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Prevalence of functional defecation disorders in European children: A systematic review and meta‐analysis

Michelle N. Bloem Orcid Logo, Desiree F. Baaleman Orcid Logo, Nikhil Thapar Orcid Logo, Stephen Roberts Orcid Logo, Ilan J. N. Koppen Orcid Logo, Marc A. Benninga Orcid Logo

Journal of Pediatric Gastroenterology and Nutrition, Pages: 1 - 18

Swansea University Author: Stephen Roberts Orcid Logo

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DOI (Published version): 10.1002/jpn3.12437

Abstract

Objectives: Functional defecation disorders (FDDs) are common among children worldwide. The prevalence of these disorders has not been clearly described in Europe. This study performed a systematic review and meta‐analysis on the prevalence of FDD in European children and assessed geographical, age,...

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Published in: Journal of Pediatric Gastroenterology and Nutrition
ISSN: 0277-2116 1536-4801
Published: Wiley 2025
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Methods: PubMed, Embase, Psycinfo, Cochrane Library, and Cinahl were searched from 1999 to July 2023. Included studies were (1) prospective or cross&#x2010;sectional studies of European population&#x2010;based samples; (2) reporting the prevalence of infant dyschezia (ID) according to Rome II, III, or IV criteria or functional constipation (FC) or functional non&#x2010;retentive fecal incontinence (FNRFI) according to Rome III or IV criteria; (3) aged 0&#x2013;18 years; and (4) published in English, Dutch or Spanish. PRISMA guidelines for extracting data and assessing data quality were followed. Results: Twenty&#x2010;eight studies were included. Pooled prevalence was 6.9% (95% confidence interval [CI]: 3.1%&#x2013;11.9%) for ID in infants 0&#x2013;12 months (9 studies, n = 5611), 8.17% (95% CI: 6.33%&#x2013;10.22%) for FC in children &lt;4 years (25 studies, n = 35,189), 11.39% (95% CI: 9.34%&#x2013;14.11%) for FC in children 4&#x2013;18 years, and 0.24% (95% CI: 0.07%&#x2013;0.49%) for FNRFI in children 4&#x2013;18 years (7 studies, n = 16,873). No sex predominance was found for FC. FC prevalence did not differ significantly when diagnosed according to Rome III versus IV. FC prevalence differed between countries, with greatest rates in Italy, Germany, and Spain. No meta&#x2010;analysis could be performed on other factors associated with FDD. Conclusions: FDD is common in European children. 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N.</firstname><surname>Koppen</surname><orcid>0000-0002-1856-0968</orcid><order>5</order></author><author><firstname>Marc A.</firstname><surname>Benninga</surname><orcid>0000-0001-9406-9188</orcid><order>6</order></author></authors><documents><document><filename>68685__33306__99080025ee664121bb1a056de9900d25.pdf</filename><originalFilename>jpn3.12437.pdf</originalFilename><uploaded>2025-01-13T14:56:50.5855537</uploaded><type>Output</type><contentLength>2295338</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>&#xA9; 2025 The Author(s). This is an open access article under the terms of the Creative Commons Attribution&#x2010;NonCommercial&#x2010;NoDerivs License (CC BY-NC-ND 4.0).</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by-nc-nd/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2025-03-31T16:36:36.4830022 v2 68685 2025-01-13 Prevalence of functional defecation disorders in European children: A systematic review and meta‐analysis cb60dd928f72fe7ea03595dab995f070 0000-0001-7981-520X Stephen Roberts Stephen Roberts true false 2025-01-13 MEDS Objectives: Functional defecation disorders (FDDs) are common among children worldwide. The prevalence of these disorders has not been clearly described in Europe. This study performed a systematic review and meta‐analysis on the prevalence of FDD in European children and assessed geographical, age, and sex distribution and associated factors. Methods: PubMed, Embase, Psycinfo, Cochrane Library, and Cinahl were searched from 1999 to July 2023. Included studies were (1) prospective or cross‐sectional studies of European population‐based samples; (2) reporting the prevalence of infant dyschezia (ID) according to Rome II, III, or IV criteria or functional constipation (FC) or functional non‐retentive fecal incontinence (FNRFI) according to Rome III or IV criteria; (3) aged 0–18 years; and (4) published in English, Dutch or Spanish. PRISMA guidelines for extracting data and assessing data quality were followed. Results: Twenty‐eight studies were included. Pooled prevalence was 6.9% (95% confidence interval [CI]: 3.1%–11.9%) for ID in infants 0–12 months (9 studies, n = 5611), 8.17% (95% CI: 6.33%–10.22%) for FC in children <4 years (25 studies, n = 35,189), 11.39% (95% CI: 9.34%–14.11%) for FC in children 4–18 years, and 0.24% (95% CI: 0.07%–0.49%) for FNRFI in children 4–18 years (7 studies, n = 16,873). No sex predominance was found for FC. FC prevalence did not differ significantly when diagnosed according to Rome III versus IV. FC prevalence differed between countries, with greatest rates in Italy, Germany, and Spain. No meta‐analysis could be performed on other factors associated with FDD. Conclusions: FDD is common in European children. Future longitudinal studies are needed to provide better insight into associated factors in pathogenesis. Journal Article Journal of Pediatric Gastroenterology and Nutrition 0 1 18 Wiley 0277-2116 1536-4801 Child, constipation, dyschezia, Europe, incontinence 8 1 2025 2025-01-08 10.1002/jpn3.12437 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee None 2025-03-31T16:36:36.4830022 2025-01-13T14:56:50.6426126 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Health Data Science Michelle N. Bloem 0000-0001-9152-9505 1 Desiree F. Baaleman 0000-0002-0163-9354 2 Nikhil Thapar 0000-0002-0276-9951 3 Stephen Roberts 0000-0001-7981-520X 4 Ilan J. N. Koppen 0000-0002-1856-0968 5 Marc A. Benninga 0000-0001-9406-9188 6 68685__33306__99080025ee664121bb1a056de9900d25.pdf jpn3.12437.pdf 2025-01-13T14:56:50.5855537 Output 2295338 application/pdf Version of Record true © 2025 The Author(s). This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License (CC BY-NC-ND 4.0). true eng http://creativecommons.org/licenses/by-nc-nd/4.0/
title Prevalence of functional defecation disorders in European children: A systematic review and meta‐analysis
spellingShingle Prevalence of functional defecation disorders in European children: A systematic review and meta‐analysis
Stephen Roberts
title_short Prevalence of functional defecation disorders in European children: A systematic review and meta‐analysis
title_full Prevalence of functional defecation disorders in European children: A systematic review and meta‐analysis
title_fullStr Prevalence of functional defecation disorders in European children: A systematic review and meta‐analysis
title_full_unstemmed Prevalence of functional defecation disorders in European children: A systematic review and meta‐analysis
title_sort Prevalence of functional defecation disorders in European children: A systematic review and meta‐analysis
author_id_str_mv cb60dd928f72fe7ea03595dab995f070
author_id_fullname_str_mv cb60dd928f72fe7ea03595dab995f070_***_Stephen Roberts
author Stephen Roberts
author2 Michelle N. Bloem
Desiree F. Baaleman
Nikhil Thapar
Stephen Roberts
Ilan J. N. Koppen
Marc A. Benninga
format Journal article
container_title Journal of Pediatric Gastroenterology and Nutrition
container_volume 0
container_start_page 1
publishDate 2025
institution Swansea University
issn 0277-2116
1536-4801
doi_str_mv 10.1002/jpn3.12437
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Health Data Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Health Data Science
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description Objectives: Functional defecation disorders (FDDs) are common among children worldwide. The prevalence of these disorders has not been clearly described in Europe. This study performed a systematic review and meta‐analysis on the prevalence of FDD in European children and assessed geographical, age, and sex distribution and associated factors. Methods: PubMed, Embase, Psycinfo, Cochrane Library, and Cinahl were searched from 1999 to July 2023. Included studies were (1) prospective or cross‐sectional studies of European population‐based samples; (2) reporting the prevalence of infant dyschezia (ID) according to Rome II, III, or IV criteria or functional constipation (FC) or functional non‐retentive fecal incontinence (FNRFI) according to Rome III or IV criteria; (3) aged 0–18 years; and (4) published in English, Dutch or Spanish. PRISMA guidelines for extracting data and assessing data quality were followed. Results: Twenty‐eight studies were included. Pooled prevalence was 6.9% (95% confidence interval [CI]: 3.1%–11.9%) for ID in infants 0–12 months (9 studies, n = 5611), 8.17% (95% CI: 6.33%–10.22%) for FC in children <4 years (25 studies, n = 35,189), 11.39% (95% CI: 9.34%–14.11%) for FC in children 4–18 years, and 0.24% (95% CI: 0.07%–0.49%) for FNRFI in children 4–18 years (7 studies, n = 16,873). No sex predominance was found for FC. FC prevalence did not differ significantly when diagnosed according to Rome III versus IV. FC prevalence differed between countries, with greatest rates in Italy, Germany, and Spain. No meta‐analysis could be performed on other factors associated with FDD. Conclusions: FDD is common in European children. Future longitudinal studies are needed to provide better insight into associated factors in pathogenesis.
published_date 2025-01-08T08:22:17Z
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score 11.059807

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