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The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices

Christian R. Sargent, Sabrina Ali, Venkat Kanamarlapudi Orcid Logo

Hearts, Volume: 5, Issue: 1, Pages: 105 - 121

Swansea University Author: Venkat Kanamarlapudi Orcid Logo

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DOI (Published version): 10.3390/hearts5010008

Abstract

Heart failure, a common clinical syndrome caused by functional and structural abnormalities of the heart, affects 64 million people worldwide. Long-term mechanical circulatory support can offer lifesaving treatment for end-stage systolic heart failure patients. However, this treatment is not without...

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Published in: Hearts
ISSN: 2673-3846
Published: MDPI AG 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa66726
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first_indexed 2024-07-23T13:40:00Z
last_indexed 2024-07-23T13:40:00Z
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spelling v2 66726 2024-06-13 The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices 63741801137148abfa4c00cd547dcdfa 0000-0002-8739-1483 Venkat Kanamarlapudi Venkat Kanamarlapudi true false 2024-06-13 MEDS Heart failure, a common clinical syndrome caused by functional and structural abnormalities of the heart, affects 64 million people worldwide. Long-term mechanical circulatory support can offer lifesaving treatment for end-stage systolic heart failure patients. However, this treatment is not without complications. This review covers the major complications associated with implantable mechanical circulatory support devices, including strokes, pump thrombosis and gastrointestinal bleeding. These complications were assessed in patients implanted with the following devices: Novacor, HeartMate XVE, CardioWest, Jarvik 2000, HeartMate II, EVAHEART, Incor, VentrAssist, HVAD and HeartMate 3. Complication rates vary among devices and remain despite the introduction of more advanced technology, highlighting the importance of device design and flow patterns. Beyond clinical implications, the cost of complications was explored, highlighting the difference in costs and the need for equitable healthcare, especially with the expected rise in the use of mechanical circulatory support. Future directions include continued improvement through advancements in design and technology to reduce blood stagnation and mitigate high levels of shear stress. Ultimately, these alterations can reduce complications and enhance cost-effectiveness, enhancing both the survival and quality of life for patients receiving mechanical circulatory support. Journal Article Hearts 5 1 105 121 MDPI AG 2673-3846 heart failure; mechanical circulatory support; complications; ventricular assist device 28 2 2024 2024-02-28 10.3390/hearts5010008 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University This research received no external funding. 2024-07-23T14:42:01.6501826 2024-06-13T17:23:50.8214249 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Christian R. Sargent 1 Sabrina Ali 2 Venkat Kanamarlapudi 0000-0002-8739-1483 3 66726__30950__a1a9837897fa4275bff6914e97cdc5e6.pdf 66726.VoR.pdf 2024-07-23T14:40:28.1882433 Output 1376976 application/pdf Version of Record true © 2024 by the authors.This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) license. true eng https://creativecommons.org/licenses/by/4.0/
title The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices
spellingShingle The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices
Venkat Kanamarlapudi
title_short The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices
title_full The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices
title_fullStr The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices
title_full_unstemmed The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices
title_sort The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices
author_id_str_mv 63741801137148abfa4c00cd547dcdfa
author_id_fullname_str_mv 63741801137148abfa4c00cd547dcdfa_***_Venkat Kanamarlapudi
author Venkat Kanamarlapudi
author2 Christian R. Sargent
Sabrina Ali
Venkat Kanamarlapudi
format Journal article
container_title Hearts
container_volume 5
container_issue 1
container_start_page 105
publishDate 2024
institution Swansea University
issn 2673-3846
doi_str_mv 10.3390/hearts5010008
publisher MDPI AG
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
document_store_str 1
active_str 0
description Heart failure, a common clinical syndrome caused by functional and structural abnormalities of the heart, affects 64 million people worldwide. Long-term mechanical circulatory support can offer lifesaving treatment for end-stage systolic heart failure patients. However, this treatment is not without complications. This review covers the major complications associated with implantable mechanical circulatory support devices, including strokes, pump thrombosis and gastrointestinal bleeding. These complications were assessed in patients implanted with the following devices: Novacor, HeartMate XVE, CardioWest, Jarvik 2000, HeartMate II, EVAHEART, Incor, VentrAssist, HVAD and HeartMate 3. Complication rates vary among devices and remain despite the introduction of more advanced technology, highlighting the importance of device design and flow patterns. Beyond clinical implications, the cost of complications was explored, highlighting the difference in costs and the need for equitable healthcare, especially with the expected rise in the use of mechanical circulatory support. Future directions include continued improvement through advancements in design and technology to reduce blood stagnation and mitigate high levels of shear stress. Ultimately, these alterations can reduce complications and enhance cost-effectiveness, enhancing both the survival and quality of life for patients receiving mechanical circulatory support.
published_date 2024-02-28T14:42:00Z
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