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War and peace: exploring microbial defence systems as a source of new antimicrobial therapies

Paul Dyson Orcid Logo, Ibrahim M. Banat, Gerry A. Quinn

Frontiers in Pharmacology, Volume: 15

Swansea University Author: Paul Dyson Orcid Logo

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DOI (Published version): 10.3389/fphar.2024.1504901

Abstract

The WHO has compiled a list of pathogens that urgently require new antibiotics in response to the rising reports of antibiotic resistance and a diminished supply of new antibiotics. At the top of this list is fluoroquinolone-resistant Salmonella typhi, fluoroquinolone-resistant Shigella spp. and van...

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Published in: Frontiers in Pharmacology
ISSN: 1663-9812
Published: Frontiers Media SA 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa68688
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spelling 2025-01-13T15:56:38.7112796 v2 68688 2025-01-13 War and peace: exploring microbial defence systems as a source of new antimicrobial therapies 300e3f46b70ae83f563b24f41d00cd17 0000-0002-0558-2666 Paul Dyson Paul Dyson true false 2025-01-13 MEDS The WHO has compiled a list of pathogens that urgently require new antibiotics in response to the rising reports of antibiotic resistance and a diminished supply of new antibiotics. At the top of this list is fluoroquinolone-resistant Salmonella typhi, fluoroquinolone-resistant Shigella spp. and vancomycin-resistant Enterococcus faecium. Although these problems have been covered in great detail by other contemporary reviews, there are still some fundamental gaps in the translation of current knowledge of the infectious process and the molecular ecology of antibiotic production into a sustainable protocol for the treatment of pathogenic diseases. Therefore, in this narrative review we briefly discuss newly approved antimicrobial drugs (since 2014) that could help to alleviate the burden of multiresistant pathogens listed on the WHO priority list. Being conscious that such treatments may eventually run the risk of future cycles of resistance, we also discuss how new understandings in the molecular ecology of antibiotic production and the disease process can be harnessed to create a more sustainable solution for the treatment of pathogenic diseases. Journal Article Frontiers in Pharmacology 15 Frontiers Media SA 1663-9812 7 1 2025 2025-01-07 10.3389/fphar.2024.1504901 https://doi.org/10.3389/fphar.2024.1504901 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Not Required N/A 2025-01-13T15:56:38.7112796 2025-01-13T15:48:10.9801998 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Paul Dyson 0000-0002-0558-2666 1 Ibrahim M. Banat 2 Gerry A. Quinn 3
title War and peace: exploring microbial defence systems as a source of new antimicrobial therapies
spellingShingle War and peace: exploring microbial defence systems as a source of new antimicrobial therapies
Paul Dyson
title_short War and peace: exploring microbial defence systems as a source of new antimicrobial therapies
title_full War and peace: exploring microbial defence systems as a source of new antimicrobial therapies
title_fullStr War and peace: exploring microbial defence systems as a source of new antimicrobial therapies
title_full_unstemmed War and peace: exploring microbial defence systems as a source of new antimicrobial therapies
title_sort War and peace: exploring microbial defence systems as a source of new antimicrobial therapies
author_id_str_mv 300e3f46b70ae83f563b24f41d00cd17
author_id_fullname_str_mv 300e3f46b70ae83f563b24f41d00cd17_***_Paul Dyson
author Paul Dyson
author2 Paul Dyson
Ibrahim M. Banat
Gerry A. Quinn
format Journal article
container_title Frontiers in Pharmacology
container_volume 15
publishDate 2025
institution Swansea University
issn 1663-9812
doi_str_mv 10.3389/fphar.2024.1504901
publisher Frontiers Media SA
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
url https://doi.org/10.3389/fphar.2024.1504901
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description The WHO has compiled a list of pathogens that urgently require new antibiotics in response to the rising reports of antibiotic resistance and a diminished supply of new antibiotics. At the top of this list is fluoroquinolone-resistant Salmonella typhi, fluoroquinolone-resistant Shigella spp. and vancomycin-resistant Enterococcus faecium. Although these problems have been covered in great detail by other contemporary reviews, there are still some fundamental gaps in the translation of current knowledge of the infectious process and the molecular ecology of antibiotic production into a sustainable protocol for the treatment of pathogenic diseases. Therefore, in this narrative review we briefly discuss newly approved antimicrobial drugs (since 2014) that could help to alleviate the burden of multiresistant pathogens listed on the WHO priority list. Being conscious that such treatments may eventually run the risk of future cycles of resistance, we also discuss how new understandings in the molecular ecology of antibiotic production and the disease process can be harnessed to create a more sustainable solution for the treatment of pathogenic diseases.
published_date 2025-01-07T20:37:14Z
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