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Morphology, repulsion, and ordering of red blood cells in viscoelastic flows under confinement

Steffen M. Recktenwald Orcid Logo, Yazdan Rashidi Orcid Logo, Ian Graham, Paulo E. Arratia Orcid Logo, Francesco Del Giudice Orcid Logo, Christian Wagner

Soft Matter, Volume: 20, Issue: 25, Pages: 4950 - 4963

Swansea University Author: Francesco Del Giudice Orcid Logo

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DOI (Published version): 10.1039/d4sm00446a

Abstract

Red blood cells (RBC), the primary carriers of oxygen in the body, play a crucial role across several biomedical applications, while also being an essential model system of a deformable object in the microfluidics and soft matter fields. However, RBC behavior in viscoelastic liquids, which holds pro...

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Published in: Soft Matter
ISSN: 1744-683X 1744-6848
Published: Royal Society of Chemistry (RSC) 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa69170
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spelling 2025-04-08T12:31:39.9522442 v2 69170 2025-03-28 Morphology, repulsion, and ordering of red blood cells in viscoelastic flows under confinement 742d483071479b44d7888e16166b1309 0000-0002-9414-6937 Francesco Del Giudice Francesco Del Giudice true false 2025-03-28 EAAS Red blood cells (RBC), the primary carriers of oxygen in the body, play a crucial role across several biomedical applications, while also being an essential model system of a deformable object in the microfluidics and soft matter fields. However, RBC behavior in viscoelastic liquids, which holds promise in enhancing microfluidic diagnostic applications, remains poorly studied. We here show that using viscoelastic polymer solutions as a suspending carrier causes changes in the clustering and shape of flowing RBC in microfluidic flows when compared to a standard Newtonian suspending liquid. Additionally, when the local RBC concentration increases to a point where hydrodynamic interactions take place, we observe the formation of equally-spaced RBC structures, resembling the viscoelasticity-driven ordered particles observed previously in the literature, thus providing the first experimental evidence of viscoelasticity-driven cell ordering. The observed RBC ordering, unaffected by polymer molecular architecture, persists as long as the surrounding medium exhibits shear-thinning, viscoelastic properties. Complementary numerical simulations reveal that viscoelasticity-induced repulsion between RBCs leads to equidistant structures, with shear-thinning modulating this effect. Our results open the way for the development of new biomedical technologies based on the use of viscoelastic liquids while also clarifying fundamental aspects related to multibody hydrodynamic interactions in viscoelastic microfluidic flows. Journal Article Soft Matter 20 25 4950 4963 Royal Society of Chemistry (RSC) 1744-683X 1744-6848 14 6 2024 2024-06-14 10.1039/d4sm00446a COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University Another institution paid the OA fee This research was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – project number 349558021 (WA 1336/13-1 and RE 5025/1-2). Y. R. acknowledges funding by the Marie Skłodowska-Curie grant agreement no. 860436—EVIDENCE. F. D. G. acknowledges partial support from EPSRC (Grant no. EP/S036490/1). 2025-04-08T12:31:39.9522442 2025-03-28T16:16:16.9452369 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Steffen M. Recktenwald 0000-0003-1235-1521 1 Yazdan Rashidi 0000-0002-6438-8636 2 Ian Graham 3 Paulo E. Arratia 0000-0002-2566-2663 4 Francesco Del Giudice 0000-0002-9414-6937 5 Christian Wagner 6 69170__33901__49a9ec657f4347d19c61be9b50d85f99.pdf 69170.pdf 2025-03-28T16:19:05.9778063 Output 3852690 application/pdf Version of Record true This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. true eng http://creativecommons.org/licenses/by/3.0/
title Morphology, repulsion, and ordering of red blood cells in viscoelastic flows under confinement
spellingShingle Morphology, repulsion, and ordering of red blood cells in viscoelastic flows under confinement
Francesco Del Giudice
title_short Morphology, repulsion, and ordering of red blood cells in viscoelastic flows under confinement
title_full Morphology, repulsion, and ordering of red blood cells in viscoelastic flows under confinement
title_fullStr Morphology, repulsion, and ordering of red blood cells in viscoelastic flows under confinement
title_full_unstemmed Morphology, repulsion, and ordering of red blood cells in viscoelastic flows under confinement
title_sort Morphology, repulsion, and ordering of red blood cells in viscoelastic flows under confinement
author_id_str_mv 742d483071479b44d7888e16166b1309
author_id_fullname_str_mv 742d483071479b44d7888e16166b1309_***_Francesco Del Giudice
author Francesco Del Giudice
author2 Steffen M. Recktenwald
Yazdan Rashidi
Ian Graham
Paulo E. Arratia
Francesco Del Giudice
Christian Wagner
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container_title Soft Matter
container_volume 20
container_issue 25
container_start_page 4950
publishDate 2024
institution Swansea University
issn 1744-683X
1744-6848
doi_str_mv 10.1039/d4sm00446a
publisher Royal Society of Chemistry (RSC)
college_str Faculty of Science and Engineering
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hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
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description Red blood cells (RBC), the primary carriers of oxygen in the body, play a crucial role across several biomedical applications, while also being an essential model system of a deformable object in the microfluidics and soft matter fields. However, RBC behavior in viscoelastic liquids, which holds promise in enhancing microfluidic diagnostic applications, remains poorly studied. We here show that using viscoelastic polymer solutions as a suspending carrier causes changes in the clustering and shape of flowing RBC in microfluidic flows when compared to a standard Newtonian suspending liquid. Additionally, when the local RBC concentration increases to a point where hydrodynamic interactions take place, we observe the formation of equally-spaced RBC structures, resembling the viscoelasticity-driven ordered particles observed previously in the literature, thus providing the first experimental evidence of viscoelasticity-driven cell ordering. The observed RBC ordering, unaffected by polymer molecular architecture, persists as long as the surrounding medium exhibits shear-thinning, viscoelastic properties. Complementary numerical simulations reveal that viscoelasticity-induced repulsion between RBCs leads to equidistant structures, with shear-thinning modulating this effect. Our results open the way for the development of new biomedical technologies based on the use of viscoelastic liquids while also clarifying fundamental aspects related to multibody hydrodynamic interactions in viscoelastic microfluidic flows.
published_date 2024-06-14T06:22:45Z
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