No Cover Image

Journal article 176 views 36 downloads

Organoid‐tissue extracellular vesicles

Han Liu, Ting Cheng, Guangfeng Li, Zhidao Xia Orcid Logo, Chenglong Wang, Ke Xu, Jiacan Su

Interdisciplinary Medicine, Start page: e20250006

Swansea University Author: Zhidao Xia Orcid Logo

  • INMD.20250006.pdf

    PDF | Version of Record

    © 2025 The Author(s). Interdisciplinary Medicine published by Wiley-VCH GmbH on behalf of Nanfang Hospital, Southern Medical University. This is an open access article under the terms of the Creative Commons Attribution (CC BY) License.

    Download (3.58MB)

Check full text

DOI (Published version): 10.1002/inmd.20250006

Abstract

Extracellular vesicles (EVs) are lipid bilayer structures secreted by cells that act as intercellular messengers. Tissue‐derived EVs (TEVs), harvested from the tissue interstitium, directly reflect the actual physiological or pathological state of the tissue microenvironment. However, the difficulty...

Full description

Published in: Interdisciplinary Medicine
ISSN: 2832-6245
Published: Wiley 2025
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa69452
first_indexed 2025-05-08T11:37:50Z
last_indexed 2025-05-09T07:04:50Z
id cronfa69452
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2025-05-08T12:39:34.1884707</datestamp><bib-version>v2</bib-version><id>69452</id><entry>2025-05-08</entry><title>Organoid&#x2010;tissue extracellular vesicles</title><swanseaauthors><author><sid>c9307abfed1b43987a19da0c0e30d7a4</sid><ORCID>0000-0002-2047-7282</ORCID><firstname>Zhidao</firstname><surname>Xia</surname><name>Zhidao Xia</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2025-05-08</date><deptcode>MEDS</deptcode><abstract>Extracellular vesicles (EVs) are lipid bilayer structures secreted by cells that act as intercellular messengers. Tissue&#x2010;derived EVs (TEVs), harvested from the tissue interstitium, directly reflect the actual physiological or pathological state of the tissue microenvironment. However, the difficulty in tissue acquisition severely limits the development of TEVs. In contrast, organoids are 3D cell clusters cultured from stem cells, which have spatial structures and physiological functions that are highly similar to the source tissues. Although organoid&#x2010;derived EVs (OEVs), isolated from culture supernatants, can reflect complex cellular interactions, they cannot directly reflect the state of the tissue microenvironment like TEVs. Building on the foundation of TEVs and OEVs, we introduce the innovative concept of organoid&#x2010;tissue EVs (OTEVs), where residing in the organoid interstitium. Acting as a communication bridge between OEVs and TEVs, OTEVs can accurately represent the true microenvironment. They overcome the challenges associated with the limited availability of TEVs and the inability of OEVs to directly reflect the microenvironment. We believe that OTEVs will synergize with TEVs and OEVs to enhance the understanding of the pathogenesis of complex diseases, as well as to improve their diagnosis and treatment.</abstract><type>Journal Article</type><journal>Interdisciplinary Medicine</journal><volume>0</volume><journalNumber/><paginationStart>e20250006</paginationStart><paginationEnd/><publisher>Wiley</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>2832-6245</issnElectronic><keywords>diseases diagnosis and treatment, extracellular vesicles, organoid extracellular vesicles, tissue extracellular vesicles</keywords><publishedDay>4</publishedDay><publishedMonth>5</publishedMonth><publishedYear>2025</publishedYear><publishedDate>2025-05-04</publishedDate><doi>10.1002/inmd.20250006</doi><url/><notes>Review</notes><college>COLLEGE NANME</college><department>Medical School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDS</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>This work was supported in part by grants from the Key program of the National Natural Science Foundation of China (82230071); National Natural Science Foundation of China (82202344); Jiangsu Province Natural Science Foundation project (BK20241808); Fujian Province Natural Science Foundation project (2024J01221).</funders><projectreference/><lastEdited>2025-05-08T12:39:34.1884707</lastEdited><Created>2025-05-08T12:31:44.3580542</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Biomedical Science</level></path><authors><author><firstname>Han</firstname><surname>Liu</surname><order>1</order></author><author><firstname>Ting</firstname><surname>Cheng</surname><order>2</order></author><author><firstname>Guangfeng</firstname><surname>Li</surname><order>3</order></author><author><firstname>Zhidao</firstname><surname>Xia</surname><orcid>0000-0002-2047-7282</orcid><order>4</order></author><author><firstname>Chenglong</firstname><surname>Wang</surname><order>5</order></author><author><firstname>Ke</firstname><surname>Xu</surname><order>6</order></author><author><firstname>Jiacan</firstname><surname>Su</surname><order>7</order></author></authors><documents><document><filename>69452__34202__ef9228c0e2174788b779374da76a96ce.pdf</filename><originalFilename>INMD.20250006.pdf</originalFilename><uploaded>2025-05-08T12:31:44.3541846</uploaded><type>Output</type><contentLength>3750687</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>&#xA9; 2025 The Author(s). Interdisciplinary Medicine published by Wiley-VCH GmbH on behalf of Nanfang Hospital, Southern Medical University. This is an open access article under the terms of the Creative Commons Attribution (CC BY) License.</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2025-05-08T12:39:34.1884707 v2 69452 2025-05-08 Organoid‐tissue extracellular vesicles c9307abfed1b43987a19da0c0e30d7a4 0000-0002-2047-7282 Zhidao Xia Zhidao Xia true false 2025-05-08 MEDS Extracellular vesicles (EVs) are lipid bilayer structures secreted by cells that act as intercellular messengers. Tissue‐derived EVs (TEVs), harvested from the tissue interstitium, directly reflect the actual physiological or pathological state of the tissue microenvironment. However, the difficulty in tissue acquisition severely limits the development of TEVs. In contrast, organoids are 3D cell clusters cultured from stem cells, which have spatial structures and physiological functions that are highly similar to the source tissues. Although organoid‐derived EVs (OEVs), isolated from culture supernatants, can reflect complex cellular interactions, they cannot directly reflect the state of the tissue microenvironment like TEVs. Building on the foundation of TEVs and OEVs, we introduce the innovative concept of organoid‐tissue EVs (OTEVs), where residing in the organoid interstitium. Acting as a communication bridge between OEVs and TEVs, OTEVs can accurately represent the true microenvironment. They overcome the challenges associated with the limited availability of TEVs and the inability of OEVs to directly reflect the microenvironment. We believe that OTEVs will synergize with TEVs and OEVs to enhance the understanding of the pathogenesis of complex diseases, as well as to improve their diagnosis and treatment. Journal Article Interdisciplinary Medicine 0 e20250006 Wiley 2832-6245 diseases diagnosis and treatment, extracellular vesicles, organoid extracellular vesicles, tissue extracellular vesicles 4 5 2025 2025-05-04 10.1002/inmd.20250006 Review COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee This work was supported in part by grants from the Key program of the National Natural Science Foundation of China (82230071); National Natural Science Foundation of China (82202344); Jiangsu Province Natural Science Foundation project (BK20241808); Fujian Province Natural Science Foundation project (2024J01221). 2025-05-08T12:39:34.1884707 2025-05-08T12:31:44.3580542 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Han Liu 1 Ting Cheng 2 Guangfeng Li 3 Zhidao Xia 0000-0002-2047-7282 4 Chenglong Wang 5 Ke Xu 6 Jiacan Su 7 69452__34202__ef9228c0e2174788b779374da76a96ce.pdf INMD.20250006.pdf 2025-05-08T12:31:44.3541846 Output 3750687 application/pdf Version of Record true © 2025 The Author(s). Interdisciplinary Medicine published by Wiley-VCH GmbH on behalf of Nanfang Hospital, Southern Medical University. This is an open access article under the terms of the Creative Commons Attribution (CC BY) License. true eng http://creativecommons.org/licenses/by/4.0/
title Organoid‐tissue extracellular vesicles
spellingShingle Organoid‐tissue extracellular vesicles
Zhidao Xia
title_short Organoid‐tissue extracellular vesicles
title_full Organoid‐tissue extracellular vesicles
title_fullStr Organoid‐tissue extracellular vesicles
title_full_unstemmed Organoid‐tissue extracellular vesicles
title_sort Organoid‐tissue extracellular vesicles
author_id_str_mv c9307abfed1b43987a19da0c0e30d7a4
author_id_fullname_str_mv c9307abfed1b43987a19da0c0e30d7a4_***_Zhidao Xia
author Zhidao Xia
author2 Han Liu
Ting Cheng
Guangfeng Li
Zhidao Xia
Chenglong Wang
Ke Xu
Jiacan Su
format Journal article
container_title Interdisciplinary Medicine
container_volume 0
container_start_page e20250006
publishDate 2025
institution Swansea University
issn 2832-6245
doi_str_mv 10.1002/inmd.20250006
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
document_store_str 1
active_str 0
description Extracellular vesicles (EVs) are lipid bilayer structures secreted by cells that act as intercellular messengers. Tissue‐derived EVs (TEVs), harvested from the tissue interstitium, directly reflect the actual physiological or pathological state of the tissue microenvironment. However, the difficulty in tissue acquisition severely limits the development of TEVs. In contrast, organoids are 3D cell clusters cultured from stem cells, which have spatial structures and physiological functions that are highly similar to the source tissues. Although organoid‐derived EVs (OEVs), isolated from culture supernatants, can reflect complex cellular interactions, they cannot directly reflect the state of the tissue microenvironment like TEVs. Building on the foundation of TEVs and OEVs, we introduce the innovative concept of organoid‐tissue EVs (OTEVs), where residing in the organoid interstitium. Acting as a communication bridge between OEVs and TEVs, OTEVs can accurately represent the true microenvironment. They overcome the challenges associated with the limited availability of TEVs and the inability of OEVs to directly reflect the microenvironment. We believe that OTEVs will synergize with TEVs and OEVs to enhance the understanding of the pathogenesis of complex diseases, as well as to improve their diagnosis and treatment.
published_date 2025-05-04T05:47:24Z
_version_ 1835693815752556544
score 11.065032

Similar Items