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The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices
Hearts, Volume: 5, Issue: 1, Pages: 105 - 121
Swansea University Author: Venkat Kanamarlapudi
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© 2024 by the authors.This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) license.
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DOI (Published version): 10.3390/hearts5010008
Abstract
Heart failure, a common clinical syndrome caused by functional and structural abnormalities of the heart, affects 64 million people worldwide. Long-term mechanical circulatory support can offer lifesaving treatment for end-stage systolic heart failure patients. However, this treatment is not without...
Published in: | Hearts |
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ISSN: | 2673-3846 |
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MDPI AG
2024
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URI: | https://cronfa.swan.ac.uk/Record/cronfa66726 |
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v2 66726 2024-06-13 The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices 63741801137148abfa4c00cd547dcdfa 0000-0002-8739-1483 Venkat Kanamarlapudi Venkat Kanamarlapudi true false 2024-06-13 MEDS Heart failure, a common clinical syndrome caused by functional and structural abnormalities of the heart, affects 64 million people worldwide. Long-term mechanical circulatory support can offer lifesaving treatment for end-stage systolic heart failure patients. However, this treatment is not without complications. This review covers the major complications associated with implantable mechanical circulatory support devices, including strokes, pump thrombosis and gastrointestinal bleeding. These complications were assessed in patients implanted with the following devices: Novacor, HeartMate XVE, CardioWest, Jarvik 2000, HeartMate II, EVAHEART, Incor, VentrAssist, HVAD and HeartMate 3. Complication rates vary among devices and remain despite the introduction of more advanced technology, highlighting the importance of device design and flow patterns. Beyond clinical implications, the cost of complications was explored, highlighting the difference in costs and the need for equitable healthcare, especially with the expected rise in the use of mechanical circulatory support. Future directions include continued improvement through advancements in design and technology to reduce blood stagnation and mitigate high levels of shear stress. Ultimately, these alterations can reduce complications and enhance cost-effectiveness, enhancing both the survival and quality of life for patients receiving mechanical circulatory support. Journal Article Hearts 5 1 105 121 MDPI AG 2673-3846 heart failure; mechanical circulatory support; complications; ventricular assist device 28 2 2024 2024-02-28 10.3390/hearts5010008 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University This research received no external funding. 2024-07-23T14:42:01.6501826 2024-06-13T17:23:50.8214249 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Christian R. Sargent 1 Sabrina Ali 2 Venkat Kanamarlapudi 0000-0002-8739-1483 3 66726__30950__a1a9837897fa4275bff6914e97cdc5e6.pdf 66726.VoR.pdf 2024-07-23T14:40:28.1882433 Output 1376976 application/pdf Version of Record true © 2024 by the authors.This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) license. true eng https://creativecommons.org/licenses/by/4.0/ |
title |
The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices |
spellingShingle |
The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices Venkat Kanamarlapudi |
title_short |
The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices |
title_full |
The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices |
title_fullStr |
The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices |
title_full_unstemmed |
The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices |
title_sort |
The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices |
author_id_str_mv |
63741801137148abfa4c00cd547dcdfa |
author_id_fullname_str_mv |
63741801137148abfa4c00cd547dcdfa_***_Venkat Kanamarlapudi |
author |
Venkat Kanamarlapudi |
author2 |
Christian R. Sargent Sabrina Ali Venkat Kanamarlapudi |
format |
Journal article |
container_title |
Hearts |
container_volume |
5 |
container_issue |
1 |
container_start_page |
105 |
publishDate |
2024 |
institution |
Swansea University |
issn |
2673-3846 |
doi_str_mv |
10.3390/hearts5010008 |
publisher |
MDPI AG |
college_str |
Faculty of Medicine, Health and Life Sciences |
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facultyofmedicinehealthandlifesciences |
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Faculty of Medicine, Health and Life Sciences |
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facultyofmedicinehealthandlifesciences |
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Faculty of Medicine, Health and Life Sciences |
department_str |
Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science |
document_store_str |
1 |
active_str |
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description |
Heart failure, a common clinical syndrome caused by functional and structural abnormalities of the heart, affects 64 million people worldwide. Long-term mechanical circulatory support can offer lifesaving treatment for end-stage systolic heart failure patients. However, this treatment is not without complications. This review covers the major complications associated with implantable mechanical circulatory support devices, including strokes, pump thrombosis and gastrointestinal bleeding. These complications were assessed in patients implanted with the following devices: Novacor, HeartMate XVE, CardioWest, Jarvik 2000, HeartMate II, EVAHEART, Incor, VentrAssist, HVAD and HeartMate 3. Complication rates vary among devices and remain despite the introduction of more advanced technology, highlighting the importance of device design and flow patterns. Beyond clinical implications, the cost of complications was explored, highlighting the difference in costs and the need for equitable healthcare, especially with the expected rise in the use of mechanical circulatory support. Future directions include continued improvement through advancements in design and technology to reduce blood stagnation and mitigate high levels of shear stress. Ultimately, these alterations can reduce complications and enhance cost-effectiveness, enhancing both the survival and quality of life for patients receiving mechanical circulatory support. |
published_date |
2024-02-28T14:42:00Z |
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1805377465610141696 |
score |
11.0267 |