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Accelerometer‐derived sleep measures in idiopathic dystonia: A UK Biobank cohort study

Grace Bailey Orcid Logo, Megan E. Wadon, Sandra Komarzynski, Clare Matthews, Elin Haf Davies, Kathryn J. Peall

Brain and Behavior, Volume: 13, Issue: 9

Swansea University Author: Grace Bailey Orcid Logo

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DOI (Published version): 10.1002/brb3.2933

Abstract

BackgroundSleep disturbance is an increasingly recognized non-motor trait in dystonia, with varying findings reported to date. Here, we examine sleep in a UK Biobank derived dystonia cohort using subjective self-reported sleep symptoms and objective accelerometer-derived sleep measures, with compari...

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Published in: Brain and Behavior
ISSN: 2162-3279 2162-3279
Published: Wiley 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa66531
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spelling v2 66531 2024-05-29 Accelerometer‐derived sleep measures in idiopathic dystonia: A UK Biobank cohort study 1e09a407fca9e8047e7738b18d381130 0000-0003-4646-3134 Grace Bailey Grace Bailey true false 2024-05-29 MEDS BackgroundSleep disturbance is an increasingly recognized non-motor trait in dystonia, with varying findings reported to date. Here, we examine sleep in a UK Biobank derived dystonia cohort using subjective self-reported sleep symptoms and objective accelerometer-derived sleep measures, with comparison to a control population.MethodsA total of 241 dystonia cases were compared to 964 matched controls in analysis of self-reported sleep symptoms and changes in sleep architecture using wrist-worn triaxial accelerometers.ResultsDystonia participants had poorer self-reported sleep patterns compared to controls. Accelerometery measurements demonstrated later sleep times, reduced time in bed, and shifts in circadian rhythm. No association was observed with pain, and only limited relationships with psychiatric symptoms.DiscussionThis study demonstrates the utility of accelerometers in longer term evaluation of sleep in dystonia, for measurement of disturbance and response to treatment. Compared to controls, altered sleep and circadian rhythm were more common in dystonia patients which may contribute to the clinical phenotype. Journal Article Brain and Behavior 13 9 Wiley 2162-3279 2162-3279 accelerometer, dystonia, sleep 1 9 2023 2023-09-01 10.1002/brb3.2933 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee The authors would like to thank the participants enrolled to the UKBiobank along with all the individuals involved in the conception ofthe UK Biobank, collecting the UK Biobank data, and compiling the UKBiobank database. We would also like to thank James TR Walters andSophie Smart from the MRC Centre for Neuropsychiatric Genetics andGenomics at Cardiff University for their help accessing the UK Biobankdata. GAB is funded by a KESS2, European Social Fund and CardiffUniversity PhD Studentship in partnership with Aparito Limited. MEWis funded by the Jacques and Gloria Gossweiler Foundation. KJP isfunded by an MRC Clinician-Scientist Fellowship (MR/P008593/1). 2024-06-19T15:04:43.1847682 2024-05-29T20:02:43.7388624 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Health Data Science Grace Bailey 0000-0003-4646-3134 1 Megan E. Wadon 2 Sandra Komarzynski 3 Clare Matthews 4 Elin Haf Davies 5 Kathryn J. Peall 6 66531__30680__a6cc44f42fd04a6ebbdd9d4dbbf396ff.pdf 66531.VoR.pdf 2024-06-19T15:03:12.0194385 Output 586854 application/pdf Version of Record true © 2023 The Authors. This is an open access article under the terms of the Creative Commons Attribution License. true eng http://creativecommons.org/licenses/by/4.0/
title Accelerometer‐derived sleep measures in idiopathic dystonia: A UK Biobank cohort study
spellingShingle Accelerometer‐derived sleep measures in idiopathic dystonia: A UK Biobank cohort study
Grace Bailey
title_short Accelerometer‐derived sleep measures in idiopathic dystonia: A UK Biobank cohort study
title_full Accelerometer‐derived sleep measures in idiopathic dystonia: A UK Biobank cohort study
title_fullStr Accelerometer‐derived sleep measures in idiopathic dystonia: A UK Biobank cohort study
title_full_unstemmed Accelerometer‐derived sleep measures in idiopathic dystonia: A UK Biobank cohort study
title_sort Accelerometer‐derived sleep measures in idiopathic dystonia: A UK Biobank cohort study
author_id_str_mv 1e09a407fca9e8047e7738b18d381130
author_id_fullname_str_mv 1e09a407fca9e8047e7738b18d381130_***_Grace Bailey
author Grace Bailey
author2 Grace Bailey
Megan E. Wadon
Sandra Komarzynski
Clare Matthews
Elin Haf Davies
Kathryn J. Peall
format Journal article
container_title Brain and Behavior
container_volume 13
container_issue 9
publishDate 2023
institution Swansea University
issn 2162-3279
2162-3279
doi_str_mv 10.1002/brb3.2933
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Health Data Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Health Data Science
document_store_str 1
active_str 0
description BackgroundSleep disturbance is an increasingly recognized non-motor trait in dystonia, with varying findings reported to date. Here, we examine sleep in a UK Biobank derived dystonia cohort using subjective self-reported sleep symptoms and objective accelerometer-derived sleep measures, with comparison to a control population.MethodsA total of 241 dystonia cases were compared to 964 matched controls in analysis of self-reported sleep symptoms and changes in sleep architecture using wrist-worn triaxial accelerometers.ResultsDystonia participants had poorer self-reported sleep patterns compared to controls. Accelerometery measurements demonstrated later sleep times, reduced time in bed, and shifts in circadian rhythm. No association was observed with pain, and only limited relationships with psychiatric symptoms.DiscussionThis study demonstrates the utility of accelerometers in longer term evaluation of sleep in dystonia, for measurement of disturbance and response to treatment. Compared to controls, altered sleep and circadian rhythm were more common in dystonia patients which may contribute to the clinical phenotype.
published_date 2023-09-01T15:04:41Z
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