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Blood pressure monitoring in high-risk pregnancy to improve the detection and monitoring of hypertension (the BUMP 1 and 2 trials): protocol for two linked randomised controlled trials

Greig Dougall Orcid Logo, Marloes Franssen, Katherine Louise Tucker Orcid Logo, Ly-Mee Yu, Lisa Hinton Orcid Logo, Oliver Rivero-Arias, Lucy Abel, Julie Allen, Becky Band Orcid Logo, Alison Chisholm, Carole Crawford, Marcus Green, Sheila Greenfield, James Hodgkinson, Paul Leeson, Christine McCourt, Lucy MacKillop Orcid Logo, Alecia Nickless, Jane Sandall, Mauro Santos, Lionel Tarassenko, Carmelo Velardo, Hannah Wilson, Lucy Yardley, Lucy Chappell, Richard J McManus Orcid Logo

BMJ Open, Volume: 10, Issue: 1, Start page: e034593

Swansea University Author: Becky Band Orcid Logo

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DOI (Published version): 10.1136/bmjopen-2019-034593

Abstract

Introduction Self-monitoring of blood pressure (BP) in pregnancy could improve the detection and management of pregnancy hypertension, while also empowering and engaging women in their own care. Two linked trials aim to evaluate whether BP self-monitoring in pregnancy improves the detection of raise...

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Published in: BMJ Open
ISSN: 2044-6055 2044-6055
Published: BMJ 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa67029
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Abstract: Introduction Self-monitoring of blood pressure (BP) in pregnancy could improve the detection and management of pregnancy hypertension, while also empowering and engaging women in their own care. Two linked trials aim to evaluate whether BP self-monitoring in pregnancy improves the detection of raised BP during higher risk pregnancies (BUMP 1) and whether self-monitoring reduces systolic BP during hypertensive pregnancy (BUMP 2).Methods and analyses Both are multicentre, non-masked, parallel group, randomised controlled trials. Participants will be randomised to self-monitoring with telemonitoring or usual care. BUMP 1 will recruit a minimum of 2262 pregnant women at higher risk of pregnancy hypertension and BUMP 2 will recruit a minimum of 512 pregnant women with either gestational or chronic hypertension. The BUMP 1 primary outcome is the time to the first recording of raised BP by a healthcare professional. The BUMP 2 primary outcome is mean systolic BP between baseline and delivery recorded by healthcare professionals. Other outcomes will include maternal and perinatal outcomes, quality of life and adverse events. An economic evaluation of BP self-monitoring in addition to usual care compared with usual care alone will be assessed across both study populations within trial and with modelling to estimate long-term cost-effectiveness. A linked process evaluation will combine quantitative and qualitative data to examine how BP self-monitoring in pregnancy is implemented and accepted in both daily life and routine clinical practice.Ethics and dissemination The trials have been approved by a Research Ethics Committee (17/WM/0241) and relevant research authorities. They will be published in peer-reviewed journals and presented at national and international conferences. If shown to be effective, BP self-monitoring would be applicable to a large population of pregnant women.
Item Description: Correction: Blood pressure monitoring in high risk pregnancy to improve the detection and monitoring of hypertension (The BUMP 1&2 trials): protocol for two linked randomised controlled trials available at https://doi.org/10.1136/bmjopen-2019-034593corr1
College: Faculty of Medicine, Health and Life Sciences
Funders: This work is funded from a National Institute for Health Research (NIHR) Programme grant for applied research (RP- PG-1209-10051) and an NIHR Professorship awarded to RJM (NIHR- RP- R2-12-015). RJM and KLT receive funding from the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care Oxford at Oxford Health NHS Foundation Trust. JS is a National Institute for Health Research (NIHR) Senior Investigator and supported by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care South London (NIHR CLAHRC South London) at King’s College Hospital NHS Foundation Trust. Service support costs will be administered through the NIHR Clinical Research Network.
Issue: 1
Start Page: e034593

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