Journal article 38 views
Capillary Blood Docosahexaenoic Acid Levels Predict Electrocardiographic Markers in a Sample Population of Premenopausal Women
Journal of Clinical Medicine, Volume: 13, Issue: 19, Start page: 5957
Swansea University Author: Mike Fowler
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DOI (Published version): 10.3390/jcm13195957
Abstract
Introduction: The relationship between blood N-3 polyunsaturated fatty acid (PUFA) levels and cardiovascular health is known, but direct evidence that N-3 PUFA levels influence electrocardiographic (ECG) parameters is non-existent. In the study described herein, we investigated the relationship betw...
Published in: | Journal of Clinical Medicine |
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ISSN: | 2077-0383 |
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MDPI AG
2024
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URI: | https://cronfa.swan.ac.uk/Record/cronfa67931 |
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v2 67931 2024-10-08 Capillary Blood Docosahexaenoic Acid Levels Predict Electrocardiographic Markers in a Sample Population of Premenopausal Women a3a29027498d4b43a3f082a0a5ba16b4 0000-0003-1544-0407 Mike Fowler Mike Fowler true false 2024-10-08 BGPS Introduction: The relationship between blood N-3 polyunsaturated fatty acid (PUFA) levels and cardiovascular health is known, but direct evidence that N-3 PUFA levels influence electrocardiographic (ECG) parameters is non-existent. In the study described herein, we investigated the relationship between anthropometric biomarkers and capillary blood PUFAs with ECG outputs in a sample population of healthy pre-menopausal women. Method: Twenty-three consenting females were recruited, with the study power analysis sufficiently demonstrated. Food intake, anthropometric and cardiovascular parameters were obtained. Capillary blood was collected for fatty acid chromatographic analysis. Results: Body mass index, haematocrit, heart rate (HR), mean arterial pressure (MAP) and ECG readings all fell within healthy ranges. Principal component analysis-mediated correlations were carried out controlling for combined Components 1 (age, body fat % and waist-to-hip ratio) and 2 (height, HR and MAP) as control variables. Docosahexaenoic acid (DHA) unequivocally decreased the QRS area under the curve (AUC-QRS) regardless of the impact of control variables, with each unit increase in DHA corresponding to a 2.3-unit decrease in AUC-QRS. Mediation analysis revealed a significant overall effect of DHA on AUC-QRS, with the impact of DHA on R wave amplitude accounting for 77% of the total observed effect. Discussion: Our new findings revealed an inverse relationship between AUC-QRS with capillary blood DHA, suggesting that the association between ventricular mass and its QRS depolarising voltage is mediated by DHA. Our findings bridge a knowledge gap on the relationship between ventricular mass and ventricular efficiency. Further research will confirm whether the relationship identified in our study also exists in diseased patients. Journal Article Journal of Clinical Medicine 13 19 5957 MDPI AG 2077-0383 7 10 2024 2024-10-07 10.3390/jcm13195957 http://dx.doi.org/10.3390/jcm13195957 COLLEGE NANME Biosciences Geography and Physics School COLLEGE CODE BGPS Swansea University Another institution paid the OA fee 2024-10-08T09:21:48.2347781 2024-10-08T09:14:28.4224552 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Breno P. Casagrande 0000-0001-9478-8262 1 George Sherrard 2 Mike Fowler 0000-0003-1544-0407 3 Débora Estadella 0000-0001-9853-3662 4 Allain A. Bueno 0000-0002-9456-8558 5 |
title |
Capillary Blood Docosahexaenoic Acid Levels Predict Electrocardiographic Markers in a Sample Population of Premenopausal Women |
spellingShingle |
Capillary Blood Docosahexaenoic Acid Levels Predict Electrocardiographic Markers in a Sample Population of Premenopausal Women Mike Fowler |
title_short |
Capillary Blood Docosahexaenoic Acid Levels Predict Electrocardiographic Markers in a Sample Population of Premenopausal Women |
title_full |
Capillary Blood Docosahexaenoic Acid Levels Predict Electrocardiographic Markers in a Sample Population of Premenopausal Women |
title_fullStr |
Capillary Blood Docosahexaenoic Acid Levels Predict Electrocardiographic Markers in a Sample Population of Premenopausal Women |
title_full_unstemmed |
Capillary Blood Docosahexaenoic Acid Levels Predict Electrocardiographic Markers in a Sample Population of Premenopausal Women |
title_sort |
Capillary Blood Docosahexaenoic Acid Levels Predict Electrocardiographic Markers in a Sample Population of Premenopausal Women |
author_id_str_mv |
a3a29027498d4b43a3f082a0a5ba16b4 |
author_id_fullname_str_mv |
a3a29027498d4b43a3f082a0a5ba16b4_***_Mike Fowler |
author |
Mike Fowler |
author2 |
Breno P. Casagrande George Sherrard Mike Fowler Débora Estadella Allain A. Bueno |
format |
Journal article |
container_title |
Journal of Clinical Medicine |
container_volume |
13 |
container_issue |
19 |
container_start_page |
5957 |
publishDate |
2024 |
institution |
Swansea University |
issn |
2077-0383 |
doi_str_mv |
10.3390/jcm13195957 |
publisher |
MDPI AG |
college_str |
Faculty of Science and Engineering |
hierarchytype |
|
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facultyofscienceandengineering |
hierarchy_top_title |
Faculty of Science and Engineering |
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facultyofscienceandengineering |
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Faculty of Science and Engineering |
department_str |
School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences |
url |
http://dx.doi.org/10.3390/jcm13195957 |
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description |
Introduction: The relationship between blood N-3 polyunsaturated fatty acid (PUFA) levels and cardiovascular health is known, but direct evidence that N-3 PUFA levels influence electrocardiographic (ECG) parameters is non-existent. In the study described herein, we investigated the relationship between anthropometric biomarkers and capillary blood PUFAs with ECG outputs in a sample population of healthy pre-menopausal women. Method: Twenty-three consenting females were recruited, with the study power analysis sufficiently demonstrated. Food intake, anthropometric and cardiovascular parameters were obtained. Capillary blood was collected for fatty acid chromatographic analysis. Results: Body mass index, haematocrit, heart rate (HR), mean arterial pressure (MAP) and ECG readings all fell within healthy ranges. Principal component analysis-mediated correlations were carried out controlling for combined Components 1 (age, body fat % and waist-to-hip ratio) and 2 (height, HR and MAP) as control variables. Docosahexaenoic acid (DHA) unequivocally decreased the QRS area under the curve (AUC-QRS) regardless of the impact of control variables, with each unit increase in DHA corresponding to a 2.3-unit decrease in AUC-QRS. Mediation analysis revealed a significant overall effect of DHA on AUC-QRS, with the impact of DHA on R wave amplitude accounting for 77% of the total observed effect. Discussion: Our new findings revealed an inverse relationship between AUC-QRS with capillary blood DHA, suggesting that the association between ventricular mass and its QRS depolarising voltage is mediated by DHA. Our findings bridge a knowledge gap on the relationship between ventricular mass and ventricular efficiency. Further research will confirm whether the relationship identified in our study also exists in diseased patients. |
published_date |
2024-10-07T09:21:47Z |
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11.0351515 |