No Cover Image

Journal article 34 views

Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism

Romana Stark, Harry Dempsey, Elizabeth Kleeman, Martina Sassi, Sherri Osborne-Lawrence, Sepideh Sheybani-Deloui, Karl Austin-Muttitt, Jonathan Mullins Orcid Logo, Jeffrey M Zigman, Jeffrey Davies Orcid Logo, Zane B Andrews

Molecular metabolism

Swansea University Authors: Martina Sassi, Karl Austin-Muttitt, Jonathan Mullins Orcid Logo, Jeffrey Davies Orcid Logo

Full text not available from this repository: check for access using links below.

Check full text

DOI (Published version): 10.1016/j.molmet.2024.102025

Abstract

Objective Although the metabolic state of an organism affects olfactory function, the precise mechanisms and their impact on behavior and metabolism remain unknown. Here, we assess whether ghrelin receptors (GHSRs) in the olfactory bulb (OB) increase olfactory function and influence foraging behavio...

Full description

Published in: Molecular metabolism
ISSN: 2212-8778
Published: Elsevier 2024
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa67734
Tags: Add Tag
No Tags, Be the first to tag this record!
first_indexed 2024-09-19T12:16:02Z
last_indexed 2024-09-19T12:16:02Z
id cronfa67734
recordtype SURis
fullrecord <?xml version="1.0" encoding="utf-8"?><rfc1807 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><bib-version>v2</bib-version><id>67734</id><entry>2024-09-19</entry><title>Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism</title><swanseaauthors><author><sid>73844ea9bb96bff6f83ffeffa8f64a49</sid><firstname>Martina</firstname><surname>Sassi</surname><name>Martina Sassi</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>fafc0917b48af4eaec154646854867f8</sid><firstname>Karl</firstname><surname>Austin-Muttitt</surname><name>Karl Austin-Muttitt</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>4cf2dddedbe1dacb506ec925fdbd5b40</sid><ORCID>0000-0003-0144-2962</ORCID><firstname>Jonathan</firstname><surname>Mullins</surname><name>Jonathan Mullins</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>2cb3d1d96a7870a84d2f758e865172e6</sid><ORCID>0000-0002-4234-0033</ORCID><firstname>Jeffrey</firstname><surname>Davies</surname><name>Jeffrey Davies</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2024-09-19</date><abstract>Objective Although the metabolic state of an organism affects olfactory function, the precise mechanisms and their impact on behavior and metabolism remain unknown. Here, we assess whether ghrelin receptors (GHSRs) in the olfactory bulb (OB) increase olfactory function and influence foraging behaviors and metabolism. Methods We performed a detailed behavioural and metabolic analysis in mice lacking GHSRs in the OB (OBGHSR deletion). We also analsyed OB scRNA-seq and spatial transcriptomic datasets to assess GHSR+ cells in the main and accessory olfactory bulbs, as well as the anterior olfactory nucleus. Results OBGHSR deletion affected olfactory discrimination and habituation to both food and non-food odors. Anxiety-like and depression-like behaviors were significantly greater after OBGHSR deletion, whereas exploratory behavior was reduced, with the greatest effect under fasted conditions. OBGHSR deletion impacted feeding behavior as evidenced by altered bout number and duration, as well as buried food-seeking. OBGHSR deletion increased body weight and fat mass, spared fat utilisation on a chow diet and impaired glucose metabolism indicating metabolic dysfunction. Cross referenced analysis of OB scRNA-seq and spatial transcriptomic datasets revealed GHSR+ glutamate neurons in the main and accessory olfactory bulbs, as well as the anterior olfactory nucleus. Ablation of glutamate neurons in the OB reduced ghrelin-induced food finding and phenocopied results seen after OBGHSR deletion. Conclusions OBGHSRs help to maintain olfactory function, particularly during hunger, and facilitate behavioral adaptations that optimise food-seeking in anxiogenic environments, priming metabolic pathways in preparation for food consumption.</abstract><type>Journal Article</type><journal>Molecular metabolism</journal><volume/><journalNumber/><paginationStart/><paginationEnd/><publisher>Elsevier</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>2212-8778</issnElectronic><keywords/><publishedDay>3</publishedDay><publishedMonth>9</publishedMonth><publishedYear>2024</publishedYear><publishedDate>2024-09-03</publishedDate><doi>10.1016/j.molmet.2024.102025</doi><url/><notes/><college>COLLEGE NANME</college><CollegeCode>COLLEGE CODE</CollegeCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>National Health and Medical Research Council of Australia APP1154974; APP1125960 (ZBA); APP1160065 (RS). Phenomics Australia is supported by the Australian Government Department of Education through the National Collaborative Research Infrastructure Strategy, the Super Science Initiative and the Collaborative Research Infrastructure Scheme.</funders><projectreference/><lastEdited>2024-09-20T11:15:01.4904349</lastEdited><Created>2024-09-19T13:03:03.6897763</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Biomedical Science</level></path><authors><author><firstname>Romana</firstname><surname>Stark</surname><order>1</order></author><author><firstname>Harry</firstname><surname>Dempsey</surname><order>2</order></author><author><firstname>Elizabeth</firstname><surname>Kleeman</surname><order>3</order></author><author><firstname>Martina</firstname><surname>Sassi</surname><order>4</order></author><author><firstname>Sherri</firstname><surname>Osborne-Lawrence</surname><order>5</order></author><author><firstname>Sepideh</firstname><surname>Sheybani-Deloui</surname><order>6</order></author><author><firstname>Karl</firstname><surname>Austin-Muttitt</surname><order>7</order></author><author><firstname>Jonathan</firstname><surname>Mullins</surname><orcid>0000-0003-0144-2962</orcid><order>8</order></author><author><firstname>Jeffrey M</firstname><surname>Zigman</surname><order>9</order></author><author><firstname>Jeffrey</firstname><surname>Davies</surname><orcid>0000-0002-4234-0033</orcid><order>10</order></author><author><firstname>Zane B</firstname><surname>Andrews</surname><order>11</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling v2 67734 2024-09-19 Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism 73844ea9bb96bff6f83ffeffa8f64a49 Martina Sassi Martina Sassi true false fafc0917b48af4eaec154646854867f8 Karl Austin-Muttitt Karl Austin-Muttitt true false 4cf2dddedbe1dacb506ec925fdbd5b40 0000-0003-0144-2962 Jonathan Mullins Jonathan Mullins true false 2cb3d1d96a7870a84d2f758e865172e6 0000-0002-4234-0033 Jeffrey Davies Jeffrey Davies true false 2024-09-19 Objective Although the metabolic state of an organism affects olfactory function, the precise mechanisms and their impact on behavior and metabolism remain unknown. Here, we assess whether ghrelin receptors (GHSRs) in the olfactory bulb (OB) increase olfactory function and influence foraging behaviors and metabolism. Methods We performed a detailed behavioural and metabolic analysis in mice lacking GHSRs in the OB (OBGHSR deletion). We also analsyed OB scRNA-seq and spatial transcriptomic datasets to assess GHSR+ cells in the main and accessory olfactory bulbs, as well as the anterior olfactory nucleus. Results OBGHSR deletion affected olfactory discrimination and habituation to both food and non-food odors. Anxiety-like and depression-like behaviors were significantly greater after OBGHSR deletion, whereas exploratory behavior was reduced, with the greatest effect under fasted conditions. OBGHSR deletion impacted feeding behavior as evidenced by altered bout number and duration, as well as buried food-seeking. OBGHSR deletion increased body weight and fat mass, spared fat utilisation on a chow diet and impaired glucose metabolism indicating metabolic dysfunction. Cross referenced analysis of OB scRNA-seq and spatial transcriptomic datasets revealed GHSR+ glutamate neurons in the main and accessory olfactory bulbs, as well as the anterior olfactory nucleus. Ablation of glutamate neurons in the OB reduced ghrelin-induced food finding and phenocopied results seen after OBGHSR deletion. Conclusions OBGHSRs help to maintain olfactory function, particularly during hunger, and facilitate behavioral adaptations that optimise food-seeking in anxiogenic environments, priming metabolic pathways in preparation for food consumption. Journal Article Molecular metabolism Elsevier 2212-8778 3 9 2024 2024-09-03 10.1016/j.molmet.2024.102025 COLLEGE NANME COLLEGE CODE Swansea University Another institution paid the OA fee National Health and Medical Research Council of Australia APP1154974; APP1125960 (ZBA); APP1160065 (RS). Phenomics Australia is supported by the Australian Government Department of Education through the National Collaborative Research Infrastructure Strategy, the Super Science Initiative and the Collaborative Research Infrastructure Scheme. 2024-09-20T11:15:01.4904349 2024-09-19T13:03:03.6897763 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Romana Stark 1 Harry Dempsey 2 Elizabeth Kleeman 3 Martina Sassi 4 Sherri Osborne-Lawrence 5 Sepideh Sheybani-Deloui 6 Karl Austin-Muttitt 7 Jonathan Mullins 0000-0003-0144-2962 8 Jeffrey M Zigman 9 Jeffrey Davies 0000-0002-4234-0033 10 Zane B Andrews 11
title Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism
spellingShingle Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism
Martina Sassi
Karl Austin-Muttitt
Jonathan Mullins
Jeffrey Davies
title_short Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism
title_full Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism
title_fullStr Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism
title_full_unstemmed Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism
title_sort Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism
author_id_str_mv 73844ea9bb96bff6f83ffeffa8f64a49
fafc0917b48af4eaec154646854867f8
4cf2dddedbe1dacb506ec925fdbd5b40
2cb3d1d96a7870a84d2f758e865172e6
author_id_fullname_str_mv 73844ea9bb96bff6f83ffeffa8f64a49_***_Martina Sassi
fafc0917b48af4eaec154646854867f8_***_Karl Austin-Muttitt
4cf2dddedbe1dacb506ec925fdbd5b40_***_Jonathan Mullins
2cb3d1d96a7870a84d2f758e865172e6_***_Jeffrey Davies
author Martina Sassi
Karl Austin-Muttitt
Jonathan Mullins
Jeffrey Davies
author2 Romana Stark
Harry Dempsey
Elizabeth Kleeman
Martina Sassi
Sherri Osborne-Lawrence
Sepideh Sheybani-Deloui
Karl Austin-Muttitt
Jonathan Mullins
Jeffrey M Zigman
Jeffrey Davies
Zane B Andrews
format Journal article
container_title Molecular metabolism
publishDate 2024
institution Swansea University
issn 2212-8778
doi_str_mv 10.1016/j.molmet.2024.102025
publisher Elsevier
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
document_store_str 0
active_str 0
description Objective Although the metabolic state of an organism affects olfactory function, the precise mechanisms and their impact on behavior and metabolism remain unknown. Here, we assess whether ghrelin receptors (GHSRs) in the olfactory bulb (OB) increase olfactory function and influence foraging behaviors and metabolism. Methods We performed a detailed behavioural and metabolic analysis in mice lacking GHSRs in the OB (OBGHSR deletion). We also analsyed OB scRNA-seq and spatial transcriptomic datasets to assess GHSR+ cells in the main and accessory olfactory bulbs, as well as the anterior olfactory nucleus. Results OBGHSR deletion affected olfactory discrimination and habituation to both food and non-food odors. Anxiety-like and depression-like behaviors were significantly greater after OBGHSR deletion, whereas exploratory behavior was reduced, with the greatest effect under fasted conditions. OBGHSR deletion impacted feeding behavior as evidenced by altered bout number and duration, as well as buried food-seeking. OBGHSR deletion increased body weight and fat mass, spared fat utilisation on a chow diet and impaired glucose metabolism indicating metabolic dysfunction. Cross referenced analysis of OB scRNA-seq and spatial transcriptomic datasets revealed GHSR+ glutamate neurons in the main and accessory olfactory bulbs, as well as the anterior olfactory nucleus. Ablation of glutamate neurons in the OB reduced ghrelin-induced food finding and phenocopied results seen after OBGHSR deletion. Conclusions OBGHSRs help to maintain olfactory function, particularly during hunger, and facilitate behavioral adaptations that optimise food-seeking in anxiogenic environments, priming metabolic pathways in preparation for food consumption.
published_date 2024-09-03T11:15:01Z
_version_ 1810709664097107968
score 11.028798

Similar Items