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Cohort profile: creation of the SAIL MELD-B e-cohort (SMC) and SAIL MELD-B children and young adult e-cohort (SMYC) to investigate the lived experience of the ‘burdensomeness’ of multimorbidity

Roberta Chiovoloni, Jakub J Dylag, Nisreen A Alwan, Ann Berrington, Michael Boniface, Nic Fair, Emilia Holland, Rebecca Hoyle Orcid Logo, Mozhdeh Shiranirad, Sebastian Stannard Orcid Logo, Zlatko Zlatev, Rhiannon K Owen, Simon Fraser Orcid Logo, Ashley Akbari Orcid Logo

BMJ Open, Volume: 15, Issue: 1, Start page: e087946

Swansea University Authors: Roberta Chiovoloni, Ashley Akbari Orcid Logo

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DOI (Published version): 10.1136/bmjopen-2024-087946

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Purpose We have established the SAIL MELD-B electronic cohort (e-cohort SMC) and the SAIL MELD-B children and Young adults e-cohort (SMYC) as a part of the Multidisciplinary Ecosystem to study Lifecourse Determinants and Prevention of Early-onset Burdensome Multimorbidity (MELD-B) project. Each coho...

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Published in: BMJ Open
ISSN: 2044-6055 2044-6055
Published: BMJ 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa68352
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Each cohort has been created to investigate and develop a deeper understanding of the lived experience of the &#x2018;burdensomeness&#x2019; of multimorbidity by identifying new clusters of burdensomeness concepts, exploring early life risk factors of multimorbidity and modelling hypothetical prevention scenarios.Participants The SMC and SMYC are longitudinal e-cohorts created from routinely collected individual-level population-scale anonymised data sources available within the Secure Anonymised Information Linkage (SAIL) Databank. They include individuals with available records from linked health and demographic data sources in SAIL at any time between 1 January 2000 and 31 December 2022. The SMYC e-cohort is a subset of the SMC, including only individuals born on or after the cohort start date.Findings to date The SMC and SMYC cohorts include 5 180 602 (50.3% female and 49.7% male) and 896 155 (48.7% female and 51.3% male) individuals, respectively. Considering both primary and secondary care health data, the five most common long-term conditions for individuals in SMC are &#x2018;Depression&#x2019;, affecting 21.6% of the cohort, &#x2018;Anxiety&#x2019; (21.1%), &#x2018;Asthma&#x2019; (17.5%), &#x2018;Hypertension&#x2019; (16.2%) and &#x2018;Atopic Eczema&#x2019; (14.1%) and the five most common conditions for individuals in SMYC are &#x2018;Atopic Eczema&#x2019; (21.2%), &#x2018;Asthma&#x2019; (11.6%), &#x2018;Anxiety&#x2019; (6.0%), &#x2018;Deafness&#x2019; (4.6%) and &#x2018;Depression&#x2019; (4.3%).Future plans The SMC and SMYC e-cohorts have been developed using a reproducible, maintainable concept curation pipeline, which allows for the cohorts to be updated dynamically over time and manages for the request and processing of further approved long-term conditions and burdensomeness concepts extraction. 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spelling 2025-01-20T12:52:29.4177128 v2 68352 2024-11-27 Cohort profile: creation of the SAIL MELD-B e-cohort (SMC) and SAIL MELD-B children and young adult e-cohort (SMYC) to investigate the lived experience of the ‘burdensomeness’ of multimorbidity 08502855f683911aeb83edd02904be23 Roberta Chiovoloni Roberta Chiovoloni true false aa1b025ec0243f708bb5eb0a93d6fb52 0000-0003-0814-0801 Ashley Akbari Ashley Akbari true false 2024-11-27 MEDS Purpose We have established the SAIL MELD-B electronic cohort (e-cohort SMC) and the SAIL MELD-B children and Young adults e-cohort (SMYC) as a part of the Multidisciplinary Ecosystem to study Lifecourse Determinants and Prevention of Early-onset Burdensome Multimorbidity (MELD-B) project. Each cohort has been created to investigate and develop a deeper understanding of the lived experience of the ‘burdensomeness’ of multimorbidity by identifying new clusters of burdensomeness concepts, exploring early life risk factors of multimorbidity and modelling hypothetical prevention scenarios.Participants The SMC and SMYC are longitudinal e-cohorts created from routinely collected individual-level population-scale anonymised data sources available within the Secure Anonymised Information Linkage (SAIL) Databank. They include individuals with available records from linked health and demographic data sources in SAIL at any time between 1 January 2000 and 31 December 2022. The SMYC e-cohort is a subset of the SMC, including only individuals born on or after the cohort start date.Findings to date The SMC and SMYC cohorts include 5 180 602 (50.3% female and 49.7% male) and 896 155 (48.7% female and 51.3% male) individuals, respectively. Considering both primary and secondary care health data, the five most common long-term conditions for individuals in SMC are ‘Depression’, affecting 21.6% of the cohort, ‘Anxiety’ (21.1%), ‘Asthma’ (17.5%), ‘Hypertension’ (16.2%) and ‘Atopic Eczema’ (14.1%) and the five most common conditions for individuals in SMYC are ‘Atopic Eczema’ (21.2%), ‘Asthma’ (11.6%), ‘Anxiety’ (6.0%), ‘Deafness’ (4.6%) and ‘Depression’ (4.3%).Future plans The SMC and SMYC e-cohorts have been developed using a reproducible, maintainable concept curation pipeline, which allows for the cohorts to be updated dynamically over time and manages for the request and processing of further approved long-term conditions and burdensomeness concepts extraction. Best practices from the MELD-B project can be utilised across other projects, accessing similar data with population-scale data sources and trusted research environments. Journal Article BMJ Open 15 1 e087946 BMJ 2044-6055 2044-6055 7 1 2025 2025-01-07 10.1136/bmjopen-2024-087946 Cohort Profile COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University SU Library paid the OA fee (TA Institutional Deal) NIHR 2025-01-20T12:52:29.4177128 2024-11-27T13:06:39.8839569 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Health Data Science Roberta Chiovoloni 1 Jakub J Dylag 2 Nisreen A Alwan 3 Ann Berrington 4 Michael Boniface 5 Nic Fair 6 Emilia Holland 7 Rebecca Hoyle 0000-0002-1645-1071 8 Mozhdeh Shiranirad 9 Sebastian Stannard 0000-0002-6139-1020 10 Zlatko Zlatev 11 Rhiannon K Owen 12 Simon Fraser 0000-0002-4172-4406 13 Ashley Akbari 0000-0003-0814-0801 14 68352__33377__00d26dd2f2ce4318bdc84ea9fe9aa8b9.pdf 68352.VoR.pdf 2025-01-20T12:49:46.4139536 Output 2071189 application/pdf Version of Record true © Author(s) (or their employer(s)) 2025. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license. true eng https://creativecommons.org/licenses/by/4.0/
title Cohort profile: creation of the SAIL MELD-B e-cohort (SMC) and SAIL MELD-B children and young adult e-cohort (SMYC) to investigate the lived experience of the ‘burdensomeness’ of multimorbidity
spellingShingle Cohort profile: creation of the SAIL MELD-B e-cohort (SMC) and SAIL MELD-B children and young adult e-cohort (SMYC) to investigate the lived experience of the ‘burdensomeness’ of multimorbidity
Roberta Chiovoloni
Ashley Akbari
title_short Cohort profile: creation of the SAIL MELD-B e-cohort (SMC) and SAIL MELD-B children and young adult e-cohort (SMYC) to investigate the lived experience of the ‘burdensomeness’ of multimorbidity
title_full Cohort profile: creation of the SAIL MELD-B e-cohort (SMC) and SAIL MELD-B children and young adult e-cohort (SMYC) to investigate the lived experience of the ‘burdensomeness’ of multimorbidity
title_fullStr Cohort profile: creation of the SAIL MELD-B e-cohort (SMC) and SAIL MELD-B children and young adult e-cohort (SMYC) to investigate the lived experience of the ‘burdensomeness’ of multimorbidity
title_full_unstemmed Cohort profile: creation of the SAIL MELD-B e-cohort (SMC) and SAIL MELD-B children and young adult e-cohort (SMYC) to investigate the lived experience of the ‘burdensomeness’ of multimorbidity
title_sort Cohort profile: creation of the SAIL MELD-B e-cohort (SMC) and SAIL MELD-B children and young adult e-cohort (SMYC) to investigate the lived experience of the ‘burdensomeness’ of multimorbidity
author_id_str_mv 08502855f683911aeb83edd02904be23
aa1b025ec0243f708bb5eb0a93d6fb52
author_id_fullname_str_mv 08502855f683911aeb83edd02904be23_***_Roberta Chiovoloni
aa1b025ec0243f708bb5eb0a93d6fb52_***_Ashley Akbari
author Roberta Chiovoloni
Ashley Akbari
author2 Roberta Chiovoloni
Jakub J Dylag
Nisreen A Alwan
Ann Berrington
Michael Boniface
Nic Fair
Emilia Holland
Rebecca Hoyle
Mozhdeh Shiranirad
Sebastian Stannard
Zlatko Zlatev
Rhiannon K Owen
Simon Fraser
Ashley Akbari
format Journal article
container_title BMJ Open
container_volume 15
container_issue 1
container_start_page e087946
publishDate 2025
institution Swansea University
issn 2044-6055
2044-6055
doi_str_mv 10.1136/bmjopen-2024-087946
publisher BMJ
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Health Data Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Health Data Science
document_store_str 1
active_str 0
description Purpose We have established the SAIL MELD-B electronic cohort (e-cohort SMC) and the SAIL MELD-B children and Young adults e-cohort (SMYC) as a part of the Multidisciplinary Ecosystem to study Lifecourse Determinants and Prevention of Early-onset Burdensome Multimorbidity (MELD-B) project. Each cohort has been created to investigate and develop a deeper understanding of the lived experience of the ‘burdensomeness’ of multimorbidity by identifying new clusters of burdensomeness concepts, exploring early life risk factors of multimorbidity and modelling hypothetical prevention scenarios.Participants The SMC and SMYC are longitudinal e-cohorts created from routinely collected individual-level population-scale anonymised data sources available within the Secure Anonymised Information Linkage (SAIL) Databank. They include individuals with available records from linked health and demographic data sources in SAIL at any time between 1 January 2000 and 31 December 2022. The SMYC e-cohort is a subset of the SMC, including only individuals born on or after the cohort start date.Findings to date The SMC and SMYC cohorts include 5 180 602 (50.3% female and 49.7% male) and 896 155 (48.7% female and 51.3% male) individuals, respectively. Considering both primary and secondary care health data, the five most common long-term conditions for individuals in SMC are ‘Depression’, affecting 21.6% of the cohort, ‘Anxiety’ (21.1%), ‘Asthma’ (17.5%), ‘Hypertension’ (16.2%) and ‘Atopic Eczema’ (14.1%) and the five most common conditions for individuals in SMYC are ‘Atopic Eczema’ (21.2%), ‘Asthma’ (11.6%), ‘Anxiety’ (6.0%), ‘Deafness’ (4.6%) and ‘Depression’ (4.3%).Future plans The SMC and SMYC e-cohorts have been developed using a reproducible, maintainable concept curation pipeline, which allows for the cohorts to be updated dynamically over time and manages for the request and processing of further approved long-term conditions and burdensomeness concepts extraction. Best practices from the MELD-B project can be utilised across other projects, accessing similar data with population-scale data sources and trusted research environments.
published_date 2025-01-07T14:41:55Z
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score 11.048149

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