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The effects of exercise, heat-induced hypo-hydration and rehydration on blood-brain-barrier permeability, corticospinal and peripheral excitability

Nasir Uddin, Jamie Scott, Jonathan Nixon, Stephen D Patterson, Dawson Kidgell, Alan J Pearce, Mark Waldron Orcid Logo, Jamie Tallent

European Journal of Applied Physiology

Swansea University Author: Mark Waldron Orcid Logo

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Purpose: The effects of low-intensity exercise, heat-induced hypo-hydration and rehydration on maximal strength and the underlying neurophysiological mechanisms are not well understood. Methods: To assess this, 12 participants took part in a randomised crossover study, in a prolonged (3 h) submaxima...

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Published in: European Journal of Applied Physiology
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URI: https://cronfa.swan.ac.uk/Record/cronfa67731
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spelling v2 67731 2024-09-19 The effects of exercise, heat-induced hypo-hydration and rehydration on blood-brain-barrier permeability, corticospinal and peripheral excitability 70db7c6c54d46f5e70b39e5ae0a056fa 0000-0002-2720-4615 Mark Waldron Mark Waldron true false 2024-09-19 EAAS Purpose: The effects of low-intensity exercise, heat-induced hypo-hydration and rehydration on maximal strength and the underlying neurophysiological mechanisms are not well understood. Methods: To assess this, 12 participants took part in a randomised crossover study, in a prolonged (3 h) submaximal (60 W) cycling protocol under 3 conditions: i) in 45 °C (achieving ~5% body mass reduction), with post-exercise rehydration in 2 h (RHY2), ii) with rehydration across 24 h (RHY24), and iii) a euhydrated trial in 25 °C (CON). Dependent variables included maximal voluntary contractions (MVC), maximum motor unit potential (MMAX), motor evoked potential (MEPRAW) amplitude and cortical silent period (cSP) duration. Blood-brain-barrier integrity was also assessed by serum Ubiquitin Carboxyl-terminal Hydrolase (UCH-L1) concentrations. All measures were obtained immediately pre, post, post 2 h and 24 h. Results: During both dehydration trials, MVC (RHY2: p < 0.001, RHY24: p = 0.001) and MEPRAW (RHY2: p = 0.025, RHY24: p = 0.045) decreased from pre- to post-exercise. MEPRAW returned to baseline during RHY2 and CON, but not RHY24 (p = 0.020). MEP/MMAX ratio decreased across time for all trials (p = 0.009) and returned to baseline, except RHY24 (p < 0.026). Increased cSP (p = 0.011) was observed during CON post-exercise, but not during RHY2 and RHY24. Serum UCH-L1 increased across time for all conditions (p < 0.001) but was not significantly different between conditions. Conclusion: Our findings demonstrate an increase in corticospinal inhibition after exercise with fluid ingestion, but a decrease in corticospinal excitability after heat-induced hypo-hydration. In addition, low-intensity exercise increases peripheral markers of blood-brain-barrier permeability. Journal Article European Journal of Applied Physiology 0 0 0 0001-01-01 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University 2024-09-19T11:38:41.5826029 2024-09-19T11:35:27.6753771 Faculty of Science and Engineering School of Engineering and Applied Sciences - Sport and Exercise Sciences Nasir Uddin 1 Jamie Scott 2 Jonathan Nixon 3 Stephen D Patterson 4 Dawson Kidgell 5 Alan J Pearce 6 Mark Waldron 0000-0002-2720-4615 7 Jamie Tallent 8
title The effects of exercise, heat-induced hypo-hydration and rehydration on blood-brain-barrier permeability, corticospinal and peripheral excitability
spellingShingle The effects of exercise, heat-induced hypo-hydration and rehydration on blood-brain-barrier permeability, corticospinal and peripheral excitability
Mark Waldron
title_short The effects of exercise, heat-induced hypo-hydration and rehydration on blood-brain-barrier permeability, corticospinal and peripheral excitability
title_full The effects of exercise, heat-induced hypo-hydration and rehydration on blood-brain-barrier permeability, corticospinal and peripheral excitability
title_fullStr The effects of exercise, heat-induced hypo-hydration and rehydration on blood-brain-barrier permeability, corticospinal and peripheral excitability
title_full_unstemmed The effects of exercise, heat-induced hypo-hydration and rehydration on blood-brain-barrier permeability, corticospinal and peripheral excitability
title_sort The effects of exercise, heat-induced hypo-hydration and rehydration on blood-brain-barrier permeability, corticospinal and peripheral excitability
author_id_str_mv 70db7c6c54d46f5e70b39e5ae0a056fa
author_id_fullname_str_mv 70db7c6c54d46f5e70b39e5ae0a056fa_***_Mark Waldron
author Mark Waldron
author2 Nasir Uddin
Jamie Scott
Jonathan Nixon
Stephen D Patterson
Dawson Kidgell
Alan J Pearce
Mark Waldron
Jamie Tallent
format Journal article
container_title European Journal of Applied Physiology
institution Swansea University
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Sport and Exercise Sciences
document_store_str 0
active_str 0
description Purpose: The effects of low-intensity exercise, heat-induced hypo-hydration and rehydration on maximal strength and the underlying neurophysiological mechanisms are not well understood. Methods: To assess this, 12 participants took part in a randomised crossover study, in a prolonged (3 h) submaximal (60 W) cycling protocol under 3 conditions: i) in 45 °C (achieving ~5% body mass reduction), with post-exercise rehydration in 2 h (RHY2), ii) with rehydration across 24 h (RHY24), and iii) a euhydrated trial in 25 °C (CON). Dependent variables included maximal voluntary contractions (MVC), maximum motor unit potential (MMAX), motor evoked potential (MEPRAW) amplitude and cortical silent period (cSP) duration. Blood-brain-barrier integrity was also assessed by serum Ubiquitin Carboxyl-terminal Hydrolase (UCH-L1) concentrations. All measures were obtained immediately pre, post, post 2 h and 24 h. Results: During both dehydration trials, MVC (RHY2: p < 0.001, RHY24: p = 0.001) and MEPRAW (RHY2: p = 0.025, RHY24: p = 0.045) decreased from pre- to post-exercise. MEPRAW returned to baseline during RHY2 and CON, but not RHY24 (p = 0.020). MEP/MMAX ratio decreased across time for all trials (p = 0.009) and returned to baseline, except RHY24 (p < 0.026). Increased cSP (p = 0.011) was observed during CON post-exercise, but not during RHY2 and RHY24. Serum UCH-L1 increased across time for all conditions (p < 0.001) but was not significantly different between conditions. Conclusion: Our findings demonstrate an increase in corticospinal inhibition after exercise with fluid ingestion, but a decrease in corticospinal excitability after heat-induced hypo-hydration. In addition, low-intensity exercise increases peripheral markers of blood-brain-barrier permeability.
published_date 0001-01-01T11:38:41Z
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