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E-Thesis 366 views

Sleep, Memory, Cognition and Wellbeing in Participants with Vascular Dementia and in Healthy Older and Younger Adults / Chloe Tulip

Swansea University Author: Chloe Tulip

  • E-Thesis – open access under embargo until: 7th May 2026

DOI (Published version): 10.23889/SUthesis.69454

Abstract

Vascular Cognitive Impairment (VCI) is the second most common form of dementia and may be the most prevalent due to evolving diagnostic criteria. However, the relationship between sleep disturbances, cognitive decline, and wellbeing in VCI remains poorly understood. While evidence highlights the rol...

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Published: Swansea, Wales, UK 2025
Institution: Swansea University
Degree level: Doctoral
Degree name: Ph.D
Supervisor: Blagrove, Mark ; Tales, Andrea ; Playfoot, David
URI: https://cronfa.swan.ac.uk/Record/cronfa69454
first_indexed 2025-05-08T12:04:45Z
last_indexed 2025-05-09T07:04:51Z
id cronfa69454
recordtype RisThesis
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While evidence highlights the role of sleep in cognitive health, most research has focused on Alzheimer&#x2019;s disease, overlooking how sleep disturbances uniquely affect VCI. This thesis addresses this gap through studies aimed at understanding and improving sleep and wellbeing in VCI populations. Chapter 1 utilised the National Alzheimer's Coordinating Center Uniform Data Set to show that individuals with Vascular Dementia (VaD) and sleep disturbances had significantly poorer performance in orientation, memory, executive function, and global cognition compared to those without sleep disturbances, highlighting the importance of considering sleep disturbances in VCI diagnosis and management. Chapter 2 develops and validates a narrative-based emotional memory task in healthy young adults to assess sleep-dependent memory consolidation designed for future use in VCI populations. Findings show enhanced declarative memory following sleep compared to wakefulness; however, the expected preferential consolidation of emotional over neutral content was not observed. To support future research in clinical populations, including VCI, an automatic scoring tool was developed to improve narrative analysis efficiency and reliability. Chapter 3 evaluates a bedtime fiction reading intervention, showing improved subjective sleep quality and objective Total Sleep Time in healthy older adults and those with subjective cognitive decline, with differing effects on wellbeing. A feasibility study with VaD participants confirmed its applicability in VCI. Chapter 4 explores online recruitment and retention challenges in older adults, offering recommendations to enhance participant retention and study design. 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spelling 2025-05-08T13:21:46.4273998 v2 69454 2025-05-08 Sleep, Memory, Cognition and Wellbeing in Participants with Vascular Dementia and in Healthy Older and Younger Adults dfa53c1d2be8eaecddb116e84b204561 0000-0002-8335-3842 Chloe Tulip Chloe Tulip true false 2025-05-08 MEDS Vascular Cognitive Impairment (VCI) is the second most common form of dementia and may be the most prevalent due to evolving diagnostic criteria. However, the relationship between sleep disturbances, cognitive decline, and wellbeing in VCI remains poorly understood. While evidence highlights the role of sleep in cognitive health, most research has focused on Alzheimer’s disease, overlooking how sleep disturbances uniquely affect VCI. This thesis addresses this gap through studies aimed at understanding and improving sleep and wellbeing in VCI populations. Chapter 1 utilised the National Alzheimer's Coordinating Center Uniform Data Set to show that individuals with Vascular Dementia (VaD) and sleep disturbances had significantly poorer performance in orientation, memory, executive function, and global cognition compared to those without sleep disturbances, highlighting the importance of considering sleep disturbances in VCI diagnosis and management. Chapter 2 develops and validates a narrative-based emotional memory task in healthy young adults to assess sleep-dependent memory consolidation designed for future use in VCI populations. Findings show enhanced declarative memory following sleep compared to wakefulness; however, the expected preferential consolidation of emotional over neutral content was not observed. To support future research in clinical populations, including VCI, an automatic scoring tool was developed to improve narrative analysis efficiency and reliability. Chapter 3 evaluates a bedtime fiction reading intervention, showing improved subjective sleep quality and objective Total Sleep Time in healthy older adults and those with subjective cognitive decline, with differing effects on wellbeing. A feasibility study with VaD participants confirmed its applicability in VCI. Chapter 4 explores online recruitment and retention challenges in older adults, offering recommendations to enhance participant retention and study design. Collectively, this thesis advances understanding of how sleep disturbances contribute to cognitive and wellbeing outcomes in VCI and highlights the potential of non-pharmacological interventions to improve sleep and wellbeing in this under-researched population. E-Thesis Swansea, Wales, UK Sleep, Cognition, Memory, Vascular Cognitive Impairment, Vascular Dementia, Mild Cognitive Impairment, Subjective Cognitive Decline, Sleep intervention, Fiction, Reading, Emotional Memory Consolidation, Wellbeing, Mild Cognitive Impairment 7 5 2025 2025-05-07 10.23889/SUthesis.69454 ORCiD identifier: https://orcid.org/0000-0002-8335-3842 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Blagrove, Mark ; Tales, Andrea ; Playfoot, David Doctoral Ph.D BRACE Alzheimer’s Research BRACE Alzheimer’s Research 2025-05-08T13:21:46.4273998 2025-05-08T12:57:52.0069427 Faculty of Medicine, Health and Life Sciences School of Psychology Chloe Tulip 0000-0002-8335-3842 1 Under embargo Under embargo 2025-05-08T13:18:27.7311007 Output 6376940 application/pdf E-Thesis – open access true 2026-05-07T00:00:00.0000000 Copyright: The Author, Chloe Rosalie Summer Tulip, 2025. true eng
title Sleep, Memory, Cognition and Wellbeing in Participants with Vascular Dementia and in Healthy Older and Younger Adults
spellingShingle Sleep, Memory, Cognition and Wellbeing in Participants with Vascular Dementia and in Healthy Older and Younger Adults
Chloe Tulip
title_short Sleep, Memory, Cognition and Wellbeing in Participants with Vascular Dementia and in Healthy Older and Younger Adults
title_full Sleep, Memory, Cognition and Wellbeing in Participants with Vascular Dementia and in Healthy Older and Younger Adults
title_fullStr Sleep, Memory, Cognition and Wellbeing in Participants with Vascular Dementia and in Healthy Older and Younger Adults
title_full_unstemmed Sleep, Memory, Cognition and Wellbeing in Participants with Vascular Dementia and in Healthy Older and Younger Adults
title_sort Sleep, Memory, Cognition and Wellbeing in Participants with Vascular Dementia and in Healthy Older and Younger Adults
author_id_str_mv dfa53c1d2be8eaecddb116e84b204561
author_id_fullname_str_mv dfa53c1d2be8eaecddb116e84b204561_***_Chloe Tulip
author Chloe Tulip
author2 Chloe Tulip
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publishDate 2025
institution Swansea University
doi_str_mv 10.23889/SUthesis.69454
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
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description Vascular Cognitive Impairment (VCI) is the second most common form of dementia and may be the most prevalent due to evolving diagnostic criteria. However, the relationship between sleep disturbances, cognitive decline, and wellbeing in VCI remains poorly understood. While evidence highlights the role of sleep in cognitive health, most research has focused on Alzheimer’s disease, overlooking how sleep disturbances uniquely affect VCI. This thesis addresses this gap through studies aimed at understanding and improving sleep and wellbeing in VCI populations. Chapter 1 utilised the National Alzheimer's Coordinating Center Uniform Data Set to show that individuals with Vascular Dementia (VaD) and sleep disturbances had significantly poorer performance in orientation, memory, executive function, and global cognition compared to those without sleep disturbances, highlighting the importance of considering sleep disturbances in VCI diagnosis and management. Chapter 2 develops and validates a narrative-based emotional memory task in healthy young adults to assess sleep-dependent memory consolidation designed for future use in VCI populations. Findings show enhanced declarative memory following sleep compared to wakefulness; however, the expected preferential consolidation of emotional over neutral content was not observed. To support future research in clinical populations, including VCI, an automatic scoring tool was developed to improve narrative analysis efficiency and reliability. Chapter 3 evaluates a bedtime fiction reading intervention, showing improved subjective sleep quality and objective Total Sleep Time in healthy older adults and those with subjective cognitive decline, with differing effects on wellbeing. A feasibility study with VaD participants confirmed its applicability in VCI. Chapter 4 explores online recruitment and retention challenges in older adults, offering recommendations to enhance participant retention and study design. Collectively, this thesis advances understanding of how sleep disturbances contribute to cognitive and wellbeing outcomes in VCI and highlights the potential of non-pharmacological interventions to improve sleep and wellbeing in this under-researched population.
published_date 2025-05-07T06:42:08Z
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score 11.096913

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