care prescribing or dispensing was compared in the 30-day periods before and after a positive COVID-19 test or diagnosis.ResultsThe study included 294,126 pregnant women, of whom 8943 (3.0%) tested positive for, or were diagnosed with, COVID-19 during their pregnancy. A significantly higher use of antithrombotic medications was observed particularly after COVID-19 infection in the second and third trimesters. The highest increase was observed in the Valencia region where use of antithrombotic medications in the third trimester increased from 3.8% before COVID-19 to 61.9% after the infection. Increases in other countries were lower; for example, in Norway, the prevalence of antithrombotic medication use changed from around 1–2% before to around 6% after COVID-19 in the third trimester. Smaller and less consistent increases were observed in the use of other drug classes, such as antimicrobials and systemic corticosteroids.ConclusionOur findings highlight the substantial impact of COVID-19 on primary care medication use among pregnant women, with a marked increase in the use of antithrombotic medications post-COVID-19. These results underscore the need for further research to understand the broader implications of these patterns on maternal and neonatal/fetal health outcomes. |
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| Keywords: |
COVID-19; Pregnancy; Drug utilization study; Antithrombotic medications; Anti-bacterial agents; Steroids; Antiviral agents |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
Open access funding provided by University of Oslo (incl Oslo University Hospital) The project has received support from the European Medicines Agency under the Framework service contract no. EMA/2018/28/PE (Lot 4). |
| Issue: |
5 |
| Start Page: |
707 |
| End Page: |
716 |