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The effects of exercise, heat-induced hypo-hydration and rehydration on blood–brain-barrier permeability, corticospinal and peripheral excitability

Nasir Uddin Orcid Logo, Jamie Scott, Jonathan Nixon, Stephen D. Patterson, Dawson Kidgell, Alan J. Pearce, Mark Waldron Orcid Logo, Jamie Tallent

European Journal of Applied Physiology

Swansea University Author: Mark Waldron Orcid Logo

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DOI (Published version): 10.1007/s00421-024-05616-x

Abstract

Purpose: The effects of low-intensity exercise, heat-induced hypo-hydration and rehydration on maximal strength and the underlying neurophysiological mechanisms are not well understood. Methods: To assess this, 12 participants took part in a randomised crossover study, in a prolonged (3 h) submaxima...

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Published in: European Journal of Applied Physiology
ISSN: 1439-6319 1439-6327
Published: Springer Science and Business Media LLC 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa67731
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Methods: To assess this, 12 participants took part in a randomised crossover study, in a prolonged (3 h) submaximal (60 W) cycling protocol under 3 conditions: i) in 45 °C (achieving ~5% body mass reduction), with post-exercise rehydration in 2 h (RHY2), ii) with rehydration across 24 h (RHY24), and iii) a euhydrated trial in 25 °C (CON). Dependent variables included maximal voluntary contractions (MVC), maximum motor unit potential (MMAX), motor evoked potential (MEPRAW) amplitude and cortical silent period (cSP) duration. Blood-brain-barrier integrity was also assessed by serum Ubiquitin Carboxyl-terminal Hydrolase (UCH-L1) concentrations. All measures were obtained immediately pre, post, post 2 h and 24 h. Results: During both dehydration trials, MVC (RHY2: p &lt; 0.001, RHY24: p = 0.001) and MEPRAW (RHY2: p = 0.025, RHY24: p = 0.045) decreased from pre- to post-exercise. MEPRAW returned to baseline during RHY2 and CON, but not RHY24 (p = 0.020). MEP/MMAX ratio decreased across time for all trials (p = 0.009) and returned to baseline, except RHY24 (p &lt; 0.026). Increased cSP (p = 0.011) was observed during CON post-exercise, but not during RHY2 and RHY24. Serum UCH-L1 increased across time for all conditions (p &lt; 0.001) but was not significantly different between conditions. Conclusion: Our findings demonstrate an increase in corticospinal inhibition after exercise with fluid ingestion, but a decrease in corticospinal excitability after heat-induced hypo-hydration. 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spelling v2 67731 2024-09-19 The effects of exercise, heat-induced hypo-hydration and rehydration on blood–brain-barrier permeability, corticospinal and peripheral excitability 70db7c6c54d46f5e70b39e5ae0a056fa 0000-0002-2720-4615 Mark Waldron Mark Waldron true false 2024-09-19 EAAS Purpose: The effects of low-intensity exercise, heat-induced hypo-hydration and rehydration on maximal strength and the underlying neurophysiological mechanisms are not well understood. Methods: To assess this, 12 participants took part in a randomised crossover study, in a prolonged (3 h) submaximal (60 W) cycling protocol under 3 conditions: i) in 45 °C (achieving ~5% body mass reduction), with post-exercise rehydration in 2 h (RHY2), ii) with rehydration across 24 h (RHY24), and iii) a euhydrated trial in 25 °C (CON). Dependent variables included maximal voluntary contractions (MVC), maximum motor unit potential (MMAX), motor evoked potential (MEPRAW) amplitude and cortical silent period (cSP) duration. Blood-brain-barrier integrity was also assessed by serum Ubiquitin Carboxyl-terminal Hydrolase (UCH-L1) concentrations. All measures were obtained immediately pre, post, post 2 h and 24 h. Results: During both dehydration trials, MVC (RHY2: p < 0.001, RHY24: p = 0.001) and MEPRAW (RHY2: p = 0.025, RHY24: p = 0.045) decreased from pre- to post-exercise. MEPRAW returned to baseline during RHY2 and CON, but not RHY24 (p = 0.020). MEP/MMAX ratio decreased across time for all trials (p = 0.009) and returned to baseline, except RHY24 (p < 0.026). Increased cSP (p = 0.011) was observed during CON post-exercise, but not during RHY2 and RHY24. Serum UCH-L1 increased across time for all conditions (p < 0.001) but was not significantly different between conditions. Conclusion: Our findings demonstrate an increase in corticospinal inhibition after exercise with fluid ingestion, but a decrease in corticospinal excitability after heat-induced hypo-hydration. In addition, low-intensity exercise increases peripheral markers of blood-brain-barrier permeability. Journal Article European Journal of Applied Physiology 0 Springer Science and Business Media LLC 1439-6319 1439-6327 28 9 2024 2024-09-28 10.1007/s00421-024-05616-x COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University Another institution paid the OA fee This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. 2024-10-23T14:34:15.9596498 2024-09-19T11:35:27.6753771 Faculty of Science and Engineering School of Engineering and Applied Sciences - Sport and Exercise Sciences Nasir Uddin 0000-0003-0944-7303 1 Jamie Scott 2 Jonathan Nixon 3 Stephen D. Patterson 4 Dawson Kidgell 5 Alan J. Pearce 6 Mark Waldron 0000-0002-2720-4615 7 Jamie Tallent 8 67731__32682__327cd894605a464bbc7d7bab42a7fcbb.pdf 67731.VoR.pdf 2024-10-23T14:31:20.2903922 Output 2409923 application/pdf Version of Record true © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License. true eng http://creativecommons.org/licenses/by/4.0/
title The effects of exercise, heat-induced hypo-hydration and rehydration on blood–brain-barrier permeability, corticospinal and peripheral excitability
spellingShingle The effects of exercise, heat-induced hypo-hydration and rehydration on blood–brain-barrier permeability, corticospinal and peripheral excitability
Mark Waldron
title_short The effects of exercise, heat-induced hypo-hydration and rehydration on blood–brain-barrier permeability, corticospinal and peripheral excitability
title_full The effects of exercise, heat-induced hypo-hydration and rehydration on blood–brain-barrier permeability, corticospinal and peripheral excitability
title_fullStr The effects of exercise, heat-induced hypo-hydration and rehydration on blood–brain-barrier permeability, corticospinal and peripheral excitability
title_full_unstemmed The effects of exercise, heat-induced hypo-hydration and rehydration on blood–brain-barrier permeability, corticospinal and peripheral excitability
title_sort The effects of exercise, heat-induced hypo-hydration and rehydration on blood–brain-barrier permeability, corticospinal and peripheral excitability
author_id_str_mv 70db7c6c54d46f5e70b39e5ae0a056fa
author_id_fullname_str_mv 70db7c6c54d46f5e70b39e5ae0a056fa_***_Mark Waldron
author Mark Waldron
author2 Nasir Uddin
Jamie Scott
Jonathan Nixon
Stephen D. Patterson
Dawson Kidgell
Alan J. Pearce
Mark Waldron
Jamie Tallent
format Journal article
container_title European Journal of Applied Physiology
container_volume 0
publishDate 2024
institution Swansea University
issn 1439-6319
1439-6327
doi_str_mv 10.1007/s00421-024-05616-x
publisher Springer Science and Business Media LLC
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Sport and Exercise Sciences
document_store_str 1
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description Purpose: The effects of low-intensity exercise, heat-induced hypo-hydration and rehydration on maximal strength and the underlying neurophysiological mechanisms are not well understood. Methods: To assess this, 12 participants took part in a randomised crossover study, in a prolonged (3 h) submaximal (60 W) cycling protocol under 3 conditions: i) in 45 °C (achieving ~5% body mass reduction), with post-exercise rehydration in 2 h (RHY2), ii) with rehydration across 24 h (RHY24), and iii) a euhydrated trial in 25 °C (CON). Dependent variables included maximal voluntary contractions (MVC), maximum motor unit potential (MMAX), motor evoked potential (MEPRAW) amplitude and cortical silent period (cSP) duration. Blood-brain-barrier integrity was also assessed by serum Ubiquitin Carboxyl-terminal Hydrolase (UCH-L1) concentrations. All measures were obtained immediately pre, post, post 2 h and 24 h. Results: During both dehydration trials, MVC (RHY2: p < 0.001, RHY24: p = 0.001) and MEPRAW (RHY2: p = 0.025, RHY24: p = 0.045) decreased from pre- to post-exercise. MEPRAW returned to baseline during RHY2 and CON, but not RHY24 (p = 0.020). MEP/MMAX ratio decreased across time for all trials (p = 0.009) and returned to baseline, except RHY24 (p < 0.026). Increased cSP (p = 0.011) was observed during CON post-exercise, but not during RHY2 and RHY24. Serum UCH-L1 increased across time for all conditions (p < 0.001) but was not significantly different between conditions. Conclusion: Our findings demonstrate an increase in corticospinal inhibition after exercise with fluid ingestion, but a decrease in corticospinal excitability after heat-induced hypo-hydration. In addition, low-intensity exercise increases peripheral markers of blood-brain-barrier permeability.
published_date 2024-09-28T14:34:14Z
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score 11.035634

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