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Metabolic Hormone Profiles in Breast Milk From Mothers of Moderate-Late Preterm Infants Are Associated With Growth From Birth to 4 Months in a Sex-Specific Manner

Laura Galante Orcid Logo, Clare M. Reynolds, Amber M. Milan, Tanith Alexander, Frank H. Bloomfield, Yannan Jiang, Sharin Asadi, Mariana Muelbert, David Cameron-Smith, Shikha Pundir, Mark H. Vickers, (the DIAMOND study team)

Frontiers in Nutrition, Volume: 8

Swansea University Author: Laura Galante Orcid Logo

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DOI (Published version): 10.3389/fnut.2021.641227

Abstract

Background: Differing environmental conditions experienced by mother-infant dyads may influence composition of the milk received by the infant. As a consequence, diverse milk compositional profiles may contribute to different postnatal outcomes, especially in infants facing adverse perinatal environ...

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Published in: Frontiers in Nutrition
ISSN: 2296-861X
Published: Frontiers Media SA 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa68014
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2024-12-20T12:52:30.6799227</datestamp><bib-version>v2</bib-version><id>68014</id><entry>2024-10-18</entry><title>Metabolic Hormone Profiles in Breast Milk From Mothers of Moderate-Late Preterm Infants Are Associated With Growth From Birth to 4 Months in a Sex-Specific Manner</title><swanseaauthors><author><sid>d1c6c22f6a863ef2050ed9768566884b</sid><ORCID>0000-0002-6190-7955</ORCID><firstname>Laura</firstname><surname>Galante</surname><name>Laura Galante</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2024-10-18</date><deptcode>MEDS</deptcode><abstract>Background: Differing environmental conditions experienced by mother-infant dyads may influence composition of the milk received by the infant. As a consequence, diverse milk compositional profiles may contribute to different postnatal outcomes, especially in infants facing adverse perinatal environments. We investigated whether variability in milk concentrations of key metabolic hormones is associated with different growth outcomes in infants born preterm, a perinatal complication known to impact on infant growth.Methods: Human milk samples were collected from 169 mothers of 191 infants enrolled in the DIAMOND trial, a randomized trial of nutrition for moderate-late preterm infants, at 5 and 10 days postpartum and again at 4 months' corrected age and analyzed for leptin, adiponectin and insulin-like growth factor (IGF)-1. Infant weight and body composition were measured at birth, discharge and 4 months' corrected age. Multiple linear regression models were used to examine correlations between milk hormone concentrations, weight z-scores and body composition at discharge and 4 months' corrected age, and weight gain from birth to 4 months' corrected age. Sex-specific interactions were examined.Results: Higher milk IGF-1 concentrations on day 5 after birth were associated with greater infant fat-free mass at 4 months' corrected age. Milk IGF-1 concentrations at 4 months were positively associated with fat mass and fat-free mass at 4 months in boys but not girls. Milk leptin concentrations on day 5 after birth were positively associated with fat mass at discharge from hospital, but negatively associated with fat mass at 4 months' corrected age. No significant association was found for milk adiponectin concentrations.Conclusion: Milk IGF-1 and leptin concentrations in mothers of moderate-late preterm babies are associated with different growth and body composition through to 4 months' corrected age and these associations are often different in boys and girls. The sex-specific effects of nutrient and hormone exposure during early life in preterm infants warrants further investigation to optimize the nutritional care these infants receive, particularly in hospital, where the same nutrition is provided to boys and girls.</abstract><type>Journal Article</type><journal>Frontiers in Nutrition</journal><volume>8</volume><journalNumber/><paginationStart/><paginationEnd/><publisher>Frontiers Media SA</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>2296-861X</issnElectronic><keywords>adiponectin, breastmilk, breastfeeding, human milk, IGF-1, growth trajectories, leptin, pre-term birth</keywords><publishedDay>28</publishedDay><publishedMonth>5</publishedMonth><publishedYear>2021</publishedYear><publishedDate>2021-05-28</publishedDate><doi>10.3389/fnut.2021.641227</doi><url/><notes/><college>COLLEGE NANME</college><department>Medical School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDS</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>This analysis was funded by the Liggins Institute FRDF (Faculty Research Development Fund, Grant No. 3719319) and the trial is funded by the Health Research Council of New Zealand (Grant No. 16-605) and Counties Manukau Health (Grant No. 269).</funders><projectreference/><lastEdited>2024-12-20T12:52:30.6799227</lastEdited><Created>2024-10-18T08:56:25.2675916</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">School of Health and Social Care - Public Health</level></path><authors><author><firstname>Laura</firstname><surname>Galante</surname><orcid>0000-0002-6190-7955</orcid><order>1</order></author><author><firstname>Clare M.</firstname><surname>Reynolds</surname><order>2</order></author><author><firstname>Amber M.</firstname><surname>Milan</surname><order>3</order></author><author><firstname>Tanith</firstname><surname>Alexander</surname><order>4</order></author><author><firstname>Frank H.</firstname><surname>Bloomfield</surname><order>5</order></author><author><firstname>Yannan</firstname><surname>Jiang</surname><order>6</order></author><author><firstname>Sharin</firstname><surname>Asadi</surname><order>7</order></author><author><firstname>Mariana</firstname><surname>Muelbert</surname><order>8</order></author><author><firstname>David</firstname><surname>Cameron-Smith</surname><order>9</order></author><author><firstname>Shikha</firstname><surname>Pundir</surname><order>10</order></author><author><firstname>Mark H.</firstname><surname>Vickers</surname><order>11</order></author><author><firstname>(the DIAMOND study</firstname><surname>team)</surname><order>12</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2024-12-20T12:52:30.6799227 v2 68014 2024-10-18 Metabolic Hormone Profiles in Breast Milk From Mothers of Moderate-Late Preterm Infants Are Associated With Growth From Birth to 4 Months in a Sex-Specific Manner d1c6c22f6a863ef2050ed9768566884b 0000-0002-6190-7955 Laura Galante Laura Galante true false 2024-10-18 MEDS Background: Differing environmental conditions experienced by mother-infant dyads may influence composition of the milk received by the infant. As a consequence, diverse milk compositional profiles may contribute to different postnatal outcomes, especially in infants facing adverse perinatal environments. We investigated whether variability in milk concentrations of key metabolic hormones is associated with different growth outcomes in infants born preterm, a perinatal complication known to impact on infant growth.Methods: Human milk samples were collected from 169 mothers of 191 infants enrolled in the DIAMOND trial, a randomized trial of nutrition for moderate-late preterm infants, at 5 and 10 days postpartum and again at 4 months' corrected age and analyzed for leptin, adiponectin and insulin-like growth factor (IGF)-1. Infant weight and body composition were measured at birth, discharge and 4 months' corrected age. Multiple linear regression models were used to examine correlations between milk hormone concentrations, weight z-scores and body composition at discharge and 4 months' corrected age, and weight gain from birth to 4 months' corrected age. Sex-specific interactions were examined.Results: Higher milk IGF-1 concentrations on day 5 after birth were associated with greater infant fat-free mass at 4 months' corrected age. Milk IGF-1 concentrations at 4 months were positively associated with fat mass and fat-free mass at 4 months in boys but not girls. Milk leptin concentrations on day 5 after birth were positively associated with fat mass at discharge from hospital, but negatively associated with fat mass at 4 months' corrected age. No significant association was found for milk adiponectin concentrations.Conclusion: Milk IGF-1 and leptin concentrations in mothers of moderate-late preterm babies are associated with different growth and body composition through to 4 months' corrected age and these associations are often different in boys and girls. The sex-specific effects of nutrient and hormone exposure during early life in preterm infants warrants further investigation to optimize the nutritional care these infants receive, particularly in hospital, where the same nutrition is provided to boys and girls. Journal Article Frontiers in Nutrition 8 Frontiers Media SA 2296-861X adiponectin, breastmilk, breastfeeding, human milk, IGF-1, growth trajectories, leptin, pre-term birth 28 5 2021 2021-05-28 10.3389/fnut.2021.641227 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee This analysis was funded by the Liggins Institute FRDF (Faculty Research Development Fund, Grant No. 3719319) and the trial is funded by the Health Research Council of New Zealand (Grant No. 16-605) and Counties Manukau Health (Grant No. 269). 2024-12-20T12:52:30.6799227 2024-10-18T08:56:25.2675916 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Public Health Laura Galante 0000-0002-6190-7955 1 Clare M. Reynolds 2 Amber M. Milan 3 Tanith Alexander 4 Frank H. Bloomfield 5 Yannan Jiang 6 Sharin Asadi 7 Mariana Muelbert 8 David Cameron-Smith 9 Shikha Pundir 10 Mark H. Vickers 11 (the DIAMOND study team) 12
title Metabolic Hormone Profiles in Breast Milk From Mothers of Moderate-Late Preterm Infants Are Associated With Growth From Birth to 4 Months in a Sex-Specific Manner
spellingShingle Metabolic Hormone Profiles in Breast Milk From Mothers of Moderate-Late Preterm Infants Are Associated With Growth From Birth to 4 Months in a Sex-Specific Manner
Laura Galante
title_short Metabolic Hormone Profiles in Breast Milk From Mothers of Moderate-Late Preterm Infants Are Associated With Growth From Birth to 4 Months in a Sex-Specific Manner
title_full Metabolic Hormone Profiles in Breast Milk From Mothers of Moderate-Late Preterm Infants Are Associated With Growth From Birth to 4 Months in a Sex-Specific Manner
title_fullStr Metabolic Hormone Profiles in Breast Milk From Mothers of Moderate-Late Preterm Infants Are Associated With Growth From Birth to 4 Months in a Sex-Specific Manner
title_full_unstemmed Metabolic Hormone Profiles in Breast Milk From Mothers of Moderate-Late Preterm Infants Are Associated With Growth From Birth to 4 Months in a Sex-Specific Manner
title_sort Metabolic Hormone Profiles in Breast Milk From Mothers of Moderate-Late Preterm Infants Are Associated With Growth From Birth to 4 Months in a Sex-Specific Manner
author_id_str_mv d1c6c22f6a863ef2050ed9768566884b
author_id_fullname_str_mv d1c6c22f6a863ef2050ed9768566884b_***_Laura Galante
author Laura Galante
author2 Laura Galante
Clare M. Reynolds
Amber M. Milan
Tanith Alexander
Frank H. Bloomfield
Yannan Jiang
Sharin Asadi
Mariana Muelbert
David Cameron-Smith
Shikha Pundir
Mark H. Vickers
(the DIAMOND study team)
format Journal article
container_title Frontiers in Nutrition
container_volume 8
publishDate 2021
institution Swansea University
issn 2296-861X
doi_str_mv 10.3389/fnut.2021.641227
publisher Frontiers Media SA
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care - Public Health{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Public Health
document_store_str 0
active_str 0
description Background: Differing environmental conditions experienced by mother-infant dyads may influence composition of the milk received by the infant. As a consequence, diverse milk compositional profiles may contribute to different postnatal outcomes, especially in infants facing adverse perinatal environments. We investigated whether variability in milk concentrations of key metabolic hormones is associated with different growth outcomes in infants born preterm, a perinatal complication known to impact on infant growth.Methods: Human milk samples were collected from 169 mothers of 191 infants enrolled in the DIAMOND trial, a randomized trial of nutrition for moderate-late preterm infants, at 5 and 10 days postpartum and again at 4 months' corrected age and analyzed for leptin, adiponectin and insulin-like growth factor (IGF)-1. Infant weight and body composition were measured at birth, discharge and 4 months' corrected age. Multiple linear regression models were used to examine correlations between milk hormone concentrations, weight z-scores and body composition at discharge and 4 months' corrected age, and weight gain from birth to 4 months' corrected age. Sex-specific interactions were examined.Results: Higher milk IGF-1 concentrations on day 5 after birth were associated with greater infant fat-free mass at 4 months' corrected age. Milk IGF-1 concentrations at 4 months were positively associated with fat mass and fat-free mass at 4 months in boys but not girls. Milk leptin concentrations on day 5 after birth were positively associated with fat mass at discharge from hospital, but negatively associated with fat mass at 4 months' corrected age. No significant association was found for milk adiponectin concentrations.Conclusion: Milk IGF-1 and leptin concentrations in mothers of moderate-late preterm babies are associated with different growth and body composition through to 4 months' corrected age and these associations are often different in boys and girls. The sex-specific effects of nutrient and hormone exposure during early life in preterm infants warrants further investigation to optimize the nutritional care these infants receive, particularly in hospital, where the same nutrition is provided to boys and girls.
published_date 2021-05-28T20:48:22Z
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score 11.048302

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